UniProtKB - Q14CX5 (MF13A_HUMAN)
Protein
Transmembrane protein 180
Gene
MFSD13A
Organism
Homo sapiens (Human)
Status
Functioni
Enzyme and pathway databases
PathwayCommonsi | Q14CX5 |
Protein family/group databases
TCDBi | 2.A.2.3.10, the glycoside-pentoside-hexuronide (gph):cation symporter family 2.A.2.3.14, the glycoside-pentoside-hexuronide (gph):cation symporter family |
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane protein 180ImportedAlternative name(s): Major facilitator superfamily domain-containing 13AImported |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000138111.14 |
HGNCi | HGNC:26196, MFSD13A |
neXtProti | NX_Q14CX5 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 9 – 29 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 52 – 72 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 101 – 123 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 127 – 149 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 164 – 184 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 194 – 214 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 266 – 288 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 306 – 326 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 332 – 354 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 401 – 421 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 466 – 486 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 79847 |
OpenTargetsi | ENSG00000138111 |
PharmGKBi | PA162406011 |
Miscellaneous databases
Pharosi | Q14CX5, Tdark |
Polymorphism and mutation databases
BioMutai | MFSD13A |
DMDMi | 122012175 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000256224 | 1 – 517 | Transmembrane protein 180Add BLAST | 517 |
Proteomic databases
PaxDbi | Q14CX5 |
PeptideAtlasi | Q14CX5 |
PRIDEi | Q14CX5 |
ProteomicsDBi | 60334 |
PTM databases
iPTMneti | Q14CX5 |
PhosphoSitePlusi | Q14CX5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000138111, Expressed in right hemisphere of cerebellum and 138 other tissues |
ExpressionAtlasi | Q14CX5, baseline and differential |
Genevisiblei | Q14CX5, HS |
Organism-specific databases
HPAi | ENSG00000138111, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ14CX5
With | #Exp. | IntAct |
---|---|---|
CYSRT1 [A8MQ03] | 3 | EBI-12120958,EBI-3867333 |
KRTAP8-1 [Q8IUC2] | 3 | EBI-12120958,EBI-10261141 |
NOTCH2NLC [P0DPK4] | 3 | EBI-12120958,EBI-22310682 |
Protein-protein interaction databases
BioGRIDi | 122938, 9 interactors |
IntActi | Q14CX5, 3 interactors |
STRINGi | 9606.ENSP00000238936 |
Miscellaneous databases
RNActi | Q14CX5, protein |
Family & Domainsi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QSW5, Eukaryota |
GeneTreei | ENSGT00940000160317 |
HOGENOMi | CLU_034985_0_0_1 |
InParanoidi | Q14CX5 |
OMAi | FLWFVCM |
OrthoDBi | 1041483at2759 |
PhylomeDBi | Q14CX5 |
TreeFami | TF313122 |
Family and domain databases
InterProi | View protein in InterPro IPR036259, MFS_trans_sf IPR040035, TMEM180 |
PANTHERi | PTHR28658, PTHR28658, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q14CX5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGLGQPQAWL LGLPTAVVYG SLALFTTILH NVFLLYYVDT FVSVYKINKM
60 70 80 90 100
AFWVGETVFL LWNSLNDPLF GWLSDRQFLS SQPRSGAGLS SRAVVLARVQ
110 120 130 140 150
ALGWHGPLLA LSFLAFWVPW APAGLQFLLC LCLYDGFLTL VDLHHHALLA
160 170 180 190 200
DLALSAHDRT HLNFYCSLFS AAGSLSVFAS YAFWNKEDFS SFRAFCVTLA
210 220 230 240 250
VSSGLGFLGA TQLLRRRVEA ARKDPGCSGL VVDSGLCGEE LLVGSEEADS
260 270 280 290 300
ITLGRYLRQL ARHRNFLWFV SMDLVQVFHC HFNSNFFPLF LEHLLSDHIS
310 320 330 340 350
LSTGSILLGL SYVAPHLNNL YFLSLCRRWG VYAVVRGLFL LKLGLSLLML
360 370 380 390 400
LAGPDHLSLL CLFIASNRVF TEGTCKLLTL VVTDLVDEDL VLNHRKQAAS
410 420 430 440 450
ALLFGMVALV TKPGQTFAPL LGTWLLCFYT GHDLFQQSLI TPVGSAHPWP
460 470 480 490 500
EPPAPAPAQA PTLRQGCFYL LVLVPITCAL LQLFTWSQFT LHGRRLHMVK
510
AQRQNLSQAQ TLDVKMV
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ6UWF4 | Q6UWF4_HUMAN | GLGQ5807 | MFSD13A UNQ5807 | 153 | Annotation score: | ||
A0A1B0GUX1 | A0A1B0GUX1_HUMAN | Transmembrane protein 180 | MFSD13A | 67 | Annotation score: |
Sequence cautioni
