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Protein

Keratin, type II cytoskeletal 72

Gene

KRT72

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable).Curated

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

Caution

Was initially thought to be the ortholog of mouse KRT71.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei376Stutter1

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cytoskeletal 72
Alternative name(s):
Cytokeratin-72
Short name:
CK-72
Keratin-72
Short name:
K72
Type II inner root sheath-specific keratin-K6irs2
Type-II keratin Kb35
Gene namesi
Name:KRT72
Synonyms:K6IRS2, KB35, KRT6, KRT6IRS2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000170486.10
HGNCiHGNC:28932 KRT72
MIMi608246 gene
neXtProtiNX_Q14CN4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

DisGeNETi140807
OpenTargetsiENSG00000170486
PharmGKBiPA147357719

Polymorphism and mutation databases

BioMutaiKRT72
DMDMi166218813

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003148771 – 511Keratin, type II cytoskeletal 72Add BLAST511

Proteomic databases

PaxDbiQ14CN4
PeptideAtlasiQ14CN4
PRIDEiQ14CN4
ProteomicsDBi60329
60330 [Q14CN4-2]

PTM databases

iPTMnetiQ14CN4
PhosphoSitePlusiQ14CN4
SwissPalmiQ14CN4

Expressioni

Tissue specificityi

Highly expressed in hair follicles from scalp and eyebrow. Also expressed in palmoplantar epidermis. Not expressed in face skin despite the presence of fine hairs histologically. In hair, it is specifically present in the inner root sheath (IRS) of the hair follicle. Present in the IRS cuticle, but not in Henle or Huxley layers of the IRS. In the IRS cuticle, its presence is delayed up to the height of the apex of the dermal papilla (at protein level).3 Publications

Gene expression databases

BgeeiENSG00000170486 Expressed in 49 organ(s), highest expression level in testis
CleanExiHS_KRT72
ExpressionAtlasiQ14CN4 baseline and differential
GenevisibleiQ14CN4 HS

Organism-specific databases

HPAiHPA065523

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.

Binary interactionsi

WithEntry#Exp.IntActNotes
KRT40Q6A1623EBI-1221280,EBI-10171697

Protein-protein interaction databases

BioGridi126715, 7 interactors
IntActiQ14CN4, 21 interactors
STRINGi9606.ENSP00000293745

Structurei

3D structure databases

ProteinModelPortaliQ14CN4
SMRiQ14CN4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini125 – 438IF rodPROSITE-ProRule annotationAdd BLAST314

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 124HeadAdd BLAST124
Regioni125 – 160Coil 1AAdd BLAST36
Regioni161 – 179Linker 1Add BLAST19
Regioni180 – 271Coil 1BAdd BLAST92
Regioni272 – 295Linker 12Add BLAST24
Regioni296 – 434Coil 2Add BLAST139
Regioni435 – 511TailAdd BLAST77

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi10 – 96Gly-richAdd BLAST87

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IQKP Eukaryota
ENOG4111AD7 LUCA
GeneTreeiENSGT00910000144006
HOGENOMiHOG000230976
HOVERGENiHBG013015
InParanoidiQ14CN4
KOiK07605
OMAiSYSYKTA
OrthoDBiEOG091G09KR
PhylomeDBiQ14CN4
TreeFamiTF317854

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR032444 Keratin_2_head
IPR003054 Keratin_II
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PF16208 Keratin_2_head, 1 hit
PRINTSiPR01276 TYPE2KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q14CN4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSRQLTHFPR GERLGFSGCS AVLSGGIGSS SASFRARVKG SASFGSKSLS
60 70 80 90 100
CLGGSRSLAL SAAARRGGGR LGGFVGTAFG SAGLGPKCPS VCPPGGIPQV
110 120 130 140 150
TVNKSLLAPL NVEMDPEIQR VRAQEREQIK ALNNKFASFI DKVRFLEQQN
160 170 180 190 200
QVLETKWNLL QQLDLNNCRK NLEPIYEGYI SNLQKQLEML SGDGVRLDSE
210 220 230 240 250
LRNMQDLVED YKKRYEVEIN RRTAAENEFV VLKKDVDAAY MNKVELQAKV
260 270 280 290 300
DSLTDEIKFF KCLYEGEITQ IQSHISDTSI VLSMDNNRDL DLDSIIAEVR
310 320 330 340 350
AQYEEIALKS KAEAETLYQT KIQELQVTAG QHGDDLKLTK AEISELNRLI
360 370 380 390 400
QRIRSEIGNV KKQCADLETA IADAEQRGDC ALKDARAKLD ELEGALHQAK
410 420 430 440 450
EELARMLREY QELVSLKLAL DMEIATYRKL LESEECRMSG EYPNSVSISV
460 470 480 490 500
ISSTNAGAGG AGFSMGFGAS SSYSYKTAAA DVKTKGSCGS ELKDPLAKTS
510
GSSCATKKAS R
Length:511
Mass (Da):55,877
Last modified:January 15, 2008 - v2
Checksum:i61E830C382063731
GO
Isoform 2 (identifier: Q14CN4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     363-363: Missing.

Show »
Length:510
Mass (Da):55,749
Checksum:i93AAAF9D75378EE7
GO
Isoform 3 (identifier: Q14CN4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     322-363: Missing.

