Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Lysophosphatidic acid receptor 5

Gene

Lpar5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities.By similarity

GO - Molecular functioni

GO - Biological processi

  • behavioral response to pain Source: MGI
  • positive regulation of CREB transcription factor activity Source: MGI

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophosphatidic acid receptor 5
Short name:
LPA receptor 5
Short name:
LPA-5
Alternative name(s):
G-protein coupled receptor 92
Gene namesi
Name:Lpar5
Synonyms:Gm1072, Gpr92
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2685918 Lpar5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 30ExtracellularSequence analysisAdd BLAST30
Transmembranei31 – 51Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini52 – 59CytoplasmicSequence analysis8
Transmembranei60 – 80Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini81 – 100ExtracellularSequence analysisAdd BLAST20
Transmembranei101 – 121Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini122 – 140CytoplasmicSequence analysisAdd BLAST19
Transmembranei141 – 161Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini162 – 191ExtracellularSequence analysisAdd BLAST30
Transmembranei192 – 212Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini213 – 243CytoplasmicSequence analysisAdd BLAST31
Transmembranei244 – 264Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini265 – 280ExtracellularSequence analysisAdd BLAST16
Transmembranei281 – 301Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini302 – 372CytoplasmicSequence analysisAdd BLAST71

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003032361 – 372Lysophosphatidic acid receptor 5Add BLAST372

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi8N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi13N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi98 ↔ 179PROSITE-ProRule annotation
Glycosylationi173N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ149R9
PRIDEiQ149R9

PTM databases

iPTMnetiQ149R9
PhosphoSitePlusiQ149R9

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000085630

Structurei

3D structure databases

ProteinModelPortaliQ149R9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF9D Eukaryota
ENOG410XTCM LUCA
HOGENOMiHOG000231307
HOVERGENiHBG103813
InParanoidiQ149R9
PhylomeDBiQ149R9

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

Q149R9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFANSSANTT STNSSVLQCP DYRDTHRLHM VVYSLVLATG LPLNALALWV
60 70 80 90 100
FLRVLRVHSV VSVYMCNLAA SDLLFTLSLP LRLSYYAQHH WPFPGFLCQT
110 120 130 140 150
SGAIFQMNMY GSCLFLMLIN VDRYAAIVHP LRLRHLRRPR VARRLCLGVW
160 170 180 190 200
ALILLFAVPA ARVHSPSHCT YKNITVRLCF ESFSDELWKG RLLPLLLLAE
210 220 230 240 250
ILGFLLPLAA VVYSSGRVFW TLARPDATQS QRRRKTVRLL LANLIIFLLC
260 270 280 290 300
FVPYNSTLAV YGLLRANLVK NSIQDRDQVR GVLMIMVLLA GANCVLDPLV
310 320 330 340 350
YYFSAEGFRN TLRNLGAPLN TRPLATNGAA GVLTELPSES TQNTGQDATS
360 370
QVLLQPATLG TPPDNCSQDS AL
Length:372
Mass (Da):41,394
Last modified:September 5, 2006 - v2
Checksum:i0D3EFBD489F60446
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3X9K0G3X9K0_MOUSE
Lysophosphatidic acid receptor 5
Lpar5 mCG_142734
384Annotation score:
F6S365F6S365_MOUSE
Lysophosphatidic acid receptor 5
Lpar5
163Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti186E → K in BAE20836 (PubMed:16141072).Curated1
Sequence conflicti242A → S in BAE20836 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC116702 mRNA Translation: AAI16703.2
BC117528 mRNA Translation: AAI17529.2
AK131863 mRNA Translation: BAE20836.1
AY255621 mRNA Translation: AAO85133.1
UniGeneiMm.333386

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC116702 mRNA Translation: AAI16703.2
BC117528 mRNA Translation: AAI17529.2
AK131863 mRNA Translation: BAE20836.1
AY255621 mRNA Translation: AAO85133.1
UniGeneiMm.333386

3D structure databases

ProteinModelPortaliQ149R9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000085630

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ149R9
PhosphoSitePlusiQ149R9

Proteomic databases

PaxDbiQ149R9
PRIDEiQ149R9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:2685918 Lpar5

Phylogenomic databases

eggNOGiENOG410IF9D Eukaryota
ENOG410XTCM LUCA
HOGENOMiHOG000231307
HOVERGENiHBG103813
InParanoidiQ149R9
PhylomeDBiQ149R9

Miscellaneous databases

PROiPR:Q149R9
SOURCEiSearch...

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLPAR5_MOUSE
AccessioniPrimary (citable) accession number: Q149R9
Secondary accession number(s): Q3V2G2, Q80T30
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 5, 2006
Last modified: December 20, 2017
This is version 91 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again