The sequence AAH67530 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH67531 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB15385 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 371 | T → P in AAH67531 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 489 | F → S in AAH57787 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 505 | N → S in AAH67530 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 505 | N → S in AAH67531 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL121928 Genomic DNA No translation available. BC057787 mRNA Translation: AAH57787.2 BC067530 mRNA Translation: AAH67530.2 Different initiation. BC067531 mRNA Translation: AAH67531.2 Different initiation. BC113589 mRNA Translation: AAI13590.1 AK026182 mRNA Translation: BAB15385.1 Different initiation. |
CCDSi | CCDS7535.1 |
RefSeqi | NP_079065.2, NM_024789.3 XP_006718036.1, XM_006717973.3 XP_006718037.1, XM_006717974.3 XP_011538462.1, XM_011540160.2 XP_011538465.1, XM_011540163.2 XP_016872143.1, XM_017016654.1 XP_016872144.1, XM_017016655.1 XP_016872145.1, XM_017016656.1 |
Genome annotation databases
Ensembli | ENST00000238936; ENSP00000238936; ENSG00000138111 |
GeneIDi | 79847 |
KEGGi | hsa:79847 |
UCSCi | uc001kvt.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL121928 Genomic DNA No translation available. BC057787 mRNA Translation: AAH57787.2 BC067530 mRNA Translation: AAH67530.2 Different initiation. BC067531 mRNA Translation: AAH67531.2 Different initiation. BC113589 mRNA Translation: AAI13590.1 AK026182 mRNA Translation: BAB15385.1 Different initiation. |
CCDSi | CCDS7535.1 |
RefSeqi | NP_079065.2, NM_024789.3 XP_006718036.1, XM_006717973.3 XP_006718037.1, XM_006717974.3 XP_011538462.1, XM_011540160.2 XP_011538465.1, XM_011540163.2 XP_016872143.1, XM_017016654.1 XP_016872144.1, XM_017016655.1 XP_016872145.1, XM_017016656.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 122938, 9 interactors |
IntActi | Q14CX5, 3 interactors |
STRINGi | 9606.ENSP00000238936 |
Protein family/group databases
TCDBi | 2.A.2.3.10, the glycoside-pentoside-hexuronide (gph):cation symporter family 2.A.2.3.14, the glycoside-pentoside-hexuronide (gph):cation symporter family |
PTM databases
iPTMneti | Q14CX5 |
PhosphoSitePlusi | Q14CX5 |
Polymorphism and mutation databases
BioMutai | MFSD13A |
DMDMi | 122012175 |
Proteomic databases
PaxDbi | Q14CX5 |
PeptideAtlasi | Q14CX5 |
PRIDEi | Q14CX5 |
ProteomicsDBi | 60334 |
Protocols and materials databases
Antibodypediai | 18048, 26 antibodies |
DNASUi | 79847 |
Genome annotation databases
Ensembli | ENST00000238936; ENSP00000238936; ENSG00000138111 |
GeneIDi | 79847 |
KEGGi | hsa:79847 |
UCSCi | uc001kvt.4, human |
Organism-specific databases
CTDi | 79847 |
DisGeNETi | 79847 |
EuPathDBi | HostDB:ENSG00000138111.14 |
GeneCardsi | MFSD13A |
HGNCi | HGNC:26196, MFSD13A |
HPAi | ENSG00000138111, Low tissue specificity |
neXtProti | NX_Q14CX5 |
OpenTargetsi | ENSG00000138111 |
PharmGKBi | PA162406011 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QSW5, Eukaryota |
GeneTreei | ENSGT00940000160317 |
HOGENOMi | CLU_034985_0_0_1 |
InParanoidi | Q14CX5 |
OMAi | FLWFVCM |
OrthoDBi | 1041483at2759 |
PhylomeDBi | Q14CX5 |
TreeFami | TF313122 |
Enzyme and pathway databases
PathwayCommonsi | Q14CX5 |
Miscellaneous databases
BioGRID-ORCSi | 79847, 7 hits in 845 CRISPR screens |
ChiTaRSi | MFSD13A, human |
GenomeRNAii | 79847 |
Pharosi | Q14CX5, Tdark |
PROi | PR:Q14CX5 |
RNActi | Q14CX5, protein |
Gene expression databases
Bgeei | ENSG00000138111, Expressed in right hemisphere of cerebellum and 138 other tissues |
ExpressionAtlasi | Q14CX5, baseline and differential |
Genevisiblei | Q14CX5, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036259, MFS_trans_sf IPR040035, TMEM180 |
PANTHERi | PTHR28658, PTHR28658, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MF13A_HUMAN | |
Accessioni | Q14CX5Primary (citable) accession number: Q14CX5 Secondary accession number(s): Q6NWM8 Q9H679 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 31, 2006 |
Last sequence update: | August 22, 2006 | |
Last modified: | December 2, 2020 | |
This is version 102 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM