UniProtKB - Q14997 (PSME4_HUMAN)
Proteasome activator complex subunit 4
PSME4
Functioni
Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks.
4 PublicationsGO - Molecular functioni
- lysine-acetylated histone binding Source: UniProtKB
- peptidase activator activity Source: UniProtKB
- proteasome binding Source: GO_Central
GO - Biological processi
- cellular response to DNA damage stimulus Source: UniProtKB
- DNA repair Source: UniProtKB
- proteasomal ubiquitin-independent protein catabolic process Source: UniProtKB
- spermatogenesis, exchange of chromosomal proteins Source: UniProtKB
Keywordsi
Molecular function | Developmental protein |
Biological process | Differentiation, DNA damage, DNA repair, Spermatogenesis |
Enzyme and pathway databases
PathwayCommonsi | Q14997 |
Reactomei | R-HSA-1169091, Activation of NF-kappaB in B cells R-HSA-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1236974, ER-Phagosome pathway R-HSA-1236978, Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-174113, SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174154, APC/C:Cdc20 mediated degradation of Securin R-HSA-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-180534, Vpu mediated degradation of CD4 R-HSA-180585, Vif-mediated degradation of APOBEC3G R-HSA-195253, Degradation of beta-catenin by the destruction complex R-HSA-202424, Downstream TCR signaling R-HSA-211733, Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-2467813, Separation of Sister Chromatids R-HSA-2871837, FCERI mediated NF-kB activation R-HSA-349425, Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-350562, Regulation of ornithine decarboxylase (ODC) R-HSA-382556, ABC-family proteins mediated transport R-HSA-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-4608870, Asymmetric localization of PCP proteins R-HSA-4641257, Degradation of AXIN R-HSA-4641258, Degradation of DVL R-HSA-5358346, Hedgehog ligand biogenesis R-HSA-5362768, Hh mutants are degraded by ERAD R-HSA-5607761, Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607764, CLEC7A (Dectin-1) signaling R-HSA-5610780, Degradation of GLI1 by the proteasome R-HSA-5610783, Degradation of GLI2 by the proteasome R-HSA-5610785, GLI3 is processed to GLI3R by the proteasome R-HSA-5632684, Hedgehog 'on' state R-HSA-5658442, Regulation of RAS by GAPs R-HSA-5668541, TNFR2 non-canonical NF-kB pathway R-HSA-5676590, NIK-->noncanonical NF-kB signaling R-HSA-5678895, Defective CFTR causes cystic fibrosis R-HSA-5687128, MAPK6/MAPK4 signaling R-HSA-5689603, UCH proteinases R-HSA-5689880, Ub-specific processing proteases R-HSA-68827, CDT1 association with the CDC6:ORC:origin complex R-HSA-68949, Orc1 removal from chromatin R-HSA-69017, CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69481, G2/M Checkpoints R-HSA-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-75815, Ubiquitin-dependent degradation of Cyclin D R-HSA-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8932339, ROS sensing by NFE2L2 R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939902, Regulation of RUNX2 expression and activity R-HSA-8948751, Regulation of PTEN stability and activity R-HSA-8951664, Neddylation R-HSA-9010553, Regulation of expression of SLITs and ROBOs R-HSA-9020702, Interleukin-1 signaling R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
SignaLinki | Q14997 |
Names & Taxonomyi
Protein namesi | Recommended name: Proteasome activator complex subunit 4Alternative name(s): Proteasome activator PA200 |
Gene namesi | Name:PSME4 Synonyms:KIAA0077 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20635, PSME4 |
MIMi | 607705, gene |
neXtProti | NX_Q14997 |
VEuPathDBi | HostDB:ENSG00000068878 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
- Nucleus speckle By similarity
Cytoplasm and Cytosol
- cytosol By similarity
Note: Found in nuclear foci following treatment with ionizing radiation, but not with ultraviolet irradiation or H2O2.
