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Protein

Acyl-CoA synthetase short-chain family member 3, mitochondrial

Gene

Acss3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Activates acetate so that it can be used for lipid synthesis or for energy generation.By similarity

Catalytic activityi

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei534ATPBy similarity1
Binding sitei549ATPBy similarity1
Binding sitei560ATPBy similarity1
Binding sitei619Coenzyme ABy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi420 – 422ATPBy similarity3
Nucleotide bindingi441 – 446ATPBy similarity6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-77111 Synthesis of Ketone Bodies

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA synthetase short-chain family member 3, mitochondrial (EC:6.2.1.1)
Gene namesi
Name:Acss3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2685720 Acss3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 29MitochondrionSequence analysisAdd BLAST29
ChainiPRO_000032062530 – 682Acyl-CoA synthetase short-chain family member 3, mitochondrialAdd BLAST653

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei513N6-succinyllysineCombined sources1
Modified residuei519N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ14DH7
PaxDbiQ14DH7
PeptideAtlasiQ14DH7
PRIDEiQ14DH7

PTM databases

iPTMnetiQ14DH7
PhosphoSitePlusiQ14DH7

Expressioni

Gene expression databases

BgeeiENSMUSG00000035948 Expressed in 23 organ(s), highest expression level in brown adipose tissue
CleanExiMM_ACSS3

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000128209

Structurei

3D structure databases

ProteinModelPortaliQ14DH7
SMRiQ14DH7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni222 – 225Coenzyme A bindingBy similarity4

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1175 Eukaryota
COG0365 LUCA
GeneTreeiENSGT00760000119178
HOGENOMiHOG000229981
HOVERGENiHBG014401
InParanoidiQ14DH7
KOiK01908
OMAiPGYNVMI
OrthoDBiEOG091G03IL
PhylomeDBiQ14DH7
TreeFamiTF354241

Family and domain databases

InterProiView protein in InterPro
IPR032387 ACAS_N
IPR025110 AMP-bd_C
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
PfamiView protein in Pfam
PF16177 ACAS_N, 1 hit
PF00501 AMP-binding, 1 hit
PF13193 AMP-binding_C, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q14DH7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKPSWLQCRK VTGAGTLGAP LPGSPSVRGA AVTRRALVAG FGGRGCRALT
60 70 80 90 100
TGSGGEYKTH FAASVADPER FWGKAAEQIS WYKPWTKTLE SRYPPSTSWF
110 120 130 140 150
VEGMLNICYN AIDRHIENGQ GDKIAIIYDS PVTDTKATIS YKEVLEQVSK
160 170 180 190 200
LAGVLVKQGV KKGDTVVIYM PMIPQAIYTM LACARIGAIH SLIFGGFASK
210 220 230 240 250
ELSTRIDHAK PKVVVTASFG IEPGRKVEYI PLLEEALRIG QHRPDRVLIY
260 270 280 290 300
SRPNMEKVPL MSGRDLDWEE EMAKAQSHDC VPVLSEHPLY ILYTSGTTGL
310 320 330 340 350
PKGVVRPTGG YAVMLNWTMS SIYGLKPGEV WWAASDLGWV VGHSYICYGP
360 370 380 390 400
LLHGNTTVLY EGKPVGTPDA GAYFRVLAEH GVAALFTAPT AIRAIRQQDP
410 420 430 440 450
GAALGKQYSL TRFKTLFVAG ERCDVETLEW SKKVFRVPVL DHWWQTETGS
460 470 480 490 500
PITASCIGLG NSKTPPPGQA GKCVPGYNVM ILDDNMQKLK ARSLGNIVVK
510 520 530 540 550
LPLPPGAFSG LWKNQEAFKH LYFEKFPGYY DTMDAGYMDE EGYLYVMSRV
560 570 580 590 600
DDVINVAGHR ISAGAIEESV LSHGTVADCA VVGKEDPLKG HVPLALCVLK
610 620 630 640 650
KDVNASEEQV LEEIVKHVRQ SIGPVAAFRN AVFVKQLPKT RSGKIPRSTL
660 670 680
SALVNGKPYK VTPTIEDPSI FGHIEEVLKQ AV
Length:682
Mass (Da):74,518
Last modified:February 26, 2008 - v2
Checksum:iB865D534C631D5D1
GO
Isoform 2 (identifier: Q14DH7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     479-479: V → GRYLLHHSAESLTPPAMGK
     480-682: Missing.

