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Protein

Serine protease 55

Gene

Prss55

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable serine protease.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei75Charge relay systemBy similarity1
Active sitei122Charge relay systemBy similarity1
Active sitei216Charge relay systemBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.415

Names & Taxonomyi

Protein namesi
Recommended name:
Serine protease 55 (EC:3.4.21.-)
Gene namesi
Name:Prss55
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1918287 Prss55

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini17 – 293ExtracellularSequence analysisAdd BLAST277
Transmembranei294 – 314HelicalSequence analysisAdd BLAST21
Topological domaini315 – 321CytoplasmicSequence analysis7

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000032881617 – 321Serine protease 55Add BLAST305

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi60 ↔ 76PROSITE-ProRule annotation
Disulfide bondi155 ↔ 222PROSITE-ProRule annotation
Glycosylationi164N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi188 ↔ 201PROSITE-ProRule annotation
Disulfide bondi212 ↔ 242PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ14BX2
PRIDEiQ14BX2

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000086752

Structurei

3D structure databases

ProteinModelPortaliQ14BX2
SMRiQ14BX2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 266Peptidase S1PROSITE-ProRule annotationAdd BLAST232

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
HOGENOMiHOG000251820
HOVERGENiHBG078102
InParanoidiQ14BX2
PhylomeDBiQ14BX2

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q14BX2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MILPSILLLV AHTLEANVEC GVRPLYDSRI QYSRIIEGQE AELGEFPWQV
60 70 80 90 100
SIQESDHHFC GGSILSEWWI LTVAHCFYAQ ELSPTDLRVR VGTNDLTTSP
110 120 130 140 150
VELEVTTIIR HKGFKRLNMD NDIALLLLAK PLAFNELTVP ICLPLWPAPP
160 170 180 190 200
SWHECWVAGW GVTNSTDKES MSTDLMKVPM RIIEWEECLQ MFPSLTTNML
210 220 230 240 250
CASYGNESYD ACQGDSGGPL VCTTDPGSRW YQVGIISWGK SCGKKGFPGI
260 270 280 290 300
YTVLAKYTLW IEKIAQTEGK PLDFRGQSSS NKKKNRQNNQ LSKSPALNCP
310 320
QSWLLPCLLS FALLRALSNW K
Length:321
Mass (Da):36,057
Last modified:August 22, 2006 - v1
Checksum:iAAFA26651F8145CA
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3X9K6G3X9K6_MOUSE
MCG15875
Prss55 mCG_15875
321Annotation score:
E9QA75E9QA75_MOUSE
Serine protease 55
Prss55
225Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC115562 mRNA Translation: AAI15563.1
CCDSiCCDS36952.1
UniGeneiMm.19977

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC115562 mRNA Translation: AAI15563.1
CCDSiCCDS36952.1
UniGeneiMm.19977

3D structure databases

ProteinModelPortaliQ14BX2
SMRiQ14BX2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000086752

Protein family/group databases

MEROPSiS01.415

Proteomic databases

PaxDbiQ14BX2
PRIDEiQ14BX2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1918287 Prss55

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
HOGENOMiHOG000251820
HOVERGENiHBG078102
InParanoidiQ14BX2
PhylomeDBiQ14BX2

Miscellaneous databases

PROiPR:Q14BX2
SOURCEiSearch...

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00135 TRYPSIN_SER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPRS55_MOUSE
AccessioniPrimary (citable) accession number: Q14BX2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: August 22, 2006
Last modified: December 20, 2017
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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