UniProtKB - Q14D33 (RTP5_HUMAN)
Protein
Receptor-transporting protein 5
Gene
RTP5
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- olfactory receptor binding Source: GO_Central
GO - Biological processi
- detection of chemical stimulus involved in sensory perception of bitter taste Source: GO_Central
- protein insertion into membrane Source: GO_Central
- protein targeting to membrane Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q14D33 |
Reactomei | R-HSA-381753, Olfactory Signaling Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Receptor-transporting protein 5Alternative name(s): 3CxxC-type zinc finger protein 5 CXXC-type zinc finger protein 11 |
Gene namesi | Name:RTP5 Synonyms:C2orf85, CXXC11, Z3CXXC5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000188011.5 |
HGNCi | HGNC:26585, RTP5 |
neXtProti | NX_Q14D33 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 544 – 560 | HelicalSequence analysisAdd BLAST | 17 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000188011 |
PharmGKBi | PA164717177 |
Miscellaneous databases
Pharosi | Q14D33, Tdark |
Polymorphism and mutation databases
BioMutai | RTP5 |
DMDMi | 281371551 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000348428 | 1 – 572 | Receptor-transporting protein 5Add BLAST | 572 |
Proteomic databases
PaxDbi | Q14D33 |
PeptideAtlasi | Q14D33 |
PRIDEi | Q14D33 |
ProteomicsDBi | 60345 |
PTM databases
iPTMneti | Q14D33 |
PhosphoSitePlusi | Q14D33 |
Expressioni
Gene expression databases
Bgeei | ENSG00000188011, Expressed in hypothalamus and 80 other tissues |
ExpressionAtlasi | Q14D33, baseline and differential |
Genevisiblei | Q14D33, HS |
Organism-specific databases
HPAi | ENSG00000188011, Tissue enriched (brain) |
Interactioni
Binary interactionsi
Q14D33
GO - Molecular functioni
- olfactory receptor binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 130013, 51 interactors |
IntActi | Q14D33, 53 interactors |
MINTi | Q14D33 |
STRINGi | 9606.ENSP00000345374 |
Miscellaneous databases
RNActi | Q14D33, protein |
Family & Domainsi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QY6R, Eukaryota |
GeneTreei | ENSGT00940000163732 |
HOGENOMi | CLU_043280_0_0_1 |
InParanoidi | Q14D33 |
OMAi | WVSMTVC |
OrthoDBi | 1504302at2759 |
PhylomeDBi | Q14D33 |
TreeFami | TF333246 |
Family and domain databases
InterProi | View protein in InterPro IPR026689, CXXC11 IPR026096, R-trans_p IPR027377, Znf-3CxxC |
PANTHERi | PTHR14402, PTHR14402, 2 hits PTHR14402:SF2, PTHR14402:SF2, 2 hits |
Pfami | View protein in Pfam PF13695, zf-3CxxC, 1 hit |
SMARTi | View protein in SMART SM01328, zf-3CxxC, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q14D33-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDRAGADMWA STFTLAMAER KPQDVWVLLP EHSLVPGCLD GGGVQYLLVG
60 70 80 90 100
LSRLQCGHCP GTWDSAHVHV LFHLWWDRAS HRGLVKMRIW GQRCRLCPAP
110 120 130 140 150
GDCQVRPPGE QPFLSRLVLH ILQDCYGDGP GPARHPREAY EGCCEACELG
160 170 180 190 200
VCFLQKAPDP AWSANATKGN FPATAWGGTG TVSRGKPLST PGDDLGKGGV
210 220 230 240 250
VIAIPFSLVG TSNDQVPIAE GPAPPAGASL PVTGSCEALV IGQGSIFLSG
260 270 280 290 300
DSVAMPGGKG FPVAIGDPLF HGPGLLGSSI QTFELKGFLF KGRGSLCSPV
310 320 330 340 350
GVAQGWGPIS LNNGLVPVGK HTPTVFYCVG LSASGEGSLT FPSSLTSIFT
360 370 380 390 400
NTLSEPTDGP VATKEASITF PFIFTDVKDA VAEVAEGNGK EGGGQGLVPV
410 420 430 440 450
GHDALPETNA GGLPSQVKGS LALPFPADVQ GKDAFTDITE GKEKEGGLVT
460 470 480 490 500
AGHDAPLEAN AEGPITVSEG CITIPFAVFD VIKRKGGGHV AYGPQGNGCF
510 520 530 540 550
SQGYYQKRQL RSRFHKARCG CRREEDERPG RACRRPHAEP YEDFWIWVSM
560 570
