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Protein

Sister chromatid cohesion protein DCC1

Gene

DSCC1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin subunit SMC3 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processCell cycle, DNA replication

Names & Taxonomyi

Protein namesi
Recommended name:
Sister chromatid cohesion protein DCC1
Alternative name(s):
Defective in sister chromatid cohesion protein 1 homolog
Gene namesi
Name:DSCC1
Synonyms:DCC1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1919357 Dscc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003180651 – 399Sister chromatid cohesion protein DCC1Add BLAST399

Proteomic databases

EPDiQ14AI0
MaxQBiQ14AI0
PaxDbiQ14AI0
PRIDEiQ14AI0

PTM databases

PhosphoSitePlusiQ14AI0

Expressioni

Gene expression databases

BgeeiENSMUSG00000022422 Expressed in 152 organ(s), highest expression level in metanephros
ExpressionAtlasiQ14AI0 baseline and differential
GenevisibleiQ14AI0 MM

Interactioni

Subunit structurei

Component of the CTF18-RFC complex which consists of CTF8, CTF18, DSCC1 and the RFC complex. Interacts with CTF8 and CTF18. Interacts with DDX11.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023059

Structurei

3D structure databases

ProteinModelPortaliQ14AI0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DCC1 family.Curated

Phylogenomic databases

eggNOGiKOG0798 Eukaryota
ENOG41108M8 LUCA
GeneTreeiENSGT00390000017400
HOGENOMiHOG000008115
HOVERGENiHBG105358
InParanoidiQ14AI0
KOiK11271
OMAiCTDERTY
PhylomeDBiQ14AI0
TreeFamiTF106104

Family and domain databases

InterProiView protein in InterPro
IPR019128 Dcc1
PANTHERiPTHR13395 PTHR13395, 1 hit
PfamiView protein in Pfam
PF09724 Dcc1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q14AI0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSPPSASRRT REEVDATLQV AKLNATELLP TVHCLSFSSG TGGAATGDFC
60 70 80 90 100
LLELEPALCQ QLEAGDSFVI RGDKDEQAVL CSKDKTYDLK IADTSNMLLF
110 120 130 140 150
IPGCKTPDQL KEEETPSAIV HTEIFGFSNN YWELRRCRPK LKKLKRLLME
160 170 180 190 200
NTYEGPDSQK EEDASRSKYT TEDLLNHIQA SEEEIMAQLQ VLNACEIGGY
210 220 230 240 250
WRILEFDYEI KLLNHVTQLV DSESWSLDRV PLTVCLQELG PLEPEEMIEH
260 270 280 290 300
CLKCYGKRYV DKDDVYFELD ADKICRVTAE MLLQNAVKFN LAEFQEVWQQ
310 320 330 340 350
SVPEGMTTRL DQLKGLALVD RNSRPEIIFL LKVDDLPEGT QDRFNSLFSL
360 370 380 390
REKWTEEDIT PYIQDLCGEK QTIGALLTKY SRSSMQNGIK VYNSRRLIS
Length:399
Mass (Da):45,522
Last modified:August 22, 2006 - v1
Checksum:i7AF16514EF64D9E5
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YVY9D3YVY9_MOUSE
DNA replication and sister chromati...
Dscc1
462Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099382 mRNA Translation: AAH99382.1
BC116833 mRNA Translation: AAI16834.1
BC116835 mRNA Translation: AAI16836.1
CCDSiCCDS27473.1
RefSeqiNP_898912.2, NM_183089.2
UniGeneiMm.486550

Genome annotation databases

EnsembliENSMUST00000023059; ENSMUSP00000023059; ENSMUSG00000022422
GeneIDi72107
KEGGimmu:72107
UCSCiuc007vrw.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099382 mRNA Translation: AAH99382.1
BC116833 mRNA Translation: AAI16834.1
BC116835 mRNA Translation: AAI16836.1
CCDSiCCDS27473.1
RefSeqiNP_898912.2, NM_183089.2
UniGeneiMm.486550

3D structure databases

ProteinModelPortaliQ14AI0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023059

PTM databases

PhosphoSitePlusiQ14AI0

Proteomic databases

EPDiQ14AI0
MaxQBiQ14AI0
PaxDbiQ14AI0
PRIDEiQ14AI0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023059; ENSMUSP00000023059; ENSMUSG00000022422
GeneIDi72107
KEGGimmu:72107
UCSCiuc007vrw.1 mouse

Organism-specific databases

CTDi79075
MGIiMGI:1919357 Dscc1

Phylogenomic databases

eggNOGiKOG0798 Eukaryota
ENOG41108M8 LUCA
GeneTreeiENSGT00390000017400
HOGENOMiHOG000008115
HOVERGENiHBG105358
InParanoidiQ14AI0
KOiK11271
OMAiCTDERTY
PhylomeDBiQ14AI0
TreeFamiTF106104

Miscellaneous databases

PROiPR:Q14AI0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022422 Expressed in 152 organ(s), highest expression level in metanephros
ExpressionAtlasiQ14AI0 baseline and differential
GenevisibleiQ14AI0 MM

Family and domain databases

InterProiView protein in InterPro
IPR019128 Dcc1
PANTHERiPTHR13395 PTHR13395, 1 hit
PfamiView protein in Pfam
PF09724 Dcc1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDCC1_MOUSE
AccessioniPrimary (citable) accession number: Q14AI0
Secondary accession number(s): Q4FZL5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 22, 2006
Last modified: November 7, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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