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Protein

Rho GTPase-activating protein 19

Gene

ARHGAP19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

ReactomeiR-HSA-194840 Rho GTPase cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GTPase-activating protein 19
Alternative name(s):
Rho-type GTPase-activating protein 19
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000213390.10
HGNCiHGNC:23724 ARHGAP19
MIMi611587 gene
neXtProtiNX_Q14CB8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000213390
ENSG00000269891
PharmGKBiPA134917415

Polymorphism and mutation databases

BioMutaiARHGAP19
DMDMi121948181

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002804652 – 494Rho GTPase-activating protein 19Add BLAST493

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei7PhosphoserineCombined sources1
Modified residuei31PhosphoserineBy similarity1
Modified residuei422PhosphoserineCombined sources1
Modified residuei438PhosphoserineCombined sources1
Modified residuei470PhosphoserineCombined sources1
Modified residuei478PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ14CB8
PaxDbiQ14CB8
PeptideAtlasiQ14CB8
PRIDEiQ14CB8
ProteomicsDBi60317
60318 [Q14CB8-2]
60319 [Q14CB8-3]
60320 [Q14CB8-4]
60321 [Q14CB8-5]
60322 [Q14CB8-6]
60323 [Q14CB8-7]

PTM databases

iPTMnetiQ14CB8
PhosphoSitePlusiQ14CB8

Expressioni

Tissue specificityi

Strong expression in fetal heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Weak expression in adult pancreas, spleen, thymus, and ovary.1 Publication

Gene expression databases

BgeeiENSG00000213390 Expressed in 195 organ(s), highest expression level in trigeminal ganglion
ExpressionAtlasiQ14CB8 baseline and differential
GenevisibleiQ14CB8 HS

Organism-specific databases

HPAiHPA035777
HPA043231

Interactioni

Protein-protein interaction databases

BioGridi124412, 14 interactors
IntActiQ14CB8, 2 interactors
STRINGi9606.ENSP00000351333

Structurei

3D structure databases

ProteinModelPortaliQ14CB8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini102 – 308Rho-GAPPROSITE-ProRule annotationAdd BLAST207

Phylogenomic databases

eggNOGiENOG410IPRZ Eukaryota
ENOG4110H3V LUCA
GeneTreeiENSGT00920000149153
HOVERGENiHBG055569
InParanoidiQ14CB8
KOiK20640
OMAiTHKHFHA
OrthoDBiEOG091G06NP
PhylomeDBiQ14CB8
TreeFamiTF326309

Family and domain databases

Gene3Di1.10.555.10, 1 hit
InterProiView protein in InterPro
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
PfamiView protein in Pfam
PF00620 RhoGAP, 1 hit
SMARTiView protein in SMART
SM00324 RhoGAP, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50238 RHOGAP, 1 hit

Sequences (7+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q14CB8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATEAQSEGE VPARESGRSD AICSFVICND SSLRGQPIIF NPDFFVEKLR
60 70 80 90 100
HEKPEIFTEL VVSNITRLID LPGTELAQLM GEVDLKLPGG AGPASGFFRS
110 120 130 140 150
LMSLKRKEKG VIFGSPLTEE GIAQIYQLIE YLHKNLRVEG LFRVPGNSVR
160 170 180 190 200
QQILRDALNN GTDIDLESGE FHSNDVATLL KMFLGELPEP LLTHKHFNAH
210 220 230 240 250
LKIADLMQFD DKGNKTNIPD KDRQIEALQL LFLILPPPNR NLLKLLLDLL
260 270 280 290 300
YQTAKKQDKN KMSAYNLALM FAPHVLWPKN VTANDLQENI TKLNSGMAFM
310 320 330 340 350
IKHSQKLFKA PAYIRECARL HYLGSRTQAS KDDLDLIASC HTKSFQLAKS
360 370 380 390 400
QKRNRVDSCP HQEETQHHTE EALRELFQHV HDMPESAKKK QLIRQFNKQS
410 420 430 440 450
LTQTPGREPS TSQVQKRARS RSFSGLIKRK VLGNQMMSEK KKKNPTPESV
460 470 480 490
AIGELKGTSK ENRNLLFSGS PAVTMTPTRL KWSEGKKEGK KGFL
Length:494
Mass (Da):55,756
Last modified:August 22, 2006 - v1
Checksum:iEAE8DF3FD1253858
GO
Isoform 2 (identifier: Q14CB8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     493-494: FL → NSMATTSLGSIRMTLRGSSSCGCCS

Note: No experimental confirmation available.
Show »
Length:517
Mass (Da):57,989
Checksum:iED0204FB3AEA0BFA
GO
Isoform 3 (identifier: Q14CB8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: MATEAQSEGEVPARESGRS → MPHQKLSALI

Note: No experimental confirmation available.
Show »
Length:485
Mass (Da):54,901
Checksum:i9127F52FD96F4DF7
GO
Isoform 4 (identifier: Q14CB8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-382: Missing.

Note: No experimental confirmation available.
Show »
Length:112
Mass (Da):12,548
Checksum:iA7F67459CA61C860
GO
Isoform 5 (identifier: Q14CB8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     281-301: VTANDLQENITKLNSGMAFMI → GLVLLPTLEESNTITTHCSLI
     302-494: Missing.

Note: No experimental confirmation available.
Show »
Length:301
Mass (Da):33,708
Checksum:i7909659144913AEB
GO
Isoform 6 (identifier: Q14CB8-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     281-309: Missing.

Note: No experimental confirmation available.
Show »
Length:465
Mass (Da):52,466
Checksum:iA427B1C7CC5ADEA2
GO
Isoform 7 (identifier: Q14CB8-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     332-346: Missing.

Show »
Length:479
Mass (Da):54,081
Checksum:iB4B5048BCB255B21
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
R4GNI4R4GNI4_HUMAN
Rho GTPase-activating protein 19
ARHGAP19
197Annotation score:
R4GMS4R4GMS4_HUMAN
Rho GTPase-activating protein 19
ARHGAP19
300Annotation score:

Sequence cautioni

The sequence BAB84948 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC04165 differs from that shown. Reason: Frameshift at position 280.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28C → Y in AAR02412 (PubMed:17454002).Curated1
Sequence conflicti28C → Y in ABC69298 (PubMed:17454002).Curated1
Sequence conflicti170E → A in CAH18254 (PubMed:17974005).Curated1
Sequence conflicti170E → G in BAC04165 (PubMed:14702039).Curated1
Sequence conflicti420S → L in BAC04165 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031152305Q → R. Corresponds to variant dbSNP:rs17112598Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0236951 – 382Missing in isoform 4. 1 PublicationAdd BLAST382
Alternative sequenceiVSP_0236961 – 19MATEA…ESGRS → MPHQKLSALI in isoform 3. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_023697281 – 309Missing in isoform 6. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_023698281 – 301VTAND…MAFMI → GLVLLPTLEESNTITTHCSL I in isoform 5. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_023699302 – 494Missing in isoform 5. 1 PublicationAdd BLAST193
Alternative sequenceiVSP_023700332 – 346Missing in isoform 7. CuratedAdd BLAST15
Alternative sequenceiVSP_023701493 – 494FL → NSMATTSLGSIRMTLRGSSS CGCCS in isoform 2. 1 Publication2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ338460 mRNA Translation: ABC69298.1
AY336750 mRNA Translation: AAR02412.1
AK093441 mRNA Translation: BAC04165.1 Frameshift.
AK074122 mRNA Translation: BAB84948.1 Different initiation.
AK090447 mRNA Translation: BAC03428.1
AK303055 mRNA Translation: BAG64173.1
CR749412 mRNA Translation: CAH18254.1
AL359385 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49952.1
BC113888 mRNA Translation: AAI13889.1
BC114490 mRNA Translation: AAI14491.1
CCDSiCCDS58092.1 [Q14CB8-3]
CCDS73175.1 [Q14CB8-6]
CCDS7454.2 [Q14CB8-1]
RefSeqiNP_001191229.1, NM_001204300.1 [Q14CB8-6]
NP_001243352.1, NM_001256423.1 [Q14CB8-3]
NP_116289.4, NM_032900.5 [Q14CB8-1]
UniGeneiHs.80305

Genome annotation databases

EnsembliENST00000358308; ENSP00000351058; ENSG00000213390 [Q14CB8-6]
ENST00000358531; ENSP00000351333; ENSG00000213390 [Q14CB8-1]
ENST00000371027; ENSP00000360066; ENSG00000213390 [Q14CB8-3]
GeneIDi84986
KEGGihsa:84986
UCSCiuc001kna.5 human [Q14CB8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ338460 mRNA Translation: ABC69298.1
AY336750 mRNA Translation: AAR02412.1
AK093441 mRNA Translation: BAC04165.1 Frameshift.
AK074122 mRNA Translation: BAB84948.1 Different initiation.
AK090447 mRNA Translation: BAC03428.1
AK303055 mRNA Translation: BAG64173.1
CR749412 mRNA Translation: CAH18254.1
AL359385 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49952.1
BC113888 mRNA Translation: AAI13889.1
BC114490 mRNA Translation: AAI14491.1
CCDSiCCDS58092.1 [Q14CB8-3]
CCDS73175.1 [Q14CB8-6]
CCDS7454.2 [Q14CB8-1]
RefSeqiNP_001191229.1, NM_001204300.1 [Q14CB8-6]
NP_001243352.1, NM_001256423.1 [Q14CB8-3]
NP_116289.4, NM_032900.5 [Q14CB8-1]
UniGeneiHs.80305

3D structure databases

ProteinModelPortaliQ14CB8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124412, 14 interactors
IntActiQ14CB8, 2 interactors
STRINGi9606.ENSP00000351333

PTM databases

iPTMnetiQ14CB8
PhosphoSitePlusiQ14CB8

Polymorphism and mutation databases

BioMutaiARHGAP19
DMDMi121948181

Proteomic databases

MaxQBiQ14CB8
PaxDbiQ14CB8
PeptideAtlasiQ14CB8
PRIDEiQ14CB8
ProteomicsDBi60317
60318 [Q14CB8-2]
60319 [Q14CB8-3]
60320 [Q14CB8-4]
60321 [Q14CB8-5]
60322 [Q14CB8-6]
60323 [Q14CB8-7]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358308; ENSP00000351058; ENSG00000213390 [Q14CB8-6]
ENST00000358531; ENSP00000351333; ENSG00000213390 [Q14CB8-1]
ENST00000371027; ENSP00000360066; ENSG00000213390 [Q14CB8-3]
GeneIDi84986
KEGGihsa:84986
UCSCiuc001kna.5 human [Q14CB8-1]

Organism-specific databases

CTDi84986
EuPathDBiHostDB:ENSG00000213390.10
GeneCardsiARHGAP19
H-InvDBiHIX0009085
HIX0079267
HGNCiHGNC:23724 ARHGAP19
HPAiHPA035777
HPA043231
MIMi611587 gene
neXtProtiNX_Q14CB8
OpenTargetsiENSG00000213390
ENSG00000269891
PharmGKBiPA134917415
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IPRZ Eukaryota
ENOG4110H3V LUCA
GeneTreeiENSGT00920000149153
HOVERGENiHBG055569
InParanoidiQ14CB8
KOiK20640
OMAiTHKHFHA
OrthoDBiEOG091G06NP
PhylomeDBiQ14CB8
TreeFamiTF326309

Enzyme and pathway databases

ReactomeiR-HSA-194840 Rho GTPase cycle

Miscellaneous databases

ChiTaRSiARHGAP19 human
GeneWikiiARHGAP19
GenomeRNAii84986
PROiPR:Q14CB8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000213390 Expressed in 195 organ(s), highest expression level in trigeminal ganglion
ExpressionAtlasiQ14CB8 baseline and differential
GenevisibleiQ14CB8 HS

Family and domain databases

Gene3Di1.10.555.10, 1 hit
InterProiView protein in InterPro
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
PfamiView protein in Pfam
PF00620 RhoGAP, 1 hit
SMARTiView protein in SMART
SM00324 RhoGAP, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50238 RHOGAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRHG19_HUMAN
AccessioniPrimary (citable) accession number: Q14CB8
Secondary accession number(s): A1XCP1
, B4DZR1, Q14CF2, Q5J8M2, Q5T460, Q5T462, Q68DG6, Q8N9X1, Q8NF34, Q8TEK1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: August 22, 2006
Last modified: September 12, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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