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Entry version 81 (29 Sep 2021)
Sequence version 2 (06 Feb 2007)
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Protein

Mesenteric estrogen-dependent adipogenesis protein

Gene

Medag

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in processes that promote adipocyte differentiation, lipid accumulation, and glucose uptake in mature adipocytes.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • positive regulation of fat cell differentiation Source: UniProtKB

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mesenteric estrogen-dependent adipogenesis protein
Alternative name(s):
Activated in W/Wv mouse stomach 3
Short name:
mAWMS3
Mesenteric estrogen-dependent adipose 4
Short name:
MEDA-4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Medag
Synonyms:Awms3, Meda4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1917967, Medag

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000029659

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002743341 – 303Mesenteric estrogen-dependent adipogenesis proteinAdd BLAST303

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q14BA6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q14BA6

PRoteomics IDEntifications database

More...
PRIDEi
Q14BA6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
292290 [Q14BA6-1]
292291 [Q14BA6-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q14BA6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q14BA6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in white adipose tissue compared with other organs with higher expression in mature adipocyte fraction. Significant expression is also detected in the heart, brain, and pancreas.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Down-regulated by estrogen treatment.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000029659, Expressed in fibroblast and 83 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q14BA6, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
214218, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000090798

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q14BA6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502REG3, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000018451

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_080194_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q14BA6

Identification of Orthologs from Complete Genome Data

More...
OMAi
PFPCVLE

Database of Orthologous Groups

More...
OrthoDBi
1192582at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q14BA6

TreeFam database of animal gene trees

More...
TreeFami
TF328824

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039230, MEDAG
IPR043460, MEDAG/TEX26

The PANTHER Classification System

More...
PANTHERi
PTHR33769, PTHR33769, 1 hit
PTHR33769:SF3, PTHR33769:SF3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q14BA6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATAACEPVA RPSLTSISSG ELRSLWTCDC ELALLPLSQL LRLQPGAFQL
60 70 80 90 100
RGEQLLVPGP GEPAAARGGF NVFGDGLVRL EGQLYRLSSY IKRYVELTNY
110 120 130 140 150
CDYKDYRETI LSKPMVFFIN VQTKKDISKE RTYAFLVNTR HPKIRRQIEQ
160 170 180 190 200
GMDMVISSVI GESYRLQFDF QEVVKNFFPP GTIVLNGENL SFTYEFKADA
210 220 230 240 250
LFDFFYWFGL SNSTVKVHGK VLNLTSTNPE KKETIKLFLE KMSEPLIRRS
260 270 280 290 300
SFSDRKFSVT SRGSIDDVFN CNLSPRSSVT EPLLAEFSFP SLLECEETSS

QLI
Length:303
Mass (Da):34,364
Last modified:February 6, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE06A5C25AF6B80EC
GO
Isoform 2 (identifier: Q14BA6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-114: Missing.

Show »
Length:189
Mass (Da):21,800
Checksum:i0B802991D370AFBB
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC31291 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC53804 differs from that shown. Reason: Frameshift.Curated
The sequence BAE23601 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAE37424 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti5A → W in BAB31084 (PubMed:16141072).Curated1
Sequence conflicti8P → S in BAB31084 (PubMed:16141072).Curated1
Sequence conflicti66A → E in AAH26658 (PubMed:15489334).Curated1
Sequence conflicti66A → E in AAI16247 (PubMed:15489334).Curated1
Sequence conflicti81E → D in AAH26658 (PubMed:15489334).Curated1
Sequence conflicti81E → D in AAI16247 (PubMed:15489334).Curated1
Sequence conflicti121V → L in BAC53804 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0227161 – 114Missing in isoform 2. 1 PublicationAdd BLAST114

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK018128 mRNA Translation: BAB31084.1
AK036605 mRNA Translation: BAC29504.1
AK042557 mRNA Translation: BAC31291.2 Different initiation.
AK047657 mRNA Translation: BAC33115.1
AK086092 mRNA Translation: BAC39607.1
AK138268 mRNA Translation: BAE23601.1 Different initiation.
AK160904 mRNA Translation: BAE36082.1
AK162725 mRNA Translation: BAE37037.1
AK163617 mRNA Translation: BAE37424.1 Different initiation.
AK165529 mRNA Translation: BAE38240.1
BC026658 mRNA Translation: AAH26658.1
BC116246 mRNA Translation: AAI16247.1
BC116247 mRNA Translation: AAI16248.1
AB055406 mRNA Translation: BAC53804.1 Frameshift.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS19884.1 [Q14BA6-1]
CCDS90023.1 [Q14BA6-2]

NCBI Reference Sequences

More...
RefSeqi
NP_081795.1, NM_027519.3 [Q14BA6-1]
XP_006505005.1, XM_006504942.3 [Q14BA6-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000093110; ENSMUSP00000090798; ENSMUSG00000029659 [Q14BA6-1]
ENSMUST00000201083; ENSMUSP00000144535; ENSMUSG00000029659 [Q14BA6-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
70717

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:70717

UCSC genome browser

More...
UCSCi
uc009apt.1, mouse [Q14BA6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018128 mRNA Translation: BAB31084.1
AK036605 mRNA Translation: BAC29504.1
AK042557 mRNA Translation: BAC31291.2 Different initiation.
AK047657 mRNA Translation: BAC33115.1
AK086092 mRNA Translation: BAC39607.1
AK138268 mRNA Translation: BAE23601.1 Different initiation.
AK160904 mRNA Translation: BAE36082.1
AK162725 mRNA Translation: BAE37037.1
AK163617 mRNA Translation: BAE37424.1 Different initiation.
AK165529 mRNA Translation: BAE38240.1
BC026658 mRNA Translation: AAH26658.1
BC116246 mRNA Translation: AAI16247.1
BC116247 mRNA Translation: AAI16248.1
AB055406 mRNA Translation: BAC53804.1 Frameshift.
CCDSiCCDS19884.1 [Q14BA6-1]
CCDS90023.1 [Q14BA6-2]
RefSeqiNP_081795.1, NM_027519.3 [Q14BA6-1]
XP_006505005.1, XM_006504942.3 [Q14BA6-2]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi214218, 1 interactor
STRINGi10090.ENSMUSP00000090798

PTM databases

iPTMnetiQ14BA6
PhosphoSitePlusiQ14BA6

Proteomic databases

jPOSTiQ14BA6
PaxDbiQ14BA6
PRIDEiQ14BA6
ProteomicsDBi292290 [Q14BA6-1]
292291 [Q14BA6-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
53455, 17 antibodies

The DNASU plasmid repository

More...
DNASUi
70717

Genome annotation databases

EnsembliENSMUST00000093110; ENSMUSP00000090798; ENSMUSG00000029659 [Q14BA6-1]
ENSMUST00000201083; ENSMUSP00000144535; ENSMUSG00000029659 [Q14BA6-2]
GeneIDi70717
KEGGimmu:70717
UCSCiuc009apt.1, mouse [Q14BA6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84935
MGIiMGI:1917967, Medag
VEuPathDBiHostDB:ENSMUSG00000029659

Phylogenomic databases

eggNOGiENOG502REG3, Eukaryota
GeneTreeiENSGT00390000018451
HOGENOMiCLU_080194_0_0_1
InParanoidiQ14BA6
OMAiPFPCVLE
OrthoDBi1192582at2759
PhylomeDBiQ14BA6
TreeFamiTF328824

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
70717, 1 hit in 61 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Medag, mouse

Protein Ontology

More...
PROi
PR:Q14BA6
RNActiQ14BA6, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000029659, Expressed in fibroblast and 83 other tissues
GenevisibleiQ14BA6, MM

Family and domain databases

InterProiView protein in InterPro
IPR039230, MEDAG
IPR043460, MEDAG/TEX26
PANTHERiPTHR33769, PTHR33769, 1 hit
PTHR33769:SF3, PTHR33769:SF3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMEDAG_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14BA6
Secondary accession number(s): Q8BFY2
, Q8C9B3, Q8CHK6, Q8R0K5, Q9CU47
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: February 6, 2007
Last modified: September 29, 2021
This is version 81 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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