Slc24a2 protein

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• calcium, potassium:sodium antiporter activity Source: MGIInferred from sequence orthologyⁱ
  • "SLC24A5 encodes a trans-Golgi network protein with potassium-dependent sodium-calcium exchange activity that regulates human epidermal melanogenesis."
    Ginger R.S., Askew S.E., Ogborne R.M., Wilson S., Ferdinando D., Dadd T., Smith A.M., Kazi S., Szerencsei R.T., Winkfein R.J., Schnetkamp P.P., Green M.R.
    J. Biol. Chem. 283:5486-5495(2008) [PubMed] [Europe PMC] [Abstract]
• calcium channel activity Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Importance of K+-dependent Na+/Ca2+-exchanger 2, NCKX2, in motor learning and memory."
    Li X.F., Kiedrowski L., Tremblay F., Fernandez F.R., Perizzolo M., Winkfein R.J., Turner R.W., Bains J.S., Rancourt D.E., Lytton J.
    J. Biol. Chem. 281:6273-6282(2006) [PubMed] [Europe PMC] [Abstract]
• protein dimerization activity Source: MGI

GO - Biological processⁱ

• calcium ion transmembrane transport Source: MGI
• calcium ion transport Source: MGIInferred from direct assayⁱ
  • "Importance of K+-dependent Na+/Ca2+-exchanger 2, NCKX2, in motor learning and memory."
    Li X.F., Kiedrowski L., Tremblay F., Fernandez F.R., Perizzolo M., Winkfein R.J., Turner R.W., Bains J.S., Rancourt D.E., Lytton J.
    J. Biol. Chem. 281:6273-6282(2006) [PubMed] [Europe PMC] [Abstract]
• cellular calcium ion homeostasis Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Importance of K+-dependent Na+/Ca2+-exchanger 2, NCKX2, in motor learning and memory."
    Li X.F., Kiedrowski L., Tremblay F., Fernandez F.R., Perizzolo M., Winkfein R.J., Turner R.W., Bains J.S., Rancourt D.E., Lytton J.
    J. Biol. Chem. 281:6273-6282(2006) [PubMed] [Europe PMC] [Abstract]
• ion transmembrane transport Source: MGIInferred from sequence orthologyⁱ
  • "SLC24A5 encodes a trans-Golgi network protein with potassium-dependent sodium-calcium exchange activity that regulates human epidermal melanogenesis."
    Ginger R.S., Askew S.E., Ogborne R.M., Wilson S., Ferdinando D., Dadd T., Smith A.M., Kazi S., Szerencsei R.T., Winkfein R.J., Schnetkamp P.P., Green M.R.
    J. Biol. Chem. 283:5486-5495(2008) [PubMed] [Europe PMC] [Abstract]
• learning Source: MGIInferred from mutant phenotypeⁱ
  • "Importance of K+-dependent Na+/Ca2+-exchanger 2, NCKX2, in motor learning and memory."
    Li X.F., Kiedrowski L., Tremblay F., Fernandez F.R., Perizzolo M., Winkfein R.J., Turner R.W., Bains J.S., Rancourt D.E., Lytton J.
    J. Biol. Chem. 281:6273-6282(2006) [PubMed] [Europe PMC] [Abstract]
• long-term synaptic depression Source: MGIInferred from mutant phenotypeⁱ
  • "Importance of K+-dependent Na+/Ca2+-exchanger 2, NCKX2, in motor learning and memory."
    Li X.F., Kiedrowski L., Tremblay F., Fernandez F.R., Perizzolo M., Winkfein R.J., Turner R.W., Bains J.S., Rancourt D.E., Lytton J.
    J. Biol. Chem. 281:6273-6282(2006) [PubMed] [Europe PMC] [Abstract]
• long-term synaptic potentiation Source: MGIInferred from mutant phenotypeⁱ
  • "Importance of K+-dependent Na+/Ca2+-exchanger 2, NCKX2, in motor learning and memory."
    Li X.F., Kiedrowski L., Tremblay F., Fernandez F.R., Perizzolo M., Winkfein R.J., Turner R.W., Bains J.S., Rancourt D.E., Lytton J.
    J. Biol. Chem. 281:6273-6282(2006) [PubMed] [Europe PMC] [Abstract]
• memory Source: MGIInferred from mutant phenotypeⁱ
  • "Importance of K+-dependent Na+/Ca2+-exchanger 2, NCKX2, in motor learning and memory."
    Li X.F., Kiedrowski L., Tremblay F., Fernandez F.R., Perizzolo M., Winkfein R.J., Turner R.W., Bains J.S., Rancourt D.E., Lytton J.
    J. Biol. Chem. 281:6273-6282(2006) [PubMed] [Europe PMC] [Abstract]
• visual perception Source: InterPro

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• protein dimerization activity Source: MGI

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MDLHQSPTAR LLQKWCSHES PFGCRRHYNS RKKLKLIRVI GLVMGLVAVS 
        60         70         80         90        100
TVPFSISAFT ETDSQSNRGE ASDMSGPRVA QGHRQRTLLD LNDKIRDYTP 
       110        120        130        140        150
QPPASQEDQA ENSTEHTQGD YPKDIFSLEE RRKGAIILHV IGMIYMFIAL 
       160        170        180        190        200
AIVCDEFFVP SLTVITEKLG ISDDVAGATF MAAGGSAPEL FTSLIGVFIA 
       210        220        230        240        250
HSNVGIGTIV GSAVFNILFV IGMCALFSRE ILNLTWWPLF RDVSFYIVDL 
       260        270        280        290        300
LMLITFFLDN VIMWWESLLL LTAYFAYVVF MKFNVQVERW VKQMISRNNV 
       310        320        330        340        350
IKVTVPEAQA KLSEFPPASQ ADGRTACPTI TNDPDCQSLC FEVYPETARH 
       360        370        380        390        400
GSCITNVNGE PLKEKTQNSC MEESPTAGDK DGPTLPSKPR LQRGGSSASL 
       410        420        430        440        450
HNSLMRNSIF QLMIHTLDPL AEGRFREKAS ILHKIAKKKC QVDENERQNG 
       460        470        480        490        500
AANHVEKIEL PNSTSTEVEM TPSSEASEPV QNGNLSHNIE AADAPKATET 
       510        520        530        540        550
AEEEDDQPLS LSWPTNTRKQ ATFLIVFPIV FPLWITLPDV RKPASRKFFP 
       560        570        580        590        600
ITFFGSITWI AVFSYLMVWW AHQVGETIGI SEEIMGLTIL AAGTSIPDLI 
       610        620        630        640        650
TSVIVARKGL GDMAVSSSVG SNIFDITVGL PLPWLLYTII HRFSPVTVSS 
       660        670        680        690        700
NGLFCAIVLL FIMLLFVILS IALCKWRMNK ILGFIMFGLY FVFLVVSVLL 
       710 
EDKVLVCPVS I                                           

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