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Protein

Cyclin-dependent kinase 12

Gene

Cdk12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei752ATPPROSITE-ProRule annotation1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei855Proton acceptorPROSITE-ProRule annotation1
Binding sitei1036ATPPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi729 – 737ATPPROSITE-ProRule annotation9
Nucleotide bindingi810 – 815ATPPROSITE-ProRule annotation6

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processmRNA processing, mRNA splicing
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-6796648 TP53 Regulates Transcription of DNA Repair Genes

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cyclin-dependent kinase 12 (EC:2.7.11.22, EC:2.7.11.23)
Alternative name(s):
Cdc2-related kinase, arginine/serine-rich
Short name:
CrkRS
Cell division cycle 2-related protein kinase 7
Short name:
CDC2-related protein kinase 7
Cell division protein kinase 12
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cdk12
Synonyms:Crk7, Crkrs, Kiaa0904
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1098802 Cdk12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003144701 – 1484Cyclin-dependent kinase 12Add BLAST1484

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei57PhosphothreonineBy similarity1
Modified residuei73PhosphotyrosineBy similarity1
Modified residuei235PhosphoserineCombined sources1
Modified residuei248PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki262Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei264PhosphoserineBy similarity1
Modified residuei273PhosphoserineBy similarity1
Modified residuei275PhosphoserineBy similarity1
Modified residuei300PhosphoserineBy similarity1
Modified residuei302PhosphoserineBy similarity1
Modified residuei309PhosphoserineBy similarity1
Modified residuei311PhosphoserineBy similarity1
Modified residuei317PhosphoserineBy similarity1
Modified residuei322PhosphoserineBy similarity1
Modified residuei324PhosphoserineBy similarity1
Modified residuei331PhosphoserineBy similarity1
Modified residuei332PhosphoserineBy similarity1
Modified residuei333PhosphoserineBy similarity1
Modified residuei337PhosphoserineBy similarity1
Modified residuei340PhosphoserineBy similarity1
Modified residuei342PhosphoserineBy similarity1
Modified residuei344PhosphoserineBy similarity1
Modified residuei382PhosphoserineCombined sources1
Modified residuei384PhosphoserineCombined sources1
Modified residuei399PhosphoserineBy similarity1
Modified residuei419PhosphoserineBy similarity1
Modified residuei422PhosphoserineBy similarity1
Cross-linki506Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei511PhosphothreonineBy similarity1
Modified residuei610PhosphoserineBy similarity1
Modified residuei640PhosphoserineBy similarity1
Cross-linki651Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei677PhosphoserineCombined sources1
Modified residuei681PhosphoserineCombined sources1
Modified residuei688PhosphothreonineBy similarity1
Modified residuei885PhosphoserineBy similarity1
Modified residuei889PhosphothreonineCombined sources1
Modified residuei1049PhosphoserineBy similarity1
Modified residuei1079PhosphoserineCombined sources1
Modified residuei1240PhosphothreonineCombined sources1
Modified residuei1242PhosphothreonineCombined sources1
Isoform 3 (identifier: Q14AX6-3)
Modified residuei1240PhosphothreonineCombined sources1
Modified residuei1242PhosphothreonineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Thr-889 increases kinase activity.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q14AX6

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q14AX6

PeptideAtlas

More...
PeptideAtlasi
Q14AX6

PRoteomics IDEntifications database

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PRIDEi
Q14AX6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q14AX6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q14AX6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000003119 Expressed in 231 organ(s), highest expression level in secondary oocyte

CleanEx database of gene expression profiles

More...
CleanExi
MM_CRKRS

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q14AX6 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CCNL1 and CCNL2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
213247, 2 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-251 Cyclin K-CDK12 complex

Protein interaction database and analysis system

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IntActi
Q14AX6, 1 interactor

Molecular INTeraction database

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MINTi
Q14AX6

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000103162

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q14AX6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q14AX6

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini723 – 1016Protein kinasePROSITE-ProRule annotationAdd BLAST294

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi137 – 393Ser-richAdd BLAST257
Compositional biasi406 – 412Poly-Ala7
Compositional biasi524 – 703Pro-richAdd BLAST180
Compositional biasi1234 – 1276Pro-richAdd BLAST43

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0600 Eukaryota
ENOG410XPIR LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157595

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000049118

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG050852

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q14AX6

KEGG Orthology (KO)

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KOi
K08819

Identification of Orthologs from Complete Genome Data

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OMAi
PHPNRTY

Database of Orthologous Groups

More...
OrthoDBi
EOG091G08Z8

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q14AX6

TreeFam database of animal gene trees

More...
TreeFami
TF101060

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q14AX6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPNSERHGGK KDGSGGASGT SQPSSGGGSS NSRERHRLVS KHKRHKSKHS
60 70 80 90 100
KDVGLVTPEA ASLGTIIKPL VEYDDISSDS DTFSDDTAFK SDRRENEERR
110 120 130 140 150
GTDRSDRLHR HRHHQHRRSR DLLKTKQTEK EKNQEVSKSG SMKDRVSGSS
160 170 180 190 200
KRSVEGSDDY GKAQLSKSGS KESRSSKMHK EKTRKERELK SGYKDRSKSH
210 220 230 240 250
RKRETPKSYK TVASPKRRSR SPHRKWSDSS KQDDSPSGAS YGQDYDLSPP
260 270 280 290 300
RSHTSSNYDS YKKSPGSTSR RQSISPPYKE PSAYQSSTRS PSPYSRRQRS
310 320 330 340 350
VSPYSRRRSS SYERSGSYSG RSPSPYGRRR SSSPFLSKRS LSRSPLPSRK
360 370 380 390 400
SMKSRSRSPA YSRHSSSHSK KKRSGSRSRH SSISPVRLPL NSSLGAELSR
410 420 430 440 450
KKKERAAAAA AAKMDGKESK SSPIILPKKE KLEVKESGLE SKKLPRSIKS
460 470 480 490 500
EKSTPDTELV TVAHSNPEVK HCLDTGKVRL DENLQKHPAK DLKAQGTKDV
510 520 530 540 550
KPVAPKEVIV TSKETETSEK ETLPPLPTIT SPPPLPATTP PPQTPPLPPL
560 570 580 590 600
PPLPAIPLQP PLPPPQPPFS QVPVSSTSIL PSSPHPRTST LSSQTNSQPP
610 620 630 640 650
VQVSMKTQVS ITAAIPHLKT STLPPLPLPP LLPGDDDMDS PKETLPSKPA
660 670 680 690 700
KKEKEQRTRH LLTDLPLPPE LPGGDPSPPD SPEPKAITPP QQPYKKRPKI
710 720 730 740 750
CCPRYGERRQ TESDWGKRCV DKFDIIGIIG EGTYGQVYKA KDKDTGELVA
760 770 780 790 800
LKKVRLDNEK EGFPITAIRE IKILRQLVHQ SVVNMKEIVT DKQDALDFKK
810 820 830 840 850
DKGAFYLVFE YMDHDLMGLL ESGLVHFSED HIKSFMKQLM EGLDYCHKKN
860 870 880 890 900
FLHRDIKCSN ILLNNSGQIK LADFGLARLY NSEESRPYTN KVITLWYRPP
910 920 930 940 950
ELLLGEERYT PAIDVWSCGC ILGELFTKKP IFQANLELAQ LELISRLCGS
960 970 980 990 1000
PCPAVWPDVI KLPYFNTMKP KKQYRRRLRE EFSFIPSAAL DLLDHMLTLD
1010 1020 1030 1040 1050
PSKRCTAEQT LQSDFLKDVE LSKMAPPDLP HWQDCHELWS KKRRRQRQSG
1060 1070 1080 1090 1100
IVIEDPPPSK ASRKETTSGT TAEPVKNNSP APPQPAPVKA EPGPGDAVGL
1110 1120 1130 1140 1150
GDITQQLNQS ELAVLLNLLQ SQTDLSIPQM AQLLNIHSNP EMQQQLEALN
1160 1170 1180 1190 1200
QSISALTEAS SQQQDSESIA PEESLKEVPS VPVVLPPAEQ TTPEASNTPA
1210 1220 1230 1240 1250
DMQNVLAVLL SQLMKTQEPA GNLEENTNDK NSGPQGPRRT PTMPQEEAAA
1260 1270 1280 1290 1300
CPPHILPPEK RPPEPPGPPP PPPPPPLVEG DLSSAPQELN PAVTAALLQL
1310 1320 1330 1340 1350
LSQPEAEPPG HLPHEHQALR PMEYSTRSHP NRTYGNTDGP ETGFSSADTD
1360 1370 1380 1390 1400
ERSSGPALTE SLVQTPVKNR TFSGSVSHLG ESNSYQGTGS VQFPGDQDLR
1410 1420 1430 1440 1450
FTRVPLALHS VVGQPFLKSE GNSNSVVHAE TKLQNYGELG PGTTGANSSG
1460 1470 1480
TTLQWGGPAQ SYGKPYRGAA RVLPRGGRGR GVPY
Length:1,484
Mass (Da):163,681
Last modified:January 15, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5FCEE8D1903DF803
GO
Isoform 2 (identifier: Q14AX6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1250-1258: ACPPHILPP → GKQTGHESH
     1259-1484: Missing.

Show »
Length:1,258
Mass (Da):139,883
Checksum:iF21408B379D9EFB5
GO
Isoform 3 (identifier: Q14AX6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1250-1258: Missing.

