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UniProtKB - Q14997 (PSME4_HUMAN)

Protein

Proteasome activator complex subunit 4

Gene

PSME4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks.4 Publications

GO - Molecular functioni

  • lysine-acetylated histone binding Source: UniProtKB
  • peptidase activator activity Source: UniProtKB
  • proteasome binding Source: GO_Central
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, DNA damage, DNA repair, Spermatogenesis

Enzyme and pathway databases

ReactomeiR-HSA-1169091 Activation of NF-kappaB in B cells
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-HSA-1236974 ER-Phagosome pathway
R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-HSA-180534 Vpu mediated degradation of CD4
R-HSA-180585 Vif-mediated degradation of APOBEC3G
R-HSA-195253 Degradation of beta-catenin by the destruction complex
R-HSA-202424 Downstream TCR signaling
R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1
R-HSA-350562 Regulation of ornithine decarboxylase (ODC)
R-HSA-382556 ABC-family proteins mediated transport
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-HSA-4608870 Asymmetric localization of PCP proteins
R-HSA-4641257 Degradation of AXIN
R-HSA-4641258 Degradation of DVL
R-HSA-5358346 Hedgehog ligand biogenesis
R-HSA-5362768 Hh mutants that don't undergo autocatalytic processing are degraded by ERAD
R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-HSA-5607764 CLEC7A (Dectin-1) signaling
R-HSA-5610780 Degradation of GLI1 by the proteasome
R-HSA-5610783 Degradation of GLI2 by the proteasome
R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome
R-HSA-5632684 Hedgehog 'on' state
R-HSA-5658442 Regulation of RAS by GAPs
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway
R-HSA-5676590 NIK-->noncanonical NF-kB signaling
R-HSA-5678895 Defective CFTR causes cystic fibrosis
R-HSA-5687128 MAPK6/MAPK4 signaling
R-HSA-5689603 UCH proteinases
R-HSA-5689880 Ub-specific processing proteases
R-HSA-68827 CDT1 association with the CDC6:ORC:origin complex
R-HSA-68949 Orc1 removal from chromatin
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6
R-HSA-69229 Ubiquitin-dependent degradation of Cyclin D1
R-HSA-69481 G2/M Checkpoints
R-HSA-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint
R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-HSA-8939902 Regulation of RUNX2 expression and activity
R-HSA-8948751 Regulation of PTEN stability and activity
R-HSA-8951664 Neddylation
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-9020702 Interleukin-1 signaling
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome activator complex subunit 4
Alternative name(s):
Proteasome activator PA200
Gene namesi
Name:PSME4
Synonyms:KIAA0077
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000068878.14
HGNCiHGNC:20635 PSME4
MIMi607705 gene
neXtProtiNX_Q14997

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi1716 – 1717NF → TS: Abolihes binding to acetylated histones. 1 Publication2

Organism-specific databases

DisGeNETi23198
OpenTargetsiENSG00000068878
PharmGKBiPA134872587

Polymorphism and mutation databases

BioMutaiPSME4
DMDMi134034993

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002807181 – 1843Proteasome activator complex subunit 4Add BLAST1843

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1121PhosphoserineCombined sources1
Modified residuei1614PhosphoserineCombined sources1
Modified residuei1746PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ14997
MaxQBiQ14997
PaxDbiQ14997
PeptideAtlasiQ14997
PRIDEiQ14997
ProteomicsDBi60286
60287 [Q14997-2]
60288 [Q14997-3]
60289 [Q14997-4]

PTM databases

iPTMnetiQ14997
PhosphoSitePlusiQ14997

Expressioni

Gene expression databases

BgeeiENSG00000068878 Expressed in 235 organ(s), highest expression level in epithelium of mammary gland
CleanExiHS_PSME4
ExpressionAtlasiQ14997 baseline and differential
GenevisibleiQ14997 HS

Organism-specific databases

HPAiHPA060922

Interactioni

Subunit structurei

Homodimer. Interacts with the 20S and 26S proteasomes. Component of the spermatoproteasome, a form of the proteasome specifically found in testis.1 Publication

Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi116807, 45 interactors
DIPiDIP-38203N
IntActiQ14997, 17 interactors
MINTiQ14997
STRINGi9606.ENSP00000384211

Structurei

3D structure databases

ProteinModelPortaliQ14997
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati475 – 519HEAT 1Add BLAST45
Repeati998 – 1037HEAT 2Add BLAST40
Repeati1179 – 1217HEAT 3Add BLAST39
Repeati1354 – 1392HEAT 4Add BLAST39
Repeati1636 – 1674HEAT 5Add BLAST39
Repeati1680 – 1718HEAT 6Add BLAST39

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1650 – 1738Bromodomain-like (BRDL)Add BLAST89

