Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Lysosomal-associated transmembrane protein 4A

Gene

LAPTM4A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment.By similarity

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosomal-associated transmembrane protein 4A
Alternative name(s):
Golgi 4-transmembrane-spanning transporter MTP
Gene namesi
Name:LAPTM4A
Synonyms:KIAA0108, LAPTM4, MBNT, MTRP
ORF Names:UNQ1846/PRO3574
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000068697.6
HGNCiHGNC:6924 LAPTM4A
neXtProtiNX_Q15012

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei29 – 49HelicalSequence analysisAdd BLAST21
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Transmembranei108 – 128HelicalSequence analysisAdd BLAST21
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000068697
PharmGKBiPA30295

Polymorphism and mutation databases

BioMutaiLAPTM4A
DMDMi3122413

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000966371 – 233Lysosomal-associated transmembrane protein 4AAdd BLAST233

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ15012
PaxDbiQ15012
PeptideAtlasiQ15012
PRIDEiQ15012
ProteomicsDBi60364

PTM databases

iPTMnetiQ15012
PhosphoSitePlusiQ15012
SwissPalmiQ15012

Expressioni

Gene expression databases

BgeeiENSG00000068697 Expressed in 248 organ(s), highest expression level in seminal vesicle
CleanExiHS_LAPTM4A
ExpressionAtlasiQ15012 baseline and differential
GenevisibleiQ15012 HS

Organism-specific databases

HPAiHPA031402
HPA031404
HPA068554

Interactioni

Protein-protein interaction databases

BioGridi115089, 13 interactors
IntActiQ15012, 9 interactors
MINTiQ15012
STRINGi9606.ENSP00000175091

Structurei

3D structure databases

ProteinModelPortaliQ15012
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi226 – 229Poly-Pro4

Domaini

The C-terminal domain is necessary for retention within intracellular membranes.By similarity

Sequence similaritiesi

Belongs to the LAPTM4/LAPTM5 transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEGH Eukaryota
ENOG4111K1Z LUCA
GeneTreeiENSGT00390000013359
HOGENOMiHOG000007698
HOVERGENiHBG000908
InParanoidiQ15012
KOiK12387
OMAiFTISAMM
OrthoDBiEOG091G0MA5
PhylomeDBiQ15012
TreeFamiTF330843

Family and domain databases

InterProiView protein in InterPro
IPR004687 LAPTM4/5
IPR018396 LAPTM_4A/5
PfamiView protein in Pfam
PF03821 Mtp, 2 hits
TIGRFAMsiTIGR00799 mtp, 1 hit

Sequencei

Sequence statusi: Complete.

Q15012-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVSMSFKRNR SDRFYSTRCC GCCHVRTGTI ILGTWYMVVN LLMAILLTVE
60 70 80 90 100
VTHPNSMPAV NIQYEVIGNY YSSERMADNA CVLFAVSVLM FIISSMLVYG
110 120 130 140 150
AISYQVGWLI PFFCYRLFDF VLSCLVAISS LTYLPRIKEY LDQLPDFPYK
160 170 180 190 200
DDLLALDSSC LLFIVLVFFA LFIIFKAYLI NCVWNCYKYI NNRNVPEIAV
210 220 230
YPAFEAPPQY VLPTYEMAVK MPEKEPPPPY LPA
Length:233
Mass (Da):26,801
Last modified:November 1, 1996 - v1
Checksum:i9BB76152B6E1365E
GO

Sequence cautioni

The sequence AAQ89387 differs from that shown. Reason: Frameshift at position 206.Curated
The sequence BAA03522 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14696 mRNA Translation: BAA03522.2 Different initiation.
AY359028 mRNA Translation: AAQ89387.1 Frameshift.
BC000421 mRNA Translation: AAH00421.1
CCDSiCCDS1696.1
RefSeqiNP_055528.1, NM_014713.4
UniGeneiHs.467807

Genome annotation databases

EnsembliENST00000175091; ENSP00000175091; ENSG00000068697
GeneIDi9741
KEGGihsa:9741

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14696 mRNA Translation: BAA03522.2 Different initiation.
AY359028 mRNA Translation: AAQ89387.1 Frameshift.
BC000421 mRNA Translation: AAH00421.1
CCDSiCCDS1696.1
RefSeqiNP_055528.1, NM_014713.4
UniGeneiHs.467807

3D structure databases

ProteinModelPortaliQ15012
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115089, 13 interactors
IntActiQ15012, 9 interactors
MINTiQ15012
STRINGi9606.ENSP00000175091

PTM databases

iPTMnetiQ15012
PhosphoSitePlusiQ15012
SwissPalmiQ15012

Polymorphism and mutation databases

BioMutaiLAPTM4A
DMDMi3122413

Proteomic databases

EPDiQ15012
PaxDbiQ15012
PeptideAtlasiQ15012
PRIDEiQ15012
ProteomicsDBi60364

Protocols and materials databases

DNASUi9741
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000175091; ENSP00000175091; ENSG00000068697
GeneIDi9741
KEGGihsa:9741

Organism-specific databases

CTDi9741
EuPathDBiHostDB:ENSG00000068697.6
GeneCardsiLAPTM4A
HGNCiHGNC:6924 LAPTM4A
HPAiHPA031402
HPA031404
HPA068554
neXtProtiNX_Q15012
OpenTargetsiENSG00000068697
PharmGKBiPA30295
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEGH Eukaryota
ENOG4111K1Z LUCA
GeneTreeiENSGT00390000013359
HOGENOMiHOG000007698
HOVERGENiHBG000908
InParanoidiQ15012
KOiK12387
OMAiFTISAMM
OrthoDBiEOG091G0MA5
PhylomeDBiQ15012
TreeFamiTF330843

Miscellaneous databases

ChiTaRSiLAPTM4A human
GenomeRNAii9741
PROiPR:Q15012

Gene expression databases

BgeeiENSG00000068697 Expressed in 248 organ(s), highest expression level in seminal vesicle
CleanExiHS_LAPTM4A
ExpressionAtlasiQ15012 baseline and differential
GenevisibleiQ15012 HS

Family and domain databases

InterProiView protein in InterPro
IPR004687 LAPTM4/5
IPR018396 LAPTM_4A/5
PfamiView protein in Pfam
PF03821 Mtp, 2 hits
TIGRFAMsiTIGR00799 mtp, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLAP4A_HUMAN
AccessioniPrimary (citable) accession number: Q15012
Secondary accession number(s): Q6UW22
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again