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Entry version 156 (13 Feb 2019)
Sequence version 1 (01 Nov 1996)
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Protein

PCNA-associated factor

Gene

PCLAF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number.2 Publications

Miscellaneous

Overexpression in adrenocortical neoplasms (ACC), may promote growth and invasion in adrenal cancer.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • chromatin binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDNA damage, DNA repair

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-5656169 Termination of translesion DNA synthesis

SIGNOR Signaling Network Open Resource

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SIGNORi
Q15004

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PCNA-associated factorCurated
Alternative name(s):
Hepatitis C virus NS5A-transactivated protein 9
Short name:
HCV NS5A-transactivated protein 9
Overexpressed in anaplastic thyroid carcinoma 1
Short name:
OEATC-1
PCNA-associated factor of 15 kDa
Short name:
PAF15
Short name:
p15PAF
PCNA-clamp-associated factorImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PCLAFImported
Synonyms:KIAA0101, NS5ATP9, PAF
ORF Names:L5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000166803.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28961 PCLAF

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610696 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q15004

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi15K → R: Loss of monoubiquitination; when associated with R-24. 1 Publication1
Mutagenesisi24K → R: Loss of monoubiquitination; when associated with R-15. 1 Publication1
Mutagenesisi65I → A: Loss of binding to PCNA. 1 Publication1
Mutagenesisi68 – 69FF → AA: Loss of binding to PCNA. 1 Publication2
Mutagenesisi68F → A: Loss of binding to PCNA. 1 Publication1
Mutagenesisi78K → A: Stabilizes the protein in G1 by preventing association with the APC/C complex and degradation by the proteasome. 1 Publication1
Mutagenesisi93 – 97KAKRK → AAAAA: Inhibits chain initiation by APC/C. 1 Publication5
Mutagenesisi93 – 97KAKRK → RARRR: No effect on chain initiation by APC/C. 1 Publication5

Organism-specific databases

DisGeNET

More...
DisGeNETi
9768

Open Targets

More...
OpenTargetsi
ENSG00000166803
ENSG00000259316

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134974023

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5574

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PCLAF

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000966841 – 111PCNA-associated factorAdd BLAST111

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei8PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki15Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei24N6-acetyllysine; alternateBy similarity1
Cross-linki24Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate1 Publication
Modified residuei28PhosphoserineCombined sources1
Modified residuei31Phosphoserine1 Publication1
Modified residuei72PhosphoserineCombined sources1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Monoubiquitinated at Lys-15 and Lys-24 during normal S phase, promoting its association with PCNA. Also diubiquitinated at these 2 sites. Following DNA damage, monoubiquitin chains at Lys-15 and Lys-24 are probably extended, leading to disrupt the interaction with PCNA. Polyubiquitinated by the APC/C complex at the mitotic exit, leading to its degradation by the proteasome.3 Publications

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q15004

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q15004

MaxQB - The MaxQuant DataBase

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MaxQBi
Q15004

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q15004

PeptideAtlas

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PeptideAtlasi
Q15004

PRoteomics IDEntifications database

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PRIDEi
Q15004

ProteomicsDB human proteome resource

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ProteomicsDBi
60355

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q15004

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q15004

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed predominantly in liver, pancreas and placenta. Not detected in heart or brain. Highly expressed in a number of tumors, especially esophageal tumors, in anaplastic thyroid carcinomas, adrenocortical carcinomas, and in non-small-cell lung cancer lines.3 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Present only during S and G2 phases of the cell cycle. Peaks at the G2/M phase of the cell cycle and drops rapidly at mitotic exit in an APC/C-dependent manner (at protein level).

