Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q14BI7 (TDRD9_MOUSE)

Entry version 116 (02 Dec 2020)
Sequence version 3 (02 Mar 2010)
Previous versions | rss
Add a publicationFeedback
Protein

ATP-dependent RNA helicase TDRD9

Gene

Tdrd9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

ATP-binding RNA helicase which plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity (PubMed:20059948, PubMed:28633017). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (PubMed:20059948, PubMed:28633017). Acts downstream of piRNA biogenesis: exclusively required for transposon silencing in the nucleus, suggesting that it acts as a nuclear effector in the nucleus together with PIWIL4 (PubMed:28633017).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi157 – 164ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATPase activity Source: UniProtKB
  • ATP binding Source: UniProtKB-KW
  • RNA binding Source: GO_Central
  • RNA helicase activity Source: UniProtKB-EC
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Helicase, Hydrolase
Biological processDifferentiation, Meiosis, RNA-mediated gene silencing, Spermatogenesis
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATP-dependent RNA helicase TDRD9Curated (EC:3.6.4.131 Publication)
Alternative name(s):
Tudor domain-containing protein 9Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tdrd9Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1921941, Tdrd9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice are viable but show male sterility with chromosome synapsis failure. In fetal testes, LINE-1 (L1) transposable elements derepression and an aberrant piRNA profile in prospermatogonia, followed by cognate DNA demethylation are observed.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi257E → Q in Tdrd9(KI); heterozygous and homozygous knockin male mice are infertile due to derepression of transposable elements. PiRNA biogenesis in not affected but piRNAs fail to accumulate in the nucleus. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003338141 – 1383ATP-dependent RNA helicase TDRD9Add BLAST1383

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q14BI7

PRoteomics IDEntifications database

More...PRIDEi		Q14BI7

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q14BI7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q14BI7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in reproductive organs. Detected in mitotic spermatogonia, meiotic spermatocytes (predominantly at the pachytene stage), haploid spermatids in the testis, and in growing oocytes in the ovary (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000054003, Expressed in spermatocyte and 67 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q14BI7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q14BI7, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with piRNA-associated proteins PIWIL1 and PIWIL4.

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		216946, 1 interactor

Protein interaction database and analysis system

More...IntActi		Q14BI7, 1 interactor

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000078022

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q14BI7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q14BI7

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini144 – 310Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST167
Domaini378 – 545Helicase C-terminalPROSITE-ProRule annotationAdd BLAST168
Domaini945 – 1005TudorPROSITE-ProRule annotationAdd BLAST61

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi256 – 259DEAH box1 Publication4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DEAD box helicase family. DEAH subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0920, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157035

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002601_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q14BI7

Database of Orthologous Groups

More...OrthoDBi		278674at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q14BI7

TreeFam database of animal gene trees

More...TreeFami		TF324869

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.40.50.90, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011545, DEAD/DEAH_box_helicase_dom
IPR007502, Helicase-assoc_dom
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR035437, SNase_OB-fold_sf
IPR002999, Tudor

