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Entry version 104 (02 Jun 2021)
Sequence version 2 (17 Apr 2007)
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Protein

Transmembrane protein 132B

Gene

TMEM132B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q14DG7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane protein 132B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM132B
Synonyms:KIAA1786, KIAA1906
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29397, TMEM132B

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q14DG7

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000139364.10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 903ExtracellularSequence analysisAdd BLAST903
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei904 – 924HelicalSequence analysisAdd BLAST21
Topological domaini925 – 1078CytoplasmicSequence analysisAdd BLAST154

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
114795

Open Targets

More...
OpenTargetsi
ENSG00000139364

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA143485652

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q14DG7, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TMEM132B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
145566963

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002846201 – 1078Transmembrane protein 132BAdd BLAST1078

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi343N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi366N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi381N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q14DG7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q14DG7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q14DG7

PeptideAtlas

More...
PeptideAtlasi
Q14DG7

PRoteomics IDEntifications database

More...
PRIDEi
Q14DG7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
60346 [Q14DG7-1]
60347 [Q14DG7-2]
60348 [Q14DG7-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q14DG7, 4 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q14DG7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q14DG7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000139364, Expressed in ventricular zone and 149 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q14DG7, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000139364, Tissue enriched (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
125357, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000299308

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q14DG7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q14DG7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni834 – 887DisorderedSequence analysisAdd BLAST54

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi838 – 856Polar residuesSequence analysisAdd BLAST19
Compositional biasi868 – 887Polar residuesSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TMEM132 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4789, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159630

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_009871_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q14DG7

Identification of Orthologs from Complete Genome Data

More...
OMAi
CTGGVTE

Database of Orthologous Groups

More...
OrthoDBi
598074at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q14DG7

TreeFam database of animal gene trees

More...
TreeFami
TF314981

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026307, TMEM132
IPR031436, TMEM132_C
IPR031437, TMEM132_M
IPR031435, TMEM132_N

The PANTHER Classification System

More...
PANTHERi
PTHR13388, PTHR13388, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16070, TMEM132, 1 hit
PF15706, TMEM132D_C, 1 hit
PF15705, TMEM132D_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q14DG7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFGAASRMDT TAVCTGGVTE SRGIVDSLQK FSSLPAYLPT NLHISNAEES
60 70 80 90 100
FFLKEANQDL TRNSSLQARV EPFFIYRART PPIINASYGP FSVEKIIPQE
110 120 130 140 150
LLLTSTAFGN MDKFPFNWKL KSHILDSSIY SNRPKVQTLF YVTGMGWDDS
160 170 180 190 200
DLTEDLPCVK MFAFPEAREV AASCRLQGAP GLCVAELELL PEWFSSGLDL
210 220 230 240 250
EPEEEIPALL GGTTMELFFT LYPADKAGQC PLEEEGKWEN NIHSGLESPQ
260 270 280 290 300
QAFPARERIG SVVVYPTQDD LKWSLVSLDE NVVISVPLNL VREGDTATFL
310 320 330 340 350
VSLTSSSVAD QFTLRIKAAA GVKITAVRVS SEDQWAVQEE IDNGSTQTSA
360 370 380 390 400
TLTCMGHRPD TQSRVNGSFY EILQVDFGID NSSDLAGAQQ ITWQVEYPIE
410 420 430 440 450
DSMSELVVSE IFVSQTTFVG IVPLAMDTEV LNTAILTGKP VSVPVKVVGV
460 470 480 490 500
QEDGSVVDVS ESVECKSADE DVIKVSNNCD SIFVNGKEMK SKVDTIVNFT
510 520 530 540 550
HQHFTSQFEV TVWAPRLPLQ IEISDTELSQ IKGWRIPVAA NRRPTRESDD
560 570 580 590 600
EDDEEKKGRG CSLQYQHATV RVLTQFVAES PDLGQLTYML GPDWQFDITD
610 620 630 640 650
LVTEFMKVEE PKIAQLQDGR TLAGREPGIT TVQVLSPLSD SILAEKTVIV
660 670 680 690 700
LDDRVTIAEL GVQLVAGMSL SLQPHRADKR AIVSTAAALD VLQSPQQEAI
710 720 730 740 750
VSSWILFSDG SVTPLDIYDP KDYSVTVSSL DEMVVSVQAN LESKWPIVVA
760 770 780 790 800
EGEGQGPLIK LEMMISEPCQ KTKRKSVLAV GKGNVKVKFE PSSDEHQGGS
810 820 830 840 850
NDIEGINREY KDHLSNSIER EGNQERAVQE WFHRGTPVGQ EESTNKSTTP
860 870 880 890 900
QSPMEGKNKL LKSGGPDAFT SFPTQGKSPD PNNPSDLTVT SRGLTDLEIG
910 920 930 940 950
MYALLCVFCL AILVFLINCV AFAWKYRHKR FAVSEQGNIP HSHDWVWLGN
960 970 980 990 1000
EVELLENPVD ITLPSEECTT MIDRGLQFEE RNFLLNGSSQ KTFHSQLLRP
1010 1020 1030 1040 1050
SDYVYEKEIK NEPMNSSGPK RKRVKFTSYT TILPEDGGPY TNSILFDSDD
1060 1070
NIKWVCQDMG LGDSQDFRDY MESLQDQM
Length:1,078
Mass (Da):119,477
Last modified:April 17, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i05119ADDA42AF379
GO
Isoform 2 (identifier: Q14DG7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     476-502: SNNCDSIFVNGKEMKSKVDTIVNFTHQ → RGDLSTAVLSAQSFLSFLLLSPRSCSH
     503-1078: Missing.

Show »
Length:502
Mass (Da):54,864
Checksum:i4F0BB45B9DB02306
GO
Isoform 3 (identifier: Q14DG7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-488: Missing.

Show »
Length:590
Mass (Da):66,097
Checksum:i1E16CF04D33A4F28
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti735V → G in BAC04053 (PubMed:14702039).Curated1
Sequence conflicti957N → D in BAC04053 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_031786658A → V1 PublicationCorresponds to variant dbSNP:rs16919359EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0245761 – 488Missing in isoform 3. 2 PublicationsAdd BLAST488
Alternative sequenceiVSP_024577476 – 502SNNCD…NFTHQ → RGDLSTAVLSAQSFLSFLLL SPRSCSH in isoform 2. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_024578503 – 1078Missing in isoform 2. 1 PublicationAdd BLAST576

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC093028 Genomic DNA No translation available.
AC026370 Genomic DNA No translation available.
AC073618 Genomic DNA No translation available.
AC004806 Genomic DNA No translation available.
AC005146 Genomic DNA No translation available.
AK093097 mRNA Translation: BAC04053.1
BC113366 mRNA Translation: AAI13367.1
BC113368 mRNA Translation: AAI13369.1
BC131621 mRNA Translation: AAI31622.1
AB058689 mRNA Translation: BAB47415.1
AB067493 mRNA Translation: BAB67799.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41859.1 [Q14DG7-1]
CCDS66501.1 [Q14DG7-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001273148.1, NM_001286219.1 [Q14DG7-3]
NP_443139.2, NM_052907.3 [Q14DG7-1]
XP_011536156.1, XM_011537854.2 [Q14DG7-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000299308; ENSP00000299308; ENSG00000139364 [Q14DG7-1]
ENST00000613307; ENSP00000482788; ENSG00000139364 [Q14DG7-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
114795

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:114795

UCSC genome browser

More...
UCSCi
uc001uhe.3, human [Q14DG7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093028 Genomic DNA No translation available.
AC026370 Genomic DNA No translation available.
AC073618 Genomic DNA No translation available.
AC004806 Genomic DNA No translation available.
AC005146 Genomic DNA No translation available.
AK093097 mRNA Translation: BAC04053.1
BC113366 mRNA Translation: AAI13367.1
BC113368 mRNA Translation: AAI13369.1
BC131621 mRNA Translation: AAI31622.1
AB058689 mRNA Translation: BAB47415.1
AB067493 mRNA Translation: BAB67799.1
CCDSiCCDS41859.1 [Q14DG7-1]
CCDS66501.1 [Q14DG7-3]
RefSeqiNP_001273148.1, NM_001286219.1 [Q14DG7-3]
NP_443139.2, NM_052907.3 [Q14DG7-1]
XP_011536156.1, XM_011537854.2 [Q14DG7-3]

3D structure databases

SMRiQ14DG7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi125357, 1 interactor
STRINGi9606.ENSP00000299308

PTM databases

GlyGeniQ14DG7, 4 sites
iPTMnetiQ14DG7
PhosphoSitePlusiQ14DG7

Genetic variation databases

BioMutaiTMEM132B
DMDMi145566963

Proteomic databases

EPDiQ14DG7
MassIVEiQ14DG7
PaxDbiQ14DG7
PeptideAtlasiQ14DG7
PRIDEiQ14DG7
ProteomicsDBi60346 [Q14DG7-1]
60347 [Q14DG7-2]
60348 [Q14DG7-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
31916, 42 antibodies

The DNASU plasmid repository

More...
DNASUi
114795

Genome annotation databases

EnsembliENST00000299308; ENSP00000299308; ENSG00000139364 [Q14DG7-1]
ENST00000613307; ENSP00000482788; ENSG00000139364 [Q14DG7-3]
GeneIDi114795
KEGGihsa:114795
UCSCiuc001uhe.3, human [Q14DG7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
114795
DisGeNETi114795

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TMEM132B
HGNCiHGNC:29397, TMEM132B
HPAiENSG00000139364, Tissue enriched (brain)
neXtProtiNX_Q14DG7
OpenTargetsiENSG00000139364
PharmGKBiPA143485652
VEuPathDBiHostDB:ENSG00000139364.10

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4789, Eukaryota
GeneTreeiENSGT00940000159630
HOGENOMiCLU_009871_0_0_1
InParanoidiQ14DG7
OMAiCTGGVTE
OrthoDBi598074at2759
PhylomeDBiQ14DG7
TreeFamiTF314981

Enzyme and pathway databases

PathwayCommonsiQ14DG7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
114795, 6 hits in 983 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TMEM132B, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
114795
PharosiQ14DG7, Tdark

Protein Ontology

More...
PROi
PR:Q14DG7
RNActiQ14DG7, protein

Gene expression databases

BgeeiENSG00000139364, Expressed in ventricular zone and 149 other tissues
GenevisibleiQ14DG7, HS

Family and domain databases

InterProiView protein in InterPro
IPR026307, TMEM132
IPR031436, TMEM132_C
IPR031437, TMEM132_M
IPR031435, TMEM132_N
PANTHERiPTHR13388, PTHR13388, 1 hit
PfamiView protein in Pfam
PF16070, TMEM132, 1 hit
PF15706, TMEM132D_C, 1 hit
PF15705, TMEM132D_N, 1 hit

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiT132B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14DG7
Secondary accession number(s): A2RRG8
, Q8NA73, Q96JN9, Q96PY1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: April 17, 2007
Last modified: June 2, 2021
This is version 104 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. SIMILARITY comments
    Index of protein domains and families
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