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Protein

Molybdenum cofactor sulfurase

Gene

Mocos

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.UniRule annotation

Catalytic activityi

Molybdenum cofactor + L-cysteine + reduced acceptor + 2 H+ = thio-molybdenum cofactor + L-alanine + H2O + oxidized acceptor.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei424UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processMolybdenum cofactor biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

ReactomeiR-MMU-947581 Molybdenum cofactor biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Molybdenum cofactor sulfuraseUniRule annotation (EC:2.8.1.9UniRule annotation)
Short name:
MCSUniRule annotation
Short name:
MOSUniRule annotation
Short name:
MoCo sulfuraseUniRule annotation
Alternative name(s):
Molybdenum cofactor sulfurtransferaseUniRule annotation
Gene namesi
Name:Mocos
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1915841 Mocos

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002499531 – 862Molybdenum cofactor sulfuraseAdd BLAST862

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34PhosphoserineBy similarity1
Modified residuei264N6-(pyridoxal phosphate)lysineUniRule annotation1
Modified residuei517PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ14CH1
MaxQBiQ14CH1
PaxDbiQ14CH1
PeptideAtlasiQ14CH1
PRIDEiQ14CH1

PTM databases

iPTMnetiQ14CH1
PhosphoSitePlusiQ14CH1

Expressioni

Gene expression databases

BgeeiENSMUSG00000039616 Expressed in 162 organ(s), highest expression level in left lobe of liver
CleanExiMM_MOCOS
GenevisibleiQ14CH1 MM

Interactioni

Protein-protein interaction databases

IntActiQ14CH1, 1 interactor
STRINGi10090.ENSMUSP00000063609

Structurei

3D structure databases

ProteinModelPortaliQ14CH1
SMRiQ14CH1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini704 – 855MOSCUniRule annotationAdd BLAST152

Sequence similaritiesi

Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG2142 Eukaryota
COG0520 LUCA
COG3217 LUCA
GeneTreeiENSGT00530000063150
HOGENOMiHOG000029698
HOVERGENiHBG081980
InParanoidiQ14CH1
KOiK15631
OMAiRVNTYDC
OrthoDBiEOG091G03KL
PhylomeDBiQ14CH1
TreeFamiTF105761

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
HAMAPiMF_03050 MOCOS, 1 hit
InterProiView protein in InterPro
IPR000192 Aminotrans_V_dom
IPR005302 MoCF_Sase_C
IPR028886 MoCo_sulfurase
IPR005303 MOSC_N
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
IPR011037 Pyrv_Knase-like_insert_dom_sf
PfamiView protein in Pfam
PF00266 Aminotran_5, 1 hit
PF03473 MOSC, 1 hit
PF03476 MOSC_N, 1 hit
SUPFAMiSSF50800 SSF50800, 1 hit
SSF53383 SSF53383, 1 hit
PROSITEiView protein in PROSITE
PS51340 MOSC, 1 hit

Sequencei

Sequence statusi: Complete.

Q14CH1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MACGAAERGP EPPAFQRHLE ASTQRLAHGY GLRSMSELRD QEFGRLAGTV
60 70 80 90 100
YLDHAGATLF PQSQLTNFTK DLMENVYGNP HSQNITSKLT HDTVEQVRYR
110 120 130 140 150
ILTHFHTTPE DYIVIFTAGS TAALRLVAEA FPWVSRSPEN SGSHFCYLTD
160 170 180 190 200
NHTSVVGMRK VAAAMSVTSI PVKPEDMWSA EGKDAGACDP DCQLPHLFCY
210 220 230 240 250
PAQSNFSGTR YPLSWVEEVK SGRRSPVNAP GKWFVLLDAA SYVSTSPLDL
260 270 280 290 300
SAHQADFIPI SFYKIFGLPT GLGALLVNKH VAPLLRKGYF GGGTAAAYLA
310 320 330 340 350
GEDFYVPRSS VAERFEDGTI SFLDVIALKH GFDALEHLTG GMVNIQQHTF
360 370 380 390 400
ALVQYTHSAL SSLRYLNGAP VVRIYSDSEF SSPDVQGPII NFNVLDDGGK
410 420 430 440 450
IIGYSQVDKM ASLYNIHLRT GCFCNLGACQ RHLGLSDEMV KKHFQAGHVC
460 470 480 490 500
GDDVDIIDGR PTGSVRISFG YMSTLEDAQA FLRFISTIYL RSPSDQPVPQ
510 520 530 540 550
ASISDAGALT SKSDCHSPQE GSCTDPSVCN GSYPDTNIMD LHPSLSKASS
560 570 580 590 600
AQQTPQDKAA GILNGDPGSH IVTNIYLYPI KSCAAFEVTK WPVGSQGLLY
610 620 630 640 650
DRSWMVVNHN GICMSQKQEP RLCLIQPFID LQQRIMVIKA EGMEPIQVPL
660 670 680 690 700
EEDGEQTQIC QSRVCADRVN TYDCGENVSR WLSKFLGRLC HLIKQSPHFQ
710 720 730 740 750
RNARKTPKKG QPPGTTVALS LVNEAQYLLV NTSSILELQR QLNASDEHGK
760 770 780 790 800
EESFSMKDLI SRFRANIITK GARAFEEEKW DEISIGSLHF QVLGPCHRCQ
810 820 830 840 850
MICINQQTGQ RNQDVFQTLS ESRGRKVNFG VYLMHSYLDL SSPCFLSVGS
860
EVLPVLKDCG VS
Length:862
Mass (Da):95,013
Last modified:August 22, 2006 - v1
Checksum:iE422CF97C6E91878
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC113180 mRNA Translation: AAI13181.1
BC113786 mRNA Translation: AAI13787.1
CCDSiCCDS37750.1
RefSeqiNP_081055.1, NM_026779.1
UniGeneiMm.28252

Genome annotation databases

EnsembliENSMUST00000068006; ENSMUSP00000063609; ENSMUSG00000039616
GeneIDi68591
KEGGimmu:68591
UCSCiuc008egy.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC113180 mRNA Translation: AAI13181.1
BC113786 mRNA Translation: AAI13787.1
CCDSiCCDS37750.1
RefSeqiNP_081055.1, NM_026779.1
UniGeneiMm.28252

3D structure databases

ProteinModelPortaliQ14CH1
SMRiQ14CH1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ14CH1, 1 interactor
STRINGi10090.ENSMUSP00000063609

PTM databases

iPTMnetiQ14CH1
PhosphoSitePlusiQ14CH1

Proteomic databases

EPDiQ14CH1
MaxQBiQ14CH1
PaxDbiQ14CH1
PeptideAtlasiQ14CH1
PRIDEiQ14CH1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068006; ENSMUSP00000063609; ENSMUSG00000039616
GeneIDi68591
KEGGimmu:68591
UCSCiuc008egy.1 mouse

Organism-specific databases

CTDi55034
MGIiMGI:1915841 Mocos

Phylogenomic databases

eggNOGiKOG2142 Eukaryota
COG0520 LUCA
COG3217 LUCA
GeneTreeiENSGT00530000063150
HOGENOMiHOG000029698
HOVERGENiHBG081980
InParanoidiQ14CH1
KOiK15631
OMAiRVNTYDC
OrthoDBiEOG091G03KL
PhylomeDBiQ14CH1
TreeFamiTF105761

Enzyme and pathway databases

ReactomeiR-MMU-947581 Molybdenum cofactor biosynthesis

Miscellaneous databases

PROiPR:Q14CH1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039616 Expressed in 162 organ(s), highest expression level in left lobe of liver
CleanExiMM_MOCOS
GenevisibleiQ14CH1 MM

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
HAMAPiMF_03050 MOCOS, 1 hit
InterProiView protein in InterPro
IPR000192 Aminotrans_V_dom
IPR005302 MoCF_Sase_C
IPR028886 MoCo_sulfurase
IPR005303 MOSC_N
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
IPR011037 Pyrv_Knase-like_insert_dom_sf
PfamiView protein in Pfam
PF00266 Aminotran_5, 1 hit
PF03473 MOSC, 1 hit
PF03476 MOSC_N, 1 hit
SUPFAMiSSF50800 SSF50800, 1 hit
SSF53383 SSF53383, 1 hit
PROSITEiView protein in PROSITE
PS51340 MOSC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMOCOS_MOUSE
AccessioniPrimary (citable) accession number: Q14CH1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: August 22, 2006
Last modified: November 7, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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