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00270, DEAD, 1 hit
PF04408, HA2, 1 hit
PF00271, Helicase_C, 1 hit
PF00567, TUDOR, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00487, DEXDc, 1 hit
SM00847, HA2, 1 hit
SM00490, HELICc, 1 hit
SM00333, TUDOR, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS50304, TUDOR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q14BI7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLRKLTVDQI NDWFTIGKTV TNVELLGLPP AFPAEAPREE VQRSEEVPNE 
        60         70         80         90        100
DPTAQAQVPV KATAPARPAS TSGRSLSQRS SEMEYINKYR QLEEQELDIY 
       110        120        130        140        150
GQDQPPSGPG LRSPLAKLSN VACIPETTYK YPDLPINRCK EEVISLIESN 
       160        170        180        190        200
SVVIIHGATG SGKSTQLPQY VLDHYTQRSA FCNIVVTQPR KIGASSIARW 
       210        220        230        240        250
ISKERSWTLG GLVGYQVGLE KIATEDTRLI YMTTGVLLQK IVSAKSLMEF 
       260        270        280        290        300
THIFIDEVHE RTEEMDFLLL VVRKLLRTNS RFVKVVLMSA TINCKQFADY 
       310        320        330        340        350
FAVPVQNKMN PAYVFEVEGK PHAIEEYYLN DLGHIYHSGL PYRLEEPVIT 
       360        370        380        390        400
KDVYEVAVSL IQMFDDLDMK ESGNKTWSGA QFVSERSSVL VFLPGLGEIN 
       410        420        430        440        450
YMHELLTNMI HKRLQVYPLH SSVTLEEQNN VFLSPVPGYR KIILSTNIAE 
       460        470        480        490        500
SSVTVPDVKY VIDFCLTRTL VCDEDTNYQS LRLSWASKTS CDQRKGRAGR 
       510        520        530        540        550
VSKGYCYRLI PRDFWDSAIP DHVVPEMLRC PLGSTILKVK LLDMGEPRAL 
       560        570        580        590        600
LATALSPPSL SDIERTILLL KEVGALAVSG QREDENPHDG ELTFLGRVLA 
       610        620        630        640        650
QLPVSQQLGK LVVLGHVFGC LDECLIIAAA LSLKNFFTMP FRQHLDGYRN 
       660        670        680        690        700
KVHFSGSSRS DCLALVEAFR AWQACRQRGE LRRPKDELDW GRLNYIQIKR 
       710        720        730        740        750
IREVAELYEE LKNRISQFNM FVGPHHPVLD QEYPYKQRFI LQVVLAGAFY 
       760        770        780        790        800
PNYFTFGQPD EEMAVRELAG KDPKTTVVLK HIPPYGFLYY KQLQSLFRQC 
       810        820        830        840        850
GQVKSIVFDG AKAFVEFSRN PTERFKTLPA VNLAVKMSQL KVSLELSVHA 
       860        870        880        890        900
AEEIEGKVQG GSVSKLRNTR VNVDFQKQTV DPMQVSFNTL DRPRTVADLL 
       910        920        930        940        950
LTIDVTEVVE VGHFWGYRID ERNAELLKQL TAEINRLELV PLPIHPHPDL 
       960        970        980        990       1000
VCLAPFTDYN KESYFRAQIL YVSGNSAEVF FVDYGNRSHV DLDLLREIPC 
      1010       1020       1030       1040       1050
QFLELPFQAL EFKICKMRPS AKSLICGEHW SGGAHGRFAA LVGGCPLLVK 
      1060       1070       1080       1090       1100
VFSIVHSVLH VDVYRYSGAQ DAVNVRDVLI REGYAELAEE SYESKQSYEV 
      1110       1120       1130       1140       1150
LKGFFAKSVD TMPDGSVSSP LKDDEKHLLR ILLESFASNR LGAPNCKAVL 
      1160       1170       1180       1190       1200
HGPFNPYELK CHSLTRISKF RCVWIEKESI NSVVISDSPA DLHQRMLVAA 
      1210       1220       1230       1240       1250
SLSVNETGST MLLRETSLMP HIPGLPALLS MLFAPVMELR VDREGKCYTG 
      1260       1270       1280       1290       1300
VLCGLGWNSA TEAPILPEHD IELAFDVRLN VEDIVEINIL RAAINKLVCD 
      1310       1320       1330       1340       1350
GPNGSKYLGP ERIAQLQENA RQKLLGLFCR LKPREKITPQ WHEKPYEWNQ 
      1360       1370       1380 
VDPRLIMEQA EPEGSPGKST SLYQLHTPVV LSP
Length:1,383
Mass (Da):155,980
Last modified:March 2, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i55946F4F639B5777
GO
Isoform 2 (identifier: Q14BI7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-401: Missing.

Show »
Length:982
Mass (Da):110,899
Checksum:i0F9C78208DD4792F
GO
Isoform 3 (identifier: Q14BI7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-772: Missing.
     773-813: PKTTVVLKHI...KSIVFDGAKA → MDIGTKCTSQ...SEESCGVPRA

Show »
Length:611
Mass (Da):68,306
Checksum:i43784340033630A0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A6YWV8A0A0A6YWV8_MOUSE
ATP-dependent RNA helicase TDRD9
Tdrd9
540Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YY15A0A0A6YY15_MOUSE
ATP-dependent RNA helicase TDRD9
Tdrd9
217Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0335531 – 772Missing in isoform 3. 1 PublicationAdd BLAST772
Alternative sequenceiVSP_0335541 – 401Missing in isoform 2. 1 PublicationAdd BLAST401
Alternative sequenceiVSP_033555773 – 813PKTTV…DGAKA → MDIGTKCTSQVAAGVTAWHL WRRSGPGRLADSEESCGVPR A in isoform 3. 1 PublicationAdd BLAST41

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB362563 mRNA Translation: BAG15992.1
AC112520 Genomic DNA No translation available.
AC132623 Genomic DNA No translation available.
BC115831 mRNA Translation: AAI15832.1
BC116656 mRNA Translation: AAI16657.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS49184.1 [Q14BI7-1]

NCBI Reference Sequences

More...RefSeqi		NP_083332.1, NM_029056.1 [Q14BI7-1]
XP_006516384.1, XM_006516321.3 [Q14BI7-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000079009; ENSMUSP00000078022; ENSMUSG00000054003 [Q14BI7-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		74691

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:74691

UCSC genome browser

More...UCSCi		uc007pei.1, mouse [Q14BI7-1]
uc007pej.1, mouse [Q14BI7-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB362563 mRNA Translation: BAG15992.1
AC112520 Genomic DNA No translation available.
AC132623 Genomic DNA No translation available.
BC115831 mRNA Translation: AAI15832.1
BC116656 mRNA Translation: AAI16657.1
CCDSiCCDS49184.1 [Q14BI7-1]
RefSeqiNP_083332.1, NM_029056.1 [Q14BI7-1]
XP_006516384.1, XM_006516321.3 [Q14BI7-2]

3D structure databases

SMRiQ14BI7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi216946, 1 interactor
IntActiQ14BI7, 1 interactor
STRINGi10090.ENSMUSP00000078022

PTM databases

iPTMnetiQ14BI7
PhosphoSitePlusiQ14BI7

Proteomic databases

PaxDbiQ14BI7
PRIDEiQ14BI7

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		47449, 63 antibodies

Genome annotation databases

EnsembliENSMUST00000079009; ENSMUSP00000078022; ENSMUSG00000054003 [Q14BI7-1]
GeneIDi74691
KEGGimmu:74691
UCSCiuc007pei.1, mouse [Q14BI7-1]
uc007pej.1, mouse [Q14BI7-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		122402
MGIiMGI:1921941, Tdrd9

Phylogenomic databases

eggNOGiKOG0920, Eukaryota
GeneTreeiENSGT00940000157035
HOGENOMiCLU_002601_1_0_1
InParanoidiQ14BI7
OrthoDBi278674at2759
PhylomeDBiQ14BI7
TreeFamiTF324869

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		74691, 1 hit in 19 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Tdrd9, mouse

Protein Ontology

More...PROi		PR:Q14BI7
RNActiQ14BI7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000054003, Expressed in spermatocyte and 67 other tissues
ExpressionAtlasiQ14BI7, baseline and differential
GenevisibleiQ14BI7, MM

Family and domain databases

Gene3Di2.40.50.90, 1 hit
InterProiView protein in InterPro
IPR011545, DEAD/DEAH_box_helicase_dom
IPR007502, Helicase-assoc_dom
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR035437, SNase_OB-fold_sf
IPR002999, Tudor
PfamiView protein in Pfam
PF00270, DEAD, 1 hit
PF04408, HA2, 1 hit
PF00271, Helicase_C, 1 hit
PF00567, TUDOR, 1 hit
SMARTiView protein in SMART
SM00487, DEXDc, 1 hit
SM00847, HA2, 1 hit
SM00490, HELICc, 1 hit
SM00333, TUDOR, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS50304, TUDOR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTDRD9_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14BI7
Secondary accession number(s): B1Q3J8, Q14AW6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 2, 2010
Last modified: December 2, 2020
This is version 116 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again