UniProtKB - Q14BI1 (Q14BI1_MOUSE)
Protein
Submitted name:
Slc24a2 protein
Gene
Slc24a2
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- calcium, potassium:sodium antiporter activity Source: MGI
- calcium channel activity Source: MGI
GO - Biological processi
- calcium ion import across plasma membrane Source: MGI
- calcium ion transmembrane transport Source: MGI
- calcium ion transport Source: MGI
- cellular calcium ion homeostasis Source: MGI
- ion transmembrane transport Source: MGI
- learning Source: MGI
- long-term synaptic depression Source: MGI
- long-term synaptic potentiation Source: MGI
- memory Source: MGI
- potassium ion transmembrane transport Source: MGI
- protein-containing complex assembly Source: MGI
- sodium ion transmembrane transport Source: MGI
- visual perception Source: InterPro
Keywordsi
Biological process | AntiportARBA annotation, Calcium transportARBA annotation, Ion transport, Transport |
Ligand | Calcium |
Enzyme and pathway databases
Reactomei | R-MMU-425561, Sodium/Calcium exchangers |
Names & Taxonomyi
Protein namesi | Submitted name: Slc24a2 proteinImportedSubmitted name: Solute carrier family 24 (sodium/potassium/calcium exchanger), member 2Imported |
Gene namesi | Name:Slc24a2Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1923626, Slc24a2 |
Subcellular locationi
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- intrinsic component of plasma membrane Source: MGI
- plasma membrane Source: MGI
Other locations
- membrane Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 36 – 56 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 136 – 154 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 175 – 200 | HelicalSequence analysisAdd BLAST | 26 | |
Transmembranei | 206 – 227 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 239 – 258 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 264 – 285 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 551 – 572 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 618 – 639 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 651 – 674 | HelicalSequence analysisAdd BLAST | 24 | |
Transmembranei | 681 – 700 | HelicalSequence analysisAdd BLAST | 20 |
Keywords - Cellular componenti
MembranePTM / Processingi
Proteomic databases
PRIDEi | Q14BI1 |
PTM databases
GlyConnecti | 2724, 1 N-Linked glycan (1 site) |
SwissPalmi | Q14BI1 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000037996, Expressed in Ammon's horn and 133 other tissues |
ExpressionAtlasi | Q14BI1, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 140 – 281 | Na_Ca_exInterPro annotationAdd BLAST | 142 | |
Domaini | 549 – 698 | Na_Ca_exInterPro annotationAdd BLAST | 150 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 63 – 122 | DisorderedSequence analysisAdd BLAST | 60 | |
Regioni | 364 – 399 | DisorderedSequence analysisAdd BLAST | 36 | |
Regioni | 441 – 512 | DisorderedSequence analysisAdd BLAST | 72 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 458 – 488 | PolarSequence analysisAdd BLAST | 31 |
Sequence similaritiesi
Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily. [View classification]ARBA annotation
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00990000203658 |
OrthoDBi | 1168500at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR004481, K/Na/Ca-exchanger IPR004837, NaCa_Exmemb IPR030236, SLC24A2 |
PANTHERi | PTHR10846, PTHR10846, 1 hit PTHR10846:SF41, PTHR10846:SF41, 1 hit |
Pfami | View protein in Pfam PF01699, Na_Ca_ex, 2 hits |
TIGRFAMsi | TIGR00367, TIGR00367, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
Q14BI1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDLHQSPTAR LLQKWCSHES PFGCRRHYNS RKKLKLIRVI GLVMGLVAVS
60 70 80 90 100
TVPFSISAFT ETDSQSNRGE ASDMSGPRVA QGHRQRTLLD LNDKIRDYTP
110 120 130 140 150
QPPASQEDQA ENSTEHTQGD YPKDIFSLEE RRKGAIILHV IGMIYMFIAL
160 170 180 190 200
AIVCDEFFVP SLTVITEKLG ISDDVAGATF MAAGGSAPEL FTSLIGVFIA
210 220 230 240 250
HSNVGIGTIV GSAVFNILFV IGMCALFSRE ILNLTWWPLF RDVSFYIVDL
260 270 280 290 300
LMLITFFLDN VIMWWESLLL LTAYFAYVVF MKFNVQVERW VKQMISRNNV
310 320 330 340 350
IKVTVPEAQA KLSEFPPASQ ADGRTACPTI TNDPDCQSLC FEVYPETARH
360 370 380 390 400
GSCITNVNGE PLKEKTQNSC MEESPTAGDK DGPTLPSKPR LQRGGSSASL
410 420 430 440 450
HNSLMRNSIF QLMIHTLDPL AEGRFREKAS ILHKIAKKKC QVDENERQNG
460 470 480 490 500
AANHVEKIEL PNSTSTEVEM TPSSEASEPV QNGNLSHNIE AADAPKATET
510 520 530 540 550
AEEEDDQPLS LSWPTNTRKQ ATFLIVFPIV FPLWITLPDV RKPASRKFFP
560 570 580 590 600
ITFFGSITWI AVFSYLMVWW AHQVGETIGI SEEIMGLTIL AAGTSIPDLI
610 620 630 640 650
TSVIVARKGL GDMAVSSSVG SNIFDITVGL PLPWLLYTII HRFSPVTVSS
660 670 680 690 700
NGLFCAIVLL FIMLLFVILS IALCKWRMNK ILGFIMFGLY FVFLVVSVLL
710
EDKVLVCPVS I
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ8BUN9 | Q8BUN9_MOUSE | Solute carrier family 24 (sodium/po... | Slc24a2 | 666 | Annotation score: | ||
B1AXF3 | B1AXF3_MOUSE | Solute carrier family 24 (sodium/po... | Slc24a2 | 645 | Annotation score: | ||
B1AXF2 | B1AXF2_MOUSE | Solute carrier family 24 (sodium/po... | Slc24a2 | 662 | Annotation score: | ||
F6RT95 | F6RT95_MOUSE | Solute carrier family 24 (sodium/po... | Slc24a2 | 168 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL807763 Genomic DNA No translation available. AL953839 Genomic DNA No translation available. AL954377 Genomic DNA No translation available. BC115867 mRNA Translation: AAI15868.1 |
RefSeqi | NP_001103710.1, NM_001110240.1 XP_006538409.1, XM_006538346.3 |
Genome annotation databases
Ensembli | ENSMUST00000107158; ENSMUSP00000102776; ENSMUSG00000037996 |
GeneIDi | 76376 |
KEGGi | mmu:76376 |
UCSCi | uc008tmj.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL807763 Genomic DNA No translation available. AL953839 Genomic DNA No translation available. AL954377 Genomic DNA No translation available. BC115867 mRNA Translation: AAI15868.1 |
RefSeqi | NP_001103710.1, NM_001110240.1 XP_006538409.1, XM_006538346.3 |
3D structure databases
SMRi | Q14BI1 |
ModBasei | Search... |
PTM databases
GlyConnecti | 2724, 1 N-Linked glycan (1 site) |
SwissPalmi | Q14BI1 |
Proteomic databases
PRIDEi | Q14BI1 |
Protocols and materials databases
Antibodypediai | 64282, 47 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000107158; ENSMUSP00000102776; ENSMUSG00000037996 |
GeneIDi | 76376 |
KEGGi | mmu:76376 |
UCSCi | uc008tmj.1, mouse |
Organism-specific databases
CTDi | 25769 |
MGIi | MGI:1923626, Slc24a2 |
Phylogenomic databases
GeneTreei | ENSGT00990000203658 |
OrthoDBi | 1168500at2759 |
Enzyme and pathway databases
Reactomei | R-MMU-425561, Sodium/Calcium exchangers |
Miscellaneous databases
BioGRID-ORCSi | 76376, 0 hits in 17 CRISPR screens |
ChiTaRSi | Slc24a2, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000037996, Expressed in Ammon's horn and 133 other tissues |
ExpressionAtlasi | Q14BI1, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR004481, K/Na/Ca-exchanger IPR004837, NaCa_Exmemb IPR030236, SLC24A2 |
PANTHERi | PTHR10846, PTHR10846, 1 hit PTHR10846:SF41, PTHR10846:SF41, 1 hit |
Pfami | View protein in Pfam PF01699, Na_Ca_ex, 2 hits |
TIGRFAMsi | TIGR00367, TIGR00367, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q14BI1_MOUSE | |
Accessioni | Q14BI1Primary (citable) accession number: Q14BI1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | August 22, 2006 |
Last sequence update: | August 22, 2006 | |
Last modified: | February 10, 2021 | |
This is version 113 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |