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Protein

UBX domain-containing protein 2B

Gene

UBXN2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adapter protein required for Golgi and endoplasmic reticulum biogenesis (PubMed:17141156). Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis (PubMed:17141156). The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L (PubMed:17141156). VCPIP1 is also required, but not its deubiquitinating activity (PubMed:17141156). Together with NSFL1C/p47, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807). Also, regulates spindle orientation during mitosis (PubMed:23649807).2 Publications

GO - Molecular functioni

  • ubiquitin binding Source: GO_Central

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
UBX domain-containing protein 2B
Alternative name(s):
NSFL1 cofactor p37
p97 cofactor p37
Gene namesi
Name:UBXN2B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000215114.7
HGNCiHGNC:27035 UBXN2B
MIMi610686 gene
neXtProtiNX_Q14CS0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Endoplasmic reticulum, Golgi apparatus, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi137886
OpenTargetsiENSG00000215114
PharmGKBiPA162408394

Polymorphism and mutation databases

BioMutaiUBXN2B
DMDMi121946691

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00003152282 – 331UBX domain-containing protein 2BAdd BLAST330

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei56PhosphoserineCombined sources1
Modified residuei59PhosphothreonineCombined sources1
Modified residuei66PhosphoserineCombined sources1
Modified residuei231PhosphoserineCombined sources1
Modified residuei234PhosphoserineBy similarity1
Modified residuei235PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ14CS0
MaxQBiQ14CS0
PaxDbiQ14CS0
PeptideAtlasiQ14CS0
PRIDEiQ14CS0
ProteomicsDBi60331

PTM databases

iPTMnetiQ14CS0
PhosphoSitePlusiQ14CS0

Expressioni

Gene expression databases

BgeeiENSG00000215114 Expressed in 226 organ(s), highest expression level in cerebral cortex
CleanExiHS_UBXN2B
ExpressionAtlasiQ14CS0 baseline and differential
GenevisibleiQ14CS0 HS

Organism-specific databases

HPAiHPA045278

Interactioni

Subunit structurei

Interacts with VCP. Does not bind ubiquitin.By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi126491, 27 interactors
IntActiQ14CS0, 17 interactors
STRINGi9606.ENSP00000382507

Structurei

3D structure databases

ProteinModelPortaliQ14CS0
SMRiQ14CS0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini141 – 206SEPPROSITE-ProRule annotationAdd BLAST66
Domaini252 – 329UBXPROSITE-ProRule annotationAdd BLAST78

Sequence similaritiesi

Belongs to the NSFL1C family.Curated

Phylogenomic databases

eggNOGiKOG2086 Eukaryota
ENOG410YGXU LUCA
GeneTreeiENSGT00520000055567
HOGENOMiHOG000159961
HOVERGENiHBG054517
InParanoidiQ14CS0
OMAiFIIQSRP
OrthoDBiEOG091G0QFZ
PhylomeDBiQ14CS0
TreeFamiTF312973

Family and domain databases

Gene3Di3.30.420.210, 1 hit
InterProiView protein in InterPro
IPR036241 NSFL1C_SEP_dom_sf
IPR012989 SEP_domain
IPR029071 Ubiquitin-like_domsf
IPR001012 UBX_dom
PfamiView protein in Pfam
PF08059 SEP, 1 hit
PF00789 UBX, 1 hit
SMARTiView protein in SMART
SM00553 SEP, 1 hit
SM00166 UBX, 1 hit
SUPFAMiSSF102848 SSF102848, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS51399 SEP, 1 hit
PS50033 UBX, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q14CS0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEGGGPEPG EQERRSSGPR PPSARDLQLA LAELYEDEVK CKSSKSNRPK
60 70 80 90 100
ATVFKSPRTP PQRFYSSEHE YSGLNIVRPS TGKIVNELFK EAREHGAVPL
110 120 130 140 150
NEATRASGDD KSKSFTGGGY RLGSSFCKRS EYIYGENQLQ DVQILLKLWS
160 170 180 190 200
NGFSLDDGEL RPYNEPTNAQ FLESVKRGEI PLELQRLVHG GQVNLDMEDH
210 220 230 240 250
QDQEYIKPRL RFKAFSGEGQ KLGSLTPEIV STPSSPEEED KSILNAVVLI
260 270 280 290 300
DDSVPTTKIQ IRLADGSRLI QRFNSTHRIL DVRNFIVQSR PEFAALDFIL
310 320 330
VTSFPNKELT DESLTLLEAD ILNTVLLQQL K
Length:331
Mass (Da):37,077
Last modified:August 22, 2006 - v1
Checksum:i7CE8029B9E56A867
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RJ36E5RJ36_HUMAN
UBX domain-containing protein 2B
UBXN2B
196Annotation score:
H0YAX6H0YAX6_HUMAN
UBX domain-containing protein 2B
UBXN2B
142Annotation score:
E5RGJ4E5RGJ4_HUMAN
UBX domain-containing protein 2B
UBXN2B
104Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126300 mRNA Translation: BAG54305.1
BC113645 mRNA Translation: AAI13646.1
CCDSiCCDS43741.1
RefSeqiNP_001071087.1, NM_001077619.1
NP_001317464.1, NM_001330535.1
UniGeneiHs.155572
Hs.668402