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By UV irradiation. By ATF3 in response to UV-stress.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000166803 Expressed in 217 organ(s), highest expression level in bone marrow

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q15004 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q15004 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA047929

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (when monoubiquitinated at Lys-15 and Lys-24) with PCNA. Interacts with isoform 2/p33ING1b of ING1. Interacts with BRCA1.7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
PCNAP120043EBI-10971436,EBI-358311

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
115114, 33 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q15004

Protein interaction database and analysis system

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IntActi
Q15004, 3 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000300035

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1111
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4D2GX-ray2.65D/E52-69[»]
6EHTX-ray3.20D/E52-71[»]
6GWSX-ray2.90D/E/F41-72[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q15004

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q15004

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi23 – 34D-boxAdd BLAST12
Motifi62 – 72PIP-boxAdd BLAST11
Motifi78 – 80KEN box3
Motifi85 – 97Initiation motifAdd BLAST13

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PIP-box mediates the interaction with PCNA (PubMed:21628590, PubMed:23000965).2 Publications
The KEN box is required for the association with the APC/C complex.1 Publication
The D-box (destruction box) mediates the interaction with APC/C proteins, and acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.By similarity
The initiation motif is required for efficient chain initiation by the APC/C complex E2 ligase UBE2C. It determines the rate of substrate's degradation without affecting its affinity for the APC/C, a mechanism used by the APC/C to control the timing of substrate proteolysis during the cell cycle (PubMed:21700221).1 Publication

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410J101 Eukaryota
ENOG410Y3KP LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00510000048252

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000013069

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG052567

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q15004

Identification of Orthologs from Complete Genome Data

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OMAi
QPDHSDD

Database of Orthologous Groups

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OrthoDBi
1508906at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q15004

TreeFam database of animal gene trees

More...
TreeFami
TF333199

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR040444 PCNA-AF
IPR031444 PCNA-AF_dom

The PANTHER Classification System

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PANTHERi
PTHR15679 PTHR15679, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15715 PAF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q15004-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVRTKADSVP GTYRKVVAAR APRKVLGSST SATNSTSVSS RKAENKYAGG
60 70 80 90 100
NPVCVRPTPK WQKGIGEFFR LSPKDSEKEN QIPEEAGSSG LGKAKRKACP
110
LQPDHTNDEK E
Length:111
Mass (Da):11,986
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFEF2C4E398B70E40
GO
Isoform 2 (identifier: Q15004-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-111: AENKYAGGNP...QPDHTNDEKE → EHVLCNLITQMMKKNRTFSFIFE

Note: No experimental confirmation available.
Show »
Length:65
Mass (Da):7,221
Checksum:iEC33192CECBF8430
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YMA4H0YMA4_HUMAN
HCG2039386, isoform CRA_b
PCLAF hCG_2039386
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YKX3H0YKX3_HUMAN
PCNA-associated factor
PCLAF
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA03491 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05126279E → K. Corresponds to variant dbSNP:rs11554313Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04565943 – 111AENKY…NDEKE → EHVLCNLITQMMKKNRTFSF IFE in isoform 2. 1 PublicationAdd BLAST69