TVCVFWLMCM CRLNPGIYPQ QV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF8WB75 | F8WB75_HUMAN | Receptor-transporting protein 5 | RTP5 | 55 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 241 | I → T in BAC03544 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_060791 | 101 | G → E3 PublicationsCorresponds to variant dbSNP:rs7420371Ensembl. | 1 | |
Natural variantiVAR_069402 | 412 | G → D1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK090909 mRNA Translation: BAC03544.1 AC131097 Genomic DNA No translation available. CH471063 Genomic DNA Translation: EAW71299.1 BC113517 mRNA Translation: AAI13518.1 BC113519 mRNA Translation: AAI13520.1 |
CCDSi | CCDS42843.1 |
RefSeqi | NP_776182.2, NM_173821.2 |
Genome annotation databases
Ensembli | ENST00000343216; ENSP00000345374; ENSG00000188011 ENST00000617264; ENSP00000482049; ENSG00000277949 |
GeneIDi | 285093 |
KEGGi | hsa:285093 |
UCSCi | uc010fzu.2, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK090909 mRNA Translation: BAC03544.1 AC131097 Genomic DNA No translation available. CH471063 Genomic DNA Translation: EAW71299.1 BC113517 mRNA Translation: AAI13518.1 BC113519 mRNA Translation: AAI13520.1 |
CCDSi | CCDS42843.1 |
RefSeqi | NP_776182.2, NM_173821.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 130013, 51 interactors |
IntActi | Q14D33, 53 interactors |
MINTi | Q14D33 |
STRINGi | 9606.ENSP00000345374 |
PTM databases
iPTMneti | Q14D33 |
PhosphoSitePlusi | Q14D33 |
Polymorphism and mutation databases
BioMutai | RTP5 |
DMDMi | 281371551 |
Proteomic databases
PaxDbi | Q14D33 |
PeptideAtlasi | Q14D33 |
PRIDEi | Q14D33 |
ProteomicsDBi | 60345 |
Protocols and materials databases
Antibodypediai | 64441, 19 antibodies |
Genome annotation databases
Ensembli | ENST00000343216; ENSP00000345374; ENSG00000188011 ENST00000617264; ENSP00000482049; ENSG00000277949 |
GeneIDi | 285093 |
KEGGi | hsa:285093 |
UCSCi | uc010fzu.2, human |
Organism-specific databases
CTDi | 285093 |
EuPathDBi | HostDB:ENSG00000188011.5 |
GeneCardsi | RTP5 |
HGNCi | HGNC:26585, RTP5 |
HPAi | ENSG00000188011, Tissue enriched (brain) |
neXtProti | NX_Q14D33 |
OpenTargetsi | ENSG00000188011 |
PharmGKBi | PA164717177 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QY6R, Eukaryota |
GeneTreei | ENSGT00940000163732 |
HOGENOMi | CLU_043280_0_0_1 |
InParanoidi | Q14D33 |
OMAi | WVSMTVC |
OrthoDBi | 1504302at2759 |
PhylomeDBi | Q14D33 |
TreeFami | TF333246 |
Enzyme and pathway databases
PathwayCommonsi | Q14D33 |
Reactomei | R-HSA-381753, Olfactory Signaling Pathway |
Miscellaneous databases
BioGRID-ORCSi | 285093, 5 hits in 832 CRISPR screens |
GenomeRNAii | 285093 |
Pharosi | Q14D33, Tdark |
PROi | PR:Q14D33 |
RNActi | Q14D33, protein |
Gene expression databases
Bgeei | ENSG00000188011, Expressed in hypothalamus and 80 other tissues |
ExpressionAtlasi | Q14D33, baseline and differential |
Genevisiblei | Q14D33, HS |
Family and domain databases
InterProi | View protein in InterPro IPR026689, CXXC11 IPR026096, R-trans_p IPR027377, Znf-3CxxC |
PANTHERi | PTHR14402, PTHR14402, 2 hits PTHR14402:SF2, PTHR14402:SF2, 2 hits |
Pfami | View protein in Pfam PF13695, zf-3CxxC, 1 hit |
SMARTi | View protein in SMART SM01328, zf-3CxxC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RTP5_HUMAN | |
Accessioni | Q14D33Primary (citable) accession number: Q14D33 Secondary accession number(s): Q8N2A5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 2, 2008 |
Last sequence update: | December 15, 2009 | |
Last modified: | December 2, 2020 | |
This is version 109 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations