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Protein

Condensin complex subunit 2

Gene

NCAPH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (PubMed:11136719). Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959).2 Publications

GO - Molecular functioni

  • chromatin binding Source: GO_Central
  • DNA topoisomerase (ATP-hydrolyzing) activator activity Source: GO_Central
  • DNA topoisomerase binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, DNA condensation, Mitosis

Enzyme and pathway databases

ReactomeiR-HSA-2514853 Condensation of Prometaphase Chromosomes

Names & Taxonomyi

Protein namesi
Recommended name:
Condensin complex subunit 2
Alternative name(s):
Barren homolog protein 1
Chromosome-associated protein H
Short name:
hCAP-H
Non-SMC condensin I complex subunit H
XCAP-H homolog
Gene namesi
Name:NCAPH1 PublicationImported
Synonyms:BRRN, BRRN1, CAPH, KIAA0074
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000121152.9
HGNCiHGNC:1112 NCAPH
MIMi602332 gene
neXtProtiNX_Q15003

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

Microcephaly 23, primary, autosomal recessive (MCPH23)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of microcephaly, a disease defined as a head circumference more than 3 standard deviations below the age, sex and ethnically matched mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small.
See also OMIM:617985
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_080954243P → L in MCPH23; impairs mitotic chromosome compaction. 1 Publication1

Keywords - Diseasei

Disease mutation, Primary microcephaly

Organism-specific databases

MalaCardsiNCAPH
MIMi617985 phenotype
OpenTargetsiENSG00000121152
PharmGKBiPA162397273

Polymorphism and mutation databases

DMDMi116241306

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000950381 – 741Condensin complex subunit 2Add BLAST741

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei15PhosphoserineCombined sources1
Modified residuei25PhosphoserineCombined sources1
Modified residuei28PhosphoserineBy similarity1
Modified residuei49PhosphothreonineCombined sources1
Modified residuei70PhosphoserineCombined sources1
Modified residuei78PhosphoserineCombined sources1
Modified residuei81PhosphoserineCombined sources1
Modified residuei87PhosphoserineCombined sources1
Modified residuei89PhosphoserineCombined sources1
Modified residuei92PhosphoserineCombined sources1
Modified residuei96PhosphoserineCombined sources1
Modified residuei201PhosphoserineCombined sources1
Modified residuei233PhosphoserineCombined sources1
Modified residuei432PhosphoserineCombined sources1
Cross-linki488Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei496PhosphoserineCombined sources1
Modified residuei598PhosphothreonineCombined sources1
Modified residuei605PhosphothreonineCombined sources1
Modified residuei637N6-acetyllysineCombined sources1

Post-translational modificationi

Phosphorylated by CDK1. Its phosphorylation, as well as that of NCAPD2 and NCAPG subunits, activates the condensin complex and is required for chromosome condensation (By similarity).By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ15003
MaxQBiQ15003
PaxDbiQ15003
PeptideAtlasiQ15003
PRIDEiQ15003
ProteomicsDBi60354

PTM databases

iPTMnetiQ15003
PhosphoSitePlusiQ15003

Miscellaneous databases

PMAP-CutDBiQ15003

Expressioni

Tissue specificityi

Widely expressed at low level. Expressed in proliferating cells.1 Publication

Gene expression databases

BgeeiENSG00000121152 Expressed in 110 organ(s), highest expression level in testis
CleanExiHS_NCAPH
ExpressionAtlasiQ15003 baseline and differential
GenevisibleiQ15003 HS

Organism-specific databases

HPAiHPA002647
HPA003008

Interactioni

Subunit structurei

Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: NCAPH/BRRN1, NCAPD2/CAPD2 and NCAPG.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116970, 53 interactors
ComplexPortaliCPX-979 Condensin I complex
CORUMiQ15003
DIPiDIP-43899N
IntActiQ15003, 27 interactors
MINTiQ15003
STRINGi9606.ENSP00000240423

Structurei

3D structure databases

ProteinModelPortaliQ15003
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CND2 (condensin subunit 2) family.Curated

