UniProtKB - Q14999 (CUL7_HUMAN)
Cullin-7
CUL7
Functioni
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
GO - Molecular functioni
- ubiquitin protein ligase binding Source: InterPro
GO - Biological processi
- epithelial to mesenchymal transition Source: UniProtKB
- Golgi organization Source: UniProtKB
- IRE1-mediated unfolded protein response Source: Reactome
- microtubule cytoskeleton organization Source: UniProtKB
- mitotic cytokinesis Source: UniProtKB
- placenta development Source: UniProtKB
- positive regulation of dendrite morphogenesis Source: UniProtKB
- post-translational protein modification Source: Reactome
- protein ubiquitination Source: UniProtKB
- proteolysis Source: UniProtKB
- regulation of mitotic nuclear division Source: UniProtKB
- ubiquitin-dependent protein catabolic process Source: InterPro
- vasculogenesis Source: UniProtKB
- viral process Source: UniProtKB-KW
Keywordsi
Biological process | Host-virus interaction, Ubl conjugation pathway |
Enzyme and pathway databases
Reactomei | R-HSA-381038 XBP1(S) activates chaperone genes R-HSA-8951664 Neddylation R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation |
SIGNORi | Q14999 |
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: Cullin-7Short name: CUL-7 |
Gene namesi | Name:CUL7 Synonyms:KIAA0076 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:21024 CUL7 |
MIMi | 609577 gene |
neXtProti | NX_Q14999 |
Subcellular locationi
Cytoskeleton
- centrosome Source: UniProtKB
Cytosol
- cytosol Source: Reactome
Golgi apparatus
- Golgi apparatus Source: UniProtKB
Nucleus
- anaphase-promoting complex Source: UniProtKB
Other locations
- 3M complex Source: UniProtKB
- Cul7-RING ubiquitin ligase complex Source: UniProtKB
- cytoplasm Source: UniProtKB
- perinuclear region of cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, Golgi apparatusPathology & Biotechi
Involvement in diseasei
3M syndrome 1 (3M1)3 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_026122 | 1014 | L → R in 3M1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs61752334EnsemblClinVar. | 1 | |
Natural variantiVAR_026123 | 1246 | Q → G in 3M1; requires 2 nucleotide substitutions. 1 Publication | 1 | |
Natural variantiVAR_026124 | 1464 | H → P in 3M1; impairs the ability to interact with RBX1, thus hampers the assembly of polyubiquitin chains. 1 PublicationCorresponds to variant dbSNP:rs121918229EnsemblClinVar. | 1 | |
Natural variantiVAR_071120 | 1588 | L → P in 3M1. 1 PublicationCorresponds to variant dbSNP:rs759300846Ensembl. | 1 |
Keywords - Diseasei
Disease mutation, DwarfismOrganism-specific databases
DisGeNETi | 9820 |
GeneReviewsi | CUL7 |
MalaCardsi | CUL7 |
MIMi | 273750 phenotype |
OpenTargetsi | ENSG00000044090 |
Orphaneti | 2616 3M syndrome |
PharmGKBi | PA134897835 |
Miscellaneous databases
Pharosi | Q14999 |
Polymorphism and mutation databases
BioMutai | CUL7 |
DMDMi | 160370003 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000119802 | 1 – 1698 | Cullin-7Add BLAST | 1698 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 339 | PhosphoserineCombined sources | 1 | |
Cross-linki | 1576 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in NEDD8)Sequence analysis |
Post-translational modificationi
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q14999 |
jPOSTi | Q14999 |
MassIVEi | Q14999 |
MaxQBi | Q14999 |
PaxDbi | Q14999 |
PeptideAtlasi | Q14999 |
PRIDEi | Q14999 |
ProteomicsDBi | 25372 60290 [Q14999-1] |
PTM databases
iPTMneti | Q14999 |
PhosphoSitePlusi | Q14999 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | ENSG00000044090 Expressed in 208 organ(s), highest expression level in adenohypophysis |
Genevisiblei | Q14999 HS |
Organism-specific databases
HPAi | CAB015449 HPA030095 HPA030096 |
Interactioni
Subunit structurei
Component of the 3M complex, composed of core components CUL7, CCDC8 and OBSL1.
Part of a Cul7-RING complex consisting of CUL7, RBX1, SKP1 and FBXW8.
Interacts with a complex of SKP1 and FBXW8, but not with SKP1 alone.
Interacts with CUL9; leading to inhibit CUL9 activity.
Interacts with FBXW8; interaction is mutually exclusive of binding to CUL9 or p53/TP53.
Interacts with p53/TP53; the interaction preferentially involves tetrameric and dimeric p53/TP53. The CUL7-CUL9 heterodimer seems to interact specifically with p53/TP53.
Interacts with CUL1; the interactions seems to be mediated by FBXW8.
Interacts with OBSL1.
Interacts (as part of the 3M complex) with HDAC4 and HDAC5; it is negatively regulated by ANKRA2.
12 Publications(Microbial infection) Interacts with SV40 Large T antigen; this interaction seems to inhibit CUL7.
1 PublicationBinary interactionsi
GO - Molecular functioni
- ubiquitin protein ligase binding Source: InterPro
Protein-protein interaction databases
BioGridi | 115159, 662 interactors |
CORUMi | Q14999 |
DIPi | DIP-31618N DIP-60187N |
IntActi | Q14999, 29 interactors |
MINTi | Q14999 |
STRINGi | 9606.ENSP00000438788 |
Structurei
Secondary structure
3D structure databases
SMRi | Q14999 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q14999 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 814 – 993 | DOCPROSITE-ProRule annotationAdd BLAST | 180 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 360 – 460 | Interaction with TP53Add BLAST | 101 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1815 Eukaryota ENOG410XP9Y LUCA |
GeneTreei | ENSGT00940000153954 |
HOGENOMi | HOG000024831 |
InParanoidi | Q14999 |
KOi | K10613 |
OMAi | DDRPQML |
OrthoDBi | 469819at2759 |
PhylomeDBi | Q14999 |
TreeFami | TF101154 |
Family and domain databases
Gene3Di | 2.30.30.30, 1 hit 2.60.120.260, 1 hit |
InterProi | View protein in InterPro IPR004939 APC_su10/DOC_dom IPR016024 ARM-type_fold IPR021097 CPH_domain IPR031223 CUL7 IPR016158 Cullin_homology IPR036317 Cullin_homology_sf IPR001373 Cullin_N IPR019559 Cullin_neddylation_domain IPR008979 Galactose-bd-like_sf IPR014722 Rib_L2_dom2 |
PANTHERi | PTHR22771:SF3 PTHR22771:SF3, 1 hit |
Pfami | View protein in Pfam PF03256 ANAPC10, 1 hit PF11515 Cul7, 1 hit PF00888 Cullin, 1 hit |
SMARTi | View protein in SMART SM01337 APC10, 1 hit SM00884 Cullin_Nedd8, 1 hit |
SUPFAMi | SSF48371 SSF48371, 1 hit SSF49785 SSF49785, 1 hit SSF75632 SSF75632, 1 hit |
PROSITEi | View protein in PROSITE PS50069 CULLIN_2, 1 hit PS51284 DOC, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVGELRYREF RVPLGPGLHA YPDELIRQRV GHDGHPEYQI RWLILRRGDE
60 70 80 90 100
GDGGSGQVDC KAEHILLWMS KDEIYANCHK MLGEDGQVIG PSQESAGEVG
110 120 130 140 150
ALDKSVLEEM ETDVKSLIQR ALRQLEECVG TIPPAPLLHT VHVLSAYASI
160 170 180 190 200
EPLTGVFKDP RVLDLLMHML SSPDYQIRWS AGRMIQALSS HDAGTRTQIL
210 220 230 240 250
LSLSQQEAIE KHLDFDSRCA LLALFAQATL SEHPMSFEGI QLPQVPGRVL
260 270 280 290 300
FSLVKRYLHV TSLLDQLNDS AAEPGAQNTS APEELSGERG QLELEFSMAM
310 320 330 340 350
GTLISELVQA MRWDQASDRP RSSARSPGSI FQPQLADVSP GLPAAQAQPS
360 370 380 390 400
FRRSRRFRPR SEFASGNTYA LYVRDTLQPG MRVRMLDDYE EISAGDEGEF
410 420 430 440 450
RQSNNGVPPV QVFWESTGRT YWVHWHMLEI LGFEEDIEDM VEADEYQGAV
460 470 480 490 500
ASRVLGRALP AWRWRPMTEL YAVPYVLPED EDTEECEHLT LAEWWELLFF
510 520 530 540 550
IKKLDGPDHQ EVLQILQENL DGEILDDEIL AELAVPIELA QDLLLTLPQR
560 570 580 590 600
LNDSALRDLI NCHVYKKYGP EALAGNQAYP SLLEAQEDVL LLDAQAQAKD
610 620 630 640 650
SEDAAKVEAK EPPSQSPNTP LQRLVEGYGP AGKILLDLEQ ALSSEGTQEN
660 670 680 690 700
KVKPLLLQLQ RQPQPFLALM QSLDTPETNR TLHLTVLRIL KQLVDFPEAL
710 720 730 740 750
LLPWHEAVDA CMACLRSPNT DREVLQELIF FLHRLTSVSR DYAVVLNQLG
760 770 780 790 800
ARDAISKALE KHLGKLELAQ ELRDMVFKCE KHAHLYRKLI TNILGGCIQM
810 820 830 840 850
VLGQIEDHRR THQPINIPFF DVFLRYLCQG SSVEVKEDKC WEKVEVSSNP
860 870 880 890 900
HRASKLTDHN PKTYWESNGS AGSHYITLHM RRGILIRQLT LLVASEDSSY
910 920 930 940 950
MPARVVVCGG DSTSSLHTEL NSVNVMPSAS RVILLENLTR FWPIIQIRIK
960 970 980 990 1000
RCQQGGIDTR IRGLEILGPK PTFWPVFREQ LCRHTRLFYM VRAQAWSQDM
1010 1020 1030 1040 1050
AEDRRSLLHL SSRLNGALRQ EQNFADRFLP DDEAAQALGK TCWEALVSPV
1060 1070 1080 1090 1100
VQNITSPDED GISPLGWLLD QYLECQEAVF NPQSRGPAFF SRVRRLTHLL
1110 1120 1130 1140 1150
VHVEPCEAPP PVVATPRPKG RNRSHDWSSL ATRGLPSSIM RNLTRCWRAV
1160 1170 1180 1190 1200
VEKQVNNFLT SSWRDDDFVP RYCEHFNILQ NSSSELFGPR AAFLLALQNG
1210 1220 1230 1240 1250
CAGALLKLPF LKAAHVSEQF ARHIDQQIQG SRIGGAQEME RLAQLQQCLQ
1260 1270 1280 1290 1300
AVLIFSGLEI ATTFEHYYQH YMADRLLGVV SSWLEGAVLE QIGPCFPNRL
1310 1320 1330 1340 1350
PQQMLQSLST SKELQRQFHV YQLQQLDQEL LKLEDTEKKI QVGLGASGKE
1360 1370 1380 1390 1400
HKSEKEEEAG AAAVVDVAEG EEEEEENEDL YYEGAMPEVS VLVLSRHSWP
1410 1420 1430 1440 1450
VASICHTLNP RTCLPSYLRG TLNRYSNFYN KSQSHPALER GSQRRLQWTW
1460 1470 1480 1490 1500
LGWAELQFGN QTLHVSTVQM WLLLYLNDLK AVSVESLLAF SGLSADMLNQ
1510 1520 1530 1540 1550
AIGPLTSSRG PLDLHEQKDI PGGVLKIRDG SKEPRSRWDI VRLIPPQTYL
1560 1570 1580 1590 1600
QAEGEDGQNL EKRRNLLNCL IVRILKAHGD EGLHIDQLVC LVLEAWQKGP
1610 1620 1630 1640 1650
CPPRGLVSSL GKGSACSSTD VLSCILHLLG KGTLRRHDDR PQVLSYAVPV
1660 1670 1680 1690
TVMEPHTESL NPGSSGPNPP LTFHTLQIRS RGVPYASCTA TQSFSTFR
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_048841 | 616 | S → G. Corresponds to variant dbSNP:rs7774330EnsemblClinVar. | 1 | |
Natural variantiVAR_026121 | 813 | Q → R3 PublicationsCorresponds to variant dbSNP:rs9381231EnsemblClinVar. | 1 | |
Natural variantiVAR_048842 | 852 | R → Q. Corresponds to variant dbSNP:rs34574340EnsemblClinVar. | 1 | |
Natural variantiVAR_026122 | 1014 | L → R in 3M1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs61752334EnsemblClinVar. | 1 | |
Natural variantiVAR_026123 | 1246 | Q → G in 3M1; requires 2 nucleotide substitutions. 1 Publication | 1 | |
Natural variantiVAR_048843 | 1246 | Q → H. Corresponds to variant dbSNP:rs36071170Ensembl. | 1 | |
Natural variantiVAR_026124 | 1464 | H → P in 3M1; impairs the ability to interact with RBX1, thus hampers the assembly of polyubiquitin chains. 1 PublicationCorresponds to variant dbSNP:rs121918229EnsemblClinVar. | 1 | |
Natural variantiVAR_071120 | 1588 | L → P in 3M1. 1 PublicationCorresponds to variant dbSNP:rs759300846Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_046105 | 1 | M → MSRGFWLAEPLAGTGPHPAP VAADSRGCSSVPRRHAPSRL SVSTPSRGPGARM in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_046106 | 194 | G → GEGQCGEEGKAGEGLGRLRD SQDTVAGASDLIR in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D38548 mRNA Translation: BAA07551.2 Different initiation. AK302668 mRNA Translation: BAG63902.1 AL355385 Genomic DNA No translation available. AL136304 Genomic DNA No translation available. BC033647 mRNA Translation: AAH33647.1 |
CCDSi | CCDS4881.1 [Q14999-1] CCDS55003.1 [Q14999-2] |
RefSeqi | NP_001161842.1, NM_001168370.1 [Q14999-2] NP_055595.2, NM_014780.4 [Q14999-1] |
Genome annotation databases
Ensembli | ENST00000265348; ENSP00000265348; ENSG00000044090 [Q14999-1] ENST00000535468; ENSP00000438788; ENSG00000044090 [Q14999-2] |
GeneIDi | 9820 |
KEGGi | hsa:9820 |
UCSCi | uc003otq.4 human [Q14999-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D38548 mRNA Translation: BAA07551.2 Different initiation. AK302668 mRNA Translation: BAG63902.1 AL355385 Genomic DNA No translation available. AL136304 Genomic DNA No translation available. BC033647 mRNA Translation: AAH33647.1 |
CCDSi | CCDS4881.1 [Q14999-1] CCDS55003.1 [Q14999-2] |
RefSeqi | NP_001161842.1, NM_001168370.1 [Q14999-2] NP_055595.2, NM_014780.4 [Q14999-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2JNG | NMR | - | A | 360-460 | [»] | |
SMRi | Q14999 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGridi | 115159, 662 interactors |
CORUMi | Q14999 |
DIPi | DIP-31618N DIP-60187N |
IntActi | Q14999, 29 interactors |
MINTi | Q14999 |
STRINGi | 9606.ENSP00000438788 |
PTM databases
iPTMneti | Q14999 |
PhosphoSitePlusi | Q14999 |
Polymorphism and mutation databases
BioMutai | CUL7 |
DMDMi | 160370003 |
Proteomic databases
EPDi | Q14999 |
jPOSTi | Q14999 |
MassIVEi | Q14999 |
MaxQBi | Q14999 |
PaxDbi | Q14999 |
PeptideAtlasi | Q14999 |
PRIDEi | Q14999 |
ProteomicsDBi | 25372 60290 [Q14999-1] |
Genome annotation databases
Ensembli | ENST00000265348; ENSP00000265348; ENSG00000044090 [Q14999-1] ENST00000535468; ENSP00000438788; ENSG00000044090 [Q14999-2] |
GeneIDi | 9820 |
KEGGi | hsa:9820 |
UCSCi | uc003otq.4 human [Q14999-1] |
Organism-specific databases
CTDi | 9820 |
DisGeNETi | 9820 |
GeneCardsi | CUL7 |
GeneReviewsi | CUL7 |
HGNCi | HGNC:21024 CUL7 |
HPAi | CAB015449 HPA030095 HPA030096 |
MalaCardsi | CUL7 |
MIMi | 273750 phenotype 609577 gene |
neXtProti | NX_Q14999 |
OpenTargetsi | ENSG00000044090 |
Orphaneti | 2616 3M syndrome |
PharmGKBi | PA134897835 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1815 Eukaryota ENOG410XP9Y LUCA |
GeneTreei | ENSGT00940000153954 |
HOGENOMi | HOG000024831 |
InParanoidi | Q14999 |
KOi | K10613 |
OMAi | DDRPQML |
OrthoDBi | 469819at2759 |
PhylomeDBi | Q14999 |
TreeFami | TF101154 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
Reactomei | R-HSA-381038 XBP1(S) activates chaperone genes R-HSA-8951664 Neddylation R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation |
SIGNORi | Q14999 |
Miscellaneous databases
ChiTaRSi | CUL7 human |
EvolutionaryTracei | Q14999 |
GeneWikii | CUL7 |
GenomeRNAii | 9820 |
Pharosi | Q14999 |
PROi | PR:Q14999 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000044090 Expressed in 208 organ(s), highest expression level in adenohypophysis |
Genevisiblei | Q14999 HS |
Family and domain databases
Gene3Di | 2.30.30.30, 1 hit 2.60.120.260, 1 hit |
InterProi | View protein in InterPro IPR004939 APC_su10/DOC_dom IPR016024 ARM-type_fold IPR021097 CPH_domain IPR031223 CUL7 IPR016158 Cullin_homology IPR036317 Cullin_homology_sf IPR001373 Cullin_N IPR019559 Cullin_neddylation_domain IPR008979 Galactose-bd-like_sf IPR014722 Rib_L2_dom2 |
PANTHERi | PTHR22771:SF3 PTHR22771:SF3, 1 hit |
Pfami | View protein in Pfam PF03256 ANAPC10, 1 hit PF11515 Cul7, 1 hit PF00888 Cullin, 1 hit |
SMARTi | View protein in SMART SM01337 APC10, 1 hit SM00884 Cullin_Nedd8, 1 hit |
SUPFAMi | SSF48371 SSF48371, 1 hit SSF49785 SSF49785, 1 hit SSF75632 SSF75632, 1 hit |
PROSITEi | View protein in PROSITE PS50069 CULLIN_2, 1 hit PS51284 DOC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CUL7_HUMAN | |
Accessioni | Q14999Primary (citable) accession number: Q14999 Secondary accession number(s): B4DYZ0, F5H0L1, Q5T654 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | October 23, 2007 | |
Last modified: | October 16, 2019 | |
This is version 190 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - SIMILARITY comments
Index of protein domains and families - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references