UniProtKB - Q15003 (CND2_HUMAN)
Condensin complex subunit 2
NCAPH
Functioni
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (PubMed:11136719).
Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959).
2 PublicationsGO - Molecular functioni
- chromatin binding Source: GO_Central
GO - Biological processi
- cell division Source: UniProtKB-KW
- female meiosis chromosome separation Source: Ensembl
- meiotic chromosome condensation Source: Ensembl
- mitotic chromosome condensation Source: UniProtKB
- positive regulation of chromosome condensation Source: ComplexPortal
- positive regulation of chromosome segregation Source: Ensembl
- positive regulation of chromosome separation Source: Ensembl
Keywordsi
Biological process | Cell cycle, Cell division, DNA condensation, Mitosis |
Enzyme and pathway databases
PathwayCommonsi | Q15003 |
Reactomei | R-HSA-2514853, Condensation of Prometaphase Chromosomes |
SignaLinki | Q15003 |
SIGNORi | Q15003 |
Names & Taxonomyi
Protein namesi | Recommended name: Condensin complex subunit 2Alternative name(s): Barren homolog protein 1 Chromosome-associated protein H Short name: hCAP-H Non-SMC condensin I complex subunit H XCAP-H homolog |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1112, NCAPH |
MIMi | 602332, gene |
neXtProti | NX_Q15003 |
VEuPathDBi | HostDB:ENSG00000121152 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Other locations
- Chromosome 1 Publication
Note: In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
Cytosol
- cytosol Source: HPA
Nucleus
- condensed nuclear chromosome Source: Ensembl
- nucleoplasm Source: HPA
Other locations
- condensin complex Source: UniProtKB
- membrane Source: UniProtKB
Keywords - Cellular componenti
Chromosome, Cytoplasm, NucleusPathology & Biotechi
Involvement in diseasei
Microcephaly 23, primary, autosomal recessive (MCPH23)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_080954 | 243 | P → L in MCPH23; impairs mitotic chromosome compaction. 1 PublicationCorresponds to variant dbSNP:rs1553446603EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variant, Primary microcephalyOrganism-specific databases
DisGeNETi | 23397 |
MalaCardsi | NCAPH |
MIMi | 617985, phenotype |
OpenTargetsi | ENSG00000121152 |
PharmGKBi | PA162397273 |
Miscellaneous databases
Pharosi | Q15003, Tbio |
Genetic variation databases
BioMutai | NCAPH |
DMDMi | 116241306 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000095038 | 1 – 741 | Condensin complex subunit 2Add BLAST | 741 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 15 | PhosphoserineCombined sources | 1 | |
Modified residuei | 25 | PhosphoserineCombined sources | 1 | |
Modified residuei | 28 | PhosphoserineBy similarity | 1 | |
Modified residuei | 49 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 70 | PhosphoserineCombined sources | 1 | |
Modified residuei | 78 | PhosphoserineCombined sources | 1 | |
Modified residuei | 81 | PhosphoserineCombined sources | 1 | |
Modified residuei | 87 | PhosphoserineCombined sources | 1 | |
Modified residuei | 89 | PhosphoserineCombined sources | 1 | |
Modified residuei | 92 | PhosphoserineCombined sources | 1 | |
Modified residuei | 96 | PhosphoserineCombined sources | 1 | |
Modified residuei | 201 | PhosphoserineCombined sources | 1 | |
Modified residuei | 233 | PhosphoserineCombined sources | 1 | |
Modified residuei | 432 | PhosphoserineCombined sources | 1 | |
Cross-linki | 488 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 496 | PhosphoserineCombined sources | 1 | |
Modified residuei | 598 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 605 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 637 | N6-acetyllysineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q15003 |
jPOSTi | Q15003 |
MassIVEi | Q15003 |
MaxQBi | Q15003 |
PaxDbi | Q15003 |
PeptideAtlasi | Q15003 |
PRIDEi | Q15003 |
ProteomicsDBi | 5736 60354 [Q15003-1] |
PTM databases
GlyGeni | Q15003, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q15003 |
MetOSitei | Q15003 |
PhosphoSitePlusi | Q15003 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000121152, Expressed in testis and 129 other tissues |
ExpressionAtlasi | Q15003, baseline and differential |
Genevisiblei | Q15003, HS |
Organism-specific databases
HPAi | ENSG00000121152, Tissue enhanced (bone marrow, lymphoid tissue, testis) |
Interactioni
Subunit structurei
Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: NCAPH/BRRN1, NCAPD2/CAPD2 and NCAPG.
