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Entry version 70 (02 Dec 2020)
Sequence version 1 (22 Aug 2006)
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Protein

Spike glycoprotein

Gene

S

Organism
Human coronavirus HKU1 (isolate N2) (HCoV-HKU1)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

attaches the virion to the cell membrane by interacting with host receptor, initiating the infection.UniRule annotation
mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.UniRule annotation
Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.UniRule annotation

Miscellaneous

Isolate N2 belongs to genotype B.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processFusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Virulence, Virus entry into host cell

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Spike glycoproteinUniRule annotation
Short name:
S glycoproteinUniRule annotation
Alternative name(s):
E2UniRule annotation
Peplomer proteinUniRule annotation
Cleaved into the following 3 chains:
Spike protein S1UniRule annotation
Spike protein S2UniRule annotation
Spike protein S2'UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SUniRule annotation
ORF Names:3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHuman coronavirus HKU1 (isolate N2) (HCoV-HKU1)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri443240 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaOrthornaviraePisuviricotaPisoniviricetesNidoviralesCornidovirineaeCoronaviridaeOrthocoronavirinaeBetacoronavirusEmbecovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiHomo sapiens (Human) [TaxID: 9606]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006551 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini13 – 1295ExtracellularUniRule annotationAdd BLAST1283
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1296 – 1316HelicalUniRule annotationAdd BLAST21
Topological domaini1317 – 1351CytoplasmicUniRule annotationAdd BLAST35

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 12UniRule annotationAdd BLAST12
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000029780613 – 1351Spike glycoproteinAdd BLAST1339
ChainiPRO_000029780713 – 756Spike protein S1Add BLAST744
ChainiPRO_0000297808757 – 1351Spike protein S2Add BLAST595
ChainiPRO_0000444079901 – 1351Spike protein S2'UniRule annotationAdd BLAST451

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi19N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi20 ↔ 156PROSITE-ProRule annotation
Glycosylationi29N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi58N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi114N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi132N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Disulfide bondi151 ↔ 183PROSITE-ProRule annotation
Disulfide bondi163 ↔ 242PROSITE-ProRule annotation
Glycosylationi171N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi188N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi192N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi251N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Disulfide bondi282 ↔ 292PROSITE-ProRule annotation
Disulfide bondi327 ↔ 352PROSITE-ProRule annotation
Glycosylationi335N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi355N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Disulfide bondi370 ↔ 423PROSITE-ProRule annotation
Disulfide bondi382 ↔ 603PROSITE-ProRule annotation
Glycosylationi433N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi454N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi561N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi664N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi684N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi703N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi725N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi771N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi776N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi793N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi924N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Disulfide bondi925 ↔ 936UniRule annotation
Glycosylationi1181N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi1211N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi1221N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi1226N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi1240N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi1247N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi1255N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi1276N-linked (GlcNAc...) asparagine; by hostUniRule annotation1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Specific enzymatic cleavages in vivo yield mature proteins. The precursor is processed into S1 and S2 by host cell furin or another cellular protease to yield the mature S1 and S2 proteins. Additionally, a second cleavage leads to the release of a fusion peptide after viral attachment to host cell receptor.UniRule annotation
The cytoplasmic Cys-rich domain is palmitoylated. Spike glycoprotein is digested within host endosomes.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei756 – 757Cleavage; by hostBy similarity2
Sitei900 – 901CleavageUniRule annotation2

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer; each monomer consists of a S1 and a S2 subunit. The resulting peplomers protrude from the virus surface as spikes.