Show »
Length:497
Mass (Da):54,137
Checksum:i129841385217FAF1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti477Y → N in BAC28254 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_031693479V → GRYLLHHSAESLTPPAMGK in isoform 2. 2 Publications1
Alternative sequenceiVSP_031694480 – 682Missing in isoform 2. 2 PublicationsAdd BLAST203

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033376 mRNA Translation: BAC28254.1
AC111014 Genomic DNA No translation available.
AC121946 Genomic DNA No translation available.
AC134457 Genomic DNA No translation available.
BC113198 mRNA Translation: AAI13199.1
CCDSiCCDS24159.1 [Q14DH7-2]
CCDS48688.1 [Q14DH7-1]
RefSeqiNP_001136276.1, NM_001142804.1 [Q14DH7-1]
NP_941038.2, NM_198636.3 [Q14DH7-2]
UniGeneiMm.336072

Genome annotation databases

EnsembliENSMUST00000044668; ENSMUSP00000040823; ENSMUSG00000035948 [Q14DH7-2]
ENSMUST00000165067; ENSMUSP00000128209; ENSMUSG00000035948 [Q14DH7-1]
GeneIDi380660
KEGGimmu:380660
UCSCiuc007gyv.2 mouse [Q14DH7-2]
uc011xna.1 mouse [Q14DH7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033376 mRNA Translation: BAC28254.1
AC111014 Genomic DNA No translation available.
AC121946 Genomic DNA No translation available.
AC134457 Genomic DNA No translation available.
BC113198 mRNA Translation: AAI13199.1
CCDSiCCDS24159.1 [Q14DH7-2]
CCDS48688.1 [Q14DH7-1]
RefSeqiNP_001136276.1, NM_001142804.1 [Q14DH7-1]
NP_941038.2, NM_198636.3 [Q14DH7-2]
UniGeneiMm.336072

3D structure databases

ProteinModelPortaliQ14DH7
SMRiQ14DH7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000128209

PTM databases

iPTMnetiQ14DH7
PhosphoSitePlusiQ14DH7

Proteomic databases

MaxQBiQ14DH7
PaxDbiQ14DH7
PeptideAtlasiQ14DH7
PRIDEiQ14DH7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044668; ENSMUSP00000040823; ENSMUSG00000035948 [Q14DH7-2]
ENSMUST00000165067; ENSMUSP00000128209; ENSMUSG00000035948 [Q14DH7-1]
GeneIDi380660
KEGGimmu:380660
UCSCiuc007gyv.2 mouse [Q14DH7-2]
uc011xna.1 mouse [Q14DH7-1]

Organism-specific databases

CTDi79611
MGIiMGI:2685720 Acss3

Phylogenomic databases

eggNOGiKOG1175 Eukaryota
COG0365 LUCA
GeneTreeiENSGT00760000119178
HOGENOMiHOG000229981
HOVERGENiHBG014401
InParanoidiQ14DH7
KOiK01908
OMAiPGYNVMI
OrthoDBiEOG091G03IL
PhylomeDBiQ14DH7
TreeFamiTF354241

Enzyme and pathway databases

ReactomeiR-MMU-77111 Synthesis of Ketone Bodies

Miscellaneous databases

PROiPR:Q14DH7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035948 Expressed in 23 organ(s), highest expression level in brown adipose tissue
CleanExiMM_ACSS3

Family and domain databases

InterProiView protein in InterPro
IPR032387 ACAS_N
IPR025110 AMP-bd_C
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
PfamiView protein in Pfam
PF16177 ACAS_N, 1 hit
PF00501 AMP-binding, 1 hit
PF13193 AMP-binding_C, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiACSS3_MOUSE
AccessioniPrimary (citable) accession number: Q14DH7
Secondary accession number(s): Q8BZX0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: September 12, 2018
This is version 94 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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