UniProtKB - Q15008 (PSMD6_HUMAN)
26S proteasome non-ATPase regulatory subunit 6
PSMD6
Functioni
GO - Molecular functioni
- ATPase activity Source: UniProtKB
- enzyme regulator activity Source: InterPro
GO - Biological processi
- anaphase-promoting complex-dependent catabolic process Source: Reactome
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
- Fc-epsilon receptor signaling pathway Source: Reactome
- interleukin-1-mediated signaling pathway Source: Reactome
- MAPK cascade Source: Reactome
- negative regulation of canonical Wnt signaling pathway Source: Reactome
- negative regulation of G2/M transition of mitotic cell cycle Source: Reactome
- neutrophil degranulation Source: Reactome
- NIK/NF-kappaB signaling Source: Reactome
- positive regulation of canonical Wnt signaling pathway Source: Reactome
- post-translational protein modification Source: Reactome
- proteasome-mediated ubiquitin-dependent protein catabolic process Source: GO_Central
- protein deubiquitination Source: Reactome
- protein polyubiquitination Source: Reactome
- proteolysis Source: UniProtKB
- regulation of cellular amino acid metabolic process Source: Reactome
- regulation of hematopoietic stem cell differentiation Source: Reactome
- regulation of mitotic cell cycle phase transition Source: Reactome
- regulation of mRNA stability Source: Reactome
- regulation of transcription from RNA polymerase II promoter in response to hypoxia Source: Reactome
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: Reactome
- stimulatory C-type lectin receptor signaling pathway Source: Reactome
- T cell receptor signaling pathway Source: Reactome
- transmembrane transport Source: Reactome
- tumor necrosis factor-mediated signaling pathway Source: Reactome
- Wnt signaling pathway, planar cell polarity pathway Source: Reactome
Enzyme and pathway databases
PathwayCommonsi | Q15008 |
Reactomei | R-HSA-1169091, Activation of NF-kappaB in B cells R-HSA-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1236974, ER-Phagosome pathway R-HSA-1236978, Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-174084, Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174113, SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174154, APC/C:Cdc20 mediated degradation of Securin R-HSA-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-180534, Vpu mediated degradation of CD4 R-HSA-180585, Vif-mediated degradation of APOBEC3G R-HSA-187577, SCF(Skp2)-mediated degradation of p27/p21 R-HSA-195253, Degradation of beta-catenin by the destruction complex R-HSA-202424, Downstream TCR signaling R-HSA-211733, Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-2467813, Separation of Sister Chromatids R-HSA-2871837, FCERI mediated NF-kB activation R-HSA-349425, Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-350562, Regulation of ornithine decarboxylase (ODC) R-HSA-382556, ABC-family proteins mediated transport R-HSA-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-4608870, Asymmetric localization of PCP proteins R-HSA-4641257, Degradation of AXIN R-HSA-4641258, Degradation of DVL R-HSA-5358346, Hedgehog ligand biogenesis R-HSA-5362768, Hh mutants that don't undergo autocatalytic processing are degraded by ERAD R-HSA-5607761, Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607764, CLEC7A (Dectin-1) signaling R-HSA-5610780, Degradation of GLI1 by the proteasome R-HSA-5610783, Degradation of GLI2 by the proteasome R-HSA-5610785, GLI3 is processed to GLI3R by the proteasome R-HSA-5632684, Hedgehog 'on' state R-HSA-5658442, Regulation of RAS by GAPs R-HSA-5668541, TNFR2 non-canonical NF-kB pathway R-HSA-5676590, NIK-->noncanonical NF-kB signaling R-HSA-5678895, Defective CFTR causes cystic fibrosis R-HSA-5687128, MAPK6/MAPK4 