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UniProtKB - Q149G7 (Q149G7_MOUSE)

Entry version 126 (02 Dec 2020)
Sequence version 1 (22 Aug 2006)
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Protein
Submitted name:

Interleukin 1 receptor-like 2

Gene

Il1rl2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptorImported
LigandNADARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Interleukin 1 receptor-like 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Il1rl2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1913107, Il1rl2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

GlycoproteinARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000070942, Expressed in ear and 159 other tissues

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the interleukin-1 receptor family.ARBA annotation

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_025552_3_0_1

Identification of Orthologs from Complete Genome Data

More...OMAi		LTCHLHF

Database of Orthologous Groups

More...OrthoDBi		1109920at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 3 hits
3.40.50.10140, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR015621, IL-1_rcpt_fam
IPR004076, IL-1_rcpt_I-typ
IPR004074, IL-1_rcpt_I/II-typ
IPR000157, TIR_dom
IPR035897, Toll_tir_struct_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR11890, PTHR11890, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13895, Ig_2, 2 hits
PF01582, TIR, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01538, INTRLEUKN1R1
PR01536, INTRLKN1R12F

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00409, IG, 3 hits
SM00408, IGc2, 2 hits
SM00255, TIR, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726, SSF48726, 3 hits
SSF52200, SSF52200, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50835, IG_LIKE, 2 hits
PS50104, TIR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q149G7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGVTSLLFCG VFFLLLLFVA ADTCEDIFMH NVIISEGQPF PFNCTYPPET 
        60         70         80         90        100
NGAVNLTWYK TPSKSPVSNN RHLRVHQDQT WILFLPLTLE DSGIYQCVIR 
       110        120        130        140        150
NAHNCYQIAV NLTVLKNHWC DSSMEGSPVN SPDVYQQILP IGKSGSLNCH 
       160        170        180        190        200
LYFPESCALD SIKWYKGCEE IKAGKKYSPS GAKLLVNNVA VEDGGSYACS 
       210        220        230        240        250
ARLTHLGRHF TIRNYIAVNT KEVEYGRRIP NITYPKNNSI EVPLGSTLIV 
       260        270        280        290        300
NCNITDTKEN TNLRCWRVNN TLVDDYYKDS KRIQEGIETN VSLRDQIRYT 
       310        320        330        340        350
VNITFLKVKM EDYGRPFTCH AGVSAAYIIL IYPVPDFRAY LLGGLMAFLL 
       360        370        380        390        400
LVVSVLFIYN SFKIDIMLWY RSAFHTAQAP DDEKLYDAYV LYPKYPRGSQ 
       410        420        430        440        450
GHDVDTLVLK ILPEVLEKQC GYKLFIFGRD EFPGQAVASV IDENIKLCRR 
       460        470        480        490        500
LMVFVAPESS SFGFLKNLSE EQIAVYNALI QHGMKVILIE LEKVKDYSTM 
       510        520        530        540        550
PESIQYIRQK HGAIQWDGDF TEQSQCAKTK FWKKVRYHMP PRRYPASSPV 
       560        570 
QLLGHIPCNC KAGKCNAATG LITP
Length:574
Mass (Da):65,108
Last modified:August 22, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA677A77BBFA50A76
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BC117797 mRNA Translation: AAI17798.1

NCBI Reference Sequences

More...RefSeqi		NP_573456.1, NM_133193.3
XP_006495671.1, XM_006495608.3
XP_006495672.1, XM_006495609.3
XP_006495673.1, XM_006495610.3
XP_006495674.1, XM_006495611.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		107527

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:107527

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC117797 mRNA Translation: AAI17798.1
RefSeqiNP_573456.1, NM_133193.3
XP_006495671.1, XM_006495608.3
XP_006495672.1, XM_006495609.3
XP_006495673.1, XM_006495610.3
XP_006495674.1, XM_006495611.3

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2361, 261 antibodies

Genome annotation databases

GeneIDi107527
KEGGimmu:107527

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8808
MGIiMGI:1913107, Il1rl2

Phylogenomic databases

HOGENOMiCLU_025552_3_0_1
OMAiLTCHLHF
OrthoDBi1109920at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		107527, 1 hit in 17 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Il1rl2, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000070942, Expressed in ear and 159 other tissues

Family and domain databases

Gene3Di2.60.40.10, 3 hits
3.40.50.10140, 1 hit
InterProiView protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR015621, IL-1_rcpt_fam
IPR004076, IL-1_rcpt_I-typ
IPR004074, IL-1_rcpt_I/II-typ
IPR000157, TIR_dom
IPR035897, Toll_tir_struct_dom_sf
PANTHERiPTHR11890, PTHR11890, 1 hit
PfamiView protein in Pfam
PF13895, Ig_2, 2 hits
PF01582, TIR, 1 hit
PRINTSiPR01538, INTRLEUKN1R1
PR01536, INTRLKN1R12F
SMARTiView protein in SMART
SM00409, IG, 3 hits
SM00408, IGc2, 2 hits
SM00255, TIR, 1 hit
SUPFAMiSSF48726, SSF48726, 3 hits
SSF52200, SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS50835, IG_LIKE, 2 hits
PS50104, TIR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ149G7_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q149G7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: August 22, 2006
Last sequence update: August 22, 2006
Last modified: December 2, 2020
This is version 126 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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