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UniProtKB - Q14B66 (Q14B66_MOUSE)

Entry version 76 (07 Oct 2020)
Sequence version 1 (22 Aug 2006)
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Protein
Submitted name:

Kcnq3 protein

Gene

Kcnq3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Potassium channelARBA annotation, Voltage-gated channelARBA annotation
Biological processIon transport, Potassium transport, Transport
LigandPotassium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Kcnq3 proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Kcnq3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1336181, Kcnq3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei121 – 141HelicalSequence analysisAdd BLAST21
Transmembranei153 – 175HelicalSequence analysisAdd BLAST23
Transmembranei196 – 213HelicalSequence analysisAdd BLAST18
Transmembranei259 – 280HelicalSequence analysisAdd BLAST22
Transmembranei329 – 355HelicalSequence analysisAdd BLAST27

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation, Ubl conjugationARBA annotation

Proteomic databases

PeptideAtlas

More...PeptideAtlasi		Q14B66

PRoteomics IDEntifications database

More...PRIDEi		Q14B66

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q14B66

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini124 – 351Ion_transInterPro annotationAdd BLAST228
Domaini445 – 647KCNQ_channelInterPro annotationAdd BLAST203

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 41DisorderedSequence analysisAdd BLAST41
Regioni572 – 600DisorderedSequence analysisAdd BLAST29
Regioni720 – 739DisorderedSequence analysisAdd BLAST20
Regioni763 – 870DisorderedSequence analysisAdd BLAST108

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi577 – 600PolarSequence analysisAdd BLAST24
Compositional biasi722 – 739PolarSequence analysisAdd BLAST18
Compositional biasi839 – 870PolarSequence analysisAdd BLAST32

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisARBA annotation

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR020969, Ankyrin-G_BS
IPR005821, Ion_trans_dom
IPR003937, K_chnl_volt-dep_KCNQ
IPR003948, K_chnl_volt-dep_KCNQ3
IPR013821, K_chnl_volt-dep_KCNQ_C
IPR028325, VG_K_chnl

The PANTHER Classification System

More...PANTHERi		PTHR11537, PTHR11537, 1 hit
PTHR11537:SF5, PTHR11537:SF5, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00520, Ion_trans, 1 hit
PF03520, KCNQ_channel, 1 hit
PF11956, KCNQC3-Ank-G_bd, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01462, KCNQ3CHANNEL
PR01459, KCNQCHANNEL

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q14B66-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLKARTAAG GGGGEGGGGG GGAANPAGGD SAVAGDEERK VGLAPGDVEQ 
        60         70         80         90        100
VTLALGAGAD KDGTLLLEGG GREEGQRRTP QGIGLLAKTP LSRPVKRNNA 
       110        120        130        140        150
KYRRIQTLIY DALERPRGWA LLYHALVFLI VLGCLILAVL TTFKEYETVS 
       160        170        180        190        200
GDWLLLLETF AIFIFGAEFA LRIWAAGCCC RYKGWRGRLK FARKPLCMLD 
       210        220        230        240        250
IFVLIASVPV VAVGNQGNVL ATSLRSLRFL QILRMLRMDR RGGTWKLLGS 
       260        270        280        290        300
AICAHSKELI TAWYIGFLTL ILSSFLVYLV EKDVPEMDAQ GEEMKEEFET 
       310        320        330        340        350
YADALWWGLI TLATIGYGDK TPKTWEGRLI AATFSLIGVS FFALPAGILG 
       360        370        380        390        400
SGLALKVQEQ HRQKHFEKRR KPAAELIQAA WRYYATNPNR LDLVATWRFY 
       410        420        430        440        450
ESVVSFPFFR KEQLEAAASQ KLGLLDRVRL SNPRGSNTKG KLFTPLNVDA 
       460        470        480        490        500
IEESPSKEPK PVGLNNKERF RTAFRMKAYA FWQSSEDAGT GDPMAEDRGY 
       510        520        530        540        550
GNDFLIEDMI PTLKAAIRAV RILQFRLYKK KFKETLRPYD VKDVIEQYSA 
       560        570        580        590        600
GHLDMLSRIK YLQTRIDMIF TPGPPSTPKH KKSQKGSAFT YPSQQSPRNE 
       610        620        630        640        650
PYVARAATSE TEDQSMMGKF VKVERQVHDM GKKLDFLVDM HMQHMERLQV 
       660        670        680        690        700
HVTEYYPTKG ASSPAEGEKK EDNRYSDLKT IICNYSETGP PDPPYSFHQV 
       710        720        730        740        750
PIDRVGPYGF FAHDPVKLTR GGPSSTKAQA NLPSSGSTYA ERPTVLPILT 
       760        770        780        790        800
LLDSCVSYHS QTELQGPYSD HISPRQRRSI TRDSDTPLSL MSVNHEELER 
       810        820        830        840        850
SPSGFSISQD RDDYVFGPSG GSSWMREKRY LAEGETDTDT DPFTPSGSMP 
       860        870
MSSTGDGISD SIWTPSNKPT
Length:870
Mass (Da):96,597
Last modified:August 22, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCE86676B072F073C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BC116306 mRNA Translation: AAI16307.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC116306 mRNA Translation: AAI16307.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

PTM databases

iPTMnetiQ14B66

Proteomic databases

PeptideAtlasiQ14B66
PRIDEiQ14B66

Organism-specific databases

MGIiMGI:1336181, Kcnq3

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Kcnq3, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Family and domain databases

InterProiView protein in InterPro
IPR020969, Ankyrin-G_BS
IPR005821, Ion_trans_dom
IPR003937, K_chnl_volt-dep_KCNQ
IPR003948, K_chnl_volt-dep_KCNQ3
IPR013821, K_chnl_volt-dep_KCNQ_C
IPR028325, VG_K_chnl
PANTHERiPTHR11537, PTHR11537, 1 hit
PTHR11537:SF5, PTHR11537:SF5, 1 hit
PfamiView protein in Pfam
PF00520, Ion_trans, 1 hit
PF03520, KCNQ_channel, 1 hit
PF11956, KCNQC3-Ank-G_bd, 1 hit
PRINTSiPR01462, KCNQ3CHANNEL
PR01459, KCNQCHANNEL

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ14B66_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14B66
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: August 22, 2006
Last sequence update: August 22, 2006
Last modified: October 7, 2020
This is version 76 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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