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Entry version 120 (17 Jun 2020)
Sequence version 1 (22 Aug 2006)
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Protein

Rho GTPase-activating protein 19

Gene

ARHGAP19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-194840 Rho GTPase cycle

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho GTPase-activating protein 19
Alternative name(s):
Rho-type GTPase-activating protein 19
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000213390.10

Human Gene Nomenclature Database

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HGNCi
HGNC:23724 ARHGAP19

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611587 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q14CB8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000213390
ENSG00000269891

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134917415

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q14CB8 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ARHGAP19

Domain mapping of disease mutations (DMDM)

More...
DMDMi
121948181

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002804652 – 494Rho GTPase-activating protein 19Add BLAST493

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei7PhosphoserineCombined sources1
Modified residuei31PhosphoserineBy similarity1
Modified residuei422PhosphoserineCombined sources1
Modified residuei438PhosphoserineCombined sources1
Modified residuei470PhosphoserineCombined sources1
Modified residuei478PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q14CB8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q14CB8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q14CB8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q14CB8

PeptideAtlas

More...
PeptideAtlasi
Q14CB8

PRoteomics IDEntifications database

More...
PRIDEi
Q14CB8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
60317 [Q14CB8-1]
60318 [Q14CB8-2]
60319 [Q14CB8-3]
60320 [Q14CB8-4]
60321 [Q14CB8-5]
60322 [Q14CB8-6]
60323 [Q14CB8-7]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q14CB8

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
Q14CB8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q14CB8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Strong expression in fetal heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Weak expression in adult pancreas, spleen, thymus, and ovary.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000213390 Expressed in trigeminal ganglion and 194 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q14CB8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q14CB8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000213390 Tissue enhanced (lymphoid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
124412, 15 interactors

Protein interaction database and analysis system

More...
IntActi
Q14CB8, 28 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000351333

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q14CB8 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini102 – 308Rho-GAPPROSITE-ProRule annotationAdd BLAST207

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IPRZ Eukaryota
ENOG4110H3V LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157331

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_046228_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q14CB8

KEGG Orthology (KO)

More...
KOi
K20640

Identification of Orthologs from Complete Genome Data

More...
OMAi
RQFNKHS

Database of Orthologous Groups

More...
OrthoDBi
878646at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q14CB8

TreeFam database of animal gene trees

More...
TreeFami
TF326309

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.555.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00620 RhoGAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00324 RhoGAP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48350 SSF48350, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50238 RHOGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q14CB8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATEAQSEGE VPARESGRSD AICSFVICND SSLRGQPIIF NPDFFVEKLR
60 70 80 90 100
HEKPEIFTEL VVSNITRLID LPGTELAQLM GEVDLKLPGG AGPASGFFRS
110 120 130 140 150
LMSLKRKEKG VIFGSPLTEE GIAQIYQLIE YLHKNLRVEG LFRVPGNSVR
160 170 180 190 200
QQILRDALNN GTDIDLESGE FHSNDVATLL KMFLGELPEP LLTHKHFNAH
210 220 230 240 250
LKIADLMQFD DKGNKTNIPD KDRQIEALQL LFLILPPPNR NLLKLLLDLL
260 270 280 290 300
YQTAKKQDKN KMSAYNLALM FAPHVLWPKN VTANDLQENI TKLNSGMAFM
310 320 330 340 350
IKHSQKLFKA PAYIRECARL HYLGSRTQAS KDDLDLIASC HTKSFQLAKS
360 370 380 390 400
QKRNRVDSCP HQEETQHHTE EALRELFQHV HDMPESAKKK QLIRQFNKQS
410 420 430 440 450
LTQTPGREPS TSQVQKRARS RSFSGLIKRK VLGNQMMSEK KKKNPTPESV
460 470 480 490
AIGELKGTSK ENRNLLFSGS PAVTMTPTRL KWSEGKKEGK KGFL
Length:494
Mass (Da):55,756
Last modified:August 22, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEAE8DF3FD1253858
GO
Isoform 2 (identifier: Q14CB8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     493-494: FL → NSMATTSLGSIRMTLRGSSSCGCCS

Show »
Length:517
Mass (Da):57,989
Checksum:iED0204FB3AEA0BFA
GO
Isoform 3 (identifier: Q14CB8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: MATEAQSEGEVPARESGRS → MPHQKLSALI

Show »
Length:485
Mass (Da):54,901
Checksum:i9127F52FD96F4DF7
GO
Isoform 4 (identifier: Q14CB8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-382: Missing.

