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UniProtKB - Q14DL0 (UBQLN_MOUSE)

Entry version 85 (08 May 2019)
Sequence version 2 (27 Jul 2011)
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Protein

Ubiquilin-like protein

Gene

Ubqlnl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • polyubiquitin modification-dependent protein binding Source: GO_Central
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ubiquilin-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ubqlnl
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:2685336 Ubqlnl

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003077921 – 610Ubiquilin-like proteinAdd BLAST610

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q14DL0

PRoteomics IDEntifications database

More...PRIDEi		Q14DL0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q14DL0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q14DL0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000051437 Expressed in 17 organ(s), highest expression level in testis

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q14DL0 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000056365

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1610
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DNANMR-A557-610[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q14DL0

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q14DL0

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 105Ubiquitin-likePROSITE-ProRule annotationAdd BLAST75
Domaini562 – 607UBAAdd BLAST46

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0010 Eukaryota
COG5272 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000163345

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000234878

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q14DL0

KEGG Orthology (KO)

More...KOi		K22254

Identification of Orthologs from Complete Genome Data

More...OMAi		VAPYLWG

Database of Orthologous Groups

More...OrthoDBi		1553668at2759

TreeFam database of animal gene trees

More...TreeFami		TF314412

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR009060 UBA-like_sf
IPR015496 Ubiquilin
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom

The PANTHER Classification System

More...PANTHERi		PTHR10677 PTHR10677, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00240 ubiquitin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00213 UBQ, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46934 SSF46934, 1 hit
SSF54236 SSF54236, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50053 UBIQUITIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q14DL0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRIISRSPK MPQSRYTAGV PADGKISPGV IRVIVKTPGN QIIFTVADDT 
        60         70         80         90        100
LVRQFKEILS AHFKCQMEQL VLVFMGRLLK DHDTLSQRGI TDGHIIHVVI 
       110        120        130        140        150
KSKHGPRSLA HSFRNLVTNN PCHQDRNPKG NSSMVCQSAG MNETKVESSL 
       160        170        180        190        200
LMEPEAPKVG TESPEVGSLE HIAQVLENLC VQSLLSNMDF VHQMPPEQPY 
       210        220        230        240        250
MEELIQQNPE VSHLLDNSEI LCQTLELVRH LAIIQEIMQI QQPAQNPEYP 
       260        270        280        290        300
PNSQPFLGLE TVPNGNNHLG QSYVNNNDHM LNGVPDLLEG NCFTALLDEQ 
       310        320        330        340        350
VLEQVQTPSL SQPLPQEQWD QLSSSQVIYA NSCGLSSITP TNATPNHTNN 
       360        370        380        390        400
VSRENPAIVA TQGQSNVCAV QQPAEIPVLP TISINQKPQV DKDTTITLGI 
       410        420        430        440        450
SDQWLEEDLQ QSDDQTSSQI TGGMIQLLRN HPQMAAQMLL LMNTSQLNEQ 
       460        470        480        490        500
WRQETPTPLQ SSQLHDLLLA LANPKTSQAL LQIEHGLQLL ATEAPALLPY 
       510        520        530        540        550
IEPYLWGLGW LIPSICSYPD IVPWTWNVQD MAEPQCPESC HKSETVLQKV 
       560        570        580        590        600
QPPSGDPSHS LQAPEVRFSK EMECLQAMGF VNYNANLQAL IATDGDTNAA 
       610
IYKLKSSQGF
Length:610
Mass (Da):67,566
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i48F57D85DA7CF840
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti17T → P in AAI11902 (PubMed:15489334).Curated1
Sequence conflicti52V → G in BAC36434 (PubMed:16141072).Curated1
Sequence conflicti58I → M in AAI11902 (PubMed:15489334).Curated1
Sequence conflicti82H → Y in AAI11902 (PubMed:15489334).Curated1
Sequence conflicti132S → C in AAI11902 (PubMed:15489334).Curated1
Sequence conflicti142N → S in AAI11902 (PubMed:15489334).Curated1
Sequence conflicti145K → I in AAI11902 (PubMed:15489334).Curated1
Sequence conflicti150Missing in AAI11902 (PubMed:15489334).Curated1
Sequence conflicti163S → G in AAI11902 (PubMed:15489334).Curated1
Sequence conflicti196P → Q in AAI11902 (PubMed:15489334).Curated1
Sequence conflicti256F → Y in AAI11902 (PubMed:15489334).Curated1
Sequence conflicti284V → A in AAI11902 (PubMed:15489334).Curated1
Sequence conflicti345P → S in AAI11902 (PubMed:15489334).Curated1
Sequence conflicti383S → P in AAI11902 (PubMed:15489334).Curated1
Sequence conflicti387K → E in AAI11902 (PubMed:15489334).Curated1
Sequence conflicti395T → A in AAI11902 (PubMed:15489334).Curated1
Sequence conflicti423G → R in AAI13135 (PubMed:15489334).Curated1
Sequence conflicti445S → P in AAI11902 (PubMed:15489334).Curated1
Sequence conflicti445S → P in AAI13135 (PubMed:15489334).Curated1
Sequence conflicti460Q → H in AAI11902 (PubMed:15489334).Curated1
Sequence conflicti517S → G in AAI11902 (PubMed:15489334).Curated1
Sequence conflicti522V → E in BAC36434 (PubMed:16141072).Curated1
Sequence conflicti553P → L in AAI11902 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK076645 mRNA Translation: BAC36434.1
AC123830 Genomic DNA No translation available.
BC111901 mRNA Translation: AAI11902.1
BC113134 mRNA Translation: AAI13135.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS21611.1

NCBI Reference Sequences

More...RefSeqi		NP_941026.2, NM_198624.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000059121; ENSMUSP00000056365; ENSMUSG00000051437

Database of genes from NCBI RefSeq genomes

More...GeneIDi		244179

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:244179

UCSC genome browser

More...UCSCi		uc009ivl.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK076645 mRNA Translation: BAC36434.1
AC123830 Genomic DNA No translation available.
BC111901 mRNA Translation: AAI11902.1
BC113134 mRNA Translation: AAI13135.1
CCDSiCCDS21611.1
RefSeqiNP_941026.2, NM_198624.3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DNANMR-A557-610[»]
SMRiQ14DL0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056365

PTM databases

iPTMnetiQ14DL0
PhosphoSitePlusiQ14DL0

Proteomic databases

PaxDbiQ14DL0
PRIDEiQ14DL0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000059121; ENSMUSP00000056365; ENSMUSG00000051437
GeneIDi244179
KEGGimmu:244179
UCSCiuc009ivl.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		143630
MGIiMGI:2685336 Ubqlnl

Phylogenomic databases

eggNOGiKOG0010 Eukaryota
COG5272 LUCA
GeneTreeiENSGT00940000163345
HOGENOMiHOG000234878
InParanoidiQ14DL0
KOiK22254
OMAiVAPYLWG
OrthoDBi1553668at2759
TreeFamiTF314412

Miscellaneous databases

EvolutionaryTraceiQ14DL0

Protein Ontology

More...PROi		PR:Q14DL0

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000051437 Expressed in 17 organ(s), highest expression level in testis
GenevisibleiQ14DL0 MM

Family and domain databases

InterProiView protein in InterPro
IPR009060 UBA-like_sf
IPR015496 Ubiquilin
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
PANTHERiPTHR10677 PTHR10677, 1 hit
PfamiView protein in Pfam
PF00240 ubiquitin, 1 hit
SMARTiView protein in SMART
SM00213 UBQ, 1 hit
SUPFAMiSSF46934 SSF46934, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50053 UBIQUITIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUBQLN_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14DL0
Secondary accession number(s): E9QM12, Q14DR8, Q8BVT0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: July 27, 2011
Last modified: May 8, 2019
This is version 85 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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