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Protein

Unique cartilage matrix-associated protein

Gene

Ucma

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface.1 Publication

GO - Biological processi

  • negative regulation of osteoblast differentiation Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Unique cartilage matrix-associated protein
Alternative name(s):
Upper zone of growth plate and cartilage matrix associated protein
Cleaved into the following chain:
Alternative name(s):
Gla-rich protein
Short name:
GRP
Gene namesi
Name:Ucma
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1915777 Ucma

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Extracellular matrix, Golgi apparatus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000034706528 – 138Unique cartilage matrix-associated proteinAdd BLAST111
PropeptideiPRO_000034706628 – 64Ucma-N1 PublicationAdd BLAST37
ChainiPRO_000034706765 – 138Unique cartilage matrix-associated protein C-terminal fragmentAdd BLAST74

Post-translational modificationi

Proteolytically cleaved by a furin-like convertase to generate a persistent C-terminal fragment found in almost the entire cartilage matrix, and affecting osteoblast differentiation.
Sulfated on one or two tyrosine residues within the tryptic peptide 121-135.1 Publication

Keywords - PTMi

Sulfation

Proteomic databases

PaxDbiQ14BU0
PRIDEiQ14BU0

Expressioni

Tissue specificityi

Predominantly expressed in resting chondrocytes.1 Publication

Developmental stagei

Transiently expressed in the developing mouse skeleton between day E13.5 of embryonic development and 5 months of postnatal development. Absent in undifferentiated mesenchymal cells. Isoforms 1 and 3 are significantly increased with the onset of chondrogenesis, whereas Isoforms 2 and 4 are detected at a later stage.2 Publications

Inductioni

Expression inhibited by TGFB1, and weakly inhibited by BMP2.1 Publication

Gene expression databases

BgeeiENSMUSG00000026668 Expressed in 150 organ(s), highest expression level in utricle of membranous labyrinth
GenevisibleiQ14BU0 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000110662

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili78 – 122Sequence analysisAdd BLAST45

Sequence similaritiesi

Belongs to the UCMA family.Curated

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiENOG410IY09 Eukaryota
ENOG4111U8I LUCA
GeneTreeiENSGT00390000011492
HOGENOMiHOG000253965
HOVERGENiHBG098812
InParanoidiQ14BU0
OMAiYLYNRHH
OrthoDBiEOG091G10F8
PhylomeDBiQ14BU0
TreeFamiTF332568

Family and domain databases

InterProiView protein in InterPro
IPR031386 UCMA
PANTHERiPTHR28647 PTHR28647, 1 hit
PfamiView protein in Pfam
PF17085 UCMA, 1 hit

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q14BU0-1) [UniParc]FASTAAdd to basket
Also known as: Ucma/GRP-F1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSWRRVILLS SLLALVLLCM LQEGTSASVG SRQAAAEGVQ EGVKQKIFMQ
60 70 80 90 100
ESDASNFLKR RGKRSPKSRD EVNAENRQRL RDDELRREYY EEQRNEFENF
110 120 130
VEEQRDEQEE RTREAVEQWR QWHYDGLYPS YLYNRQNI
Length:138
Mass (Da):16,579
Last modified:August 22, 2006 - v1
Checksum:i11914F39960348DC
GO
Isoform 2 (identifier: Q14BU0-2) [UniParc]FASTAAdd to basket
Also known as: Ucma/GRP-F2

The sequence of this isoform differs from the canonical sequence as follows:
     20-42: MLQEGTSASVGSRQAAAEGVQEG → S

Show »
Length:116
Mass (Da):14,421
Checksum:iC11712CC2196184D
GO
Isoform 3 (identifier: Q14BU0-3) [UniParc]FASTAAdd to basket
Also known as: Ucma/GRP-F3

The sequence of this isoform differs from the canonical sequence as follows:
     74-106: Missing.

Show »
Length:105
Mass (Da):12,235
Checksum:i6F165579608C833C
GO
Isoform 4 (identifier: Q14BU0-4) [UniParc]FASTAAdd to basket
Also known as: Ucma/GRP-F4

The sequence of this isoform differs from the canonical sequence as follows:
     20-42: MLQEGTSASVGSRQAAAEGVQEG → S
     74-106: Missing.

Show »
Length:83
Mass (Da):10,077
Checksum:iAF10EB403DA27266
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03505120 – 42MLQEG…GVQEG → S in isoform 2 and isoform 4. 2 PublicationsAdd BLAST23
Alternative sequenceiVSP_04080774 – 106Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST33

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF529510 mRNA Translation: ABP88975.1
EU368184 mRNA Translation: ABY65726.1
FJ217397 mRNA Translation: ACO35746.1
FJ217398 mRNA Translation: ACO35747.1
FJ217399 mRNA Translation: ACO35748.1
FJ217400 mRNA Translation: ACO35749.1
AK003750 mRNA Translation: BAB22978.2
BX682541, AL928662 Genomic DNA Translation: CAM21763.1
BX682541, AL928662 Genomic DNA Translation: CAM21764.1
AL928662, BX682541 Genomic DNA Translation: CAM22576.1
AL928662, BX682541 Genomic DNA Translation: CAM22577.1
CH466542 Genomic DNA Translation: EDL07955.1
BC115608 mRNA Translation: AAI15609.1
BC115609 mRNA Translation: AAI15610.1
CCDSiCCDS15661.1 [Q14BU0-2]
CCDS50489.1 [Q14BU0-1]
CCDS50490.1 [Q14BU0-3]
CCDS84467.1 [Q14BU0-4]
RefSeqiNP_001107030.1, NM_001113558.2 [Q14BU0-1]
NP_001159404.1, NM_001165932.1 [Q14BU0-3]
NP_001298137.1, NM_001311208.1 [Q14BU0-4]
NP_081030.1, NM_026754.3 [Q14BU0-2]
UniGeneiMm.27791

Genome annotation databases

EnsembliENSMUST00000027978; ENSMUSP00000027978; ENSMUSG00000026668 [Q14BU0-2]
ENSMUST00000115010; ENSMUSP00000110662; ENSMUSG00000026668 [Q14BU0-1]
ENSMUST00000167607; ENSMUSP00000126371; ENSMUSG00000026668 [Q14BU0-3]
ENSMUST00000195688; ENSMUSP00000141304; ENSMUSG00000026668 [Q14BU0-4]
GeneIDi68527
KEGGimmu:68527
UCSCiuc008ife.2 mouse [Q14BU0-2]
uc008iff.2 mouse [Q14BU0-1]
uc012bov.1 mouse [Q14BU0-3]
uc012bow.1 mouse [Q14BU0-4]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF529510 mRNA Translation: ABP88975.1
EU368184 mRNA Translation: ABY65726.1
FJ217397 mRNA Translation: ACO35746.1
FJ217398 mRNA Translation: ACO35747.1
FJ217399 mRNA Translation: ACO35748.1
FJ217400 mRNA Translation: ACO35749.1
AK003750 mRNA Translation: BAB22978.2
BX682541, AL928662 Genomic DNA Translation: CAM21763.1
BX682541, AL928662 Genomic DNA Translation: CAM21764.1
AL928662, BX682541 Genomic DNA Translation: CAM22576.1
AL928662, BX682541 Genomic DNA Translation: CAM22577.1
CH466542 Genomic DNA Translation: EDL07955.1
BC115608 mRNA Translation: AAI15609.1
BC115609 mRNA Translation: AAI15610.1
CCDSiCCDS15661.1 [Q14BU0-2]
CCDS50489.1 [Q14BU0-1]
CCDS50490.1 [Q14BU0-3]
CCDS84467.1 [Q14BU0-4]
RefSeqiNP_001107030.1, NM_001113558.2 [Q14BU0-1]
NP_001159404.1, NM_001165932.1 [Q14BU0-3]
NP_001298137.1, NM_001311208.1 [Q14BU0-4]
NP_081030.1, NM_026754.3 [Q14BU0-2]
UniGeneiMm.27791

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000110662

Proteomic databases

PaxDbiQ14BU0
PRIDEiQ14BU0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027978; ENSMUSP00000027978; ENSMUSG00000026668 [Q14BU0-2]
ENSMUST00000115010; ENSMUSP00000110662; ENSMUSG00000026668 [Q14BU0-1]
ENSMUST00000167607; ENSMUSP00000126371; ENSMUSG00000026668 [Q14BU0-3]
ENSMUST00000195688; ENSMUSP00000141304; ENSMUSG00000026668 [Q14BU0-4]
GeneIDi68527
KEGGimmu:68527
UCSCiuc008ife.2 mouse [Q14BU0-2]
uc008iff.2 mouse [Q14BU0-1]
uc012bov.1 mouse [Q14BU0-3]
uc012bow.1 mouse [Q14BU0-4]

Organism-specific databases

CTDi221044
MGIiMGI:1915777 Ucma

Phylogenomic databases

eggNOGiENOG410IY09 Eukaryota
ENOG4111U8I LUCA
GeneTreeiENSGT00390000011492
HOGENOMiHOG000253965
HOVERGENiHBG098812
InParanoidiQ14BU0
OMAiYLYNRHH
OrthoDBiEOG091G10F8
PhylomeDBiQ14BU0
TreeFamiTF332568

Miscellaneous databases

PROiPR:Q14BU0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026668 Expressed in 150 organ(s), highest expression level in utricle of membranous labyrinth
GenevisibleiQ14BU0 MM

Family and domain databases

InterProiView protein in InterPro
IPR031386 UCMA
PANTHERiPTHR28647 PTHR28647, 1 hit
PfamiView protein in Pfam
PF17085 UCMA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUCMA_MOUSE
AccessioniPrimary (citable) accession number: Q14BU0
Secondary accession number(s): C9W8R6
, C9W8R7, C9W8R8, C9W8R9, Q9D1A9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: August 22, 2006
Last modified: September 12, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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