signaling R-HSA-5689603, UCH proteinases R-HSA-5689880, Ub-specific processing proteases R-HSA-6798695, Neutrophil degranulation R-HSA-68827, CDT1 association with the CDC6:ORC:origin complex R-HSA-68949, Orc1 removal from chromatin R-HSA-69017, CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69481, G2/M Checkpoints R-HSA-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-75815, Ubiquitin-dependent degradation of Cyclin D R-HSA-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939902, Regulation of RUNX2 expression and activity R-HSA-8941858, Regulation of RUNX3 expression and activity R-HSA-8948751, Regulation of PTEN stability and activity R-HSA-8951664, Neddylation R-HSA-9010553, Regulation of expression of SLITs and ROBOs R-HSA-9020702, Interleukin-1 signaling R-HSA-9604323, Negative regulation of NOTCH4 signaling R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Names & Taxonomyi
Protein namesi | Recommended name: 26S proteasome non-ATPase regulatory subunit 6Alternative name(s): 26S proteasome regulatory subunit RPN7 26S proteasome regulatory subunit S10 Breast cancer-associated protein SGA-113M Phosphonoformate immuno-associated protein 4 Proteasome regulatory particle subunit p44S10 p42A |
Gene namesi | Name:PSMD6 Synonyms:KIAA0107, PFAAP4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000163636.10 |
HGNCi | HGNC:9564, PSMD6 |
MIMi | 617857, gene |
neXtProti | NX_Q15008 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular region Source: Reactome
Nucleus
- nucleoplasm Source: Reactome
Other locations
- ficolin-1-rich granule lumen Source: Reactome
- proteasome accessory complex Source: UniProtKB
- proteasome complex Source: UniProtKB
- proteasome regulatory particle Source: GO_Central
- secretory granule lumen Source: Reactome
Keywords - Cellular componenti
ProteasomePathology & Biotechi
Organism-specific databases
DisGeNETi | 9861 |
OpenTargetsi | ENSG00000163636 |
PharmGKBi | PA33910 |
Miscellaneous databases
Pharosi | Q15008, Tbio |
Chemistry databases
ChEMBLi | CHEMBL2364701 |
Polymorphism and mutation databases
BioMutai | PSMD6 |
DMDMi | 2494625 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000173838 | 2 – 389 | 26S proteasome non-ATPase regulatory subunit 6Add BLAST | 388 |
Proteomic databases
EPDi | Q15008 |
jPOSTi | Q15008 |
MassIVEi | Q15008 |
MaxQBi | Q15008 |
PaxDbi | Q15008 |
PeptideAtlasi | Q15008 |
PRIDEi | Q15008 |
ProteomicsDBi | 20548 60360 [Q15008-1] 67429 |
TopDownProteomicsi | Q15008-1 [Q15008-1] |
PTM databases
iPTMneti | Q15008 |
MetOSitei | Q15008 |
PhosphoSitePlusi | Q15008 |
SwissPalmi | Q15008 |
Expressioni
Gene expression databases
Bgeei | ENSG00000163636, Expressed in body of pancreas and 242 other tissues |
ExpressionAtlasi | Q15008, baseline and differential |
Genevisiblei | Q15008, HS |
Organism-specific databases
HPAi | ENSG00000163636, Low tissue specificity |
Interactioni
Subunit structurei
Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD6, a base containing 6 ATPases and few additional components.
2 PublicationsBinary interactionsi
Hide detailsQ15008
With | #Exp. | IntAct |
---|---|---|
CMTM7 [Q96FZ5] | 3 | EBI-359701,EBI-2807956 |
GORASP2 [Q9H8Y8] | 5 | EBI-359701,EBI-739467 |
UBQLN1 [Q9UMX0] | 3 | EBI-359701,EBI-741480 |
UBQLN1 - isoform 2 [Q9UMX0-2] | 3 | EBI-359701,EBI-10173939 |
Protein-protein interaction databases
BioGRIDi | 115195, 165 interactors |
CORUMi | Q15008 |
DIPi | DIP-27590N |
IntActi | Q15008, 62 interactors |
MINTi | Q15008 |
Miscellaneous databases
RNActi | Q15008, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 193 – 361 | PCIPROSITE-ProRule annotationAdd BLAST | 169 |
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00510000046608 |
HOGENOMi | CLU_031814_0_0_1 |