Cytosol
- cytosol Source: UniProtKB
Nucleus
- nuclear speck Source: UniProtKB-SubCell
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- spermatoproteasome complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Nucleus, ProteasomePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 1716 – 1717 | NF → TS: Abolihes binding to acetylated histones. 1 Publication | 2 |
Organism-specific databases
DisGeNETi | 23198 |
OpenTargetsi | ENSG00000068878 |
PharmGKBi | PA134872587 |
Miscellaneous databases
Pharosi | Q14997, Tbio |
Genetic variation databases
BioMutai | PSME4 |
DMDMi | 134034993 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000280718 | 1 – 1843 | Proteasome activator complex subunit 4Add BLAST | 1843 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1121 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1614 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1746 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q14997 |
jPOSTi | Q14997 |
MassIVEi | Q14997 |
MaxQBi | Q14997 |
PaxDbi | Q14997 |
PeptideAtlasi | Q14997 |
PRIDEi | Q14997 |
ProteomicsDBi | 60286 [Q14997-1] 60287 [Q14997-2] 60288 [Q14997-3] 60289 [Q14997-4] |
PTM databases
GlyGeni | Q14997, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q14997 |
PhosphoSitePlusi | Q14997 |
Expressioni
Gene expression databases
Bgeei | ENSG00000068878, Expressed in epithelium of mammary gland and 246 other tissues |
ExpressionAtlasi | Q14997, baseline and differential |
Genevisiblei | Q14997, HS |
Organism-specific databases
HPAi | ENSG00000068878, Tissue enhanced (skeletal) |
Interactioni
Subunit structurei
Homodimer.
Interacts with the 20S and 26S proteasomes.
Component of the spermatoproteasome, a form of the proteasome specifically found in testis.
1 PublicationBinary interactionsi
Q14997
With | #Exp. | IntAct |
---|---|---|
CALCOCO2 [Q13137] | 3 | EBI-1236916,EBI-739580 |
NUTM1 [Q86Y26] | 3 | EBI-1236916,EBI-10178410 |
GO - Molecular functioni
- lysine-acetylated histone binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 116807, 64 interactors |
DIPi | DIP-38203N |
IntActi | Q14997, 32 interactors |
MINTi | Q14997 |
STRINGi | 9606.ENSP00000384211 |
Miscellaneous databases
RNActi | Q14997, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q14997 |
SMRi | Q14997 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 475 – 519 | HEAT 1Add BLAST | 45 | |
Repeati | 998 – 1037 | HEAT 2Add BLAST | 40 | |
Repeati | 1179 – 1217 | HEAT 3Add BLAST | 39 | |
Repeati | 1354 – 1392 | HEAT 4Add BLAST | 39 | |
Repeati | 1636 – 1674 | HEAT 5Add BLAST | 39 | |
Repeati | 1680 – 1718 | HEAT 6Add BLAST | 39 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 25 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 1650 – 1738 | Bromodomain-like (BRDL)Add BLAST | 89 |
Domaini
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG1851, Eukaryota |
GeneTreei | ENSGT00390000011433 |
HOGENOMi | CLU_000772_2_0_1 |
InParanoidi | Q14997 |
OMAi | GKDWSDE |
OrthoDBi | 83617at2759 |
PhylomeDBi | Q14997 |
TreeFami | TF106237 |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR032430, Blm10_mid IPR035309, PSME4 IPR021843, PSME4_C |
PANTHERi | PTHR32170, PTHR32170, 1 hit |
Pfami | View protein in Pfam PF16507, BLM10_mid, 1 hit PF11919, DUF3437, 1 hit |
SUPFAMi | SSF48371, SSF48371, 2 hits |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEPAERAGVG EPPEPGGRPE PGPRGFVPQK EIVYNKLLPY AERLDAESDL
60 70 80 90 100
QLAQIKCNLG RAVQLQELWP GGLFWTRKLS TYIRLYGRKF SKEDHVLFIK
110 120 130 140 150
LLYELVSIPK LEISMMQGFA RLLINLLKKK ELLSRADLEL PWRPLYDMVE
160 170 180 190 200
RILYSKTEHL GLNWFPNSVE NILKTLVKSC RPYFPADATA EMLEEWRPLM
210 220 230 240 250
CPFDVTMQKA ITYFEIFLPT SLPPELHHKG FKLWFDELIG LWVSVQNLPQ
260 270 280 290 300
WEGQLVNLFA RLATDNIGYI DWDPYVPKIF TRILRSLNLP VGSSQVLVPR
310 320 330 340 350
FLTNAYDIGH AVIWITAMMG GPSKLVQKHL AGLFNSITSF YHPSNNGRWL
360 370 380 390 400
NKLMKLLQRL PNSVVRRLHR ERYKKPSWLT PVPDSHKLTD QDVTDFVQCI
410 420 430 440 450
IQPVLLAMFS KTGSLEAAQA LQNLALMRPE LVIPPVLERT YPALETLTEP
460 470 480 490 500
HQLTATLSCV IGVARSLVSG GRWFPEGPTH MLPLLMRALP GVDPNDFSKC
510 520 530 540 550
MITFQFIATF STLVPLVDCS SVLQERNDLT EVERELCSAT AEFEDFVLQF
560 570 580 590 600
MDRCFGLIES STLEQTREET ETEKMTHLES LVELGLSSTF STILTQCSKE
610 620 630 640 650
IFMVALQKVF NFSTSHIFET RVAGRMVADM CRAAVKCCPE ESLKLFVPHC
660 670 680 690 700
CSVITQLTMN DDVLNDEELD KELLWNLQLL SEITRVDGRK LLLYREQLVK
710 720 730 740 750
ILQRTLHLTC KQGYTLSCNL LHHLLRSTTL IYPTEYCSVP GGFDKPPSEY
760 770 780 790 800
FPIKDWGKPG DLWNLGIQWH VPSSEEVSFA FYLLDSFLQP ELVKLQHCGD
810 820 830 840 850
GKLEMSRDDI LQSLTIVHNC LIGSGNLLPP LKGEPVTNLV PSMVSLEETK
860 870 880 890 900
LYTGLEYDLS RENHREVIAT VIRKLLNHIL DNSEDDTKSL FLIIKIIGDL
910 920 930 940 950
LQFQGSHKHE FDSRWKSFNL VKKSMENRLH GKKQHIRALL IDRVMLQHEL
960 970 980 990 1000
RTLTVEGCEY KKIHQDMIRD LLRLSTSSYS QVRNKAQQTF FAALGAYNFC
1010 1020 1030 1040 1050
CRDIIPLVLE FLRPDRQGVT QQQFKGALYC LLGNHSGVCL ANLHDWDCIV
1060 1070 1080 1090 1100
QTWPAIVSSG LSQAMSLEKP SIVRLFDDLA EKIHRQYETI GLDFTIPKSC
1110 1120 1130 1140 1150
VEIAELLQQS KNPSINQILL SPEKIKEGIK RQQEKNADAL RNYENLVDTL
1160 1170 1180 1190 1200
LDGVEQRNLP WKFEHIGIGL LSLLLRDDRV LPLRAIRFFV ENLNHDAIVV
1210 1220 1230 1240 1250
RKMAISAVAG ILKQLKRTHK KLTINPCEIS GCPKPTQIIA GDRPDNHWLH
1260 1270 1280 1290 1300
YDSKTIPRTK KEWESSCFVE KTHWGYYTWP KNMVVYAGVE EQPKLGRSRE
1310 1320 1330 1340 1350
DMTEAEQIIF DHFSDPKFVE QLITFLSLED RKGKDKFNPR RFCLFKGIFR
1360 1370 1380 1390 1400
NFDDAFLPVL KPHLEHLVAD SHESTQRCVA EIIAGLIRGS KHWTFEKVEK
1410 1420 1430 1440 1450
LWELLCPLLR TALSNITVET YNDWGACIAT SCESRDPRKL HWLFELLLES
1460 1470 1480 1490 1500
PLSGEGGSFV DACRLYVLQG GLAQQEWRVP ELLHRLLKYL EPKLTQVYKN
1510 1520 1530 1540 1550
VRERIGSVLT YIFMIDVSLP NTTPTISPHV PEFTARILEK LKPLMDVDEE
1560 1570 1580 1590 1600
IQNHVMEENG IGEEDERTQG IKLLKTILKW LMASAGRSFS TAVTEQLQLL
1610 1620 1630 1640 1650
PLFFKIAPVE NDNSYDELKR DAKLCLSLMS QGLLYPHQVP LVLQVLKQTA
1660 1670 1680 1690 1700
RSSSWHARYT VLTYLQTMVF YNLFIFLNNE DAVKDIRWLV ISLLEDEQLE
1710 1720 1730 1740 1750
VREMAATTLS GLLQCNFLTM DSPMQIHFEQ LCKTKLPKKR KRDPGSVGDT
1760 1770 1780 1790 1800
IPSAELVKRH AGVLGLGACV LSSPYDVPTW MPQLLMNLSA HLNDPQPIEM
1810 1820 1830 1840
TVKKTLSNFR RTHHDNWQEH KQQFTDDQLL VLTDLLVSPC YYA
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF8WBH5 | F8WBH5_HUMAN | Proteasome activator complex subuni... | PSME4 | 571 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 217 | F → V in AAX83871 (Ref. 1) Curated | 1 | |
Sequence conflicti | 710 | C → R in AAX83871 (Ref. 1) Curated | 1 | |
Sequence conflicti | 984 | N → S in AAX83871 (Ref. 1) Curated | 1 | |
Sequence conflicti | 1401 | L → F in AAH43602 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_031189 | 872 | I → V. Corresponds to variant dbSNP:rs2302878Ensembl. | 1 | |
Natural variantiVAR_031190 | 1371 | S → T. Corresponds to variant dbSNP:rs805408Ensembl. | 1 | |
Natural variantiVAR_059755 | 1825 | T → A. Corresponds to variant dbSNP:rs35903236Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_023876 | 1 – 1628 | Missing in isoform 4. 1 PublicationAdd BLAST | 1628 | |
Alternative sequenceiVSP_023877 | 1 – 856 | Missing in isoform 3. 1 PublicationAdd BLAST | 856 | |
Alternative sequenceiVSP_023878 | 1 – 625 | Missing in isoform 2. 1 PublicationAdd BLAST | 625 | |
Alternative sequenceiVSP_023879 | 857 – 871 | YDLSR…VIATV → MGENLAKKIMFFLLI in isoform 3. 1 PublicationAdd BLAST | 15 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY894754 mRNA Translation: AAX83869.1 AY894755 mRNA Translation: AAX83870.1 AY894756 mRNA Translation: AAX83871.1 BC043602 mRNA Translation: AAH43602.1 BC071768 mRNA Translation: AAH71768.1 BC112169 mRNA Translation: AAI12170.1 Different initiation. BC113668 mRNA Translation: AAI13669.1 Different initiation. D38521 mRNA Translation: BAA07526.1 |
CCDSi | CCDS33197.2 [Q14997-1] |
RefSeqi | NP_055429.2, NM_014614.2 [Q14997-1] |
Genome annotation databases
Ensembli | ENST00000404125.6; ENSP00000384211.1; ENSG00000068878.15 |
GeneIDi | 23198 |
KEGGi | hsa:23198 |
MANE-Selecti | ENST00000404125.6; ENSP00000384211.1; NM_014614.3; NP_055429.2 |
UCSCi | uc002rxp.2, human [Q14997-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY894754 mRNA Translation: AAX83869.1 AY894755 mRNA Translation: AAX83870.1 AY894756 mRNA Translation: AAX83871.1 BC043602 mRNA Translation: AAH43602.1 BC071768 mRNA Translation: AAH71768.1 BC112169 mRNA Translation: AAI12170.1 Different initiation. BC113668 mRNA Translation: AAI13669.1 Different initiation. D38521 mRNA Translation: BAA07526.1 |
CCDSi | CCDS33197.2 [Q14997-1] |
RefSeqi | NP_055429.2, NM_014614.2 [Q14997-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6KWX | electron microscopy | 3.75 | A | 1-1843 | [»] | |
6KWY | electron microscopy | 2.72 | c | 1-1843 | [»] | |
6REY | electron microscopy | 3.00 | c/d | 1-1843 | [»] | |
AlphaFoldDBi | Q14997 | |||||
SMRi | Q14997 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 116807, 64 interactors |
DIPi | DIP-38203N |
IntActi | Q14997, 32 interactors |
MINTi | Q14997 |
STRINGi | 9606.ENSP00000384211 |
PTM databases
GlyGeni | Q14997, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q14997 |
PhosphoSitePlusi | Q14997 |
Genetic variation databases
BioMutai | PSME4 |
DMDMi | 134034993 |
Proteomic databases
EPDi | Q14997 |
jPOSTi | Q14997 |
MassIVEi | Q14997 |
MaxQBi | Q14997 |
PaxDbi | Q14997 |
PeptideAtlasi | Q14997 |
PRIDEi | Q14997 |
ProteomicsDBi | 60286 [Q14997-1] 60287 [Q14997-2] 60288 [Q14997-3] 60289 [Q14997-4] |
Protocols and materials databases
Antibodypediai | 30226, 110 antibodies from 23 providers |
DNASUi | 23198 |
Genome annotation databases
Ensembli | ENST00000404125.6; ENSP00000384211.1; ENSG00000068878.15 |
GeneIDi | 23198 |
KEGGi | hsa:23198 |
MANE-Selecti | ENST00000404125.6; ENSP00000384211.1; NM_014614.3; NP_055429.2 |
UCSCi | uc002rxp.2, human [Q14997-1] |
Organism-specific databases
CTDi | 23198 |
DisGeNETi | 23198 |
GeneCardsi | PSME4 |
HGNCi | HGNC:20635, PSME4 |
HPAi | ENSG00000068878, Tissue enhanced (skeletal) |
MIMi | 607705, gene |
neXtProti | NX_Q14997 |
OpenTargetsi | ENSG00000068878 |
PharmGKBi | PA134872587 |
VEuPathDBi | HostDB:ENSG00000068878 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1851, Eukaryota |
GeneTreei | ENSGT00390000011433 |
HOGENOMi | CLU_000772_2_0_1 |
InParanoidi | Q14997 |
OMAi | GKDWSDE |
OrthoDBi | 83617at2759 |
PhylomeDBi | Q14997 |
TreeFami | TF106237 |
Enzyme and pathway databases
PathwayCommonsi | Q14997 |