Domaini

The bromodomain-like (BRDL) region specifically recognizes and binds acetylated histones.1 Publication

Sequence similaritiesi

Belongs to the BLM10 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1851 Eukaryota
ENOG410XP7J LUCA
GeneTreeiENSGT00390000011433
HOVERGENiHBG082223
InParanoidiQ14997
KOiK06699
OMAiRFASMFM
OrthoDBiEOG091G0DWV
PhylomeDBiQ14997
TreeFamiTF106237

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR032430 Blm10_mid
IPR035309 PSME4
IPR021843 PSME4_C
PANTHERiPTHR32170 PTHR32170, 1 hit
PfamiView protein in Pfam
PF16507 BLM10_mid, 1 hit
PF11919 DUF3437, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q14997-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPAERAGVG EPPEPGGRPE PGPRGFVPQK EIVYNKLLPY AERLDAESDL 
        60         70         80         90        100
QLAQIKCNLG RAVQLQELWP GGLFWTRKLS TYIRLYGRKF SKEDHVLFIK 
       110        120        130        140        150
LLYELVSIPK LEISMMQGFA RLLINLLKKK ELLSRADLEL PWRPLYDMVE 
       160        170        180        190        200
RILYSKTEHL GLNWFPNSVE NILKTLVKSC RPYFPADATA EMLEEWRPLM 
       210        220        230        240        250
CPFDVTMQKA ITYFEIFLPT SLPPELHHKG FKLWFDELIG LWVSVQNLPQ 
       260        270        280        290        300
WEGQLVNLFA RLATDNIGYI DWDPYVPKIF TRILRSLNLP VGSSQVLVPR 
       310        320        330        340        350
FLTNAYDIGH AVIWITAMMG GPSKLVQKHL AGLFNSITSF YHPSNNGRWL 
       360        370        380        390        400
NKLMKLLQRL PNSVVRRLHR ERYKKPSWLT PVPDSHKLTD QDVTDFVQCI 
       410        420        430        440        450
IQPVLLAMFS KTGSLEAAQA LQNLALMRPE LVIPPVLERT YPALETLTEP 
       460        470        480        490        500
HQLTATLSCV IGVARSLVSG GRWFPEGPTH MLPLLMRALP GVDPNDFSKC 
       510        520        530        540        550
MITFQFIATF STLVPLVDCS SVLQERNDLT EVERELCSAT AEFEDFVLQF 
       560        570        580        590        600
MDRCFGLIES STLEQTREET ETEKMTHLES LVELGLSSTF STILTQCSKE 
       610        620        630        640        650
IFMVALQKVF NFSTSHIFET RVAGRMVADM CRAAVKCCPE ESLKLFVPHC 
       660        670        680        690        700
CSVITQLTMN DDVLNDEELD KELLWNLQLL SEITRVDGRK LLLYREQLVK 
       710        720        730        740        750
ILQRTLHLTC KQGYTLSCNL LHHLLRSTTL IYPTEYCSVP GGFDKPPSEY 
       760        770        780        790        800
FPIKDWGKPG DLWNLGIQWH VPSSEEVSFA FYLLDSFLQP ELVKLQHCGD 
       810        820        830        840        850
GKLEMSRDDI LQSLTIVHNC LIGSGNLLPP LKGEPVTNLV PSMVSLEETK 
       860        870        880        890        900
LYTGLEYDLS RENHREVIAT VIRKLLNHIL DNSEDDTKSL FLIIKIIGDL 
       910        920        930        940        950
LQFQGSHKHE FDSRWKSFNL VKKSMENRLH GKKQHIRALL IDRVMLQHEL 
       960        970        980        990       1000
RTLTVEGCEY KKIHQDMIRD LLRLSTSSYS QVRNKAQQTF FAALGAYNFC 
      1010       1020       1030       1040       1050
CRDIIPLVLE FLRPDRQGVT QQQFKGALYC LLGNHSGVCL ANLHDWDCIV 
      1060       1070       1080       1090       1100
QTWPAIVSSG LSQAMSLEKP SIVRLFDDLA EKIHRQYETI GLDFTIPKSC 
      1110       1120       1130       1140       1150
VEIAELLQQS KNPSINQILL SPEKIKEGIK RQQEKNADAL RNYENLVDTL 
      1160       1170       1180       1190       1200
LDGVEQRNLP WKFEHIGIGL LSLLLRDDRV LPLRAIRFFV ENLNHDAIVV 
      1210       1220       1230       1240       1250
RKMAISAVAG ILKQLKRTHK KLTINPCEIS GCPKPTQIIA GDRPDNHWLH 
      1260       1270       1280       1290       1300
YDSKTIPRTK KEWESSCFVE KTHWGYYTWP KNMVVYAGVE EQPKLGRSRE 
      1310       1320       1330       1340       1350
DMTEAEQIIF DHFSDPKFVE QLITFLSLED RKGKDKFNPR RFCLFKGIFR 
      1360       1370       1380       1390       1400
NFDDAFLPVL KPHLEHLVAD SHESTQRCVA EIIAGLIRGS KHWTFEKVEK 
      1410       1420       1430       1440       1450
LWELLCPLLR TALSNITVET YNDWGACIAT SCESRDPRKL HWLFELLLES 
      1460       1470       1480       1490       1500
PLSGEGGSFV DACRLYVLQG GLAQQEWRVP ELLHRLLKYL EPKLTQVYKN 
      1510       1520       1530       1540       1550
VRERIGSVLT YIFMIDVSLP NTTPTISPHV PEFTARILEK LKPLMDVDEE 
      1560       1570       1580       1590       1600
IQNHVMEENG IGEEDERTQG IKLLKTILKW LMASAGRSFS TAVTEQLQLL 
      1610       1620       1630       1640       1650
PLFFKIAPVE NDNSYDELKR DAKLCLSLMS QGLLYPHQVP LVLQVLKQTA 
      1660       1670       1680       1690       1700
RSSSWHARYT VLTYLQTMVF YNLFIFLNNE DAVKDIRWLV ISLLEDEQLE 
      1710       1720       1730       1740       1750
VREMAATTLS GLLQCNFLTM DSPMQIHFEQ LCKTKLPKKR KRDPGSVGDT 
      1760       1770       1780       1790       1800
IPSAELVKRH AGVLGLGACV LSSPYDVPTW MPQLLMNLSA HLNDPQPIEM 
      1810       1820       1830       1840 
TVKKTLSNFR RTHHDNWQEH KQQFTDDQLL VLTDLLVSPC YYA
Length:1,843
Mass (Da):211,334
Last modified:March 20, 2007 - v2
Checksum:i2D2C3A594E4FA4E7
GO
Isoform 2 (identifier: Q14997-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-625: Missing.

Show »
Length:1,218
Mass (Da):139,963
Checksum:i1ABE87B5DCED3915
GO
Isoform 3 (identifier: Q14997-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-856: Missing.
     857-871: YDLSRENHREVIATV → MGENLAKKIMFFLLI

Show »
Length:987
Mass (Da):113,757
Checksum:i38486C4A85C31995
GO
Isoform 4 (identifier: Q14997-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1628: Missing.

Note: No experimental confirmation available.
Show »
Length:215
Mass (Da):24,699
Checksum:i035FA5A26BF4457F
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WBH5F8WBH5_HUMAN
Proteasome activator complex subuni...
PSME4
571Annotation score:

Sequence cautioni

The sequence AAI12170 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI13669 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti217F → V in AAX83871 (Ref. 1) Curated1
Sequence conflicti710C → R in AAX83871 (Ref. 1) Curated1
Sequence conflicti984N → S in AAX83871 (Ref. 1) Curated1
Sequence conflicti1401L → F in AAH43602 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031189872I → V. Corresponds to variant dbSNP:rs2302878Ensembl.1
Natural variantiVAR_0311901371S → T. Corresponds to variant dbSNP:rs805408Ensembl.1
Natural variantiVAR_0597551825T → A. Corresponds to variant dbSNP:rs35903236Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0238761 – 1628Missing in isoform 4. 1 PublicationAdd BLAST1628
Alternative sequenceiVSP_0238771 – 856Missing in isoform 3. 1 PublicationAdd BLAST856
Alternative sequenceiVSP_0238781 – 625Missing in isoform 2. 1 PublicationAdd BLAST625
Alternative sequenceiVSP_023879857 – 871YDLSR…VIATV → MGENLAKKIMFFLLI in isoform 3. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY894754 mRNA Translation: AAX83869.1
AY894755 mRNA Translation: AAX83870.1
AY894756 mRNA Translation: AAX83871.1
BC043602 mRNA Translation: AAH43602.1
BC071768 mRNA Translation: AAH71768.1
BC112169 mRNA Translation: AAI12170.1 Different initiation.
BC113668 mRNA Translation: AAI13669.1 Different initiation.
D38521 mRNA Translation: BAA07526.1
CCDSiCCDS33197.2 [Q14997-1]
RefSeqiNP_055429.2, NM_014614.2 [Q14997-1]
UniGeneiHs.413801

Genome annotation databases

EnsembliENST00000404125; ENSP00000384211; ENSG00000068878 [Q14997-1]
GeneIDi23198
KEGGihsa:23198
UCSCiuc002rxp.2 human [Q14997-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY894754 mRNA Translation: AAX83869.1
AY894755 mRNA Translation: AAX83870.1
AY894756 mRNA Translation: AAX83871.1
BC043602 mRNA Translation: AAH43602.1
BC071768 mRNA Translation: AAH71768.1
BC112169 mRNA Translation: AAI12170.1 Different initiation.
BC113668 mRNA Translation: AAI13669.1 Different initiation.
D38521 mRNA Translation: BAA07526.1
CCDSiCCDS33197.2 [Q14997-1]
RefSeqiNP_055429.2, NM_014614.2 [Q14997-1]
UniGeneiHs.413801

3D structure databases

ProteinModelPortaliQ14997
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116807, 45 interactors
DIPiDIP-38203N
IntActiQ14997, 17 interactors
MINTiQ14997
STRINGi9606.ENSP00000384211

PTM databases

iPTMnetiQ14997
PhosphoSitePlusiQ14997

Polymorphism and mutation databases

BioMutaiPSME4
DMDMi134034993

Proteomic databases

EPDiQ14997
MaxQBiQ14997
PaxDbiQ14997
PeptideAtlasiQ14997
PRIDEiQ14997
ProteomicsDBi60286
60287 [Q14997-2]
60288 [Q14997-3]
60289 [Q14997-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000404125; ENSP00000384211; ENSG00000068878 [Q14997-1]
GeneIDi23198
KEGGihsa:23198
UCSCiuc002rxp.2 human [Q14997-1]

Organism-specific databases

CTDi23198
DisGeNETi23198
EuPathDBiHostDB:ENSG00000068878.14
GeneCardsiPSME4
H-InvDBiHIX0200268
HGNCiHGNC:20635 PSME4
HPAiHPA060922
MIMi607705 gene
neXtProtiNX_Q14997
OpenTargetsiENSG00000068878
PharmGKBiPA134872587
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1851 Eukaryota
ENOG410XP7J LUCA
GeneTreeiENSGT00390000011433
HOVERGENiHBG082223
InParanoidiQ14997
KOiK06699
OMAiRFASMFM
OrthoDBiEOG091G0DWV
PhylomeDBiQ14997
TreeFamiTF106237

Enzyme and pathway databases

ReactomeiR-HSA-1169091 Activation of NF-kappaB in B cells
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-HSA-1236974 ER-Phagosome pathway
R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-HSA-180534 Vpu mediated degradation of CD4
R-HSA-180585 Vif-mediated degradation of APOBEC3G
R-HSA-195253 Degradation of beta-catenin by the destruction complex
R-HSA-202424 Downstream TCR signaling
R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1
R-HSA-350562 Regulation of ornithine decarboxylase (ODC)
R-HSA-382556 ABC-family proteins mediated transport
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-HSA-4608870 Asymmetric localization of PCP proteins
R-HSA-4641257 Degradation of AXIN
R-HSA-4641258 Degradation of DVL
R-HSA-5358346 Hedgehog ligand biogenesis
R-HSA-5362768 Hh mutants that don't undergo autocatalytic processing are degraded by ERAD
R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-HSA-5607764 CLEC7A (Dectin-1) signaling
R-HSA-5610780 Degradation of GLI1 by the proteasome
R-HSA-5610783 Degradation of GLI2 by the proteasome
R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome
R-HSA-5632684 Hedgehog 'on' state
R-HSA-5658442 Regulation of RAS by GAPs
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway
R-HSA-5676590 NIK-->noncanonical NF-kB signaling
R-HSA-5678895 Defective CFTR causes cystic fibrosis
R-HSA-5687128 MAPK6/MAPK4 signaling
R-HSA-5689603 UCH proteinases
R-HSA-5689880 Ub-specific processing proteases
R-HSA-68827 CDT1 association with the CDC6:ORC:origin complex
R-HSA-68949 Orc1 removal from chromatin
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6
R-HSA-69229 Ubiquitin-dependent degradation of Cyclin D1
R-HSA-69481 G2/M Checkpoints
R-HSA-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint
R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-HSA-8939902 Regulation of RUNX2 expression and activity
R-HSA-8948751 Regulation of PTEN stability and activity
R-HSA-8951664 Neddylation
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-9020702 Interleukin-1 signaling
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRSiPSME4 human
GeneWikiiPSME4
GenomeRNAii23198
PROiPR:Q14997
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000068878 Expressed in 235 organ(s), highest expression level in epithelium of mammary gland
CleanExiHS_PSME4
ExpressionAtlasiQ14997 baseline and differential
GenevisibleiQ14997 HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR032430 Blm10_mid
IPR035309 PSME4
IPR021843 PSME4_C
PANTHERiPTHR32170 PTHR32170, 1 hit
PfamiView protein in Pfam
PF16507 BLM10_mid, 1 hit
PF11919 DUF3437, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPSME4_HUMAN
AccessioniPrimary (citable) accession number: Q14997
Secondary accession number(s): Q1XBG4
, Q1XBG5, Q1XBG6, Q2M1Z0, Q6IPR2, Q86XF8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: November 7, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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