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Protein

Proteasome activator complex subunit 4

Gene

PSME4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks.4 Publications

GO - Molecular functioni

  • lysine-acetylated histone binding Source: UniProtKB
  • peptidase activator activity Source: UniProtKB
  • proteasome binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, DNA damage, DNA repair, Spermatogenesis

Enzyme and pathway databases

ReactomeiR-HSA-1169091 Activation of NF-kappaB in B cells
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-HSA-1236974 ER-Phagosome pathway
R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-HSA-180534 Vpu mediated degradation of CD4
R-HSA-180585 Vif-mediated degradation of APOBEC3G
R-HSA-195253 Degradation of beta-catenin by the destruction complex
R-HSA-202424 Downstream TCR signaling
R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1
R-HSA-350562 Regulation of ornithine decarboxylase (ODC)
R-HSA-382556 ABC-family proteins mediated transport
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-HSA-4608870 Asymmetric localization of PCP proteins
R-HSA-4641257 Degradation of AXIN
R-HSA-4641258 Degradation of DVL
R-HSA-5358346 Hedgehog ligand biogenesis
R-HSA-5362768 Hh mutants that don't undergo autocatalytic processing are degraded by ERAD
R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-HSA-5607764 CLEC7A (Dectin-1) signaling
R-HSA-5610780 Degradation of GLI1 by the proteasome
R-HSA-5610783 Degradation of GLI2 by the proteasome
R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome
R-HSA-5632684 Hedgehog 'on' state
R-HSA-5658442 Regulation of RAS by GAPs
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway
R-HSA-5676590 NIK-->noncanonical NF-kB signaling
R-HSA-5678895 Defective CFTR causes cystic fibrosis
R-HSA-5687128 MAPK6/MAPK4 signaling
R-HSA-5689603 UCH proteinases
R-HSA-5689880 Ub-specific processing proteases
R-HSA-68827 CDT1 association with the CDC6:ORC:origin complex
R-HSA-68949 Orc1 removal from chromatin
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6
R-HSA-69229 Ubiquitin-dependent degradation of Cyclin D1
R-HSA-69481 G2/M Checkpoints
R-HSA-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint
R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-HSA-8939902 Regulation of RUNX2 expression and activity
R-HSA-8948751 Regulation of PTEN stability and activity
R-HSA-8951664 Neddylation
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-9020702 Interleukin-1 signaling
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome activator complex subunit 4
Alternative name(s):
Proteasome activator PA200
Gene namesi
Name:PSME4
Synonyms:KIAA0077
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000068878.14
HGNCiHGNC:20635 PSME4
MIMi607705 gene
neXtProtiNX_Q14997

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi1716 – 1717NF → TS: Abolihes binding to acetylated histones. 1 Publication2

Organism-specific databases

DisGeNETi23198
OpenTargetsiENSG00000068878
PharmGKBiPA134872587

Polymorphism and mutation databases

BioMutaiPSME4
DMDMi134034993

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002807181 – 1843Proteasome activator complex subunit 4Add BLAST1843

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1121PhosphoserineCombined sources1
Modified residuei1614PhosphoserineCombined sources1
Modified residuei1746PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ14997
MaxQBiQ14997
PaxDbiQ14997
PeptideAtlasiQ14997
PRIDEiQ14997
ProteomicsDBi60286
60287 [Q14997-2]
60288 [Q14997-3]
60289 [Q14997-4]

PTM databases

iPTMnetiQ14997
PhosphoSitePlusiQ14997

Expressioni

Gene expression databases

BgeeiENSG00000068878 Expressed in 235 organ(s), highest expression level in epithelium of mammary gland
CleanExiHS_PSME4
ExpressionAtlasiQ14997 baseline and differential
GenevisibleiQ14997 HS

Organism-specific databases

HPAiHPA060922

Interactioni

Subunit structurei

Homodimer. Interacts with the 20S and 26S proteasomes. Component of the spermatoproteasome, a form of the proteasome specifically found in testis.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116807, 45 interactors
DIPiDIP-38203N
IntActiQ14997, 17 interactors
MINTiQ14997
STRINGi9606.ENSP00000384211

Structurei

3D structure databases

ProteinModelPortaliQ14997
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati475 – 519HEAT 1Add BLAST45
Repeati998 – 1037HEAT 2Add BLAST40
Repeati1179 – 1217HEAT 3Add BLAST39
Repeati1354 – 1392HEAT 4Add BLAST39
Repeati1636 – 1674HEAT 5Add BLAST39
Repeati1680 – 1718HEAT 6Add BLAST39

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1650 – 1738Bromodomain-like (BRDL)Add BLAST89

Domaini

The bromodomain-like (BRDL) region specifically recognizes and binds acetylated histones.1 Publication

Sequence similaritiesi

Belongs to the BLM10 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1851 Eukaryota
ENOG410XP7J LUCA
GeneTreeiENSGT00390000011433
HOVERGENiHBG082223
InParanoidiQ14997
KOiK06699
OMAiRFASMFM
OrthoDBiEOG091G0DWV
PhylomeDBiQ14997
TreeFamiTF106237

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR032430 Blm10_mid
IPR035309 PSME4
IPR021843 PSME4_C
PANTHERiPTHR32170 PTHR32170, 1 hit
PfamiView protein in Pfam
PF16507 BLM10_mid, 1 hit
PF11919 DUF3437, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q14997-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPAERAGVG EPPEPGGRPE PGPRGFVPQK EIVYNKLLPY AERLDAESDL
60 70 80 90 100
QLAQIKCNLG RAVQLQELWP GGLFWTRKLS TYIRLYGRKF SKEDHVLFIK
110 120 130 140 150
LLYELVSIPK LEISMMQGFA RLLINLLKKK ELLSRADLEL PWRPLYDMVE
160 170 180 190 200
RILYSKTEHL GLNWFPNSVE NILKTLVKSC RPYFPADATA EMLEEWRPLM
210 220 230 240 250
CPFDVTMQKA ITYFEIFLPT SLPPELHHKG FKLWFDELIG LWVSVQNLPQ
260 270 280 290 300
WEGQLVNLFA RLATDNIGYI DWDPYVPKIF TRILRSLNLP VGSSQVLVPR
310 320 330 340 350
FLTNAYDIGH AVIWITAMMG GPSKLVQKHL AGLFNSITSF YHPSNNGRWL
360 370 380 390 400
NKLMKLLQRL PNSVVRRLHR ERYKKPSWLT PVPDSHKLTD QDVTDFVQCI
410 420 430 440 450
IQPVLLAMFS KTGSLEAAQA LQNLALMRPE LVIPPVLERT YPALETLTEP
460 470 480 490 500
HQLTATLSCV IGVARSLVSG GRWFPEGPTH MLPLLMRALP GVDPNDFSKC
510 520 530 540 550
MITFQFIATF STLVPLVDCS SVLQERNDLT EVERELCSAT AEFEDFVLQF
560 570 580 590 600
MDRCFGLIES STLEQTREET ETEKMTHLES LVELGLSSTF STILTQCSKE
610 620 630 640 650
IFMVALQKVF NFSTSHIFET RVAGRMVADM CRAAVKCCPE ESLKLFVPHC
660 670 680 690 700
CSVITQLTMN DDVLNDEELD KELLWNLQLL SEITRVDGRK LLLYREQLVK
710 720 730 740 750
ILQRTLHLTC KQGYTLSCNL LHHLLRSTTL IYPTEYCSVP GGFDKPPSEY
760 770 780 790 800
FPIKDWGKPG DLWNLGIQWH VPSSEEVSFA FYLLDSFLQP ELVKLQHCGD
810 820 830 840 850
GKLEMSRDDI LQSLTIVHNC LIGSGNLLPP LKGEPVTNLV PSMVSLEETK
860 870 880 890 900
LYTGLEYDLS RENHREVIAT VIRKLLNHIL DNSEDDTKSL FLIIKIIGDL
910 920 930 940 950
LQFQGSHKHE FDSRWKSFNL VKKSMENRLH GKKQHIRALL IDRVMLQHEL
960 970 980 990 1000
RTLTVEGCEY KKIHQDMIRD LLRLSTSSYS QVRNKAQQTF FAALGAYNFC
1010 1020 1030 1040 1050
CRDIIPLVLE FLRPDRQGVT QQQFKGALYC LLGNHSGVCL ANLHDWDCIV
1060 1070 1080 1090 1100
QTWPAIVSSG LSQAMSLEKP SIVRLFDDLA EKIHRQYETI GLDFTIPKSC
1110 1120 1130 1140 1150
VEIAELLQQS KNPSINQILL SPEKIKEGIK RQQEKNADAL RNYENLVDTL
1160 1170 1180 1190 1200
LDGVEQRNLP WKFEHIGIGL LSLLLRDDRV LPLRAIRFFV ENLNHDAIVV
1210 1220 1230 1240 1250
RKMAISAVAG ILKQLKRTHK KLTINPCEIS GCPKPTQIIA GDRPDNHWLH
1260 1270 1280 1290 1300
YDSKTIPRTK KEWESSCFVE KTHWGYYTWP KNMVVYAGVE EQPKLGRSRE
1310 1320 1330 1340 1350
DMTEAEQIIF DHFSDPKFVE QLITFLSLED RKGKDKFNPR RFCLFKGIFR
1360 1370 1380 1390 1400
NFDDAFLPVL KPHLEHLVAD SHESTQRCVA EIIAGLIRGS KHWTFEKVEK
1410 1420 1430 1440 1450
LWELLCPLLR TALSNITVET YNDWGACIAT SCESRDPRKL HWLFELLLES
1460 1470 1480 1490 1500
PLSGEGGSFV DACRLYVLQG GLAQQEWRVP ELLHRLLKYL EPKLTQVYKN
1510 1520 1530 1540 1550
VRERIGSVLT YIFMIDVSLP NTTPTISPHV PEFTARILEK LKPLMDVDEE
1560 1570 1580 1590 1600
IQNHVMEENG IGEEDERTQG IKLLKTILKW LMASAGRSFS TAVTEQLQLL
1610 1620 1630 1640 1650
PLFFKIAPVE NDNSYDELKR DAKLCLSLMS QGLLYPHQVP LVLQVLKQTA
1660 1670 1680 1690 1700
RSSSWHARYT VLTYLQTMVF YNLFIFLNNE DAVKDIRWLV ISLLEDEQLE
1710 1720 1730 1740 1750
VREMAATTLS GLLQCNFLTM DSPMQIHFEQ LCKTKLPKKR KRDPGSVGDT
1760 1770 1780 1790 1800
IPSAELVKRH AGVLGLGACV LSSPYDVPTW MPQLLMNLSA HLNDPQPIEM
1810 1820 1830 1840
TVKKTLSNFR RTHHDNWQEH KQQFTDDQLL VLTDLLVSPC YYA
Length:1,843
Mass (Da):211,334
Last modified:March 20, 2007 - v2
Checksum:i2D2C3A594E4FA4E7
GO
Isoform 2 (identifier: Q14997-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-625: Missing.

