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Entry version 167 (16 Oct 2019)
Sequence version 2 (10 May 2004)
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Protein

Pre-mRNA-splicing regulator WTAP

Gene

WTAP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Required for accumulation of METTL3 and METTL14 to nuclear speckle (PubMed:24316715, PubMed:24407421, PubMed:24981863). Acts as a mRNA splicing regulator (PubMed:12444081). Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability (PubMed:17088532). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (PubMed:17095724).7 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processCell cycle, mRNA processing, mRNA splicing

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pre-mRNA-splicing regulator WTAPCurated
Alternative name(s):
Female-lethal(2)D homolog1 Publication
Short name:
hFL(2)D1 Publication
WT1-associated protein1 Publication
Wilms tumor 1-associating protein1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WTAP1 PublicationImported
Synonyms:KIAA01051 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16846 WTAP

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605442 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q15007

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9589

Open Targets

More...
OpenTargetsi
ENSG00000146457

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134864847

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q15007

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
WTAP

Domain mapping of disease mutations (DMDM)

More...
DMDMi
47117889

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000659831 – 396Pre-mRNA-splicing regulator WTAPAdd BLAST396

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1 Publication1
Modified residuei14PhosphoserineCombined sources1
Modified residuei305PhosphoserineCombined sources1
Modified residuei306PhosphoserineCombined sources1
Modified residuei341PhosphoserineBy similarity1
Modified residuei350PhosphothreonineBy similarity1
Modified residuei388PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q15007

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q15007

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q15007

MaxQB - The MaxQuant DataBase

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MaxQBi
Q15007

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q15007

PeptideAtlas

More...
PeptideAtlasi
Q15007

PRoteomics IDEntifications database

More...
PRIDEi
Q15007

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
60358 [Q15007-1]
60359 [Q15007-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q15007

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q15007

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q15007

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

In smooth muscle cells, up-regulated after serum withdrawal, when cells become mature and non proliferative.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000146457 Expressed in 237 organ(s), highest expression level in secondary oocyte

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q15007 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q15007 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA010549
HPA010550

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the WMM complex, a N6-methyltransferase complex composed of a catalytic subcomplex, named MAC, and of an associated subcomplex, named MACOM (PubMed:24407421, PubMed:24981863, PubMed:24316715, PubMed:29507755, PubMed:29506078, PubMed:29348140). The MAC subcomplex is composed of METTL3 and METTL14 (PubMed:29507755). The MACOM subcomplex is composed of WTAP, ZC3H13, CBLL1/HAKAI, VIRMA, and, in some cases of RBM15 (RBM15 or RBM15B) (PubMed:29507755).

Interacts with WT1 (PubMed:11001926, PubMed:17095724). Also component of a MACOM-like complex, named WTAP complex, composed of WTAP, ZC3H13, CBLL1, VIRMA, RBM15, BCLAF1 and THRAP3 (PubMed:24100041).

9 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114957, 138 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1605 WMM N6-adenosine-methyltransferase complex

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q15007

Database of interacting proteins

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DIPi
DIP-57185N

Protein interaction database and analysis system

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IntActi
Q15007, 130 interactors

Molecular INTeraction database

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MINTi
Q15007

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000351141

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q15007

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the fl(2)d family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2991 Eukaryota
ENOG410XNW7 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000013931

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000112606

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q15007

KEGG Orthology (KO)

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KOi
K22824

Identification of Orthologs from Complete Genome Data

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OMAi
FPMSPVV

Database of Orthologous Groups

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OrthoDBi
907345at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q15007

TreeFam database of animal gene trees

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TreeFami
TF325869

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR033757 WTAP
IPR029732 WTAP/Mum2

The PANTHER Classification System

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PANTHERi
PTHR15217 PTHR15217, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17098 Wtap, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q15007-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTNEEPLPKK VRLSETDFKV MARDELILRW KQYEAYVQAL EGKYTDLNSN
60 70 80 90 100
DVTGLRESEE KLKQQQQESA RRENILVMRL ATKEQEMQEC TTQIQYLKQV
110 120 130 140 150
QQPSVAQLRS TMVDPAINLF FLKMKGELEQ TKDKLEQAQN ELSAWKFTPD
160 170 180 190 200
SQTGKKLMAK CRMLIQENQE LGRQLSQGRI AQLEAELALQ KKYSEELKSS
210 220 230 240 250
QDELNDFIIQ LDEEVEGMQS TILVLQQQLK ETRQQLAQYQ QQQSQASAPS
260 270 280 290 300
TSRTTASEPV EQSEATSKDC SRLTNGPSNG SSSRQRTSGS GFHREGNTTE
310 320 330 340 350
DDFPSSPGNG NKSSNSSEER TGRGGSGYVN QLSAGYESVD SPTGSENSLT
360 370 380 390
HQSNDTDSSH DPQEEKAVSG KGNRTVGSRH VQNGLDSSVN VQGSVL
Length:396
Mass (Da):44,244
Last modified:May 10, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB4F81B3000F77A37
GO
Isoform 2 (identifier: Q15007-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     151-151: S → R
     152-396: Missing.

Show »
Length:151
Mass (Da):17,801
Checksum:i70C549E73369A233
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X1R4A0A087X1R4_HUMAN
Pre-mRNA-splicing regulator WTAP
WTAP hCG_34028
170Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03685484E → D. Corresponds to variant dbSNP:rs35059844Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_010278151S → R in isoform 2. 3 Publications1
Alternative sequenceiVSP_010279152 – 396Missing in isoform 2. 3 PublicationsAdd BLAST245

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF374416 mRNA Translation: AAK54764.1
D14661 mRNA Translation: BAA03495.1
AK127822 mRNA Translation: BAG54579.1
AL135914 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47622.1
CH471051 Genomic DNA Translation: EAW47624.1
CH471051 Genomic DNA Translation: EAW47625.1
BC000383 mRNA Translation: AAH00383.1
BC004432 mRNA Translation: AAH04432.1
BC069192 mRNA Translation: AAH69192.1
AJ276706 mRNA Translation: CAC10188.1
AL583911 mRNA Translation: CAC29495.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS5266.1 [Q15007-1]
CCDS5267.1 [Q15007-2]

NCBI Reference Sequences

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RefSeqi
NP_001257460.1, NM_001270531.1 [Q15007-1]
NP_001257461.1, NM_001270532.1
NP_001257462.1, NM_001270533.1
NP_004897.2, NM_004906.4 [Q15007-1]
NP_690596.1, NM_152857.2 [Q15007-2]
NP_690597.1, NM_152858.2 [Q15007-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000337387; ENSP00000336911; ENSG00000146457 [Q15007-2]
ENST00000358372; ENSP00000351141; ENSG00000146457 [Q15007-1]
ENST00000621533; ENSP00000479438; ENSG00000146457 [Q15007-1]
ENST00000650096; ENSP00000497840; ENSG00000146457 [Q15007-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9589

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9589

UCSC genome browser

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UCSCi
uc003qsl.6 human [Q15007-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF374416 mRNA Translation: AAK54764.1
D14661 mRNA Translation: BAA03495.1
AK127822 mRNA Translation: BAG54579.1
AL135914 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47622.1
CH471051 Genomic DNA Translation: EAW47624.1
CH471051 Genomic DNA Translation: EAW47625.1
BC000383 mRNA Translation: AAH00383.1
BC004432 mRNA Translation: AAH04432.1
BC069192 mRNA Translation: AAH69192.1
AJ276706 mRNA Translation: CAC10188.1
AL583911 mRNA Translation: CAC29495.1
CCDSiCCDS5266.1 [Q15007-1]
CCDS5267.1 [Q15007-2]
RefSeqiNP_001257460.1, NM_001270531.1 [Q15007-1]
NP_001257461.1, NM_001270532.1
NP_001257462.1, NM_001270533.1
NP_004897.2, NM_004906.4 [Q15007-1]
NP_690596.1, NM_152857.2 [Q15007-2]
NP_690597.1, NM_152858.2 [Q15007-2]

3D structure databases

SMRiQ15007
ModBaseiSearch...

Protein-protein interaction databases

BioGridi114957, 138 interactors
ComplexPortaliCPX-1605 WMM N6-adenosine-methyltransferase complex
CORUMiQ15007
DIPiDIP-57185N
IntActiQ15007, 130 interactors
MINTiQ15007
STRINGi9606.ENSP00000351141

PTM databases

iPTMnetiQ15007
PhosphoSitePlusiQ15007
SwissPalmiQ15007

Polymorphism and mutation databases

BioMutaiWTAP
DMDMi47117889

Proteomic databases

EPDiQ15007
jPOSTiQ15007
MassIVEiQ15007
MaxQBiQ15007
PaxDbiQ15007
PeptideAtlasiQ15007
PRIDEiQ15007
ProteomicsDBi60358 [Q15007-1]
60359 [Q15007-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
9589

Genome annotation databases

EnsembliENST00000337387; ENSP00000336911; ENSG00000146457 [Q15007-2]
ENST00000358372; ENSP00000351141; ENSG00000146457 [Q15007-1]
ENST00000621533; ENSP00000479438; ENSG00000146457 [Q15007-1]
ENST00000650096; ENSP00000497840; ENSG00000146457 [Q15007-2]
GeneIDi9589
KEGGihsa:9589
UCSCiuc003qsl.6 human [Q15007-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9589
DisGeNETi9589

GeneCards: human genes, protein and diseases

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GeneCardsi
WTAP
HGNCiHGNC:16846 WTAP
HPAiHPA010549
HPA010550
MIMi605442 gene
neXtProtiNX_Q15007
OpenTargetsiENSG00000146457
PharmGKBiPA134864847

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2991 Eukaryota
ENOG410XNW7 LUCA
GeneTreeiENSGT00390000013931
HOGENOMiHOG000112606
InParanoidiQ15007
KOiK22824
OMAiFPMSPVV
OrthoDBi907345at2759
PhylomeDBiQ15007
TreeFamiTF325869

Enzyme and pathway databases

ReactomeiR-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
WTAP human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
WTAP_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9589
PharosiQ15007

Protein Ontology

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PROi
PR:Q15007

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000146457 Expressed in 237 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiQ15007 baseline and differential
GenevisibleiQ15007 HS

Family and domain databases

InterProiView protein in InterPro
IPR033757 WTAP
IPR029732 WTAP/Mum2
PANTHERiPTHR15217 PTHR15217, 1 hit
PfamiView protein in Pfam
PF17098 Wtap, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFL2D_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15007
Secondary accession number(s): Q5TCL8
, Q5TCL9, Q96T28, Q9BYJ7, Q9H4E2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 10, 2004
Last modified: October 16, 2019
This is version 167 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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