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UniProtKB - Q14D33 (RTP5_HUMAN)

Entry version 99 (08 May 2019)
Sequence version 2 (15 Dec 2009)
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Protein

Receptor-transporting protein 5

Gene

RTP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-381753 Olfactory Signaling Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Receptor-transporting protein 5
Alternative name(s):
3CxxC-type zinc finger protein 5
CXXC-type zinc finger protein 11
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RTP5
Synonyms:C2orf85, CXXC11, Z3CXXC5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:26585 RTP5

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q14D33

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei544 – 560HelicalSequence analysisAdd BLAST17

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000188011

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA164717177

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RTP5

Domain mapping of disease mutations (DMDM)

More...DMDMi		281371551

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003484281 – 572Receptor-transporting protein 5Add BLAST572

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q14D33

PeptideAtlas

More...PeptideAtlasi		Q14D33

PRoteomics IDEntifications database

More...PRIDEi		Q14D33

ProteomicsDB human proteome resource

More...ProteomicsDBi		60345

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q14D33

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q14D33

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000188011 Expressed in 64 organ(s), highest expression level in hypothalamus

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q14D33 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q14D33 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA050902

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		130013, 27 interactors

Protein interaction database and analysis system

More...IntActi		Q14D33, 53 interactors

Molecular INTeraction database

More...MINTi		Q14D33

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000345374

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410J8R5 Eukaryota
ENOG41114I2 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000163732

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000168479

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q14D33

Identification of Orthologs from Complete Genome Data

More...OMAi		FWLMCMC

Database of Orthologous Groups

More...OrthoDBi		941496at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q14D33

TreeFam database of animal gene trees

More...TreeFami		TF333246

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR026689 CXXC11
IPR026096 R-trans_p
IPR027377 Znf-3CxxC

The PANTHER Classification System

More...PANTHERi		PTHR14402 PTHR14402, 2 hits
PTHR14402:SF2 PTHR14402:SF2, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13695 zf-3CxxC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01328 zf-3CxxC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q14D33-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDRAGADMWA STFTLAMAER KPQDVWVLLP EHSLVPGCLD GGGVQYLLVG 
        60         70         80         90        100
LSRLQCGHCP GTWDSAHVHV LFHLWWDRAS HRGLVKMRIW GQRCRLCPAP 
       110        120        130        140        150
GDCQVRPPGE QPFLSRLVLH ILQDCYGDGP GPARHPREAY EGCCEACELG 
       160        170        180        190        200
VCFLQKAPDP AWSANATKGN FPATAWGGTG TVSRGKPLST PGDDLGKGGV 
       210        220        230        240        250
VIAIPFSLVG TSNDQVPIAE GPAPPAGASL PVTGSCEALV IGQGSIFLSG 
       260        270        280        290        300
DSVAMPGGKG FPVAIGDPLF HGPGLLGSSI QTFELKGFLF KGRGSLCSPV 
       310        320        330        340        350
GVAQGWGPIS LNNGLVPVGK HTPTVFYCVG LSASGEGSLT FPSSLTSIFT 
       360        370        380        390        400
NTLSEPTDGP VATKEASITF PFIFTDVKDA VAEVAEGNGK EGGGQGLVPV 
       410        420        430        440        450
GHDALPETNA GGLPSQVKGS LALPFPADVQ GKDAFTDITE GKEKEGGLVT 
       460        470        480        490        500
AGHDAPLEAN AEGPITVSEG CITIPFAVFD VIKRKGGGHV AYGPQGNGCF 
       510        520        530        540        550
SQGYYQKRQL RSRFHKARCG CRREEDERPG RACRRPHAEP YEDFWIWVSM 
       560        570 
TVCVFWLMCM CRLNPGIYPQ QV
Length:572
Mass (Da):60,488
Last modified:December 15, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i00A839AA4AEC48BC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WB75F8WB75_HUMAN
Receptor-transporting protein 5
RTP5
55Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti241I → T in BAC03544 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_060791101G → E3 PublicationsCorresponds to variant dbSNP:rs7420371Ensembl.1
Natural variantiVAR_069402412G → D1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK090909 mRNA Translation: BAC03544.1
AC131097 Genomic DNA No translation available.
CH471063 Genomic DNA Translation: EAW71299.1
BC113517 mRNA Translation: AAI13518.1
BC113519 mRNA Translation: AAI13520.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS42843.1

NCBI Reference Sequences

More...RefSeqi		NP_776182.2, NM_173821.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000343216; ENSP00000345374; ENSG00000188011
ENST00000617264; ENSP00000482049; ENSG00000277949

Database of genes from NCBI RefSeq genomes

More...GeneIDi		285093

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:285093

UCSC genome browser

More...UCSCi		uc010fzu.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090909 mRNA Translation: BAC03544.1
AC131097 Genomic DNA No translation available.
CH471063 Genomic DNA Translation: EAW71299.1
BC113517 mRNA Translation: AAI13518.1
BC113519 mRNA Translation: AAI13520.1
CCDSiCCDS42843.1
RefSeqiNP_776182.2, NM_173821.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGridi130013, 27 interactors
IntActiQ14D33, 53 interactors
MINTiQ14D33
STRINGi9606.ENSP00000345374

PTM databases

iPTMnetiQ14D33
PhosphoSitePlusiQ14D33

Polymorphism and mutation databases

BioMutaiRTP5
DMDMi281371551

Proteomic databases

PaxDbiQ14D33
PeptideAtlasiQ14D33
PRIDEiQ14D33
ProteomicsDBi60345

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343216; ENSP00000345374; ENSG00000188011
ENST00000617264; ENSP00000482049; ENSG00000277949
GeneIDi285093
KEGGihsa:285093
UCSCiuc010fzu.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		285093

GeneCards: human genes, protein and diseases

More...GeneCardsi		RTP5
HGNCiHGNC:26585 RTP5
HPAiHPA050902
neXtProtiNX_Q14D33
OpenTargetsiENSG00000188011
PharmGKBiPA164717177

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410J8R5 Eukaryota
ENOG41114I2 LUCA
GeneTreeiENSGT00940000163732
HOGENOMiHOG000168479
InParanoidiQ14D33
OMAiFWLMCMC
OrthoDBi941496at2759
PhylomeDBiQ14D33
TreeFamiTF333246

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		285093

Protein Ontology

More...PROi		PR:Q14D33

Gene expression databases

BgeeiENSG00000188011 Expressed in 64 organ(s), highest expression level in hypothalamus
ExpressionAtlasiQ14D33 baseline and differential
GenevisibleiQ14D33 HS

Family and domain databases

InterProiView protein in InterPro
IPR026689 CXXC11
IPR026096 R-trans_p
IPR027377 Znf-3CxxC
PANTHERiPTHR14402 PTHR14402, 2 hits
PTHR14402:SF2 PTHR14402:SF2, 2 hits
PfamiView protein in Pfam
PF13695 zf-3CxxC, 1 hit
SMARTiView protein in SMART
SM01328 zf-3CxxC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRTP5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14D33
Secondary accession number(s): Q8N2A5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: December 15, 2009
Last modified: May 8, 2019
This is version 99 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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