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Entry version 119 (02 Jun 2021)
Sequence version 3 (30 Nov 2010)
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Protein

NACHT domain- and WD repeat-containing protein 1

Gene

NWD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in the control of androgen receptor (AR) protein steady-state levels.

1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi341 – 348ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q149M9

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q149M9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NACHT domain- and WD repeat-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NWD1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:27619, NWD1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616250, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q149M9

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000188039.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
284434

Open Targets

More...
OpenTargetsi
ENSG00000188039

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q149M9, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NWD1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
313104204

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003082541 – 1564NACHT domain- and WD repeat-containing protein 1Add BLAST1564

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q149M9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q149M9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q149M9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q149M9

PeptideAtlas

More...
PeptideAtlasi
Q149M9

PRoteomics IDEntifications database

More...
PRIDEi
Q149M9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
60291 [Q149M9-1]
60292 [Q149M9-2]
60293 [Q149M9-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q149M9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q149M9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at highest levels in prostate, followed by testis, retina, trachea and optic nerve. Also detected in brain, epididymis, lung, vagina and pituitary. In the prostate, tends to be up-regulated during malignant progression compared to normal epithelium (at protein level).1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

May be up-regulated by SOX9 and SRY.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000188039, Expressed in olfactory segment of nasal mucosa and 72 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q149M9, baseline and differential

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000188039, Tissue enhanced (brain, fallopian tube)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May interact with HSP90AA1, HSP90AB1 and BAG2.

1 Publication

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q149M9, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000428579

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q149M9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini335 – 661NACHTAdd BLAST327
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati866 – 905WD 1Add BLAST40
Repeati908 – 947WD 2Add BLAST40
Repeati956 – 994WD 3Add BLAST39
Repeati998 – 1037WD 4Add BLAST40
Repeati1044 – 1082WD 5Add BLAST39
Repeati1083 – 1121WD 6Add BLAST39
Repeati1126 – 1165WD 7Add BLAST40
Repeati1167 – 1207WD 8Add BLAST41
Repeati1212 – 1251WD 9Add BLAST40
Repeati1253 – 1290WD 10Add BLAST38
Repeati1291 – 1327WD 11Add BLAST37
Repeati1338 – 1376WD 12Add BLAST39
Repeati1380 – 1418WD 13Add BLAST39
Repeati1425 – 1462WD 14Add BLAST38

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0265, Eukaryota
KOG3602, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161635

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_2653829_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q149M9

Identification of Orthologs from Complete Genome Data

More...
OMAi
HHLPWSR

Database of Orthologous Groups

More...
OrthoDBi
20367at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q149M9

TreeFam database of animal gene trees

More...
TreeFami
TF332647

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007111, NACHT_NTPase
IPR043365, NWD1
IPR027417, P-loop_NTPase
IPR011047, Quinoprotein_ADH-like_supfam
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR019775, WD40_repeat_CS
IPR017986, WD40_repeat_dom

The PANTHER Classification System

More...
PANTHERi
PTHR45013, PTHR45013, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05729, NACHT, 1 hit
PF00400, WD40, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320, WD40, 11 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50998, SSF50998, 2 hits
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00678, WD_REPEATS_1, 2 hits
PS50082, WD_REPEATS_2, 4 hits
PS50294, WD_REPEATS_REGION, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q149M9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQRGKPCRAL PTLKCQTFCQ RHGLMFEVVD LRWGIRNIEA TDHLTTELCL
60 70 80 90 100
EEVDRCWKTS IGPAFVALIG DQYGPCLIPS RIDEKEWEVL RDHLTARPSD
110 120 130 140 150
LELVARYFQR DENAFPPTYV LQAPGTGEAC EPEEATLTSV LRSGAQEARR
160 170 180 190 200
LGLITQEQWQ HYHRSVIEWE IERSLLSSED REQGATVFLR EIQDLHKHIL
210 220 230 240 250
EDCALRMVDR LADGCLDADA QNLLSSLKSH ITDMHPGVLK THRLPWSRDL
260 270 280 290 300
VNPKNKTHAC YLKELGEQFV VRANHQVLTR LRELDTAGQE LAWLYQEIRH
310 320 330 340 350
HLWQSSEVIQ TFCGRQELLA RLGQQLRHDD SKQHTPLVLF GPPGIGKTAL
360 370 380 390 400
MCKLAEQMPR LLGHKTVTVL RLLGTSQMSS DARGLLKSIC FQVCLAYGLP
410 420 430 440 450
LPPAQVLDAH TRVVQFFHTL LHTVSCRNFE SLVLLLDAMD DLDSVRHARR
460 470 480 490 500
VPWLPLNCPP RVHLILSACS GALGVLDTLQ RVLLDPEAYW EVKPLSGNQG
510 520 530 540 550
QQMIQLLLAA ARRTLSPVHT DLLWASLPEC GNPGRLRLAF EEARKWASFT
560 570 580 590 600
VPVPLATTAE EATHQLCTRL EQTHGQLLVA HVLGYIVSSR HGLSEAELKD
610 620 630 640 650
VLSLDDEVLQ DVYRDWTPPS KELLRFPPLL WVRLRRDLGY YLARRPVDGF
660 670 680 690 700
TLLAIAHRQL VEVVRERYLS GSERAKRHGV LADFFSGTWS QGTKKLITLP
710 720 730 740 750
LVGKPLNLDR KVAPQPLWFS HTVANLRKLK ELPYHLLHSG RLEELKQEVL
760 770 780 790 800
GSMSWISCRG ISGGIEDLLD DFDLCAPHLD SPEVGLVREA LQLCRPAVEL
810 820 830 840 850
RGMERSLLYT ELLARLHFFA TSHPALVGQL CQQAQSWFQL CAHPVLVPLG
860 870 880 890 900
GFLQPPGGPL RATLSGCHKG ITAMAWGVEE KLLVIGTQDG IMAVWDMEEQ
910 920 930 940 950
HVIHMLTGHT GEVRCVKIFA KGTLANSASK DYTLHLWNLL SGQEKFTIWD
960 970 980 990 1000
GGSKNPAEPQ IWNLHVDEAH KVVYSASGSK INAWNLETAE PVFHILGDAS
1010 1020 1030 1040 1050
DPWMCMAVLA SQATLLTVSR DGVVSLWSSA TGKLQGKQHM SSIKEETPTC
1060 1070 1080 1090 1100
AVSVQKQGKL VTGFSNGSIS LVSSKGDRLL EKLPDAVRFL VVSEDESLLA
1110 1120 1130 1140 1150
AGFGRSVRIF LADSRGFRRF MAMDLEHEDM VETAVFGTEN NLIITGSLDA
1160 1170 1180 1190 1200
LIQVWSLSEQ GTLLDILEGV GAPVSLLARG GALVASASPQ SSSFKVWDLS
1210 1220 1230 1240 1250
DAHRSRVPAP FLDRTGLTAV SHNGSYVYFP KIGDKNKVTI WDLAEGEEQD
1260 1270 1280 1290 1300
SLDTSSEIRC LEVAEQRKLL FTGLVSGVVL VFPLNSRQDV ICIPPPEARK
1310 1320 1330 1340 1350
AINCMSLSKC EDRLAIAYDN IVLVLDITSG DPCPVIDGPR YTFYTQLPET
1360 1370 1380 1390 1400
LSSVAILTDY RVVYSMTNGD LFLYECATSK AFPLETHRSR VACVEVSHKE
1410 1420 1430 1440 1450
QLVVSGSEDA LLCLWDLQAR KWKFEMSYTS SYCRGVQCAC FSKDDKYVYV
1460 1470 1480 1490 1500
GLKDRSILVW SVLDGTLLTV QFVHAVVNRI IPTTSGFIAP TRHGYLIREN
1510 1520 1530 1540 1550
FQCLSAKASP QDPLKNFKKA MWMVKSRQRE ELVAAAGAPQ DLESESAQGN
1560
ETKSNKCSQV CLIV
Length:1,564
Mass (Da):174,552
Last modified:November 30, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAB77411A1D6FBCFF
GO
Isoform 2 (identifier: Q149M9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     67-76: ALIGDQYGPC → EKCADPCPGQ
     77-1564: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:76
Mass (Da):8,679
Checksum:i7C5431E4500AFFDD
GO
Isoform 3 (identifier: Q149M9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1430-1432: SSY → APC
     1433-1564: Missing.

Show »
Length:1,432
Mass (Da):159,853
Checksum:i067255A974EAC64D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W0U9F8W0U9_HUMAN
NACHT domain- and WD repeat-contain...
NWD1
1,522Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RJJ1E5RJJ1_HUMAN
NACHT domain- and WD repeat-contain...
NWD1
179Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A669KAX7A0A669KAX7_HUMAN
NACHT domain- and WD repeat-contain...
NWD1
194Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A669KB99A0A669KB99_HUMAN
NACHT domain- and WD repeat-contain...
NWD1
14Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI17699 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti15C → F in CAH18655 (PubMed:17974005).Curated1
Sequence conflicti78I → V in CAH18655 (PubMed:17974005).Curated1
Sequence conflicti994H → Y in CAH18655 (PubMed:17974005).Curated1
Sequence conflicti1056K → R in CAH18655 (PubMed:17974005).Curated1
Sequence conflicti1141N → S in CAH18655 (PubMed:17974005).Curated1
Sequence conflicti1171G → R in CAH18655 (PubMed:17974005).Curated1
Sequence conflicti1399K → R in CAH18655 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_036769174S → G1 PublicationCorresponds to variant dbSNP:rs3888834Ensembl.1
Natural variantiVAR_036770211L → F. Corresponds to variant dbSNP:rs11668502Ensembl.1
Natural variantiVAR_036771218A → T1 PublicationCorresponds to variant dbSNP:rs706764Ensembl.1
Natural variantiVAR_036772900Q → E. Corresponds to variant dbSNP:rs773930Ensembl.1
Natural variantiVAR_036773926N → I1 PublicationCorresponds to variant dbSNP:rs2608737Ensembl.1
Natural variantiVAR_036774935H → R. Corresponds to variant dbSNP:rs2608738Ensembl.1
Natural variantiVAR_0367751541D → V. Corresponds to variant dbSNP:rs11671361Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04065167 – 76ALIGDQYGPC → EKCADPCPGQ in isoform 2. 1 Publication10
Alternative sequenceiVSP_04065277 – 1564Missing in isoform 2. 1 PublicationAdd BLAST1488
Alternative sequenceiVSP_0289401430 – 1432SSY → APC in isoform 3. 1 Publication3
Alternative sequenceiVSP_0289411433 – 1564Missing in isoform 3. 1 PublicationAdd BLAST132

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
CR749794 mRNA Translation: CAH18655.1
AC008737 Genomic DNA No translation available.
BC117698 mRNA Translation: AAI17699.1 Sequence problems.

The Consensus CDS (CCDS) project

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CCDSi
CCDS32945.2 [Q149M9-3]

NCBI Reference Sequences

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RefSeqi
NP_001007526.3, NM_001007525.4 [Q149M9-3]
NP_001277284.1, NM_001290355.2
NP_001334923.1, NM_001347994.1
XP_011526231.1, XM_011527929.1 [Q149M9-1]
XP_011526232.1, XM_011527930.2 [Q149M9-1]
XP_011526233.1, XM_011527931.2 [Q149M9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000379808; ENSP00000369136; ENSG00000188039 [Q149M9-3]
ENST00000438489; ENSP00000400248; ENSG00000188039 [Q149M9-2]
ENST00000524140; ENSP00000428579; ENSG00000188039 [Q149M9-3]
ENST00000552788; ENSP00000447224; ENSG00000188039 [Q149M9-1]
ENST00000646016; ENSP00000496092; ENSG00000188039 [Q149M9-2]
ENST00000673803; ENSP00000501265; ENSG00000188039 [Q149M9-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
284434

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:284434

UCSC genome browser

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UCSCi
uc002neu.5, human [Q149M9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR749794 mRNA Translation: CAH18655.1
AC008737 Genomic DNA No translation available.
BC117698 mRNA Translation: AAI17699.1 Sequence problems.
CCDSiCCDS32945.2 [Q149M9-3]
RefSeqiNP_001007526.3, NM_001007525.4 [Q149M9-3]
NP_001277284.1, NM_001290355.2
NP_001334923.1, NM_001347994.1
XP_011526231.1, XM_011527929.1 [Q149M9-1]
XP_011526232.1, XM_011527930.2 [Q149M9-1]
XP_011526233.1, XM_011527931.2 [Q149M9-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ149M9, 3 interactors
STRINGi9606.ENSP00000428579

PTM databases

iPTMnetiQ149M9
PhosphoSitePlusiQ149M9

Genetic variation databases

BioMutaiNWD1
DMDMi313104204

Proteomic databases

EPDiQ149M9
jPOSTiQ149M9
MassIVEiQ149M9
PaxDbiQ149M9
PeptideAtlasiQ149M9
PRIDEiQ149M9
ProteomicsDBi60291 [Q149M9-1]
60292 [Q149M9-2]
60293 [Q149M9-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
69163, 6 antibodies

The DNASU plasmid repository

More...
DNASUi
284434

Genome annotation databases

EnsembliENST00000379808; ENSP00000369136; ENSG00000188039 [Q149M9-3]
ENST00000438489; ENSP00000400248; ENSG00000188039 [Q149M9-2]
ENST00000524140; ENSP00000428579; ENSG00000188039 [Q149M9-3]
ENST00000552788; ENSP00000447224; ENSG00000188039 [Q149M9-1]
ENST00000646016; ENSP00000496092; ENSG00000188039 [Q149M9-2]
ENST00000673803; ENSP00000501265; ENSG00000188039 [Q149M9-3]
GeneIDi284434
KEGGihsa:284434
UCSCiuc002neu.5, human [Q149M9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
284434
DisGeNETi284434

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NWD1
HGNCiHGNC:27619, NWD1
HPAiENSG00000188039, Tissue enhanced (brain, fallopian tube)
MIMi616250, gene
neXtProtiNX_Q149M9
OpenTargetsiENSG00000188039
VEuPathDBiHostDB:ENSG00000188039.13

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0265, Eukaryota
KOG3602, Eukaryota
GeneTreeiENSGT00940000161635
HOGENOMiCLU_2653829_0_0_1
InParanoidiQ149M9
OMAiHHLPWSR
OrthoDBi20367at2759
PhylomeDBiQ149M9
TreeFamiTF332647

Enzyme and pathway databases

PathwayCommonsiQ149M9
SignaLinkiQ149M9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
284434, 5 hits in 978 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NWD1, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
NWD1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
284434
PharosiQ149M9, Tdark

Protein Ontology

More...
PROi
PR:Q149M9
RNActiQ149M9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000188039, Expressed in olfactory segment of nasal mucosa and 72 other tissues
ExpressionAtlasiQ149M9, baseline and differential

Family and domain databases

Gene3Di2.130.10.10, 3 hits
InterProiView protein in InterPro
IPR007111, NACHT_NTPase
IPR043365, NWD1
IPR027417, P-loop_NTPase
IPR011047, Quinoprotein_ADH-like_supfam
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR019775, WD40_repeat_CS
IPR017986, WD40_repeat_dom
PANTHERiPTHR45013, PTHR45013, 1 hit
PfamiView protein in Pfam
PF05729, NACHT, 1 hit
PF00400, WD40, 3 hits
SMARTiView protein in SMART
SM00320, WD40, 11 hits
SUPFAMiSSF50998, SSF50998, 2 hits
SSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00678, WD_REPEATS_1, 2 hits
PS50082, WD_REPEATS_2, 4 hits
PS50294, WD_REPEATS_REGION, 3 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNWD1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q149M9
Secondary accession number(s): C9J021, Q68CT3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: November 30, 2010
Last modified: June 2, 2021
This is version 119 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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