Note: No experimental confirmation available.Combined sources
Show »
Length:1,475
Mass (Da):162,755
Checksum:i53626C566777F0CA
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAM21270 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti346L → I in AAL69526 (Ref. 1) Curated1
Sequence conflicti363R → S in AAL69526 (Ref. 1) Curated1
Sequence conflicti377R → H in AAL69526 (Ref. 1) Curated1
Sequence conflicti425 – 427ILP → FCL in BAC98047 (PubMed:14621295).Curated3
Sequence conflicti496G → V in AAL69526 (Ref. 1) Curated1
Sequence conflicti562L → V in AAL69526 (Ref. 1) Curated1
Sequence conflicti854R → Q in AAL69526 (Ref. 1) Curated1
Sequence conflicti863L → V in AAL69526 (Ref. 1) Curated1
Sequence conflicti870K → R in AAL69526 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0302851250 – 1258ACPPHILPP → GKQTGHESH in isoform 2. 2 Publications9
Alternative sequenceiVSP_0302861250 – 1258Missing in isoform 3. 1 Publication9
Alternative sequenceiVSP_0302871259 – 1484Missing in isoform 2. 2 PublicationsAdd BLAST226

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY072295 mRNA Translation: AAL69526.1
AL591205 Genomic DNA Translation: CAM21267.1
AL591205 Genomic DNA Translation: CAM21268.1
AL591205 Genomic DNA Translation: CAM21269.1
AL591205 Genomic DNA Translation: CAM21270.1 Sequence problems.
BC116645 mRNA Translation: AAI16646.1
AK129237 mRNA Translation: BAC98047.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS25342.1 [Q14AX6-2]
CCDS48901.1 [Q14AX6-1]
CCDS48902.1 [Q14AX6-3]

NCBI Reference Sequences

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RefSeqi
NP_001103096.1, NM_001109626.1 [Q14AX6-1]
NP_001103098.1, NM_001109628.1 [Q14AX6-3]
NP_081228.2, NM_026952.2 [Q14AX6-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.260516
Mm.486492
Mm.488484

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000003203; ENSMUSP00000003203; ENSMUSG00000003119 [Q14AX6-2]
ENSMUST00000107538; ENSMUSP00000103162; ENSMUSG00000003119 [Q14AX6-1]
ENSMUST00000107539; ENSMUSP00000103163; ENSMUSG00000003119 [Q14AX6-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
69131

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:69131

UCSC genome browser

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UCSCi
uc007lfr.2 mouse [Q14AX6-1]
uc007lfs.2 mouse [Q14AX6-2]
uc007lfu.2 mouse [Q14AX6-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY072295 mRNA Translation: AAL69526.1
AL591205 Genomic DNA Translation: CAM21267.1
AL591205 Genomic DNA Translation: CAM21268.1
AL591205 Genomic DNA Translation: CAM21269.1
AL591205 Genomic DNA Translation: CAM21270.1 Sequence problems.
BC116645 mRNA Translation: AAI16646.1
AK129237 mRNA Translation: BAC98047.1
CCDSiCCDS25342.1 [Q14AX6-2]
CCDS48901.1 [Q14AX6-1]
CCDS48902.1 [Q14AX6-3]
RefSeqiNP_001103096.1, NM_001109626.1 [Q14AX6-1]
NP_001103098.1, NM_001109628.1 [Q14AX6-3]
NP_081228.2, NM_026952.2 [Q14AX6-2]
UniGeneiMm.260516
Mm.486492
Mm.488484

3D structure databases

ProteinModelPortaliQ14AX6
SMRiQ14AX6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi213247, 2 interactors
ComplexPortaliCPX-251 Cyclin K-CDK12 complex
IntActiQ14AX6, 1 interactor
MINTiQ14AX6
STRINGi10090.ENSMUSP00000103162

PTM databases

iPTMnetiQ14AX6
PhosphoSitePlusiQ14AX6

Proteomic databases

MaxQBiQ14AX6
PaxDbiQ14AX6
PeptideAtlasiQ14AX6
PRIDEiQ14AX6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000003203; ENSMUSP00000003203; ENSMUSG00000003119 [Q14AX6-2]
ENSMUST00000107538; ENSMUSP00000103162; ENSMUSG00000003119 [Q14AX6-1]
ENSMUST00000107539; ENSMUSP00000103163; ENSMUSG00000003119 [Q14AX6-3]
GeneIDi69131
KEGGimmu:69131
UCSCiuc007lfr.2 mouse [Q14AX6-1]
uc007lfs.2 mouse [Q14AX6-2]
uc007lfu.2 mouse [Q14AX6-3]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
51755
MGIiMGI:1098802 Cdk12

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiKOG0600 Eukaryota
ENOG410XPIR LUCA
GeneTreeiENSGT00940000157595
HOGENOMiHOG000049118
HOVERGENiHBG050852
InParanoidiQ14AX6
KOiK08819
OMAiPHPNRTY
OrthoDBiEOG091G08Z8
PhylomeDBiQ14AX6
TreeFamiTF101060

Enzyme and pathway databases

ReactomeiR-MMU-6796648 TP53 Regulates Transcription of DNA Repair Genes

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Cdk12 mouse

Protein Ontology

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PROi
PR:Q14AX6

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000003119 Expressed in 231 organ(s), highest expression level in secondary oocyte
CleanExiMM_CRKRS
GenevisibleiQ14AX6 MM

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCDK12_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14AX6
Secondary accession number(s): A2A530
, A2A531, B1AQH7, Q6ZQ27, Q8R457
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: December 5, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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