Show »
Length:112
Mass (Da):12,548
Checksum:iA7F67459CA61C860
GO
Isoform 5 (identifier: Q14CB8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     281-301: VTANDLQENITKLNSGMAFMI → GLVLLPTLEESNTITTHCSLI
     302-494: Missing.

Show »
Length:301
Mass (Da):33,708
Checksum:i7909659144913AEB
GO
Isoform 6 (identifier: Q14CB8-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     281-309: Missing.

Show »
Length:465
Mass (Da):52,466
Checksum:iA427B1C7CC5ADEA2
GO
Isoform 7 (identifier: Q14CB8-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     332-346: Missing.

Show »
Length:479
Mass (Da):54,081
Checksum:iB4B5048BCB255B21
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
R4GNI4R4GNI4_HUMAN
Rho GTPase-activating protein 19
ARHGAP19
197Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
R4GMS4R4GMS4_HUMAN
Rho GTPase-activating protein 19
ARHGAP19
300Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB84948 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC04165 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti28C → Y in AAR02412 (PubMed:17454002).Curated1
Sequence conflicti28C → Y in ABC69298 (PubMed:17454002).Curated1
Sequence conflicti170E → A in CAH18254 (PubMed:17974005).Curated1
Sequence conflicti170E → G in BAC04165 (PubMed:14702039).Curated1
Sequence conflicti420S → L in BAC04165 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_031152305Q → R. Corresponds to variant dbSNP:rs17112598Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0236951 – 382Missing in isoform 4. 1 PublicationAdd BLAST382
Alternative sequenceiVSP_0236961 – 19MATEA…ESGRS → MPHQKLSALI in isoform 3. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_023697281 – 309Missing in isoform 6. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_023698281 – 301VTAND…MAFMI → GLVLLPTLEESNTITTHCSL I in isoform 5. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_023699302 – 494Missing in isoform 5. 1 PublicationAdd BLAST193
Alternative sequenceiVSP_023700332 – 346Missing in isoform 7. CuratedAdd BLAST15
Alternative sequenceiVSP_023701493 – 494FL → NSMATTSLGSIRMTLRGSSS CGCCS in isoform 2. 1 Publication2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ338460 mRNA Translation: ABC69298.1
AY336750 mRNA Translation: AAR02412.1
AK093441 mRNA Translation: BAC04165.1 Frameshift.
AK074122 mRNA Translation: BAB84948.1 Different initiation.
AK090447 mRNA Translation: BAC03428.1
AK303055 mRNA Translation: BAG64173.1
CR749412 mRNA Translation: CAH18254.1
AL359385 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49952.1
BC113888 mRNA Translation: AAI13889.1
BC114490 mRNA Translation: AAI14491.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS58092.1 [Q14CB8-3]
CCDS73175.1 [Q14CB8-6]
CCDS7454.2 [Q14CB8-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001191229.1, NM_001204300.1 [Q14CB8-6]
NP_001243352.1, NM_001256423.1 [Q14CB8-3]
NP_116289.4, NM_032900.5 [Q14CB8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000358308; ENSP00000351058; ENSG00000213390 [Q14CB8-6]
ENST00000358531; ENSP00000351333; ENSG00000213390 [Q14CB8-1]
ENST00000371027; ENSP00000360066; ENSG00000213390 [Q14CB8-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
84986

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84986

UCSC genome browser

More...
UCSCi
uc001kna.5 human [Q14CB8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ338460 mRNA Translation: ABC69298.1
AY336750 mRNA Translation: AAR02412.1
AK093441 mRNA Translation: BAC04165.1 Frameshift.
AK074122 mRNA Translation: BAB84948.1 Different initiation.
AK090447 mRNA Translation: BAC03428.1
AK303055 mRNA Translation: BAG64173.1
CR749412 mRNA Translation: CAH18254.1
AL359385 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49952.1
BC113888 mRNA Translation: AAI13889.1
BC114490 mRNA Translation: AAI14491.1
CCDSiCCDS58092.1 [Q14CB8-3]
CCDS73175.1 [Q14CB8-6]
CCDS7454.2 [Q14CB8-1]
RefSeqiNP_001191229.1, NM_001204300.1 [Q14CB8-6]
NP_001243352.1, NM_001256423.1 [Q14CB8-3]
NP_116289.4, NM_032900.5 [Q14CB8-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi124412, 15 interactors
IntActiQ14CB8, 28 interactors
STRINGi9606.ENSP00000351333

PTM databases

iPTMnetiQ14CB8
MetOSiteiQ14CB8
PhosphoSitePlusiQ14CB8

Polymorphism and mutation databases

BioMutaiARHGAP19
DMDMi121948181

Proteomic databases

jPOSTiQ14CB8
MassIVEiQ14CB8
MaxQBiQ14CB8
PaxDbiQ14CB8
PeptideAtlasiQ14CB8
PRIDEiQ14CB8
ProteomicsDBi60317 [Q14CB8-1]
60318 [Q14CB8-2]
60319 [Q14CB8-3]
60320 [Q14CB8-4]
60321 [Q14CB8-5]
60322 [Q14CB8-6]
60323 [Q14CB8-7]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
30829 130 antibodies

Genome annotation databases

EnsembliENST00000358308; ENSP00000351058; ENSG00000213390 [Q14CB8-6]
ENST00000358531; ENSP00000351333; ENSG00000213390 [Q14CB8-1]
ENST00000371027; ENSP00000360066; ENSG00000213390 [Q14CB8-3]
GeneIDi84986
KEGGihsa:84986
UCSCiuc001kna.5 human [Q14CB8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
84986
EuPathDBiHostDB:ENSG00000213390.10

GeneCards: human genes, protein and diseases

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GeneCardsi
ARHGAP19
HGNCiHGNC:23724 ARHGAP19
HPAiENSG00000213390 Tissue enhanced (lymphoid)
MIMi611587 gene
neXtProtiNX_Q14CB8
OpenTargetsiENSG00000213390
ENSG00000269891
PharmGKBiPA134917415

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IPRZ Eukaryota
ENOG4110H3V LUCA
GeneTreeiENSGT00940000157331
HOGENOMiCLU_046228_0_0_1
InParanoidiQ14CB8
KOiK20640
OMAiRQFNKHS
OrthoDBi878646at2759
PhylomeDBiQ14CB8
TreeFamiTF326309

Enzyme and pathway databases

ReactomeiR-HSA-194840 Rho GTPase cycle

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
84986 12 hits in 789 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ARHGAP19

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
84986
PharosiQ14CB8 Tdark

Protein Ontology

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PROi
PR:Q14CB8
RNActiQ14CB8 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000213390 Expressed in trigeminal ganglion and 194 other tissues
ExpressionAtlasiQ14CB8 baseline and differential
GenevisibleiQ14CB8 HS

Family and domain databases

Gene3Di1.10.555.10, 1 hit
InterProiView protein in InterPro
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
PfamiView protein in Pfam
PF00620 RhoGAP, 1 hit
SMARTiView protein in SMART
SM00324 RhoGAP, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50238 RHOGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRHG19_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14CB8
Secondary accession number(s): A1XCP1
, B4DZR1, Q14CF2, Q5J8M2, Q5T460, Q5T462, Q68DG6, Q8N9X1, Q8NF34, Q8TEK1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: August 22, 2006
Last modified: June 17, 2020
This is version 120 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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