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF529370 mRNA Translation: AAQ09604.1
AY598324 mRNA Translation: AAT06735.1
JN245882 Genomic DNA Translation: AEW89488.1
JN245883 Genomic DNA Translation: AEW89489.1
JN245884 Genomic DNA Translation: AEW89490.1
JN245885 Genomic DNA Translation: AEW89491.1
JN245886 Genomic DNA Translation: AEW89492.1
JN245889 Genomic DNA Translation: AEW89495.1
JN245890 Genomic DNA Translation: AEW89496.1
JN245892 Genomic DNA Translation: AEW89498.1
JN245893 Genomic DNA Translation: AEW89499.1
JN245894 Genomic DNA Translation: AEW89500.1
JN245895 Genomic DNA Translation: AEW89501.1
JN245896 Genomic DNA Translation: AEW89502.1
JN245897 Genomic DNA Translation: AEW89503.1
JN245898 Genomic DNA Translation: AEW89504.1
JN245899 Genomic DNA Translation: AEW89505.1
JN245900 Genomic DNA Translation: AEW89506.1
JN245901 Genomic DNA Translation: AEW89507.1
JN245902 Genomic DNA Translation: AEW89508.1
JN245903 Genomic DNA Translation: AEW89509.1
JN245904 Genomic DNA Translation: AEW89510.1
JN245906 Genomic DNA Translation: AEW89512.1
JN245907 Genomic DNA Translation: AEW89513.1
JN245908 Genomic DNA Translation: AEW89514.1
JN245910 Genomic DNA Translation: AEW89516.1
JN245911 Genomic DNA Translation: AEW89517.1
JN245912 Genomic DNA Translation: AEW89518.1
JN245936 Genomic DNA Translation: AEW89560.1
JN245937 Genomic DNA Translation: AEW89561.1
JN245938 Genomic DNA Translation: AEW89562.1
JN245939 Genomic DNA Translation: AEW89563.1
JN245940 Genomic DNA Translation: AEW89564.1
JN245941 Genomic DNA Translation: AEW89565.1
JN245942 Genomic DNA Translation: AEW89566.1
JN245943 Genomic DNA Translation: AEW89567.1
JN245944 Genomic DNA Translation: AEW89568.1
JN245945 Genomic DNA Translation: AEW89569.1
JN245887 Genomic DNA Translation: AEW89493.1
JN245888 Genomic DNA Translation: AEW89494.1
JN245891 Genomic DNA Translation: AEW89497.1
JN245905 Genomic DNA Translation: AEW89511.1
JN245909 Genomic DNA Translation: AEW89515.1
JN245913 Genomic DNA Translation: AEW89519.1
JN245914 Genomic DNA Translation: AEW89520.1
JN245915 Genomic DNA Translation: AEW89521.1
JN245916 Genomic DNA Translation: AEW89522.1
JN245917 Genomic DNA Translation: AEW89523.1
D14657 mRNA Translation: BAA03491.2 Different initiation.
AK290748 mRNA Translation: BAF83437.1
AC087632 Genomic DNA No translation available.
CH471082 Genomic DNA Translation: EAW77679.1
BC005832 mRNA Translation: AAH05832.1
BC007101 mRNA Translation: AAH07101.1
BC016782 mRNA Translation: AAH16782.1
BU170434 mRNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS10193.1 [Q15004-1]
CCDS32269.1 [Q15004-2]

NCBI Reference Sequences

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RefSeqi
NP_001025160.1, NM_001029989.2 [Q15004-2]
NP_055551.1, NM_014736.5 [Q15004-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.81892

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000300035; ENSP00000300035; ENSG00000166803 [Q15004-1]
ENST00000380258; ENSP00000369608; ENSG00000166803 [Q15004-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9768

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9768

UCSC genome browser

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UCSCi
uc002ank.5 human [Q15004-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF529370 mRNA Translation: AAQ09604.1
AY598324 mRNA Translation: AAT06735.1
JN245882 Genomic DNA Translation: AEW89488.1
JN245883 Genomic DNA Translation: AEW89489.1
JN245884 Genomic DNA Translation: AEW89490.1
JN245885 Genomic DNA Translation: AEW89491.1
JN245886 Genomic DNA Translation: AEW89492.1
JN245889 Genomic DNA Translation: AEW89495.1
JN245890 Genomic DNA Translation: AEW89496.1
JN245892 Genomic DNA Translation: AEW89498.1
JN245893 Genomic DNA Translation: AEW89499.1
JN245894 Genomic DNA Translation: AEW89500.1
JN245895 Genomic DNA Translation: AEW89501.1
JN245896 Genomic DNA Translation: AEW89502.1
JN245897 Genomic DNA Translation: AEW89503.1
JN245898 Genomic DNA Translation: AEW89504.1
JN245899 Genomic DNA Translation: AEW89505.1
JN245900 Genomic DNA Translation: AEW89506.1
JN245901 Genomic DNA Translation: AEW89507.1
JN245902 Genomic DNA Translation: AEW89508.1
JN245903 Genomic DNA Translation: AEW89509.1
JN245904 Genomic DNA Translation: AEW89510.1
JN245906 Genomic DNA Translation: AEW89512.1
JN245907 Genomic DNA Translation: AEW89513.1
JN245908 Genomic DNA Translation: AEW89514.1
JN245910 Genomic DNA Translation: AEW89516.1
JN245911 Genomic DNA Translation: AEW89517.1
JN245912 Genomic DNA Translation: AEW89518.1
JN245936 Genomic DNA Translation: AEW89560.1
JN245937 Genomic DNA Translation: AEW89561.1
JN245938 Genomic DNA Translation: AEW89562.1
JN245939 Genomic DNA Translation: AEW89563.1
JN245940 Genomic DNA Translation: AEW89564.1
JN245941 Genomic DNA Translation: AEW89565.1
JN245942 Genomic DNA Translation: AEW89566.1
JN245943 Genomic DNA Translation: AEW89567.1
JN245944 Genomic DNA Translation: AEW89568.1
JN245945 Genomic DNA Translation: AEW89569.1
JN245887 Genomic DNA Translation: AEW89493.1
JN245888 Genomic DNA Translation: AEW89494.1
JN245891 Genomic DNA Translation: AEW89497.1
JN245905 Genomic DNA Translation: AEW89511.1
JN245909 Genomic DNA Translation: AEW89515.1
JN245913 Genomic DNA Translation: AEW89519.1
JN245914 Genomic DNA Translation: AEW89520.1
JN245915 Genomic DNA Translation: AEW89521.1
JN245916 Genomic DNA Translation: AEW89522.1
JN245917 Genomic DNA Translation: AEW89523.1
D14657 mRNA Translation: BAA03491.2 Different initiation.
AK290748 mRNA Translation: BAF83437.1
AC087632 Genomic DNA No translation available.
CH471082 Genomic DNA Translation: EAW77679.1
BC005832 mRNA Translation: AAH05832.1
BC007101 mRNA Translation: AAH07101.1
BC016782 mRNA Translation: AAH16782.1
BU170434 mRNA No translation available.
CCDSiCCDS10193.1 [Q15004-1]
CCDS32269.1 [Q15004-2]
RefSeqiNP_001025160.1, NM_001029989.2 [Q15004-2]
NP_055551.1, NM_014736.5 [Q15004-1]
UniGeneiHs.81892

