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Protein

Transmembrane protein 180

Gene

MFSD13A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Protein family/group databases

TCDBi2.A.2.3.10 the glycoside-pentoside-hexuronide (gph):cation symporter family

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 180Imported
Alternative name(s):
Major facilitator superfamily domain-containing 13AImported
Gene namesi
Name:MFSD13AImported
Synonyms:C10orf77, TMEM180Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000138111.14
HGNCiHGNC:26196 MFSD13A
neXtProtiNX_Q14CX5

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
Transmembranei52 – 72HelicalSequence analysisAdd BLAST21
Transmembranei101 – 123HelicalSequence analysisAdd BLAST23
Transmembranei127 – 149HelicalSequence analysisAdd BLAST23
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Transmembranei194 – 214HelicalSequence analysisAdd BLAST21
Transmembranei266 – 288HelicalSequence analysisAdd BLAST23
Transmembranei306 – 326HelicalSequence analysisAdd BLAST21
Transmembranei332 – 354HelicalSequence analysisAdd BLAST23
Transmembranei401 – 421HelicalSequence analysisAdd BLAST21
Transmembranei466 – 486HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000138111
PharmGKBiPA162406011

Polymorphism and mutation databases

BioMutaiTMEM180
DMDMi122012175

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002562241 – 517Transmembrane protein 180Add BLAST517

Proteomic databases

PaxDbiQ14CX5
PeptideAtlasiQ14CX5
PRIDEiQ14CX5
ProteomicsDBi60334

PTM databases

iPTMnetiQ14CX5
PhosphoSitePlusiQ14CX5

Expressioni

Gene expression databases

BgeeiENSG00000138111
CleanExiHS_TMEM180
ExpressionAtlasiQ14CX5 baseline and differential
GenevisibleiQ14CX5 HS

Organism-specific databases

HPAiHPA018031

Interactioni

Protein-protein interaction databases

BioGridi122938, 4 interactors
IntActiQ14CX5, 3 interactors
STRINGi9606.ENSP00000238936

Structurei

3D structure databases

ProteinModelPortaliQ14CX5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFKU Eukaryota
ENOG410Z5E9 LUCA
GeneTreeiENSGT00390000012548
HOGENOMiHOG000007876
HOVERGENiHBG059516
InParanoidiQ14CX5
OMAiCFYTGHD
OrthoDBiEOG091G07HV
PhylomeDBiQ14CX5
TreeFamiTF313122

Family and domain databases

InterProiView protein in InterPro
IPR036259 MFS_trans_sf
SUPFAMiSSF103473 SSF103473, 2 hits

Sequencei

Sequence statusi: Complete.

Q14CX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLGQPQAWL LGLPTAVVYG SLALFTTILH NVFLLYYVDT FVSVYKINKM
60 70 80 90 100
AFWVGETVFL LWNSLNDPLF GWLSDRQFLS SQPRSGAGLS SRAVVLARVQ
110 120 130 140 150
ALGWHGPLLA LSFLAFWVPW APAGLQFLLC LCLYDGFLTL VDLHHHALLA
160 170 180 190 200
DLALSAHDRT HLNFYCSLFS AAGSLSVFAS YAFWNKEDFS SFRAFCVTLA
210 220 230 240 250
VSSGLGFLGA TQLLRRRVEA ARKDPGCSGL VVDSGLCGEE LLVGSEEADS
260 270 280 290 300
ITLGRYLRQL ARHRNFLWFV SMDLVQVFHC HFNSNFFPLF LEHLLSDHIS
310 320 330 340 350
LSTGSILLGL SYVAPHLNNL YFLSLCRRWG VYAVVRGLFL LKLGLSLLML
360 370 380 390 400
LAGPDHLSLL CLFIASNRVF TEGTCKLLTL VVTDLVDEDL VLNHRKQAAS
410 420 430 440 450
ALLFGMVALV TKPGQTFAPL LGTWLLCFYT GHDLFQQSLI TPVGSAHPWP
460 470 480 490 500
EPPAPAPAQA PTLRQGCFYL LVLVPITCAL LQLFTWSQFT LHGRRLHMVK
510
AQRQNLSQAQ TLDVKMV
Length:517
Mass (Da):57,381
Last modified:August 22, 2006 - v1
Checksum:i50CC5110F967D588
GO

Sequence cautioni

The sequence AAH67530 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH67531 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB15385 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI12524 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti371T → P in AAH67531 (PubMed:15489334).Curated1
Sequence conflicti489F → S in AAH57787 (PubMed:15489334).Curated1
Sequence conflicti505N → S in AAH67530 (PubMed:15489334).Curated1
Sequence conflicti505N → S in AAH67531 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121928 Genomic DNA Translation: CAI12524.1 Sequence problems.
BC057787 mRNA Translation: AAH57787.2
BC067530 mRNA Translation: AAH67530.2 Different initiation.
BC067531 mRNA Translation: AAH67531.2 Different initiation.
BC113589 mRNA Translation: AAI13590.1
AK026182 mRNA Translation: BAB15385.1 Different initiation.
CCDSiCCDS7535.1
RefSeqiNP_079065.2, NM_024789.3
XP_006718036.1, XM_006717973.3
XP_006718037.1, XM_006717974.3
XP_011538462.1, XM_011540160.2
XP_011538465.1, XM_011540163.2
XP_016872143.1, XM_017016654.1
XP_016872144.1, XM_017016655.1
XP_016872145.1, XM_017016656.1
UniGeneiHs.309069

Genome annotation databases

EnsembliENST00000238936; ENSP00000238936; ENSG00000138111
GeneIDi79847
KEGGihsa:79847
UCSCiuc001kvt.4 human

Similar proteinsi

Entry informationi

Entry nameiMF13A_HUMAN
AccessioniPrimary (citable) accession number: Q14CX5
Secondary accession number(s): Q6NWM8
, Q6NWM9, Q6PEZ7, Q9H679
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: August 22, 2006
Last modified: June 20, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM

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