InParanoidi | Q15008 |
OMAi | VDYIDQE |
OrthoDBi | 1194691at2759 |
PhylomeDBi | Q15008 |
TreeFami | TF313819 |
Family and domain databases
InterProi | View protein in InterPro IPR000717, PCI_dom IPR035268, PSMD6 IPR019585, Rpn7/CSN1 IPR011990, TPR-like_helical_dom_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR14145:SF1, PTHR14145:SF1, 1 hit |
Pfami | View protein in Pfam PF01399, PCI, 1 hit PF10602, RPN7, 1 hit |
SMARTi | View protein in SMART SM00088, PINT, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF48452, SSF48452, 1 hit |
PROSITEi | View protein in PROSITE PS50250, PCI, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPLENLEEEG LPKNPDLRIA QLRFLLSLPE HRGDAAVRDE LMAAVRDNNM
60 70 80 90 100
APYYEALCKS LDWQIDVDLL NKMKKANEDE LKRLDEELED AEKNLGESEI
110 120 130 140 150
RDAMMAKAEY LCRIGDKEGA LTAFRKTYDK TVALGHRLDI VFYLLRIGLF
160 170 180 190 200
YMDNDLITRN TEKAKSLIEE GGDWDRRNRL KVYQGLYCVA IRDFKQAAEL
210 220 230 240 250
FLDTVSTFTS YELMDYKTFV TYTVYVSMIA LERPDLREKV IKGAEILEVL
260 270 280 290 300
HSLPAVRQYL FSLYECRYSV FFQSLAVVEQ EMKKDWLFAP HYRYYVREMR
310 320 330 340 350
IHAYSQLLES YRSLTLGYMA EAFGVGVEFI DQELSRFIAA GRLHCKIDKV
360 370 380
NEIVETNRPD SKNWQYQETI KKGDLLLNRV QKLSRVINM
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9J0E9 | C9J0E9_HUMAN | 26S proteasome non-ATPase regulator... | PSMD6 | 226 | Annotation score: | ||
C9J7B7 | C9J7B7_HUMAN | 26S proteasome non-ATPase regulator... | PSMD6 | 144 | Annotation score: | ||
H7C531 | H7C531_HUMAN | 26S proteasome non-ATPase regulator... | PSMD6 | 138 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_047711 | 1 – 49 | MPLEN…VRDNN → MNESNDSTNYD in isoform 2. 1 PublicationAdd BLAST | 49 | |
Alternative sequenceiVSP_055177 | 10 – 49 | GLPKN…VRDNN → D in isoform 3. CuratedAdd BLAST | 40 | |
Alternative sequenceiVSP_055178 | 49 | N → NFWNRIRQEQTEDCPPSSPS RGWHCQDWPSRKPPTSIRLC FAKPIIKRHRMPSY in isoform 4. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF215935 mRNA Translation: AAF65540.1 AF530062 mRNA Translation: AAQ09946.1 AY359879 mRNA Translation: AAQ63402.1 AY568086 mRNA Translation: AAS68366.1 D14663 mRNA Translation: BAA03497.1 BX647742 mRNA No translation available. AK290205 mRNA Translation: BAF82894.1 AC012557 Genomic DNA No translation available. CH471055 Genomic DNA Translation: EAW65424.1 CH471055 Genomic DNA Translation: EAW65427.1 BC000630 mRNA Translation: AAH00630.1 BC000904 mRNA Translation: AAH00904.1 BC012369 mRNA Translation: AAH12369.1 |
CCDSi | CCDS2901.1 [Q15008-1] CCDS63677.1 [Q15008-4] CCDS63678.1 [Q15008-3] CCDS63679.1 [Q15008-2] |
RefSeqi | NP_001258708.1, NM_001271779.1 [Q15008-4] NP_001258709.1, NM_001271780.1 [Q15008-2] NP_001258710.1, NM_001271781.1 [Q15008-3] NP_055629.1, NM_014814.2 [Q15008-1] |
Genome annotation databases
Ensembli | ENST00000295901; ENSP00000295901; ENSG00000163636 [Q15008-1] ENST00000394431; ENSP00000377952; ENSG00000163636 [Q15008-2] ENST00000482510; ENSP00000419227; ENSG00000163636 [Q15008-3] ENST00000492933; ENSP00000418695; ENSG00000163636 [Q15008-4] |
GeneIDi | 9861 |
KEGGi | hsa:9861 |
UCSCi | uc003dma.3, human [Q15008-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF215935 mRNA Translation: AAF65540.1 AF530062 mRNA Translation: AAQ09946.1 AY359879 mRNA Translation: AAQ63402.1 AY568086 mRNA Translation: AAS68366.1 D14663 mRNA Translation: BAA03497.1 BX647742 mRNA No translation available. AK290205 mRNA Translation: BAF82894.1 AC012557 Genomic DNA No translation available. CH471055 Genomic DNA Translation: EAW65424.1 CH471055 Genomic DNA Translation: EAW65427.1 BC000630 mRNA Translation: AAH00630.1 BC000904 mRNA Translation: AAH00904.1 BC012369 mRNA Translation: AAH12369.1 |
CCDSi | CCDS2901.1 [Q15008-1] CCDS63677.1 [Q15008-4] CCDS63678.1 [Q15008-3] CCDS63679.1 [Q15008-2] |
