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Protein

Rhotekin-2

Gene

Rtkn2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play an important role in lymphopoiesis.By similarity

GO - Biological processi

  • hemopoiesis Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • signal transduction Source: InterPro

Names & Taxonomyi

Protein namesi
Recommended name:
Rhotekin-2
Alternative name(s):
Pleckstrin homology domain-containing family K member 1
Short name:
PH domain-containing family K member 1
Gene namesi
Name:Rtkn2
Synonyms:Plekhk1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2158417 Rtkn2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003093271 – 604Rhotekin-2Add BLAST604

Proteomic databases

MaxQBiQ14B46
PaxDbiQ14B46
PRIDEiQ14B46

PTM databases

iPTMnetiQ14B46
PhosphoSitePlusiQ14B46

Expressioni

Gene expression databases

BgeeiENSMUSG00000037846 Expressed in 134 organ(s), highest expression level in right lung lobe
CleanExiMM_RTKN2
ExpressionAtlasiQ14B46 baseline and differential
GenevisibleiQ14B46 MM

Interactioni

Protein-protein interaction databases

BioGridi228447, 1 interactor
IntActiQ14B46, 1 interactor
MINTiQ14B46

Structurei

3D structure databases

ProteinModelPortaliQ14B46
SMRiQ14B46
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 74REM-1PROSITE-ProRule annotationAdd BLAST74
Domaini281 – 387PHPROSITE-ProRule annotationAdd BLAST107

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili53 – 79Sequence analysisAdd BLAST27

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IIHF Eukaryota
ENOG410ZX8Y LUCA
GeneTreeiENSGT00390000000104
HOGENOMiHOG000015094
HOVERGENiHBG059480
InParanoidiQ14B46
OrthoDBiEOG091G09OJ
PhylomeDBiQ14B46
TreeFamiTF331476

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR012966 AHD
IPR011072 HR1_rho-bd
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR030469 RTKN2
PANTHERiPTHR21538:SF21 PTHR21538:SF21, 1 hit
PfamiView protein in Pfam
PF08174 Anillin, 1 hit
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00742 Hr1, 1 hit
SM00233 PH, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS51860 REM_1, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q14B46-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGQLLRGLA AQQDCSIREK IDLEIRMREG IWKLLSLSTK KDQVLHAVKN
60 70 80 90 100
LMVCSARIQA YTAELQKSKE EIANQTGARL VLDSSSENKE GESCRGKIAL
110 120 130 140 150
SDIRIPLMWK DSDHFSNKEC TQRFAIFCLF RMGAQVFDTD MVIVDQTVTD
160 170 180 190 200
ICFENVTIFN EAGPDFQIKI EVYSCSAEES SLTNTPRKLA KKLKTSISKA
210 220 230 240 250
TGRKISAALQ EESPEACLLA GSVAGAKYHL LAHTTLTLEN AGDCFKTHNL
260 270 280 290 300
SVHGDEECSF WLPLYGNVCC RLVAQPACMA ADAFAGFLNE QQTGKGLVGW
310 320 330 340 350
RRLYCALRGG KLRCFYGPEE IEAKVEPALV VPIDKETRIQ AVEKDSKKMH
360 370 380 390 400
CFSVLSTAAG RAVSHIFAAD SLADFQEWMG AFRQHFFDLS QWKHCCEELM
410 420 430 440 450
RIEIMSPRKP PLFLAKEATS VYYDMSIDSP VKLESVTDII QKKIGETNRQ
460 470 480 490 500
FLIGRDDQSA APPWAAVFDG NHEMVIEKKV LSPIGEPAPD GKRKKRRAPL
510 520 530 540 550
PPTDQPPFCI KTQGRANQSK DSATQAGVSG ASSSPSDPRL SPPTHHLQKP
560 570 580 590 600
VAAPRKLLPA RKNSSADIGH TDTKTSLDAK PVPVPRQKSI RDILDPRSWL

QAQV
Length:604
Mass (Da):66,962
Last modified:November 13, 2007 - v2
Checksum:i9DC76A294B1DE49B
GO
Isoform 2 (identifier: Q14B46-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     80-82: Missing.

Note: No experimental confirmation available.
Show »
Length:601
Mass (Da):66,636
Checksum:iFD7C23B95DE48E19
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QP76E9QP76_MOUSE
Rhotekin-2
Rtkn2
602Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti408R → L in BAC27204 (PubMed:16141072).Curated1
Sequence conflicti449R → G in AAI16342 (PubMed:15489334).Curated1
Sequence conflicti449R → G in AAI16343 (PubMed:15489334).Curated1
Sequence conflicti484I → T in AAI16342 (PubMed:15489334).Curated1
Sequence conflicti484I → T in AAI16343 (PubMed:15489334).Curated1
Sequence conflicti515R → S in AAI16342 (PubMed:15489334).Curated1
Sequence conflicti515R → S in AAI16343 (PubMed:15489334).Curated1
Sequence conflicti533 – 534SS → PL in AAI16342 (PubMed:15489334).Curated2
Sequence conflicti533 – 534SS → PL in AAI16343 (PubMed:15489334).Curated2
Sequence conflicti541 – 542SP → LL in AAI16342 (PubMed:15489334).Curated2
Sequence conflicti541 – 542SP → LL in AAI16343 (PubMed:15489334).Curated2
Sequence conflicti560A → G in BAC27204 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02914080 – 82Missing in isoform 2. 1 Publication3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030986 mRNA Translation: BAC27204.1
AK045134 mRNA Translation: BAC32237.1
AK052662 mRNA Translation: BAC35087.1
BC116341 mRNA Translation: AAI16342.1
BC116342 mRNA Translation: AAI16343.1
RefSeqiXP_006513353.1, XM_006513290.2
XP_006513354.1, XM_006513291.1
UniGeneiMm.209844

Genome annotation databases

EnsembliENSMUST00000068994; ENSMUSP00000070717; ENSMUSG00000037846 [Q14B46-1]
ENSMUST00000117086; ENSMUSP00000112419; ENSMUSG00000037846 [Q14B46-2]
ENSMUST00000118160; ENSMUSP00000112946; ENSMUSG00000037846 [Q14B46-1]
ENSMUST00000147556; ENSMUSP00000116166; ENSMUSG00000037846 [Q14B46-2]
GeneIDi170799
UCSCiuc011xfq.1 mouse [Q14B46-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030986 mRNA Translation: BAC27204.1
AK045134 mRNA Translation: BAC32237.1
AK052662 mRNA Translation: BAC35087.1
BC116341 mRNA Translation: AAI16342.1
BC116342 mRNA Translation: AAI16343.1
RefSeqiXP_006513353.1, XM_006513290.2
XP_006513354.1, XM_006513291.1
UniGeneiMm.209844

3D structure databases

ProteinModelPortaliQ14B46
SMRiQ14B46
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi228447, 1 interactor
IntActiQ14B46, 1 interactor
MINTiQ14B46

PTM databases

iPTMnetiQ14B46
PhosphoSitePlusiQ14B46

Proteomic databases

MaxQBiQ14B46
PaxDbiQ14B46
PRIDEiQ14B46

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068994; ENSMUSP00000070717; ENSMUSG00000037846 [Q14B46-1]
ENSMUST00000117086; ENSMUSP00000112419; ENSMUSG00000037846 [Q14B46-2]
ENSMUST00000118160; ENSMUSP00000112946; ENSMUSG00000037846 [Q14B46-1]
ENSMUST00000147556; ENSMUSP00000116166; ENSMUSG00000037846 [Q14B46-2]
GeneIDi170799
UCSCiuc011xfq.1 mouse [Q14B46-1]

Organism-specific databases

CTDi219790
MGIiMGI:2158417 Rtkn2

Phylogenomic databases

eggNOGiENOG410IIHF Eukaryota
ENOG410ZX8Y LUCA
GeneTreeiENSGT00390000000104
HOGENOMiHOG000015094
HOVERGENiHBG059480
InParanoidiQ14B46
OrthoDBiEOG091G09OJ
PhylomeDBiQ14B46
TreeFamiTF331476

Miscellaneous databases

PROiPR:Q14B46
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037846 Expressed in 134 organ(s), highest expression level in right lung lobe
CleanExiMM_RTKN2
ExpressionAtlasiQ14B46 baseline and differential
GenevisibleiQ14B46 MM

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR012966 AHD
IPR011072 HR1_rho-bd
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR030469 RTKN2
PANTHERiPTHR21538:SF21 PTHR21538:SF21, 1 hit
PfamiView protein in Pfam
PF08174 Anillin, 1 hit
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00742 Hr1, 1 hit
SM00233 PH, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS51860 REM_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRTKN2_MOUSE
AccessioniPrimary (citable) accession number: Q14B46
Secondary accession number(s): Q8BFP3, Q8BFP8, Q8BFQ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: November 7, 2018
This is version 84 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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