Genome annotation databases

EnsembliENST00000399598; ENSP00000382507; ENSG00000215114
GeneIDi137886
KEGGihsa:137886
UCSCiuc003xtl.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126300 mRNA Translation: BAG54305.1
BC113645 mRNA Translation: AAI13646.1
CCDSiCCDS43741.1
RefSeqiNP_001071087.1, NM_001077619.1
NP_001317464.1, NM_001330535.1
UniGeneiHs.155572
Hs.668402

3D structure databases

ProteinModelPortaliQ14CS0
SMRiQ14CS0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126491, 27 interactors
IntActiQ14CS0, 17 interactors
STRINGi9606.ENSP00000382507

PTM databases

iPTMnetiQ14CS0
PhosphoSitePlusiQ14CS0

Polymorphism and mutation databases

BioMutaiUBXN2B
DMDMi121946691

Proteomic databases

EPDiQ14CS0
MaxQBiQ14CS0
PaxDbiQ14CS0
PeptideAtlasiQ14CS0
PRIDEiQ14CS0
ProteomicsDBi60331

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000399598; ENSP00000382507; ENSG00000215114
GeneIDi137886
KEGGihsa:137886
UCSCiuc003xtl.3 human

Organism-specific databases

CTDi137886
DisGeNETi137886
EuPathDBiHostDB:ENSG00000215114.7
GeneCardsiUBXN2B
HGNCiHGNC:27035 UBXN2B
HPAiHPA045278
MIMi610686 gene
neXtProtiNX_Q14CS0
OpenTargetsiENSG00000215114
PharmGKBiPA162408394
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2086 Eukaryota
ENOG410YGXU LUCA
GeneTreeiENSGT00520000055567
HOGENOMiHOG000159961
HOVERGENiHBG054517
InParanoidiQ14CS0
OMAiFIIQSRP
OrthoDBiEOG091G0QFZ
PhylomeDBiQ14CS0
TreeFamiTF312973

Miscellaneous databases

ChiTaRSiUBXN2B human
GenomeRNAii137886
PROiPR:Q14CS0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000215114 Expressed in 226 organ(s), highest expression level in cerebral cortex
CleanExiHS_UBXN2B
ExpressionAtlasiQ14CS0 baseline and differential
GenevisibleiQ14CS0 HS

Family and domain databases

Gene3Di3.30.420.210, 1 hit
InterProiView protein in InterPro
IPR036241 NSFL1C_SEP_dom_sf
IPR012989 SEP_domain
IPR029071 Ubiquitin-like_domsf
IPR001012 UBX_dom
PfamiView protein in Pfam
PF08059 SEP, 1 hit
PF00789 UBX, 1 hit
SMARTiView protein in SMART
SM00553 SEP, 1 hit
SM00166 UBX, 1 hit
SUPFAMiSSF102848 SSF102848, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS51399 SEP, 1 hit
PS50033 UBX, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUBX2B_HUMAN
AccessioniPrimary (citable) accession number: Q14CS0
Secondary accession number(s): B3KWZ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 22, 2006
Last modified: November 7, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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