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4D2GX-ray2.65D/E52-69[»]
6EHTX-ray3.20D/E52-71[»]
6GWSX-ray2.90D/E/F41-72[»]
ProteinModelPortaliQ15004
SMRiQ15004
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115114, 33 interactors
CORUMiQ15004
IntActiQ15004, 3 interactors
STRINGi9606.ENSP00000300035

Chemistry databases

ChEMBLiCHEMBL5574

PTM databases

iPTMnetiQ15004
PhosphoSitePlusiQ15004

Polymorphism and mutation databases

BioMutaiPCLAF

Proteomic databases

EPDiQ15004
jPOSTiQ15004
MaxQBiQ15004
PaxDbiQ15004
PeptideAtlasiQ15004
PRIDEiQ15004
ProteomicsDBi60355

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
9768
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300035; ENSP00000300035; ENSG00000166803 [Q15004-1]
ENST00000380258; ENSP00000369608; ENSG00000166803 [Q15004-2]
GeneIDi9768
KEGGihsa:9768
UCSCiuc002ank.5 human [Q15004-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9768
DisGeNETi9768
EuPathDBiHostDB:ENSG00000166803.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PCLAF
HGNCiHGNC:28961 PCLAF
HPAiHPA047929
MIMi610696 gene
neXtProtiNX_Q15004
OpenTargetsiENSG00000166803
ENSG00000259316
PharmGKBiPA134974023

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J101 Eukaryota
ENOG410Y3KP LUCA
GeneTreeiENSGT00510000048252
HOGENOMiHOG000013069
HOVERGENiHBG052567
InParanoidiQ15004
OMAiQPDHSDD
OrthoDBi1508906at2759
PhylomeDBiQ15004
TreeFamiTF333199

Enzyme and pathway databases

ReactomeiR-HSA-5656169 Termination of translesion DNA synthesis
SIGNORiQ15004

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
KIAA0101 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
KIAA0101

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9768

Protein Ontology

More...
PROi
PR:Q15004

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000166803 Expressed in 217 organ(s), highest expression level in bone marrow
ExpressionAtlasiQ15004 baseline and differential
GenevisibleiQ15004 HS

Family and domain databases

InterProiView protein in InterPro
IPR040444 PCNA-AF
IPR031444 PCNA-AF_dom
PANTHERiPTHR15679 PTHR15679, 1 hit
PfamiView protein in Pfam
PF15715 PAF, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPAF15_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q15004
Secondary accession number(s): A6NNU5
, A8K3Y3, G9G694, G9G696
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: February 13, 2019
This is version 156 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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