Note: No experimental confirmation available.
Show »
Length:469
Mass (Da):51,124
Checksum:i297E42CB2BED56C8
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YHD9H0YHD9_HUMAN
Keratin, type II cytoskeletal 72
KRT72
143Annotation score:
H0YIG3H0YIG3_HUMAN
Keratin, type II cytoskeletal 72
KRT72
192Annotation score:

Sequence cautioni

The sequence BAC04039 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038087171N → D1 PublicationCorresponds to variant dbSNP:rs11170187Ensembl.1
Natural variantiVAR_038088264Y → C1 PublicationCorresponds to variant dbSNP:rs12833456Ensembl.1
Natural variantiVAR_061298326Q → E. Corresponds to variant dbSNP:rs34769047Ensembl.1
Natural variantiVAR_038089366D → E1 PublicationCorresponds to variant dbSNP:rs7310138Ensembl.1
Natural variantiVAR_038090428R → L1 PublicationCorresponds to variant dbSNP:rs11170183Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_045280322 – 363Missing in isoform 3. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_030416363Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY033496 Genomic DNA Translation: AAK55109.1
AY033495 mRNA Translation: AAK55108.1
AK093060 mRNA Translation: BAC04039.1 Different initiation.
AK293645 mRNA Translation: BAG57099.1
AC055715 Genomic DNA No translation available.
BC113686 mRNA Translation: AAI13687.1
CCDSiCCDS53795.1 [Q14CN4-3]
CCDS8833.1 [Q14CN4-1]
RefSeqiNP_001139697.1, NM_001146225.1 [Q14CN4-1]
NP_001139698.1, NM_001146226.1 [Q14CN4-3]
NP_542785.1, NM_080747.2 [Q14CN4-1]
UniGeneiHs.662013

Genome annotation databases

EnsembliENST00000293745; ENSP00000293745; ENSG00000170486 [Q14CN4-1]
ENST00000354310; ENSP00000346269; ENSG00000170486 [Q14CN4-3]
ENST00000537672; ENSP00000441160; ENSG00000170486 [Q14CN4-1]
GeneIDi140807
KEGGihsa:140807
UCSCiuc001saq.2 human [Q14CN4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY033496 Genomic DNA Translation: AAK55109.1
AY033495 mRNA Translation: AAK55108.1
AK093060 mRNA Translation: BAC04039.1 Different initiation.
AK293645 mRNA Translation: BAG57099.1
AC055715 Genomic DNA No translation available.
BC113686 mRNA Translation: AAI13687.1
CCDSiCCDS53795.1 [Q14CN4-3]
CCDS8833.1 [Q14CN4-1]
RefSeqiNP_001139697.1, NM_001146225.1 [Q14CN4-1]
NP_001139698.1, NM_001146226.1 [Q14CN4-3]
NP_542785.1, NM_080747.2 [Q14CN4-1]
UniGeneiHs.662013

3D structure databases

ProteinModelPortaliQ14CN4
SMRiQ14CN4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126715, 7 interactors
IntActiQ14CN4, 21 interactors
STRINGi9606.ENSP00000293745

PTM databases

iPTMnetiQ14CN4
PhosphoSitePlusiQ14CN4
SwissPalmiQ14CN4

Polymorphism and mutation databases

BioMutaiKRT72
DMDMi166218813

Proteomic databases

PaxDbiQ14CN4
PeptideAtlasiQ14CN4
PRIDEiQ14CN4
ProteomicsDBi60329
60330 [Q14CN4-2]

Protocols and materials databases

DNASUi140807
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000293745; ENSP00000293745; ENSG00000170486 [Q14CN4-1]
ENST00000354310; ENSP00000346269; ENSG00000170486 [Q14CN4-3]
ENST00000537672; ENSP00000441160; ENSG00000170486 [Q14CN4-1]
GeneIDi140807
KEGGihsa:140807
UCSCiuc001saq.2 human [Q14CN4-1]

Organism-specific databases

CTDi140807
DisGeNETi140807
EuPathDBiHostDB:ENSG00000170486.10
GeneCardsiKRT72
H-InvDBiHIX0010656
HGNCiHGNC:28932 KRT72
HPAiHPA065523
MIMi608246 gene
neXtProtiNX_Q14CN4
OpenTargetsiENSG00000170486
PharmGKBiPA147357719
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQKP Eukaryota
ENOG4111AD7 LUCA
GeneTreeiENSGT00910000144006
HOGENOMiHOG000230976
HOVERGENiHBG013015
InParanoidiQ14CN4
KOiK07605
OMAiSYSYKTA
OrthoDBiEOG091G09KR
PhylomeDBiQ14CN4
TreeFamiTF317854

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope

Miscellaneous databases

GenomeRNAii140807
PROiPR:Q14CN4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170486 Expressed in 49 organ(s), highest expression level in testis
CleanExiHS_KRT72
ExpressionAtlasiQ14CN4 baseline and differential
GenevisibleiQ14CN4 HS

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR032444 Keratin_2_head
IPR003054 Keratin_II
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PF16208 Keratin_2_head, 1 hit
PRINTSiPR01276 TYPE2KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiK2C72_HUMAN
AccessioniPrimary (citable) accession number: Q14CN4
Secondary accession number(s): B4DEI8
, H9KV51, Q8NA87, Q8WWY9, Q8WWZ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: September 12, 2018
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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