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Entry version 99 (12 Aug 2020)
Sequence version 2 (20 Apr 2010)
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Protein

FAST kinase domain-containing protein 3, mitochondrial

Gene

FASTKD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for normal mitochondrial respiration (PubMed:20869947). Increases steady-state levels and half-lives of a subset of mature mitochondrial mRNAs MT-ND2, MT-ND3, MT-CYTB, MT-CO2, and MT-ATP8/6. Promotes MT-CO1 mRNA translation and increases mitochondrial complex IV assembly and activity (PubMed:27789713).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q14CZ7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
FAST kinase domain-containing protein 3, mitochondrial
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FASTKD3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000124279.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28758, FASTKD3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617530, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q14CZ7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
79072

Open Targets

More...
OpenTargetsi
ENSG00000124279

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA145148868

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q14CZ7, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FASTKD3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
294862434

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – ?MitochondrionCurated
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000284715? – 662FAST kinase domain-containing protein 3, mitochondrial

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q14CZ7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q14CZ7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q14CZ7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q14CZ7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q14CZ7

PeptideAtlas

More...
PeptideAtlasi
Q14CZ7

PRoteomics IDEntifications database

More...
PRIDEi
Q14CZ7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
60338

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q14CZ7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q14CZ7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expression detected in spleen, thymus, testis, ovary, colon, heart, smooth muscle, kidney, brain, lung, liver and white adipose tissue with highest expression in liver and thyroid.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000124279, Expressed in calcaneal tendon and 229 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q14CZ7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q14CZ7, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000124279, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
122523, 19 interactors

Protein interaction database and analysis system

More...
IntActi
Q14CZ7, 76 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000264669

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q14CZ7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q14CZ7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini591 – 649RAPPROSITE-ProRule annotationAdd BLAST59

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

RAP domain is required for FASTKD3 function in mRNA stability and translation.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAST kinase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QW8P, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182779

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_028858_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q14CZ7

Identification of Orthologs from Complete Genome Data

More...
OMAi
VQIPYHE

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q14CZ7

TreeFam database of animal gene trees

More...
TreeFami
TF324885

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013579, FAST_2
IPR010622, FAST_Leu-rich
IPR013584, RAP

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06743, FAST_1, 1 hit
PF08368, FAST_2, 1 hit
PF08373, RAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00952, RAP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51286, RAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q14CZ7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALITLRKNL YRLSDFQMHR ALAALKNKPL NHVHKVVKER LCPWLCSRQP
60 70 80 90 100
EPFGVKFHHA HCKKFHSKNG NDLHPLGGPV FSQVSDCDRL EQNVKNEESQ
110 120 130 140 150
MFYRRLSNLT SSEEVLSFIS TMETLPDTMA AGALQRICEV EKKDGDQGLP
160 170 180 190 200
KEILENSIFQ ALCFQFEKEP SQLSNTSLVT ALQALILLHV DPQSSLLLNL
210 220 230 240 250
VAECQNRLRK GGMEVRNLCI LGESLITLHS SGCVTLELII NQLQGEKLET
260 270 280 290 300
FTPEDIVALY RILQACTEKV DEHQTFLNKI NNFSLSIVSN LSPKLISQML
310 320 330 340 350
TALVVLDQSQ AFPLIIKLGK YVVRHVPHFT NEELRRVLEA FIYFGHHDTF
360 370 380 390 400
FTKALEHRVA AVCLTLDPEV VCRVMEYCSR ELILSKPILN AVAETFVCQT
410 420 430 440 450
EKFSPRQISA LMEPFGKLNY LPPNASALFR KLENVLFTHF NYFPPKSLLK
460 470 480 490 500
LLHSCSLNEC HPVNFLAKIF KPLFLQRLQG KESHLDTLSR AQLTQLFLAS
510 520 530 540 550
VLECPFYKGP KLLPKYQVKS FLTPCCSLET PVDSQLYRYV KIGLTNLLGA
560 570 580 590 600
RLYFAPKVLT PYCYTIDVEI KLDEEGFVLP STANEDIHKR IALCIDGPKR
610 620 630 640 650
FCSNSKHLLG KEAIKQRHLQ LLGYQVVQIP YHEIGMLKSR RELVEYLQRK
660
LFSQNTVHWL QE
Length:662
Mass (Da):75,689
Last modified:April 20, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCE7474BC2E492D48
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RHY4D6RHY4_HUMAN
FAST kinase domain-containing prote...
FASTKD3
244Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RAR6D6RAR6_HUMAN
FAST kinase domain-containing prote...
FASTKD3
608Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RC07D6RC07_HUMAN
FAST kinase domain-containing prote...
FASTKD3
181Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RB04D6RB04_HUMAN
FAST kinase domain-containing prote...
FASTKD3
57Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0577693L → F. Corresponds to variant dbSNP:rs3733782Ensembl.1
Natural variantiVAR_03616122L → V in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_03180956K → R1 PublicationCorresponds to variant dbSNP:rs2966952Ensembl.1
Natural variantiVAR_031810459E → G. Corresponds to variant dbSNP:rs16879259Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC010346 Genomic DNA No translation available.
BC001295 mRNA Translation: AAH01295.2
BC113563 mRNA Translation: AAI13564.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3873.1

NCBI Reference Sequences

More...
RefSeqi
NP_076996.2, NM_024091.3
XP_006714561.1, XM_006714498.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000264669; ENSP00000264669; ENSG00000124279

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
79072

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:79072

UCSC genome browser

More...
UCSCi
uc003jeb.4, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010346 Genomic DNA No translation available.
BC001295 mRNA Translation: AAH01295.2
BC113563 mRNA Translation: AAI13564.1
CCDSiCCDS3873.1
RefSeqiNP_076996.2, NM_024091.3
XP_006714561.1, XM_006714498.1

3D structure databases

SMRiQ14CZ7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi122523, 19 interactors
IntActiQ14CZ7, 76 interactors
STRINGi9606.ENSP00000264669

PTM databases

iPTMnetiQ14CZ7
PhosphoSitePlusiQ14CZ7

Polymorphism and mutation databases

BioMutaiFASTKD3
DMDMi294862434

Proteomic databases

EPDiQ14CZ7
jPOSTiQ14CZ7
MassIVEiQ14CZ7
MaxQBiQ14CZ7
PaxDbiQ14CZ7
PeptideAtlasiQ14CZ7
PRIDEiQ14CZ7
ProteomicsDBi60338

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
22426, 176 antibodies

The DNASU plasmid repository

More...
DNASUi
79072

Genome annotation databases

EnsembliENST00000264669; ENSP00000264669; ENSG00000124279
GeneIDi79072
KEGGihsa:79072
UCSCiuc003jeb.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79072
DisGeNETi79072
EuPathDBiHostDB:ENSG00000124279.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FASTKD3
HGNCiHGNC:28758, FASTKD3
HPAiENSG00000124279, Low tissue specificity
MIMi617530, gene
neXtProtiNX_Q14CZ7
OpenTargetsiENSG00000124279
PharmGKBiPA145148868

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QW8P, Eukaryota
GeneTreeiENSGT00950000182779
HOGENOMiCLU_028858_0_0_1
InParanoidiQ14CZ7
OMAiVQIPYHE
PhylomeDBiQ14CZ7
TreeFamiTF324885

Enzyme and pathway databases

PathwayCommonsiQ14CZ7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
79072, 10 hits in 876 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
79072
PharosiQ14CZ7, Tbio

Protein Ontology

More...
PROi
PR:Q14CZ7
RNActiQ14CZ7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000124279, Expressed in calcaneal tendon and 229 other tissues
ExpressionAtlasiQ14CZ7, baseline and differential
GenevisibleiQ14CZ7, HS

Family and domain databases

InterProiView protein in InterPro
IPR013579, FAST_2
IPR010622, FAST_Leu-rich
IPR013584, RAP
PfamiView protein in Pfam
PF06743, FAST_1, 1 hit
PF08368, FAST_2, 1 hit
PF08373, RAP, 1 hit
SMARTiView protein in SMART
SM00952, RAP, 1 hit
PROSITEiView protein in PROSITE
PS51286, RAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFAKD3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14CZ7
Secondary accession number(s): Q9BVD3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: April 20, 2010
Last modified: August 12, 2020
This is version 99 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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