UniRule annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q14EB0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini14 – 294BetaCoV S1-NTDPROSITE-ProRule annotationAdd BLAST281
Domaini325 – 605BetaCoV S1-CTDPROSITE-ProRule annotationAdd BLAST281

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni310 – 622Receptor-binding domainUniRule annotationAdd BLAST313
Regioni901 – 922Fusion peptide 1UniRule annotationAdd BLAST22
Regioni920 – 940Fusion peptide 2UniRule annotationAdd BLAST21
Regioni1001 – 1051Heptad repeat 1UniRule annotationAdd BLAST51
Regioni1245 – 1284Heptad repeat 2UniRule annotationAdd BLAST40

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1030 – 1074UniRule annotationAdd BLAST45
Coiled coili1257 – 1285UniRule annotationAdd BLAST29

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1347 – 1351KxHxxUniRule annotation5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1317 – 1334Cys-richAdd BLAST18

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Fusion peptide 1 (FP1) and fusion peptide 2 (FP2) function cooperatively and have a membrane-ordering effect on lipid headgroups and shallow hydrophobic regions of target bilayers. They are considered as two domains of an extended, bipartite FP. The membrane-ordering activity is calcium-dependent and also dependent on correct folding, which is maintained by an internal disulfide bond in FP2.UniRule annotation

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the betacoronaviruses spike protein family.UniRule annotation

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.5.790, 1 hit
2.60.120.960, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_04099, BETA_CORONA_SPIKE, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032500, bCoV_S1_N
IPR042578, BETA_CORONA_SPIKE
IPR043607, CoV_S1_C
IPR043473, S2_sf_CoV
IPR027400, S_HR2_CoV
IPR043002, Spike_N_sf
IPR018548, Spike_rcpt-bd_bCoV
IPR036326, Spike_rcpt-bd_sf_CoV
IPR002552, Spike_S2_CoV
IPR043614, Spike_S2_CoV_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16451, bCoV_S1_N, 1 hit
PF09408, bCoV_S1_RBD, 1 hit
PF19209, CoV_S1_C, 1 hit
PF01601, CoV_S2, 1 hit
PF19214, CoV_S2_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF111474, SSF111474, 2 hits
SSF143587, SSF143587, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51921, BCOV_S1_CTD, 1 hit
PS51922, BCOV_S1_NTD, 1 hit
PS51923, COV_S2_HR1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q14EB0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFLIIFILPT TLAVIGDFNC TNSFINDYNK TIPRISEDVV DVSLGLGTYY
60 70 80 90 100
VLNRVYLNTT LLFTGYFPKS GANFRDLALK GSKYLSTLWY KPPFLSDFNN
110 120 130 140 150
GIFSKVKNTK LYVNNTLYSE FSTIVIGSVF VNTSYTIVVQ PHNGILEITA
160 170 180 190 200
CQYTMCEYPH TVCKSKGSIR NESWHIDSSE PLCLFKKNFT YNVSADWLYF
210 220 230 240 250
HFYQERGVFY AYYADVGMPT TFLFSLYLGT ILSHYYVMPL TCKAISSNTD
260 270 280 290 300
NETLEYWVTP LSRRQYLLNF DEHGVITNAV DCSSSFLSEI QCKTQSFAPN
310 320 330 340 350
TGVYDLSGFT VKPVATVYRR IPNLPDCDID NWLNNVSVPS PLNWERRIFS
360 370 380 390 400
NCNFNLSTLL RLVHVDSFSC NNLDKSKIFG SCFNSITVDK FAIPNRRRDD
410 420 430 440 450
LQLGSSGFLQ SSNYKIDISS SSCQLYYSLP LVNVTINNFN PSSWNRRYGF
460 470 480 490 500
GSFNVSSYDV VYSDHCFSVN SDFCPCADPS VVNSCVKSKP LSAICPAGTK
510 520 530 540 550
YRHCDLDTTL YVNNWCRCSC LPDPISTYSP NTCPQKKVVV GIGEHCPGLG
560 570 580 590 600
INEEKCGTQL NHSSCSCSPD AFLGWSFDSC ISNNRCNIFS NFIFNGINSG
610 620 630 640 650
TTCSNDLLYS NTEVSTGVCV NYDLYGITGQ GIFKEVSAAY YNNWQNLLYD
660 670 680 690 700
SNGNIIGFKD FLTNKTYTIL PCYSGRVSAA FYQNSSSPAL LYRNLKCSYV
710 720 730 740 750
LNNISFISQP FYFDSYLGCV LNAVNLTSYS VSSCDLRMGS GFCIDYALPS
760 770 780 790 800
SRRKRRGISS PYRFVTFEPF NVSFVNDSVE TVGGLFEIQI PTNFTIAGHE
810 820 830 840 850
EFIQTSSPKV TIDCSAFVCS NYAACHDLLS EYGTFCDNIN SILNEVNDLL
860 870 880 890 900
DITQLQVANA LMQGVTLSSN LNTNLHSDVD NIDFKSLLGC LGSQCGSSSR
910 920 930 940 950
SLLEDLLFNK VKLSDVGFVE AYNNCTGGSE IRDLLCVQSF NGIKVLPPIL
960 970 980 990 1000
SETQISGYTT AATVAAMFPP WSAAAGVPFS LNVQYRINGL GVTMDVLNKN
1010 1020 1030 1040 1050
QKLIANAFNK ALLSIQNGFT ATNSALAKIQ SVVNANAQAL NSLLQQLFNK
1060 1070 1080 1090 1100
FGAISSSLQE ILSRLDNLEA QVQIDRLING RLTALNAYVS QQLSDITLIK
1110 1120 1130 1140 1150
AGASRAIEKV NECVKSQSPR INFCGNGNHI LSLVQNAPYG LLFIHFSYKP
1160 1170 1180 1190 1200
TSFKTVLVSP GLCLSGDRGI APKQGYFIKQ NDSWMFTGSS YYYPEPISDK
1210 1220 1230 1240 1250
NVVFMNSCSV NFTKAPFIYL NNSIPNLSDF EAEFSLWFKN HTSIAPNLTF
1260 1270 1280 1290 1300
NSHINATFLD LYYEMNVIQE SIKSLNSSFI NLKEIGTYEM YVKWPWYIWL
1310 1320 1330 1340 1350
LIVILFIIFL MILFFICCCT GCGSACFSKC HNCCDEYGGH NDFVIKASHD

D
Length:1,351
Mass (Da):150,800
Last modified:August 22, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1EC5F8EBB449D413
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY884001 Genomic RNA Translation: AAX76521.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY884001 Genomic RNA Translation: AAX76521.1

3D structure databases

SMRiQ14EB0
ModBaseiSearch...

Family and domain databases

Gene3Di1.20.5.790, 1 hit
2.60.120.960, 1 hit
HAMAPiMF_04099, BETA_CORONA_SPIKE, 1 hit
InterProiView protein in InterPro
IPR032500, bCoV_S1_N
IPR042578, BETA_CORONA_SPIKE
IPR043607, CoV_S1_C
IPR043473, S2_sf_CoV
IPR027400, S_HR2_CoV
IPR043002, Spike_N_sf
IPR018548, Spike_rcpt-bd_bCoV
IPR036326, Spike_rcpt-bd_sf_CoV
IPR002552, Spike_S2_CoV
IPR043614, Spike_S2_CoV_C
PfamiView protein in Pfam
PF16451, bCoV_S1_N, 1 hit
PF09408, bCoV_S1_RBD, 1 hit
PF19209, CoV_S1_C, 1 hit
PF01601, CoV_S2, 1 hit
PF19214, CoV_S2_C, 1 hit
SUPFAMiSSF111474, SSF111474, 2 hits
SSF143587, SSF143587, 1 hit
PROSITEiView protein in PROSITE
PS51921, BCOV_S1_CTD, 1 hit
PS51922, BCOV_S1_NTD, 1 hit
PS51923, COV_S2_HR1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPIKE_CVHN2
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14EB0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 22, 2006
Last modified: December 2, 2020
This is version 70 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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