Reactomei | R-HSA-1169091, Activation of NF-kappaB in B cells R-HSA-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1236974, ER-Phagosome pathway R-HSA-1236978, Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-174113, SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174154, APC/C:Cdc20 mediated degradation of Securin R-HSA-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-180534, Vpu mediated degradation of CD4 R-HSA-180585, Vif-mediated degradation of APOBEC3G R-HSA-195253, Degradation of beta-catenin by the destruction complex R-HSA-202424, Downstream TCR signaling R-HSA-211733, Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-2467813, Separation of Sister Chromatids R-HSA-2871837, FCERI mediated NF-kB activation R-HSA-349425, Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-350562, Regulation of ornithine decarboxylase (ODC) R-HSA-382556, ABC-family proteins mediated transport R-HSA-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-4608870, Asymmetric localization of PCP proteins R-HSA-4641257, Degradation of AXIN R-HSA-4641258, Degradation of DVL R-HSA-5358346, Hedgehog ligand biogenesis R-HSA-5362768, Hh mutants are degraded by ERAD R-HSA-5607761, Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607764, CLEC7A (Dectin-1) signaling R-HSA-5610780, Degradation of GLI1 by the proteasome R-HSA-5610783, Degradation of GLI2 by the proteasome R-HSA-5610785, GLI3 is processed to GLI3R by the proteasome R-HSA-5632684, Hedgehog 'on' state R-HSA-5658442, Regulation of RAS by GAPs R-HSA-5668541, TNFR2 non-canonical NF-kB pathway R-HSA-5676590, NIK-->noncanonical NF-kB signaling R-HSA-5678895, Defective CFTR causes cystic fibrosis R-HSA-5687128, MAPK6/MAPK4 signaling R-HSA-5689603, UCH proteinases R-HSA-5689880, Ub-specific processing proteases R-HSA-68827, CDT1 association with the CDC6:ORC:origin complex R-HSA-68949, Orc1 removal from chromatin R-HSA-69017, CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69481, G2/M Checkpoints R-HSA-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-75815, Ubiquitin-dependent degradation of Cyclin D R-HSA-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8932339, ROS sensing by NFE2L2 R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939902, Regulation of RUNX2 expression and activity R-HSA-8948751, Regulation of PTEN stability and activity R-HSA-8951664, Neddylation R-HSA-9010553, Regulation of expression of SLITs and ROBOs R-HSA-9020702, Interleukin-1 signaling R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
SignaLinki | Q14997 |
Miscellaneous databases
BioGRID-ORCSi | 23198, 18 hits in 1086 CRISPR screens |
ChiTaRSi | PSME4, human |
GeneWikii | PSME4 |
GenomeRNAii | 23198 |
Pharosi | Q14997, Tbio |
PROi | PR:Q14997 |
RNActi | Q14997, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000068878, Expressed in epithelium of mammary gland and 246 other tissues |
ExpressionAtlasi | Q14997, baseline and differential |
Genevisiblei | Q14997, HS |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR032430, Blm10_mid IPR035309, PSME4 IPR021843, PSME4_C |
PANTHERi | PTHR32170, PTHR32170, 1 hit |
Pfami | View protein in Pfam PF16507, BLM10_mid, 1 hit PF11919, DUF3437, 1 hit |
SUPFAMi | SSF48371, SSF48371, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | PSME4_HUMAN | |
Accessioni | Q14997Primary (citable) accession number: Q14997 Secondary accession number(s): Q1XBG4 Q86XF8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 20, 2007 |
Last sequence update: | March 20, 2007 | |
Last modified: | May 25, 2022 | |
This is version 161 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families