1 PublicationBinary interactionsi
Q15003
Protein-protein interaction databases
BioGRIDi | 116970, 97 interactors |
ComplexPortali | CPX-979, Condensin I complex |
CORUMi | Q15003 |
DIPi | DIP-43899N |
IntActi | Q15003, 43 interactors |
MINTi | Q15003 |
STRINGi | 9606.ENSP00000240423 |
Miscellaneous databases
RNActi | Q15003, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q15003 |
SMRi | Q15003 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 67 | DisorderedSequence analysisAdd BLAST | 67 | |
Regioni | 361 – 383 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 447 – 467 | DisorderedSequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 9 – 26 | Polar residuesSequence analysisAdd BLAST | 18 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG2328, Eukaryota |
GeneTreei | ENSGT00390000004149 |
InParanoidi | Q15003 |
OMAi | KPKAKMG |
OrthoDBi | 702078at2759 |
PhylomeDBi | Q15003 |
TreeFami | TF105678 |
Family and domain databases
InterProi | View protein in InterPro IPR022816, Condensin_barren_su2 |
PANTHERi | PTHR13108, PTHR13108, 1 hit |
Pfami | View protein in Pfam PF05786, Cnd2, 1 hit |
PIRSFi | PIRSF017126, Condensin_H, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGPPGPALPA TMNNSSSETR GHPHSASSPS ERVFPMPLPR KAPLNIPGTP
60 70 80 90 100
VLEDFPQNDD EKERLQRRRS RVFDLQFSTD SPRLLASPSS RSIDISATIP
110 120 130 140 150
KFTNTQITEH YSTCIKLSTE NKITTKNAFG LHLIDFMSEI LKQKDTEPTN
160 170 180 190 200
FKVAAGTLDA STKIYAVRVD AVHADVYRVL GGLGKDAPSL EEVEGHVADG
210 220 230 240 250
SATEMGTTKK AVKPKKKHLH RTIEQNINNL NVSEADRKCE IDPMFQKTAA
260 270 280 290 300
SFDECSTAGV FLSTLHCQDY RSELLFPSDV QTLSTGEPLE LPELGCVEMT
310 320 330 340 350
DLKAPLQQCA EDRQICPSLA GFQFTQWDSE THNESVSALV DKFKKNDQVF
360 370 380 390 400
DINAEVDESD CGDFPDGSLG DDFDANDEPD HTAVGDHEEF RSWKEPCQVQ
410 420 430 440 450
SCQEEMISLG DGDIRTMCPL LSMKPGEYSY FSPRTMSMWA GPDHWRFRPR
460 470 480 490 500
RKQDAPSQSE NKKKSTKKDF EIDFEDDIDF DVYFRKTKAA TILTKSTLEN
510 520 530 540 550
QNWRATTLPT DFNYNVDTLV QLHLKPGTRL LKMAQGHRVE TEHYEEIEDY
560 570 580 590 600
DYNNPNDTSN FCPGLQAADS DDEDLDDLFV GPVGNSDLSP YPCHPPKTAQ
610 620 630 640 650
QNGDTPEAQG LDITTYGESN LVAEPQKVNK IEIHYAKTAK KMDMKKLKQS
660 670 680 690 700
MWSLLTALSG KEADAEANHR EAGKEAALAE VADEKMLSGL TKDLQRSLPP
710 720 730 740
VMAQNLSIPL AFACLLHLAN EKNLKLEGTE DLSDVLVRQG D
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PHA2 | E9PHA2_HUMAN | Condensin complex subunit 2 | NCAPH | 730 | Annotation score: | ||
C9J470 | C9J470_HUMAN | Condensin complex subunit 2 | NCAPH | 607 | Annotation score: | ||
C9JZP1 | C9JZP1_HUMAN | Condensin complex subunit 2 | NCAPH | 216 | Annotation score: | ||
H7C415 | H7C415_HUMAN | Condensin complex subunit 2 | NCAPH | 182 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_080954 | 243 | P → L in MCPH23; impairs mitotic chromosome compaction. 1 PublicationCorresponds to variant dbSNP:rs1553446603EnsemblClinVar. | 1 | |
Natural variantiVAR_027882 | 539 | V → A1 PublicationCorresponds to variant dbSNP:rs2305935Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055179 | 1 – 136 | Missing in isoform 2. 1 PublicationAdd BLAST | 136 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D38553 mRNA Translation: BAA07556.1 Different initiation. AK303725 mRNA Translation: BAG64701.1 AC021188 Genomic DNA No translation available. BC024211 mRNA Translation: AAH24211.1 |
CCDSi | CCDS2021.1 [Q15003-1] CCDS62960.1 [Q15003-2] |
RefSeqi | NP_001268639.1, NM_001281710.1 NP_001268640.1, NM_001281711.1 NP_001268641.1, NM_001281712.1 [Q15003-2] NP_056156.2, NM_015341.4 [Q15003-1] |
Genome annotation databases
Ensembli | ENST00000240423.9; ENSP00000240423.4; ENSG00000121152.10 ENST00000427946.5; ENSP00000400774.1; ENSG00000121152.10 [Q15003-2] |
