UniProtKB - Q14CW9 (AT7L3_HUMAN)
Ataxin-7-like protein 3
ATXN7L3
Functioni
Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B (PubMed:18206972, PubMed:21746879).
The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex (PubMed:18206972).
Regulates H2B monoubiquitination (H2Bub1) levels. Affects subcellular distribution of ENY2, USP22 and ATXN7L3B (PubMed:27601583).
UniRule annotation3 PublicationsRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 84 – 105 | SGF11-typeUniRule annotationAdd BLAST | 22 |
GO - Molecular functioni
- nuclear receptor coactivator activity Source: UniProtKB
- transcription coactivator activity Source: UniProtKB
- zinc ion binding Source: UniProtKB-UniRule
GO - Biological processi
- chromatin organization Source: UniProtKB-KW
- histone deubiquitination Source: UniProtKB
- histone H3 acetylation Source: ComplexPortal
- histone monoubiquitination Source: UniProtKB
- monoubiquitinated histone deubiquitination Source: ComplexPortal
- monoubiquitinated histone H2A deubiquitination Source: ComplexPortal
- positive regulation of transcription, DNA-templated Source: UniProtKB
- regulation of DNA repair Source: ComplexPortal
- regulation of RNA splicing Source: ComplexPortal
- regulation of transcription by RNA polymerase II Source: ComplexPortal
Keywordsi
Molecular function | Activator, Chromatin regulator |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q14CW9 |
Reactomei | R-HSA-3214847, HATs acetylate histones |
SignaLinki | Q14CW9 |
Names & Taxonomyi
Protein namesi | Recommended name: Ataxin-7-like protein 3UniRule annotationAlternative name(s): SAGA-associated factor 11 homologUniRule annotation |
Gene namesi | Name:ATXN7L3UniRule annotation |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25416, ATXN7L3 |
MIMi | 619010, gene |
neXtProti | NX_Q14CW9 |
VEuPathDBi | HostDB:ENSG00000087152 |
Subcellular locationi
Nucleus
- Nucleus UniRule annotation1 Publication
Nucleus
- DUBm complex Source: UniProtKB
- nucleus Source: UniProtKB
- SAGA complex Source: UniProtKB
- transcription factor TFTC complex Source: ComplexPortal
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 56970 |
OpenTargetsi | ENSG00000087152 |
PharmGKBi | PA134991793 |
Miscellaneous databases
Pharosi | Q14CW9, Tbio |
Genetic variation databases
BioMutai | ATXN7L3 |
DMDMi | 121948758 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000278301 | 1 – 347 | Ataxin-7-like protein 3Add BLAST | 347 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 129 | PhosphoserineCombined sources | 1 | |
Modified residuei | 131 | PhosphoserineCombined sources | 1 | |
Modified residuei | 278 | PhosphoserineCombined sources | 1 | |
Modified residuei | 281 | PhosphoserineCombined sources | 1 | |
Modified residuei | 326 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q14CW9 |
jPOSTi | Q14CW9 |
MassIVEi | Q14CW9 |
MaxQBi | Q14CW9 |
PaxDbi | Q14CW9 |
PeptideAtlasi | Q14CW9 |
PRIDEi | Q14CW9 |
ProteomicsDBi | 60332 [Q14CW9-1] 60333 [Q14CW9-2] |
PTM databases
iPTMneti | Q14CW9 |
PhosphoSitePlusi | Q14CW9 |
Expressioni
Gene expression databases
Bgeei | ENSG00000087152, Expressed in frontal cortex and 206 other tissues |
ExpressionAtlasi | Q14CW9, baseline and differential |
Genevisiblei | Q14CW9, HS |
Organism-specific databases
HPAi | ENSG00000087152, Low tissue specificity |
Interactioni
Subunit structurei
Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ENY2, ATXN7, ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB module (deubiquitination module) (PubMed:18206972, PubMed:21746879, PubMed:27601583).
Interacts directly with ENY2 and USP22 (PubMed:18206972).
UniRule annotation3 PublicationsBinary interactionsi
Q14CW9
With | #Exp. | IntAct |
---|---|---|
ENY2 [Q9NPA8] | 6 | EBI-949215,EBI-719226 |
USP22 - isoform 2 [Q9UPT9-2] | 3 | EBI-949215,EBI-12074414 |
Protein-protein interaction databases
BioGRIDi | 121289, 47 interactors |
ComplexPortali | CPX-6802, SAGA complex, KAT2B variant CPX-900, SAGA complex, KAT2A variant CPX-903, TFTC histone acetylation complex |
CORUMi | Q14CW9 |
IntActi | Q14CW9, 37 interactors |
MINTi | Q14CW9 |
STRINGi | 9606.ENSP00000397259 |
Miscellaneous databases
RNActi | Q14CW9, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q14CW9 |
BMRBi | Q14CW9 |
SMRi | Q14CW9 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q14CW9 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 196 – 263 | SCA7UniRule annotationAdd BLAST | 68 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 116 – 184 | DisorderedSequence analysisAdd BLAST | 69 | |
Regioni | 275 – 347 | DisorderedSequence analysisAdd BLAST | 73 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 143 – 178 | Basic and acidic residuesSequence analysisAdd BLAST | 36 | |
Compositional biasi | 275 – 303 | Polar residuesSequence analysisAdd BLAST | 29 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 84 – 105 | SGF11-typeUniRule annotationAdd BLAST | 22 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG2612, Eukaryota |
GeneTreei | ENSGT00940000158253 |
InParanoidi | Q14CW9 |
OMAi | PSNYENM |
OrthoDBi | 1244885at2759 |
PhylomeDBi | Q14CW9 |
TreeFami | TF324580 |
Family and domain databases
HAMAPi | MF_03047, Sgf11, 1 hit |
InterProi | View protein in InterPro IPR013246, SAGA_su_Sgf11 IPR013243, SCA7_dom |
Pfami | View protein in Pfam PF08313, SCA7, 1 hit PF08209, Sgf11, 1 hit |
PROSITEi | View protein in PROSITE PS51505, SCA7, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKMEEMSLSG LDNSKLEAIA QEIYADLVED SCLGFCFEVH RAVKCGYFFL
60 70 80 90 100
DDTDPDSMKD FEIVDQPGLD IFGQVFNQWK SKECVCPNCS RSIAASRFAP
110 120 130 140 150
HLEKCLGMGR NSSRIANRRI ANSNNMNKSE SDQEDNDDIN DNDWSYGSEK
160 170 180 190 200
KAKKRKSDKN PNSPRRSKSL KHKNGELSNS DPFKYNNSTG ISYETLGPEE
210 220 230 240 250
LRSLLTTQCG VISEHTKKMC TRSLRCPQHT DEQRRTVRIY FLGPSAVLPE
260 270 280 290 300
VESSLDNDSF DMTDSQALIS RLQWDGSSDL SPSDSGSSKT SENQGWGLGT
310 320 330 340
NSSESRKTKK KKSHLSLVGT ASGLGSNKKK KPKPPAPPTP SIYDDIN
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7ENZ2 | K7ENZ2_HUMAN | SAGA-associated factor 11 | ATXN7L3 | 147 | Annotation score: | ||
K7EMZ3 | K7EMZ3_HUMAN | SAGA-associated factor 11 | ATXN7L3 | 139 | Annotation score: | ||
K7EKG9 | K7EKG9_HUMAN | Ataxin-7-like protein 3 | ATXN7L3 | 308 | Annotation score: | ||
K7ENU1 | K7ENU1_HUMAN | Ataxin-7-like protein 3 | ATXN7L3 | 186 | Annotation score: | ||
K7EJK2 | K7EJK2_HUMAN | Ataxin-7-like protein 3 | ATXN7L3 | 72 | Annotation score: |
Sequence cautioni
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_036721 | 159 | K → KLWYLPFQ in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC037418 mRNA Translation: AAH37418.1 Different initiation. BC113595 mRNA Translation: AAI13596.1 BC126113 mRNA Translation: AAI26114.1 AK056002 mRNA Translation: BAB71070.1 Different initiation. AL390158 mRNA Translation: CAB99093.1 |
CCDSi | CCDS42345.1 [Q14CW9-1] CCDS45697.1 [Q14CW9-2] |
RefSeqi | NP_001092303.1, NM_001098833.1 NP_064603.1, NM_020218.1 XP_016880374.1, XM_017024885.1 XP_016880375.1, XM_017024886.1 |
Genome annotation databases
Ensembli | ENST00000389384.8; ENSP00000374035.3; ENSG00000087152.16 ENST00000454077.6; ENSP00000397259.1; ENSG00000087152.16 [Q14CW9-2] ENST00000587097.6; ENSP00000465614.2; ENSG00000087152.16 |
GeneIDi | 56970 |
MANE-Selecti | ENST00000587097.6; ENSP00000465614.2; NM_001382309.1; NP_001369238.1 |
UCSCi | uc002ifz.4, human [Q14CW9-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC037418 mRNA Translation: AAH37418.1 Different initiation. BC113595 mRNA Translation: AAI13596.1 BC126113 mRNA Translation: AAI26114.1 AK056002 mRNA Translation: BAB71070.1 Different initiation. AL390158 mRNA Translation: CAB99093.1 |
CCDSi | CCDS42345.1 [Q14CW9-1] CCDS45697.1 [Q14CW9-2] |
RefSeqi | NP_001092303.1, NM_001098833.1 NP_064603.1, NM_020218.1 XP_016880374.1, XM_017024885.1 XP_016880375.1, XM_017024886.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2KKT | NMR | - | A | 197-276 | [»] | |
AlphaFoldDBi | Q14CW9 | |||||
BMRBi | Q14CW9 | |||||
SMRi | Q14CW9 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 121289, 47 interactors |
ComplexPortali | CPX-6802, SAGA complex, KAT2B variant CPX-900, SAGA complex, KAT2A variant CPX-903, TFTC histone acetylation complex |
CORUMi | Q14CW9 |
IntActi | Q14CW9, 37 interactors |
MINTi | Q14CW9 |
STRINGi | 9606.ENSP00000397259 |
PTM databases
iPTMneti | Q14CW9 |
PhosphoSitePlusi | Q14CW9 |
Genetic variation databases
BioMutai | ATXN7L3 |
DMDMi | 121948758 |
Proteomic databases
EPDi | Q14CW9 |
jPOSTi | Q14CW9 |
MassIVEi | Q14CW9 |
MaxQBi | Q14CW9 |
PaxDbi | Q14CW9 |
PeptideAtlasi | Q14CW9 |
PRIDEi | Q14CW9 |
ProteomicsDBi | 60332 [Q14CW9-1] 60333 [Q14CW9-2] |
Protocols and materials databases
Antibodypediai | 54391, 84 antibodies from 24 providers |
DNASUi | 56970 |
Genome annotation databases
Ensembli | ENST00000389384.8; ENSP00000374035.3; ENSG00000087152.16 ENST00000454077.6; ENSP00000397259.1; ENSG00000087152.16 [Q14CW9-2] ENST00000587097.6; ENSP00000465614.2; ENSG00000087152.16 |
GeneIDi | 56970 |
MANE-Selecti | ENST00000587097.6; ENSP00000465614.2; NM_001382309.1; NP_001369238.1 |
UCSCi | uc002ifz.4, human [Q14CW9-1] |
Organism-specific databases
CTDi | 56970 |
DisGeNETi | 56970 |
GeneCardsi | ATXN7L3 |
HGNCi | HGNC:25416, ATXN7L3 |
HPAi | ENSG00000087152, Low tissue specificity |
MIMi | 619010, gene |
neXtProti | NX_Q14CW9 |
OpenTargetsi | ENSG00000087152 |
PharmGKBi | PA134991793 |
VEuPathDBi | HostDB:ENSG00000087152 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2612, Eukaryota |
GeneTreei | ENSGT00940000158253 |
InParanoidi | Q14CW9 |
OMAi | PSNYENM |
OrthoDBi | 1244885at2759 |
PhylomeDBi | Q14CW9 |
TreeFami | TF324580 |
Enzyme and pathway databases
PathwayCommonsi | Q14CW9 |
Reactomei | R-HSA-3214847, HATs acetylate histones |
SignaLinki | Q14CW9 |
Miscellaneous databases
BioGRID-ORCSi | 56970, 211 hits in 1084 CRISPR screens |
ChiTaRSi | ATXN7L3, human |
EvolutionaryTracei | Q14CW9 |
GenomeRNAii | 56970 |
Pharosi | Q14CW9, Tbio |
PROi | PR:Q14CW9 |
RNActi | Q14CW9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000087152, Expressed in frontal cortex and 206 other tissues |
ExpressionAtlasi | Q14CW9, baseline and differential |
Genevisiblei | Q14CW9, HS |
Family and domain databases
HAMAPi | MF_03047, Sgf11, 1 hit |
InterProi | View protein in InterPro IPR013246, SAGA_su_Sgf11 IPR013243, SCA7_dom |
Pfami | View protein in Pfam PF08313, SCA7, 1 hit PF08209, Sgf11, 1 hit |
PROSITEi | View protein in PROSITE PS51505, SCA7, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | AT7L3_HUMAN | |
Accessioni | Q14CW9Primary (citable) accession number: Q14CW9 Secondary accession number(s): Q8IY68, Q96N40, Q9NPU5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 20, 2007 |
Last sequence update: | August 22, 2006 | |
Last modified: | May 25, 2022 | |
This is version 126 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families