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Protein

ER membrane protein complex subunit 2

Gene

EMC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • protein folding in endoplasmic reticulum Source: GO_Central

Protein family/group databases

TCDBi3.A.27.1.1 the c-terminal tail-anchored membrane protein biogenesis/ insertion complex-2 (tamp-b2) family

Names & Taxonomyi

Protein namesi
Recommended name:
ER membrane protein complex subunit 2
Alternative name(s):
Tetratricopeptide repeat protein 35
Short name:
TPR repeat protein 35
Gene namesi
Name:EMC2
Synonyms:KIAA0103, TTC35
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000104412.7
HGNCiHGNC:28963 EMC2
MIMi607722 gene
neXtProtiNX_Q15006

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000104412
PharmGKBiPA162407224

Polymorphism and mutation databases

BioMutaiEMC2
DMDMi3183217

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001063532 – 297ER membrane protein complex subunit 2Add BLAST296

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei255N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ15006
MaxQBiQ15006
PaxDbiQ15006
PeptideAtlasiQ15006
PRIDEiQ15006
ProteomicsDBi60357

PTM databases

iPTMnetiQ15006
PhosphoSitePlusiQ15006
SwissPalmiQ15006

Expressioni

Gene expression databases

BgeeiENSG00000104412 Expressed in 236 organ(s), highest expression level in corpus callosum
CleanExiHS_TTC35
ExpressionAtlasiQ15006 baseline and differential
GenevisibleiQ15006 HS

Organism-specific databases

HPAiHPA022838

Interactioni

Subunit structurei

Component of the ER membrane protein complex (EMC).1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi115046, 123 interactors
IntActiQ15006, 107 interactors
MINTiQ15006
STRINGi9606.ENSP00000220853

Structurei

3D structure databases

ProteinModelPortaliQ15006
SMRiQ15006
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati87 – 120TPR 1Add BLAST34
Repeati155 – 188TPR 2Add BLAST34
Repeati192 – 225TPR 3Add BLAST34

Sequence similaritiesi

Belongs to the EMC2 family.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG3060 Eukaryota
ENOG410YT6B LUCA
GeneTreeiENSGT00390000011922
HOGENOMiHOG000007547
HOVERGENiHBG055231
InParanoidiQ15006
OMAiHLYCEQY
OrthoDBiEOG091G0EOK
PhylomeDBiQ15006
TreeFamiTF312997

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR039856 EMC2-like
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PANTHERiPTHR12760 PTHR12760, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 3 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 2 hits
PS50293 TPR_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q15006-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKVSELYDV TWEEMRDKMR KWREENSRNS EQIVEVGEEL INEYASKLGD
60 70 80 90 100
DIWIIYEQVM IAALDYGRDD LALFCLQELR RQFPGSHRVK RLTGMRFEAM
110 120 130 140 150
ERYDDAIQLY DRILQEDPTN TAARKRKIAI RKAQGKNVEA IRELNEYLEQ
160 170 180 190 200
FVGDQEAWHE LAELYINEHD YAKAAFCLEE LMMTNPHNHL YCQQYAEVKY
210 220 230 240 250
TQGGLENLEL SRKYFAQALK LNNRNMRALF GLYMSASHIA SNPKASAKTK
260 270 280 290
KDNMKYASWA ASQINRAYQF AGRSKKETKY SLKAVEDMLE TLQITQS
Length:297
Mass (Da):34,834
Last modified:November 1, 1996 - v1
Checksum:iCA5903AEC3B3E36A
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YAS9H0YAS9_HUMAN
ER membrane protein complex subunit...
EMC2
135Annotation score:
E5RGJ2E5RGJ2_HUMAN
ER membrane protein complex subunit...
EMC2
112Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti145N → S in AAH20753 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14659 mRNA Translation: BAA03493.1
CR457402 mRNA Translation: CAG33683.1
BC020753 mRNA Translation: AAH20753.1
BC021667 mRNA Translation: AAH21667.1
CCDSiCCDS6309.1
RefSeqiNP_055488.1, NM_014673.4
UniGeneiHs.654351

Genome annotation databases

EnsembliENST00000220853; ENSP00000220853; ENSG00000104412
GeneIDi9694
KEGGihsa:9694
UCSCiuc003ymw.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14659 mRNA Translation: BAA03493.1
CR457402 mRNA Translation: CAG33683.1
BC020753 mRNA Translation: AAH20753.1
BC021667 mRNA Translation: AAH21667.1
CCDSiCCDS6309.1
RefSeqiNP_055488.1, NM_014673.4
UniGeneiHs.654351

3D structure databases

ProteinModelPortaliQ15006
SMRiQ15006
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115046, 123 interactors
IntActiQ15006, 107 interactors
MINTiQ15006
STRINGi9606.ENSP00000220853

Protein family/group databases

TCDBi3.A.27.1.1 the c-terminal tail-anchored membrane protein biogenesis/ insertion complex-2 (tamp-b2) family

PTM databases

iPTMnetiQ15006
PhosphoSitePlusiQ15006
SwissPalmiQ15006

Polymorphism and mutation databases

BioMutaiEMC2
DMDMi3183217

Proteomic databases

EPDiQ15006
MaxQBiQ15006
PaxDbiQ15006
PeptideAtlasiQ15006
PRIDEiQ15006
ProteomicsDBi60357

Protocols and materials databases

DNASUi9694
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000220853; ENSP00000220853; ENSG00000104412
GeneIDi9694
KEGGihsa:9694
UCSCiuc003ymw.2 human

Organism-specific databases

CTDi9694
EuPathDBiHostDB:ENSG00000104412.7
GeneCardsiEMC2
HGNCiHGNC:28963 EMC2
HPAiHPA022838
MIMi607722 gene
neXtProtiNX_Q15006
OpenTargetsiENSG00000104412
PharmGKBiPA162407224
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3060 Eukaryota
ENOG410YT6B LUCA
GeneTreeiENSGT00390000011922
HOGENOMiHOG000007547
HOVERGENiHBG055231
InParanoidiQ15006
OMAiHLYCEQY
OrthoDBiEOG091G0EOK
PhylomeDBiQ15006
TreeFamiTF312997

Miscellaneous databases

ChiTaRSiEMC2 human
GeneWikiiTTC35
GenomeRNAii9694
PROiPR:Q15006
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000104412 Expressed in 236 organ(s), highest expression level in corpus callosum
CleanExiHS_TTC35
ExpressionAtlasiQ15006 baseline and differential
GenevisibleiQ15006 HS

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR039856 EMC2-like
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PANTHERiPTHR12760 PTHR12760, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 3 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 2 hits
PS50293 TPR_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEMC2_HUMAN
AccessioniPrimary (citable) accession number: Q15006
Secondary accession number(s): Q8WUE1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 165 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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