Phylogenomic databases

eggNOGiKOG2328 Eukaryota
COG5229 LUCA
GeneTreeiENSGT00390000004149
HOGENOMiHOG000231887
HOVERGENiHBG036823
InParanoidiQ15003
KOiK06676
OMAiPFEIDFA
OrthoDBiEOG091G01HE
PhylomeDBiQ15003
TreeFamiTF105678

Family and domain databases

InterProiView protein in InterPro
IPR022816 Condensin_barren_su2
PANTHERiPTHR13108 PTHR13108, 1 hit
PfamiView protein in Pfam
PF05786 Cnd2, 1 hit
PIRSFiPIRSF017126 Condensin_H, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q15003-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGPPGPALPA TMNNSSSETR GHPHSASSPS ERVFPMPLPR KAPLNIPGTP
60 70 80 90 100
VLEDFPQNDD EKERLQRRRS RVFDLQFSTD SPRLLASPSS RSIDISATIP
110 120 130 140 150
KFTNTQITEH YSTCIKLSTE NKITTKNAFG LHLIDFMSEI LKQKDTEPTN
160 170 180 190 200
FKVAAGTLDA STKIYAVRVD AVHADVYRVL GGLGKDAPSL EEVEGHVADG
210 220 230 240 250
SATEMGTTKK AVKPKKKHLH RTIEQNINNL NVSEADRKCE IDPMFQKTAA
260 270 280 290 300
SFDECSTAGV FLSTLHCQDY RSELLFPSDV QTLSTGEPLE LPELGCVEMT
310 320 330 340 350
DLKAPLQQCA EDRQICPSLA GFQFTQWDSE THNESVSALV DKFKKNDQVF
360 370 380 390 400
DINAEVDESD CGDFPDGSLG DDFDANDEPD HTAVGDHEEF RSWKEPCQVQ
410 420 430 440 450
SCQEEMISLG DGDIRTMCPL LSMKPGEYSY FSPRTMSMWA GPDHWRFRPR
460 470 480 490 500
RKQDAPSQSE NKKKSTKKDF EIDFEDDIDF DVYFRKTKAA TILTKSTLEN
510 520 530 540 550
QNWRATTLPT DFNYNVDTLV QLHLKPGTRL LKMAQGHRVE TEHYEEIEDY
560 570 580 590 600
DYNNPNDTSN FCPGLQAADS DDEDLDDLFV GPVGNSDLSP YPCHPPKTAQ
610 620 630 640 650
QNGDTPEAQG LDITTYGESN LVAEPQKVNK IEIHYAKTAK KMDMKKLKQS
660 670 680 690 700
MWSLLTALSG KEADAEANHR EAGKEAALAE VADEKMLSGL TKDLQRSLPP
710 720 730 740
VMAQNLSIPL AFACLLHLAN EKNLKLEGTE DLSDVLVRQG D
Length:741
Mass (Da):82,563
Last modified:October 17, 2006 - v3
Checksum:iB5B34A36CAE0C28E
GO
Isoform 2 (identifier: Q15003-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-136: Missing.

Note: No experimental confirmation available.
Show »
Length:605
Mass (Da):67,495
Checksum:i4ABE503B4CB20935
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PHA2E9PHA2_HUMAN
Condensin complex subunit 2
NCAPH
730Annotation score:
C9J470C9J470_HUMAN
Condensin complex subunit 2
NCAPH
607Annotation score:
C9JZP1C9JZP1_HUMAN
Condensin complex subunit 2
NCAPH
216Annotation score:
H7C415H7C415_HUMAN
Condensin complex subunit 2
NCAPH
182Annotation score:

Sequence cautioni

The sequence BAA07556 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_080954243P → L in MCPH23; impairs mitotic chromosome compaction. 1 Publication1
Natural variantiVAR_027882539V → A1 PublicationCorresponds to variant dbSNP:rs2305935Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0551791 – 136Missing in isoform 2. 1 PublicationAdd BLAST136

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38553 mRNA Translation: BAA07556.1 Different initiation.
AK303725 mRNA Translation: BAG64701.1
AC021188 Genomic DNA No translation available.
BC024211 mRNA Translation: AAH24211.1
CCDSiCCDS2021.1 [Q15003-1]
CCDS62960.1 [Q15003-2]
RefSeqiNP_001268639.1, NM_001281710.1
NP_001268640.1, NM_001281711.1
NP_001268641.1, NM_001281712.1 [Q15003-2]
NP_056156.2, NM_015341.4 [Q15003-1]
UniGeneiHs.308045

Genome annotation databases

EnsembliENST00000240423; ENSP00000240423; ENSG00000121152 [Q15003-1]
ENST00000427946; ENSP00000400774; ENSG00000121152 [Q15003-2]
GeneIDi23397
KEGGihsa:23397
UCSCiuc002svz.3 human [Q15003-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38553 mRNA Translation: BAA07556.1 Different initiation.
AK303725 mRNA Translation: BAG64701.1
AC021188 Genomic DNA No translation available.
BC024211 mRNA Translation: AAH24211.1
CCDSiCCDS2021.1 [Q15003-1]
CCDS62960.1 [Q15003-2]
RefSeqiNP_001268639.1, NM_001281710.1
NP_001268640.1, NM_001281711.1
NP_001268641.1, NM_001281712.1 [Q15003-2]
NP_056156.2, NM_015341.4 [Q15003-1]
UniGeneiHs.308045

3D structure databases

ProteinModelPortaliQ15003
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116970, 53 interactors
ComplexPortaliCPX-979 Condensin I complex
CORUMiQ15003
DIPiDIP-43899N
IntActiQ15003, 27 interactors
MINTiQ15003
STRINGi9606.ENSP00000240423

PTM databases

iPTMnetiQ15003
PhosphoSitePlusiQ15003

Polymorphism and mutation databases

DMDMi116241306

Proteomic databases

EPDiQ15003
MaxQBiQ15003
PaxDbiQ15003
PeptideAtlasiQ15003
PRIDEiQ15003
ProteomicsDBi60354

Protocols and materials databases

DNASUi23397
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000240423; ENSP00000240423; ENSG00000121152 [Q15003-1]
ENST00000427946; ENSP00000400774; ENSG00000121152 [Q15003-2]
GeneIDi23397
KEGGihsa:23397
UCSCiuc002svz.3 human [Q15003-1]

Organism-specific databases

CTDi23397
EuPathDBiHostDB:ENSG00000121152.9
GeneCardsiNCAPH
HGNCiHGNC:1112 NCAPH
HPAiHPA002647
HPA003008
MalaCardsiNCAPH
MIMi602332 gene
617985 phenotype
neXtProtiNX_Q15003
OpenTargetsiENSG00000121152
PharmGKBiPA162397273
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2328 Eukaryota
COG5229 LUCA
GeneTreeiENSGT00390000004149
HOGENOMiHOG000231887
HOVERGENiHBG036823
InParanoidiQ15003
KOiK06676
OMAiPFEIDFA
OrthoDBiEOG091G01HE
PhylomeDBiQ15003
TreeFamiTF105678

Enzyme and pathway databases

ReactomeiR-HSA-2514853 Condensation of Prometaphase Chromosomes

Miscellaneous databases

ChiTaRSiNCAPH human
GeneWikiiNCAPH
GenomeRNAii23397
PMAP-CutDBiQ15003
PROiPR:Q15003
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000121152 Expressed in 110 organ(s), highest expression level in testis
CleanExiHS_NCAPH
ExpressionAtlasiQ15003 baseline and differential
GenevisibleiQ15003 HS

Family and domain databases

InterProiView protein in InterPro
IPR022816 Condensin_barren_su2
PANTHERiPTHR13108 PTHR13108, 1 hit
PfamiView protein in Pfam
PF05786 Cnd2, 1 hit
PIRSFiPIRSF017126 Condensin_H, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCND2_HUMAN
AccessioniPrimary (citable) accession number: Q15003
Secondary accession number(s): B4E189, Q8TB87
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: October 17, 2006
Last modified: November 7, 2018
This is version 162 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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