Show »
Length:1,218
Mass (Da):139,963
Checksum:i1ABE87B5DCED3915
GO
Isoform 3 (identifier: Q14997-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-856: Missing.
     857-871: YDLSRENHREVIATV → MGENLAKKIMFFLLI

Show »
Length:987
Mass (Da):113,757
Checksum:i38486C4A85C31995
GO
Isoform 4 (identifier: Q14997-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1628: Missing.

Note: No experimental confirmation available.
Show »
Length:215
Mass (Da):24,699
Checksum:i035FA5A26BF4457F
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WBH5F8WBH5_HUMAN
Proteasome activator complex subuni...
PSME4
571Annotation score:

Sequence cautioni

The sequence AAI12170 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI13669 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti217F → V in AAX83871 (Ref. 1) Curated1
Sequence conflicti710C → R in AAX83871 (Ref. 1) Curated1
Sequence conflicti984N → S in AAX83871 (Ref. 1) Curated1
Sequence conflicti1401L → F in AAH43602 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031189872I → V. Corresponds to variant dbSNP:rs2302878Ensembl.1
Natural variantiVAR_0311901371S → T. Corresponds to variant dbSNP:rs805408Ensembl.1
Natural variantiVAR_0597551825T → A. Corresponds to variant dbSNP:rs35903236Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0238761 – 1628Missing in isoform 4. 1 PublicationAdd BLAST1628
Alternative sequenceiVSP_0238771 – 856Missing in isoform 3. 1 PublicationAdd BLAST856
Alternative sequenceiVSP_0238781 – 625Missing in isoform 2. 1 PublicationAdd BLAST625
Alternative sequenceiVSP_023879857 – 871YDLSR…VIATV → MGENLAKKIMFFLLI in isoform 3. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY894754 mRNA Translation: AAX83869.1
AY894755 mRNA Translation: AAX83870.1
AY894756 mRNA Translation: AAX83871.1
BC043602 mRNA Translation: AAH43602.1
BC071768 mRNA Translation: AAH71768.1
BC112169 mRNA Translation: AAI12170.1 Different initiation.
BC113668 mRNA Translation: AAI13669.1 Different initiation.
D38521 mRNA Translation: BAA07526.1
CCDSiCCDS33197.2 [Q14997-1]
RefSeqiNP_055429.2, NM_014614.2 [Q14997-1]
UniGeneiHs.413801

Genome annotation databases

EnsembliENST00000404125; ENSP00000384211; ENSG00000068878 [Q14997-1]
GeneIDi23198
KEGGihsa:23198
UCSCiuc002rxp.2 human [Q14997-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY894754 mRNA Translation: AAX83869.1
AY894755 mRNA Translation: AAX83870.1
AY894756 mRNA Translation: AAX83871.1
BC043602 mRNA Translation: AAH43602.1
BC071768 mRNA Translation: AAH71768.1
BC112169 mRNA Translation: AAI12170.1 Different initiation.
BC113668 mRNA Translation: AAI13669.1 Different initiation.
D38521 mRNA Translation: BAA07526.1
CCDSiCCDS33197.2 [Q14997-1]
RefSeqiNP_055429.2, NM_014614.2 [Q14997-1]
UniGeneiHs.413801

3D structure databases

ProteinModelPortaliQ14997
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116807, 45 interactors
DIPiDIP-38203N
IntActiQ14997, 17 interactors
MINTiQ14997
STRINGi9606.ENSP00000384211

PTM databases

iPTMnetiQ14997
PhosphoSitePlusiQ14997

Polymorphism and mutation databases

BioMutaiPSME4
DMDMi134034993

Proteomic databases

EPDiQ14997
MaxQBiQ14997
PaxDbiQ14997
PeptideAtlasiQ14997
PRIDEiQ14997
ProteomicsDBi60286
60287 [Q14997-2]
60288 [Q14997-3]
60289 [Q14997-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000404125; ENSP00000384211; ENSG00000068878 [Q14997-1]
GeneIDi23198
KEGGihsa:23198
UCSCiuc002rxp.2 human [Q14997-1]

Organism-specific databases

CTDi23198
DisGeNETi23198
EuPathDBiHostDB:ENSG00000068878.14
GeneCardsiPSME4
H-InvDBiHIX0200268
HGNCiHGNC:20635 PSME4
HPAiHPA060922
MIMi607705 gene
neXtProtiNX_Q14997
OpenTargetsiENSG00000068878
PharmGKBiPA134872587
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1851 Eukaryota
ENOG410XP7J LUCA
GeneTreeiENSGT00390000011433
HOVERGENiHBG082223
InParanoidiQ14997
KOiK06699
OMAiRFASMFM
OrthoDBiEOG091G0DWV
PhylomeDBiQ14997
TreeFamiTF106237

Enzyme and pathway databases

ReactomeiR-HSA-1169091 Activation of NF-kappaB in B cells
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-HSA-1236974 ER-Phagosome pathway
R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-HSA-180534 Vpu mediated degradation of CD4
R-HSA-180585 Vif-mediated degradation of APOBEC3G
R-HSA-195253 Degradation of beta-catenin by the destruction complex
R-HSA-202424 Downstream TCR signaling
R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1
R-HSA-350562 Regulation of ornithine decarboxylase (ODC)
R-HSA-382556 ABC-family proteins mediated transport
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-HSA-4608870 Asymmetric localization of PCP proteins
R-HSA-4641257 Degradation of AXIN
R-HSA-4641258 Degradation of DVL
R-HSA-5358346 Hedgehog ligand biogenesis
R-HSA-5362768 Hh mutants that don't undergo autocatalytic processing are degraded by ERAD
R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-HSA-5607764 CLEC7A (Dectin-1) signaling
R-HSA-5610780 Degradation of GLI1 by the proteasome
R-HSA-5610783 Degradation of GLI2 by the proteasome
R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome
R-HSA-5632684 Hedgehog 'on' state
R-HSA-5658442 Regulation of RAS by GAPs
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway
R-HSA-5676590 NIK-->noncanonical NF-kB signaling
R-HSA-5678895 Defective CFTR causes cystic fibrosis
R-HSA-5687128 MAPK6/MAPK4 signaling
R-HSA-5689603 UCH proteinases
R-HSA-5689880 Ub-specific processing proteases
R-HSA-68827 CDT1 association with the CDC6:ORC:origin complex
R-HSA-68949 Orc1 removal from chromatin
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6
R-HSA-69229 Ubiquitin-dependent degradation of Cyclin D1
R-HSA-69481 G2/M Checkpoints
R-HSA-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint
R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-HSA-8939902 Regulation of RUNX2 expression and activity
R-HSA-8948751 Regulation of PTEN stability and activity
R-HSA-8951664 Neddylation
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-9020702 Interleukin-1 signaling
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRSiPSME4 human
GeneWikiiPSME4
GenomeRNAii23198
PROiPR:Q14997
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000068878 Expressed in 235 organ(s), highest expression level in epithelium of mammary gland
CleanExiHS_PSME4
ExpressionAtlasiQ14997 baseline and differential
GenevisibleiQ14997 HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR032430 Blm10_mid
IPR035309 PSME4
IPR021843 PSME4_C
PANTHERiPTHR32170 PTHR32170, 1 hit
PfamiView protein in Pfam
PF16507 BLM10_mid, 1 hit
PF11919 DUF3437, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPSME4_HUMAN
AccessioniPrimary (citable) accession number: Q14997
Secondary accession number(s): Q1XBG4
, Q1XBG5, Q1XBG6, Q2M1Z0, Q6IPR2, Q86XF8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: November 7, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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