RefSeqi | NP_001258708.1, NM_001271779.1 [Q15008-4] NP_001258709.1, NM_001271780.1 [Q15008-2] NP_001258710.1, NM_001271781.1 [Q15008-3] NP_055629.1, NM_014814.2 [Q15008-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5GJQ | electron microscopy | 4.50 | R | 1-389 | [»] | |
5GJR | electron microscopy | 3.50 | 5/R | 1-389 | [»] | |
5L4K | electron microscopy | 4.50 | R | 1-389 | [»] | |
5LN3 | electron microscopy | 6.80 | R | 1-389 | [»] | |
5M32 | electron microscopy | 3.80 | m | 1-389 | [»] | |
5T0C | electron microscopy | 3.80 | AY/BY | 1-389 | [»] | |
5T0G | electron microscopy | 4.40 | Y | 1-389 | [»] | |
5T0H | electron microscopy | 6.80 | Y | 1-389 | [»] | |
5T0I | electron microscopy | 8.00 | Y | 1-389 | [»] | |
5T0J | electron microscopy | 8.00 | Y | 1-389 | [»] | |
5VFP | electron microscopy | 4.20 | Y | 12-389 | [»] | |
5VFQ | electron microscopy | 4.20 | Y | 12-389 | [»] | |
5VFR | electron microscopy | 4.90 | Y | 12-389 | [»] | |
5VFS | electron microscopy | 3.60 | Y | 12-389 | [»] | |
5VFT | electron microscopy | 7.00 | Y | 12-389 | [»] | |
5VFU | electron microscopy | 5.80 | Y | 12-389 | [»] | |
5VGZ | electron microscopy | 3.70 | Y | 12-389 | [»] | |
5VHF | electron microscopy | 5.70 | Y | 12-389 | [»] | |
5VHH | electron microscopy | 6.10 | Y | 12-389 | [»] | |
5VHI | electron microscopy | 6.80 | Y | 12-389 | [»] | |
5VHS | electron microscopy | 8.80 | Y | 12-389 | [»] | |
6MSB | electron microscopy | 3.00 | Y | 1-389 | [»] | |
6MSD | electron microscopy | 3.20 | Y | 1-389 | [»] | |
6MSG | electron microscopy | 3.50 | Y | 1-389 | [»] | |
6MSH | electron microscopy | 3.60 | Y | 1-389 | [»] | |
6MSJ | electron microscopy | 3.30 | Y | 1-389 | [»] | |
6MSK | electron microscopy | 3.20 | Y | 1-389 | [»] | |
6WJD | electron microscopy | 4.80 | Y | 1-389 | [»] | |
6WJN | electron microscopy | 5.70 | Y | 12-389 | [»] | |
SMRi | Q15008 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115195, 165 interactors |
CORUMi | Q15008 |
DIPi | DIP-27590N |
IntActi | Q15008, 62 interactors |
MINTi | Q15008 |
Chemistry databases
ChEMBLi | CHEMBL2364701 |
PTM databases
iPTMneti | Q15008 |
MetOSitei | Q15008 |
PhosphoSitePlusi | Q15008 |
SwissPalmi | Q15008 |
Polymorphism and mutation databases
BioMutai | PSMD6 |
DMDMi | 2494625 |
Proteomic databases
EPDi | Q15008 |
jPOSTi | Q15008 |
MassIVEi | Q15008 |
MaxQBi | Q15008 |
PaxDbi | Q15008 |
PeptideAtlasi | Q15008 |
PRIDEi | Q15008 |
ProteomicsDBi | 20548 60360 [Q15008-1] 67429 |
TopDownProteomicsi | Q15008-1 [Q15008-1] |
Protocols and materials databases
Antibodypediai | 31765, 276 antibodies |
Genome annotation databases
Ensembli | ENST00000295901; ENSP00000295901; ENSG00000163636 [Q15008-1] ENST00000394431; ENSP00000377952; ENSG00000163636 [Q15008-2] ENST00000482510; ENSP00000419227; ENSG00000163636 [Q15008-3] ENST00000492933; ENSP00000418695; ENSG00000163636 [Q15008-4] |
GeneIDi | 9861 |
KEGGi | hsa:9861 |
UCSCi | uc003dma.3, human [Q15008-1] |
Organism-specific databases
CTDi | 9861 |
DisGeNETi | 9861 |
EuPathDBi | HostDB:ENSG00000163636.10 |
GeneCardsi | PSMD6 |
HGNCi | HGNC:9564, PSMD6 |
HPAi | ENSG00000163636, Low tissue specificity |
MIMi | 617857, gene |
neXtProti | NX_Q15008 |
OpenTargetsi | ENSG00000163636 |
PharmGKBi | PA33910 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00510000046608 |
HOGENOMi | CLU_031814_0_0_1 |
InParanoidi | Q15008 |
OMAi | VDYIDQE |
OrthoDBi | 1194691at2759 |
PhylomeDBi | Q15008 |
TreeFami | TF313819 |
Enzyme and pathway databases
PathwayCommonsi | Q15008 |
Reactomei | R-HSA-1169091, Activation of NF-kappaB in B cells R-HSA-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1236974, ER-Phagosome pathway R-HSA-1236978, Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-174084, Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174113, SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174154, APC/C:Cdc20 mediated degradation of Securin R-HSA-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-180534, Vpu mediated degradation of CD4 R-HSA-180585, Vif-mediated degradation of APOBEC3G R-HSA-187577, SCF(Skp2)-mediated degradation of p27/p21 R-HSA-195253, Degradation of beta-catenin by the destruction complex R-HSA-202424, Downstream TCR signaling R-HSA-211733, Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-2467813, Separation of Sister Chromatids R-HSA-2871837, FCERI mediated NF-kB activation R-HSA-349425, Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-350562, Regulation of ornithine decarboxylase (ODC) R-HSA-382556, ABC-family proteins mediated transport R-HSA-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-4608870, Asymmetric localization of PCP proteins R-HSA-4641257, Degradation of AXIN R-HSA-4641258, Degradation of DVL R-HSA-5358346, Hedgehog ligand biogenesis R-HSA-5362768, Hh mutants that don't undergo autocatalytic processing are degraded by ERAD R-HSA-5607761, Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607764, CLEC7A (Dectin-1) signaling R-HSA-5610780, Degradation of GLI1 by the proteasome R-HSA-5610783, Degradation of GLI2 by the proteasome R-HSA-5610785, GLI3 is processed to GLI3R by the proteasome R-HSA-5632684, Hedgehog 'on' state R-HSA-5658442, Regulation of RAS by GAPs R-HSA-5668541, TNFR2 non-canonical NF-kB pathway R-HSA-5676590, NIK-->noncanonical NF-kB signaling R-HSA-5678895, Defective CFTR causes cystic fibrosis R-HSA-5687128, MAPK6/MAPK4 signaling R-HSA-5689603, UCH proteinases R-HSA-5689880, Ub-specific processing proteases R-HSA-6798695, Neutrophil degranulation R-HSA-68827, CDT1 association with the CDC6:ORC:origin complex R-HSA-68949, Orc1 removal from chromatin R-HSA-69017, CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69481, G2/M Checkpoints R-HSA-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-75815, Ubiquitin-dependent degradation of Cyclin D R-HSA-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939902, Regulation of RUNX2 expression and activity R-HSA-8941858, Regulation of RUNX3 expression and activity R-HSA-8948751, Regulation of PTEN stability and activity R-HSA-8951664, Neddylation R-HSA-9010553, Regulation of expression of SLITs and ROBOs R-HSA-9020702, Interleukin-1 signaling R-HSA-9604323, Negative regulation of NOTCH4 signaling R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Miscellaneous databases
BioGRID-ORCSi | 9861, 753 hits in 852 CRISPR screens |
ChiTaRSi | PSMD6, human |
GeneWikii | PSMD6 |
GenomeRNAii | 9861 |
Pharosi | Q15008, Tbio |
PROi | PR:Q15008 |
RNActi | Q15008, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000163636, Expressed in body of pancreas and 242 other tissues |
ExpressionAtlasi | Q15008, baseline and differential |
Genevisiblei | Q15008, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000717, PCI_dom IPR035268, PSMD6 IPR019585, Rpn7/CSN1 IPR011990, TPR-like_helical_dom_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR14145:SF1, PTHR14145:SF1, 1 hit |
Pfami | View protein in Pfam PF01399, PCI, 1 hit PF10602, RPN7, 1 hit |
SMARTi | View protein in SMART SM00088, PINT, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF48452, SSF48452, 1 hit |
PROSITEi | View protein in PROSITE PS50250, PCI, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PSMD6_HUMAN | |
Accessioni | Q15008Primary (citable) accession number: Q15008 Secondary accession number(s): A8K2E0, E9PHI9, Q6UV22 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 195 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families