GeneIDi | 23397 |
KEGGi | hsa:23397 |
MANE-Selecti | ENST00000240423.9; ENSP00000240423.4; NM_015341.5; NP_056156.2 |
UCSCi | uc002svz.3, human [Q15003-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D38553 mRNA Translation: BAA07556.1 Different initiation. AK303725 mRNA Translation: BAG64701.1 AC021188 Genomic DNA No translation available. BC024211 mRNA Translation: AAH24211.1 |
CCDSi | CCDS2021.1 [Q15003-1] CCDS62960.1 [Q15003-2] |
RefSeqi | NP_001268639.1, NM_001281710.1 NP_001268640.1, NM_001281711.1 NP_001268641.1, NM_001281712.1 [Q15003-2] NP_056156.2, NM_015341.4 [Q15003-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6IGX | X-ray | 3.00 | A/C | 470-526 | [»] | |
AlphaFoldDBi | Q15003 | |||||
SMRi | Q15003 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 116970, 97 interactors |
ComplexPortali | CPX-979, Condensin I complex |
CORUMi | Q15003 |
DIPi | DIP-43899N |
IntActi | Q15003, 43 interactors |
MINTi | Q15003 |
STRINGi | 9606.ENSP00000240423 |
PTM databases
GlyGeni | Q15003, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q15003 |
MetOSitei | Q15003 |
PhosphoSitePlusi | Q15003 |
Genetic variation databases
BioMutai | NCAPH |
DMDMi | 116241306 |
Proteomic databases
EPDi | Q15003 |
jPOSTi | Q15003 |
MassIVEi | Q15003 |
MaxQBi | Q15003 |
PaxDbi | Q15003 |
PeptideAtlasi | Q15003 |
PRIDEi | Q15003 |
ProteomicsDBi | 5736 60354 [Q15003-1] |
Protocols and materials databases
Antibodypediai | 1231, 343 antibodies from 38 providers |
DNASUi | 23397 |
Genome annotation databases
Ensembli | ENST00000240423.9; ENSP00000240423.4; ENSG00000121152.10 ENST00000427946.5; ENSP00000400774.1; ENSG00000121152.10 [Q15003-2] |
GeneIDi | 23397 |
KEGGi | hsa:23397 |
MANE-Selecti | ENST00000240423.9; ENSP00000240423.4; NM_015341.5; NP_056156.2 |
UCSCi | uc002svz.3, human [Q15003-1] |
Organism-specific databases
CTDi | 23397 |
DisGeNETi | 23397 |
GeneCardsi | NCAPH |
HGNCi | HGNC:1112, NCAPH |
HPAi | ENSG00000121152, Tissue enhanced (bone marrow, lymphoid tissue, testis) |
MalaCardsi | NCAPH |
MIMi | 602332, gene 617985, phenotype |
neXtProti | NX_Q15003 |
OpenTargetsi | ENSG00000121152 |
PharmGKBi | PA162397273 |
VEuPathDBi | HostDB:ENSG00000121152 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2328, Eukaryota |
GeneTreei | ENSGT00390000004149 |
InParanoidi | Q15003 |
OMAi | KPKAKMG |
OrthoDBi | 702078at2759 |
PhylomeDBi | Q15003 |
TreeFami | TF105678 |
Enzyme and pathway databases
PathwayCommonsi | Q15003 |
Reactomei | R-HSA-2514853, Condensation of Prometaphase Chromosomes |
SignaLinki | Q15003 |
SIGNORi | Q15003 |
Miscellaneous databases
BioGRID-ORCSi | 23397, 680 hits in 1085 CRISPR screens |
ChiTaRSi | NCAPH, human |
GeneWikii | NCAPH |
GenomeRNAii | 23397 |
Pharosi | Q15003, Tbio |
PROi | PR:Q15003 |
RNActi | Q15003, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000121152, Expressed in testis and 129 other tissues |
ExpressionAtlasi | Q15003, baseline and differential |
Genevisiblei | Q15003, HS |
Family and domain databases
InterProi | View protein in InterPro IPR022816, Condensin_barren_su2 |
PANTHERi | PTHR13108, PTHR13108, 1 hit |
Pfami | View protein in Pfam PF05786, Cnd2, 1 hit |
PIRSFi | PIRSF017126, Condensin_H, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CND2_HUMAN | |
Accessioni | Q15003Primary (citable) accession number: Q15003 Secondary accession number(s): B4E189, Q8TB87 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 23, 2003 |
Last sequence update: | October 17, 2006 | |
Last modified: | May 25, 2022 | |
This is version 185 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families