MFSD13A

Functionⁱ

Protein family/group databases

TCDBⁱ	2.A.2.3.10 the glycoside-pentoside-hexuronide (gph):cation symporter family

TCDBⁱ

2.A.2.3.10 the glycoside-pentoside-hexuronide (gph):cation symporter family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transmembrane protein 180Imported Alternative name(s): Major facilitator superfamily domain-containing 13AImported
Gene namesⁱ	Name:MFSD13AImported Synonyms:C10orf77, TMEM180Imported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000138111.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:26196 MFSD13A
neXtProtⁱ	NX_Q14CX5

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	9 – 29	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	52 – 72	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	101 – 123	HelicalSequence analysisAdd BLAST	23
Transmembraneⁱ	127 – 149	HelicalSequence analysisAdd BLAST	23
Transmembraneⁱ	164 – 184	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	194 – 214	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	266 – 288	HelicalSequence analysisAdd BLAST	23
Transmembraneⁱ	306 – 326	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	332 – 354	HelicalSequence analysisAdd BLAST	23
Transmembraneⁱ	401 – 421	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	466 – 486	HelicalSequence analysisAdd BLAST	21

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000138111
PharmGKBⁱ	PA162406011

Polymorphism and mutation databases

BioMutaⁱ	TMEM180
DMDMⁱ	122012175

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000256224	1 – 517	Transmembrane protein 180Add BLAST		517

Proteomic databases

PaxDbⁱ	Q14CX5
PeptideAtlas More...PeptideAtlasⁱ	Q14CX5
PRIDEⁱ	Q14CX5
ProteomicsDBⁱ	60334

PTM databases

iPTMnetⁱ	Q14CX5
PhosphoSitePlusⁱ	Q14CX5

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000138111
CleanExⁱ	HS_TMEM180
ExpressionAtlasⁱ	Q14CX5 baseline and differential
Genevisibleⁱ	Q14CX5 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA018031

HPAⁱ

HPA018031

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	122938, 4 interactors
IntActⁱ	Q14CX5, 3 interactors
STRINGⁱ	9606.ENSP00000238936

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q14CX5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IFKU Eukaryota ENOG410Z5E9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000012548
HOGENOMⁱ	HOG000007876
HOVERGENⁱ	HBG059516
InParanoidⁱ	Q14CX5
OMAⁱ	CFYTGHD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G07HV
PhylomeDBⁱ	Q14CX5
TreeFamⁱ	TF313122

Family and domain databases

InterProⁱ	View protein in InterPro IPR036259 MFS_trans_sf
SUPFAMⁱ	SSF103473 SSF103473, 2 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Q14CX5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGLGQPQAWL LGLPTAVVYG SLALFTTILH NVFLLYYVDT FVSVYKINKM 
        60         70         80         90        100
AFWVGETVFL LWNSLNDPLF GWLSDRQFLS SQPRSGAGLS SRAVVLARVQ 
       110        120        130        140        150
ALGWHGPLLA LSFLAFWVPW APAGLQFLLC LCLYDGFLTL VDLHHHALLA 
       160        170        180        190        200
DLALSAHDRT HLNFYCSLFS AAGSLSVFAS YAFWNKEDFS SFRAFCVTLA 
       210        220        230        240        250
VSSGLGFLGA TQLLRRRVEA ARKDPGCSGL VVDSGLCGEE LLVGSEEADS 
       260        270        280        290        300
ITLGRYLRQL ARHRNFLWFV SMDLVQVFHC HFNSNFFPLF LEHLLSDHIS 
       310        320        330        340        350
LSTGSILLGL SYVAPHLNNL YFLSLCRRWG VYAVVRGLFL LKLGLSLLML 
       360        370        380        390        400
LAGPDHLSLL CLFIASNRVF TEGTCKLLTL VVTDLVDEDL VLNHRKQAAS 
       410        420        430        440        450
ALLFGMVALV TKPGQTFAPL LGTWLLCFYT GHDLFQQSLI TPVGSAHPWP 
       460        470        480        490        500
EPPAPAPAQA PTLRQGCFYL LVLVPITCAL LQLFTWSQFT LHGRRLHMVK 
       510 
AQRQNLSQAQ TLDVKMV

Length:517

Mass (Da):57,381

Last modified:August 22, 2006 - v1

Checksum:ⁱ50CC5110F967D588

GO

Sequence cautionⁱ

The sequence AAH67530 differs from that shown. Reason: Erroneous initiation.Curated

The sequence AAH67531 differs from that shown. Reason: Erroneous initiation.Curated

The sequence BAB15385 differs from that shown. Reason: Erroneous initiation.Curated

The sequence CAI12524 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	371	T → P in AAH67531 (PubMed:15489334).Curated	1
Sequence conflictⁱ	489	F → S in AAH57787 (PubMed:15489334).Curated	1
Sequence conflictⁱ	505	N → S in AAH67530 (PubMed:15489334).Curated	1
Sequence conflictⁱ	505	N → S in AAH67531 (PubMed:15489334).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL121928 Genomic DNA Translation: CAI12524.1 Sequence problems. BC057787 mRNA Translation: AAH57787.2 BC067530 mRNA Translation: AAH67530.2 Different initiation. BC067531 mRNA Translation: AAH67531.2 Different initiation. BC113589 mRNA Translation: AAI13590.1 AK026182 mRNA Translation: BAB15385.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS7535.1
NCBI Reference Sequences More...RefSeqⁱ	NP_079065.2, NM_024789.3 XP_006718036.1, XM_006717973.3 XP_006718037.1, XM_006717974.3 XP_011538462.1, XM_011540160.2 XP_011538465.1, XM_011540163.2 XP_016872143.1, XM_017016654.1 XP_016872144.1, XM_017016655.1 XP_016872145.1, XM_017016656.1
UniGeneⁱ	Hs.309069

Genome annotation databases

Ensemblⁱ	ENST00000238936; ENSP00000238936; ENSG00000138111
GeneIDⁱ	79847
KEGGⁱ	hsa:79847
UCSC genome browser More...UCSCⁱ	uc001kvt.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q14CX5	cDNA FLJ60636		HUMAN		246
transmembrane protein 180 isoform X1		DIPOR		564
UPI0003290A28		DASNO		544
UPI0003C87071		VICPA		531
Transmembrane protein 180		CAMFR		531
+95

Protein	Similar proteins		Species	Score	Length
Q14CX5	cDNA FLJ60636		HUMAN		246
transmembrane protein 180 isoform X1		DIPOR		564
UPI0003290A28		DASNO		544
UPI0003C87071		VICPA		531
Transmembrane protein 180		CAMFR		531
+289

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL121928 Genomic DNA Translation: CAI12524.1 Sequence problems. BC057787 mRNA Translation: AAH57787.2 BC067530 mRNA Translation: AAH67530.2 Different initiation. BC067531 mRNA Translation: AAH67531.2 Different initiation. BC113589 mRNA Translation: AAI13590.1 AK026182 mRNA Translation: BAB15385.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS7535.1
NCBI Reference Sequences More...RefSeqⁱ	NP_079065.2, NM_024789.3 XP_006718036.1, XM_006717973.3 XP_006718037.1, XM_006717974.3 XP_011538462.1, XM_011540160.2 XP_011538465.1, XM_011540163.2 XP_016872143.1, XM_017016654.1 XP_016872144.1, XM_017016655.1 XP_016872145.1, XM_017016656.1
UniGeneⁱ	Hs.309069

3D structure databases

ProteinModelPortalⁱ	Q14CX5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	122938, 4 interactors
IntActⁱ	Q14CX5, 3 interactors
STRINGⁱ	9606.ENSP00000238936

Protein family/group databases

TCDBⁱ	2.A.2.3.10 the glycoside-pentoside-hexuronide (gph):cation symporter family

TCDBⁱ

2.A.2.3.10 the glycoside-pentoside-hexuronide (gph):cation symporter family

PTM databases

iPTMnetⁱ	Q14CX5
PhosphoSitePlusⁱ	Q14CX5

Polymorphism and mutation databases

BioMutaⁱ	TMEM180
DMDMⁱ	122012175

Proteomic databases

PaxDbⁱ	Q14CX5
PeptideAtlas More...PeptideAtlasⁱ	Q14CX5
PRIDEⁱ	Q14CX5
ProteomicsDBⁱ	60334

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	79847
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000238936; ENSP00000238936; ENSG00000138111
GeneIDⁱ	79847
KEGGⁱ	hsa:79847
UCSC genome browser More...UCSCⁱ	uc001kvt.4 human

Organism-specific databases

CTDⁱ	79847
EuPathDBⁱ	HostDB:ENSG00000138111.14
GeneCardsⁱ	MFSD13A
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:26196 MFSD13A
Human Protein Atlas More...HPAⁱ	HPA018031
neXtProtⁱ	NX_Q14CX5
Open Targets More...OpenTargetsⁱ	ENSG00000138111
PharmGKBⁱ	PA162406011
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IFKU Eukaryota ENOG410Z5E9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000012548
HOGENOMⁱ	HOG000007876
HOVERGENⁱ	HBG059516
InParanoidⁱ	Q14CX5
OMAⁱ	CFYTGHD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G07HV
PhylomeDBⁱ	Q14CX5
TreeFamⁱ	TF313122

Miscellaneous databases

ChiTaRSⁱ	MFSD13A human
GenomeRNAiⁱ	79847
Protein Ontology More...PROⁱ	PR:Q14CX5

Gene expression databases

Bgeeⁱ	ENSG00000138111
CleanExⁱ	HS_TMEM180
ExpressionAtlasⁱ	Q14CX5 baseline and differential
Genevisibleⁱ	Q14CX5 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR036259 MFS_trans_sf
SUPFAMⁱ	SSF103473 SSF103473, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MF13A_HUMAN
Accessionⁱ	Q14CX5Primary (citable) accession number: Q14CX5 Secondary accession number(s): Q6NWM8 , Q6NWM9, Q6PEZ7, Q9H679
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
	Last sequence update:	August 22, 2006
	Last modified:	June 20, 2018
	This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q14CX5 (MF13A_HUMAN)

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Transmembrane protein 180

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