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Entry version 152 (17 Jun 2020)
Sequence version 2 (20 Mar 2007)
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Protein

Proteasome activator complex subunit 4

Gene

PSME4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks.4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, DNA damage, DNA repair, Spermatogenesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1169091 Activation of NF-kappaB in B cells
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-HSA-1236974 ER-Phagosome pathway
R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-HSA-180534 Vpu mediated degradation of CD4
R-HSA-180585 Vif-mediated degradation of APOBEC3G
R-HSA-195253 Degradation of beta-catenin by the destruction complex
R-HSA-202424 Downstream TCR signaling
R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1
R-HSA-350562 Regulation of ornithine decarboxylase (ODC)
R-HSA-382556 ABC-family proteins mediated transport
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-HSA-4608870 Asymmetric localization of PCP proteins
R-HSA-4641257 Degradation of AXIN
R-HSA-4641258 Degradation of DVL
R-HSA-5358346 Hedgehog ligand biogenesis
R-HSA-5362768 Hh mutants that don't undergo autocatalytic processing are degraded by ERAD
R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-HSA-5607764 CLEC7A (Dectin-1) signaling
R-HSA-5610780 Degradation of GLI1 by the proteasome
R-HSA-5610783 Degradation of GLI2 by the proteasome
R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome
R-HSA-5632684 Hedgehog 'on' state
R-HSA-5658442 Regulation of RAS by GAPs
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway
R-HSA-5676590 NIK-->noncanonical NF-kB signaling
R-HSA-5678895 Defective CFTR causes cystic fibrosis
R-HSA-5687128 MAPK6/MAPK4 signaling
R-HSA-5689603 UCH proteinases
R-HSA-5689880 Ub-specific processing proteases
R-HSA-68827 CDT1 association with the CDC6:ORC:origin complex
R-HSA-68949 Orc1 removal from chromatin
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6
R-HSA-69481 G2/M Checkpoints
R-HSA-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-HSA-75815 Ubiquitin-dependent degradation of Cyclin D
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint
R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-HSA-8939902 Regulation of RUNX2 expression and activity
R-HSA-8948751 Regulation of PTEN stability and activity
R-HSA-8951664 Neddylation
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-9020702 Interleukin-1 signaling
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Proteasome activator complex subunit 4
Alternative name(s):
Proteasome activator PA200
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PSME4
Synonyms:KIAA0077
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000068878.14

Human Gene Nomenclature Database

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HGNCi
HGNC:20635 PSME4

Online Mendelian Inheritance in Man (OMIM)

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MIMi
607705 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q14997

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1716 – 1717NF → TS: Abolihes binding to acetylated histones. 1 Publication2

Organism-specific databases

DisGeNET

More...
DisGeNETi
23198

Open Targets

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OpenTargetsi
ENSG00000068878

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134872587

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q14997 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
PSME4

Domain mapping of disease mutations (DMDM)

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DMDMi
134034993

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002807181 – 1843Proteasome activator complex subunit 4Add BLAST1843

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1121PhosphoserineCombined sources1
Modified residuei1614PhosphoserineCombined sources1
Modified residuei1746PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q14997

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q14997

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q14997

MaxQB - The MaxQuant DataBase

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MaxQBi
Q14997

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q14997

PeptideAtlas

More...
PeptideAtlasi
Q14997

PRoteomics IDEntifications database

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PRIDEi
Q14997

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
60286 [Q14997-1]
60287 [Q14997-2]
60288 [Q14997-3]
60289 [Q14997-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q14997

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q14997

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000068878 Expressed in epithelium of mammary gland and 234 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q14997 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q14997 HS

Organism-specific databases

Human Protein Atlas

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HPAi
ENSG00000068878 Tissue enhanced (skeletal)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with the 20S and 26S proteasomes.

Component of the spermatoproteasome, a form of the proteasome specifically found in testis.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
116807, 48 interactors

Database of interacting proteins

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DIPi
DIP-38203N

Protein interaction database and analysis system

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IntActi
Q14997, 30 interactors

Molecular INTeraction database

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MINTi
Q14997

STRING: functional protein association networks

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STRINGi
9606.ENSP00000384211

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q14997 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11843
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q14997

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati475 – 519HEAT 1Add BLAST45
Repeati998 – 1037HEAT 2Add BLAST40
Repeati1179 – 1217HEAT 3Add BLAST39
Repeati1354 – 1392HEAT 4Add BLAST39
Repeati1636 – 1674HEAT 5Add BLAST39
Repeati1680 – 1718HEAT 6Add BLAST39

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1650 – 1738Bromodomain-like (BRDL)Add BLAST89

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The bromodomain-like (BRDL) region specifically recognizes and binds acetylated histones.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the BLM10 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1851 Eukaryota
ENOG410XP7J LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000011433

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_000772_2_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q14997

KEGG Orthology (KO)

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KOi
K06699

Identification of Orthologs from Complete Genome Data

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OMAi
GKDWSDE

Database of Orthologous Groups

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OrthoDBi
83617at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q14997

TreeFam database of animal gene trees

More...
TreeFami
TF106237

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR032430 Blm10_mid
IPR035309 PSME4
IPR021843 PSME4_C

The PANTHER Classification System

More...
PANTHERi
PTHR32170 PTHR32170, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF16507 BLM10_mid, 1 hit
PF11919 DUF3437, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q14997-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPAERAGVG EPPEPGGRPE PGPRGFVPQK EIVYNKLLPY AERLDAESDL
60 70 80 90 100
QLAQIKCNLG RAVQLQELWP GGLFWTRKLS TYIRLYGRKF SKEDHVLFIK
110 120 130 140 150
LLYELVSIPK LEISMMQGFA RLLINLLKKK ELLSRADLEL PWRPLYDMVE
160 170 180 190 200
RILYSKTEHL GLNWFPNSVE NILKTLVKSC RPYFPADATA EMLEEWRPLM
210 220 230 240 250
CPFDVTMQKA ITYFEIFLPT SLPPELHHKG FKLWFDELIG LWVSVQNLPQ
260 270 280 290 300
WEGQLVNLFA RLATDNIGYI DWDPYVPKIF TRILRSLNLP VGSSQVLVPR
310 320 330 340 350
FLTNAYDIGH AVIWITAMMG GPSKLVQKHL AGLFNSITSF YHPSNNGRWL
360 370 380 390 400
NKLMKLLQRL PNSVVRRLHR ERYKKPSWLT PVPDSHKLTD QDVTDFVQCI
410 420 430 440 450
IQPVLLAMFS KTGSLEAAQA LQNLALMRPE LVIPPVLERT YPALETLTEP
460 470 480 490 500
HQLTATLSCV IGVARSLVSG GRWFPEGPTH MLPLLMRALP GVDPNDFSKC
510 520 530 540 550
MITFQFIATF STLVPLVDCS SVLQERNDLT EVERELCSAT AEFEDFVLQF
560 570 580 590 600
MDRCFGLIES STLEQTREET ETEKMTHLES LVELGLSSTF STILTQCSKE
610 620 630 640 650
IFMVALQKVF NFSTSHIFET RVAGRMVADM CRAAVKCCPE ESLKLFVPHC
660 670 680 690 700
CSVITQLTMN DDVLNDEELD KELLWNLQLL SEITRVDGRK LLLYREQLVK
710 720 730 740 750
ILQRTLHLTC KQGYTLSCNL LHHLLRSTTL IYPTEYCSVP GGFDKPPSEY
760 770 780 790 800
FPIKDWGKPG DLWNLGIQWH VPSSEEVSFA FYLLDSFLQP ELVKLQHCGD
810 820 830 840 850
GKLEMSRDDI LQSLTIVHNC LIGSGNLLPP LKGEPVTNLV PSMVSLEETK
860 870 880 890 900
LYTGLEYDLS RENHREVIAT VIRKLLNHIL DNSEDDTKSL FLIIKIIGDL
910 920 930 940 950
LQFQGSHKHE FDSRWKSFNL VKKSMENRLH GKKQHIRALL IDRVMLQHEL
960 970 980 990 1000
RTLTVEGCEY KKIHQDMIRD LLRLSTSSYS QVRNKAQQTF FAALGAYNFC
1010 1020 1030 1040 1050
CRDIIPLVLE FLRPDRQGVT QQQFKGALYC LLGNHSGVCL ANLHDWDCIV
1060 1070 1080 1090 1100
QTWPAIVSSG LSQAMSLEKP SIVRLFDDLA EKIHRQYETI GLDFTIPKSC
1110 1120 1130 1140 1150
VEIAELLQQS KNPSINQILL SPEKIKEGIK RQQEKNADAL RNYENLVDTL
1160 1170 1180 1190 1200
LDGVEQRNLP WKFEHIGIGL LSLLLRDDRV LPLRAIRFFV ENLNHDAIVV
1210 1220 1230 1240 1250
RKMAISAVAG ILKQLKRTHK KLTINPCEIS GCPKPTQIIA GDRPDNHWLH
1260 1270 1280 1290 1300
YDSKTIPRTK KEWESSCFVE KTHWGYYTWP KNMVVYAGVE EQPKLGRSRE
1310 1320 1330 1340 1350
DMTEAEQIIF DHFSDPKFVE QLITFLSLED RKGKDKFNPR RFCLFKGIFR
1360 1370 1380 1390 1400
NFDDAFLPVL KPHLEHLVAD SHESTQRCVA EIIAGLIRGS KHWTFEKVEK
1410 1420 1430 1440 1450
LWELLCPLLR TALSNITVET YNDWGACIAT SCESRDPRKL HWLFELLLES
1460 1470 1480 1490 1500
PLSGEGGSFV DACRLYVLQG GLAQQEWRVP ELLHRLLKYL EPKLTQVYKN
1510 1520 1530 1540 1550
VRERIGSVLT YIFMIDVSLP NTTPTISPHV PEFTARILEK LKPLMDVDEE
1560 1570 1580 1590 1600
IQNHVMEENG IGEEDERTQG IKLLKTILKW LMASAGRSFS TAVTEQLQLL
1610 1620 1630 1640 1650
PLFFKIAPVE NDNSYDELKR DAKLCLSLMS QGLLYPHQVP LVLQVLKQTA
1660 1670 1680 1690 1700
RSSSWHARYT VLTYLQTMVF YNLFIFLNNE DAVKDIRWLV ISLLEDEQLE
1710 1720 1730 1740 1750
VREMAATTLS GLLQCNFLTM DSPMQIHFEQ LCKTKLPKKR KRDPGSVGDT
1760 1770 1780 1790 1800
IPSAELVKRH AGVLGLGACV LSSPYDVPTW MPQLLMNLSA HLNDPQPIEM
1810 1820 1830 1840
TVKKTLSNFR RTHHDNWQEH KQQFTDDQLL VLTDLLVSPC YYA
Length:1,843
Mass (Da):211,334
Last modified:March 20, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2D2C3A594E4FA4E7
GO
Isoform 2 (identifier: Q14997-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-625: Missing.

Show »
Length:1,218
Mass (Da):139,963
Checksum:i1ABE87B5DCED3915
GO
Isoform 3 (identifier: Q14997-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-856: Missing.
     857-871: YDLSRENHREVIATV → MGENLAKKIMFFLLI

Show »
Length:987
Mass (Da):113,757
Checksum:i38486C4A85C31995
GO
Isoform 4 (identifier: Q14997-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1628: Missing.

Show »
Length:215
Mass (Da):24,699
Checksum:i035FA5A26BF4457F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WBH5F8WBH5_HUMAN
Proteasome activator complex subuni...
PSME4
571Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI12170 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI13669 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti217F → V in AAX83871 (Ref. 1) Curated1
Sequence conflicti710C → R in AAX83871 (Ref. 1) Curated1
Sequence conflicti984N → S in AAX83871 (Ref. 1) Curated1
Sequence conflicti1401L → F in AAH43602 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_031189872I → V. Corresponds to variant dbSNP:rs2302878Ensembl.1
Natural variantiVAR_0311901371S → T. Corresponds to variant dbSNP:rs805408Ensembl.1
Natural variantiVAR_0597551825T → A. Corresponds to variant dbSNP:rs35903236Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0238761 – 1628Missing in isoform 4. 1 PublicationAdd BLAST1628
Alternative sequenceiVSP_0238771 – 856Missing in isoform 3. 1 PublicationAdd BLAST856
Alternative sequenceiVSP_0238781 – 625Missing in isoform 2. 1 PublicationAdd BLAST625
Alternative sequenceiVSP_023879857 – 871YDLSR…VIATV → MGENLAKKIMFFLLI in isoform 3. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY894754 mRNA Translation: AAX83869.1
AY894755 mRNA Translation: AAX83870.1
AY894756 mRNA Translation: AAX83871.1
BC043602 mRNA Translation: AAH43602.1
BC071768 mRNA Translation: AAH71768.1
BC112169 mRNA Translation: AAI12170.1 Different initiation.
BC113668 mRNA Translation: AAI13669.1 Different initiation.
D38521 mRNA Translation: BAA07526.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33197.2 [Q14997-1]

NCBI Reference Sequences

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RefSeqi
NP_055429.2, NM_014614.2 [Q14997-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000404125; ENSP00000384211; ENSG00000068878 [Q14997-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23198

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23198

UCSC genome browser

More...
UCSCi
uc002rxp.2 human [Q14997-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY894754 mRNA Translation: AAX83869.1
AY894755 mRNA Translation: AAX83870.1
AY894756 mRNA Translation: AAX83871.1
BC043602 mRNA Translation: AAH43602.1
BC071768 mRNA Translation: AAH71768.1
BC112169 mRNA Translation: AAI12170.1 Different initiation.
BC113668 mRNA Translation: AAI13669.1 Different initiation.
D38521 mRNA Translation: BAA07526.1
CCDSiCCDS33197.2 [Q14997-1]
RefSeqiNP_055429.2, NM_014614.2 [Q14997-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6REYelectron microscopy3.00c/d1-1843[»]
SMRiQ14997
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi116807, 48 interactors
DIPiDIP-38203N
IntActiQ14997, 30 interactors
MINTiQ14997
STRINGi9606.ENSP00000384211

PTM databases

iPTMnetiQ14997
PhosphoSitePlusiQ14997

Polymorphism and mutation databases

BioMutaiPSME4
DMDMi134034993

Proteomic databases

EPDiQ14997
jPOSTiQ14997
MassIVEiQ14997
MaxQBiQ14997
PaxDbiQ14997
PeptideAtlasiQ14997
PRIDEiQ14997
ProteomicsDBi60286 [Q14997-1]
60287 [Q14997-2]
60288 [Q14997-3]
60289 [Q14997-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
30226 100 antibodies

Genome annotation databases

EnsembliENST00000404125; ENSP00000384211; ENSG00000068878 [Q14997-1]
GeneIDi23198
KEGGihsa:23198
UCSCiuc002rxp.2 human [Q14997-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23198
DisGeNETi23198
EuPathDBiHostDB:ENSG00000068878.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PSME4
HGNCiHGNC:20635 PSME4
HPAiENSG00000068878 Tissue enhanced (skeletal)
MIMi607705 gene
neXtProtiNX_Q14997
OpenTargetsiENSG00000068878
PharmGKBiPA134872587

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1851 Eukaryota
ENOG410XP7J LUCA
GeneTreeiENSGT00390000011433
HOGENOMiCLU_000772_2_0_1
InParanoidiQ14997
KOiK06699
OMAiGKDWSDE
OrthoDBi83617at2759
PhylomeDBiQ14997
TreeFamiTF106237

Enzyme and pathway databases

ReactomeiR-HSA-1169091 Activation of NF-kappaB in B cells
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-HSA-1236974 ER-Phagosome pathway
R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-HSA-180534 Vpu mediated degradation of CD4
R-HSA-180585 Vif-mediated degradation of APOBEC3G
R-HSA-195253 Degradation of beta-catenin by the destruction complex
R-HSA-202424 Downstream TCR signaling
R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1
R-HSA-350562 Regulation of ornithine decarboxylase (ODC)
R-HSA-382556 ABC-family proteins mediated transport
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-HSA-4608870 Asymmetric localization of PCP proteins
R-HSA-4641257 Degradation of AXIN
R-HSA-4641258 Degradation of DVL
R-HSA-5358346 Hedgehog ligand biogenesis
R-HSA-5362768 Hh mutants that don't undergo autocatalytic processing are degraded by ERAD
R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-HSA-5607764 CLEC7A (Dectin-1) signaling
R-HSA-5610780 Degradation of GLI1 by the proteasome
R-HSA-5610783 Degradation of GLI2 by the proteasome
R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome
R-HSA-5632684 Hedgehog 'on' state
R-HSA-5658442 Regulation of RAS by GAPs
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway
R-HSA-5676590 NIK-->noncanonical NF-kB signaling
R-HSA-5678895 Defective CFTR causes cystic fibrosis
R-HSA-5687128 MAPK6/MAPK4 signaling
R-HSA-5689603 UCH proteinases
R-HSA-5689880 Ub-specific processing proteases
R-HSA-68827 CDT1 association with the CDC6:ORC:origin complex
R-HSA-68949 Orc1 removal from chromatin
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6
R-HSA-69481 G2/M Checkpoints
R-HSA-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-HSA-75815 Ubiquitin-dependent degradation of Cyclin D
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint
R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-HSA-8939902 Regulation of RUNX2 expression and activity
R-HSA-8948751 Regulation of PTEN stability and activity
R-HSA-8951664 Neddylation
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-9020702 Interleukin-1 signaling
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
23198 6 hits in 790 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PSME4 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PSME4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23198
PharosiQ14997 Tdark

Protein Ontology

More...
PROi
PR:Q14997
RNActiQ14997 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000068878 Expressed in epithelium of mammary gland and 234 other tissues
ExpressionAtlasiQ14997 baseline and differential
GenevisibleiQ14997 HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR032430 Blm10_mid
IPR035309 PSME4
IPR021843 PSME4_C
PANTHERiPTHR32170 PTHR32170, 1 hit
PfamiView protein in Pfam
PF16507 BLM10_mid, 1 hit
PF11919 DUF3437, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPSME4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14997
Secondary accession number(s): Q1XBG4
, Q1XBG5, Q1XBG6, Q2M1Z0, Q6IPR2, Q86XF8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: June 17, 2020
This is version 152 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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