UniProtKB - Q14994 (NR1I3_HUMAN)
Nuclear receptor subfamily 1 group I member 3
NR1I3
Functioni
Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 8 – 83 | Nuclear receptorPROSITE-ProRule annotationAdd BLAST | 76 | |
Zinc fingeri | 11 – 31 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 47 – 71 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity Source: ProtInc
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- nuclear receptor activity Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: NTNU_SB
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
- zinc ion binding Source: InterPro
GO - Biological processi
- cell differentiation Source: GO_Central
- negative regulation of transcription by RNA polymerase II Source: GO_Central
- osteoblast differentiation Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
- signal transduction Source: ProtInc
Keywordsi
Molecular function | Activator, DNA-binding, Receptor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q14994 |
Reactomei | R-HSA-383280, Nuclear Receptor transcription pathway |
SignaLinki | Q14994 |
SIGNORi | Q14994 |
Chemistry databases
SwissLipidsi | SLP:000001585 |
Names & Taxonomyi
Protein namesi | Recommended name: Nuclear receptor subfamily 1 group I member 3Alternative name(s): Constitutive activator of retinoid response Short name: Constitutive active response Constitutive androstane receptor Short name: CAR Orphan nuclear receptor MB67 |
Gene namesi | Name:NR1I3 Synonyms:CAR |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7969, NR1I3 |
MIMi | 603881, gene |
neXtProti | NX_Q14994 |
VEuPathDBi | HostDB:ENSG00000143257 |
Subcellular locationi
Cytoskeleton
Nucleus
Cytoplasm and Cytosol
Note: Recruited to the cytoplasm by DNAJC7.By similarity
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Cytosol
- cytosol Source: Ensembl
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 9970 |
OpenTargetsi | ENSG00000143257 |
PharmGKBi | PA391 |
Miscellaneous databases
Pharosi | Q14994, Tchem |
Chemistry databases
ChEMBLi | CHEMBL5503 |
DrugBanki | DB01889, 16,17-Androstene-3-Ol DB07557, 3,20-Pregnanedione DB01076, Atorvastatin DB04540, Cholesterol DB00366, Doxylamine DB07931, Hexestrol DB01026, Ketoconazole DB00836, Loperamide DB00737, Meclizine DB01620, Pheniramine DB04824, Phenolphthalein DB01708, Prasterone DB02709, Resveratrol DB08604, Triclosan |
DrugCentrali | Q14994 |
GuidetoPHARMACOLOGYi | 607 |
Genetic variation databases
BioMutai | NR1I3 |
DMDMi | 49066046 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000053552 | 1 – 352 | Nuclear receptor subfamily 1 group I member 3Add BLAST | 352 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 38 | Phosphothreonine; by PKC1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q14994 |
PaxDbi | Q14994 |
PeptideAtlasi | Q14994 |
PRIDEi | Q14994 |
ProteomicsDBi | 19747 20507 60278 [Q14994-1] 60279 [Q14994-2] 60280 [Q14994-3] 60281 [Q14994-4] 60282 [Q14994-5] 60283 [Q14994-6] 60284 [Q14994-7] 62261 |
PTM databases
iPTMneti | Q14994 |
PhosphoSitePlusi | Q14994 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000143257, Expressed in right lobe of liver and 125 other tissues |
ExpressionAtlasi | Q14994, baseline and differential |
Genevisiblei | Q14994, HS |
Organism-specific databases
HPAi | ENSG00000143257, Tissue enriched (liver) |
Interactioni
Subunit structurei
Interacts with ECT2 (By similarity). Heterodimer of NR1I3 and RXR.
Interacts with PSMC4. Directly interacts with DNAJC7. The DNAJC7-NR1I3 complex may also include HSP90 (By similarity).
Interacts with CRY1 (By similarity).
Interacts with CRY2 in a ligand-dependent manner (By similarity).
By similarityBinary interactionsi
Q14994
With | #Exp. | IntAct |
---|---|---|
FOS [P01100] | 3 | EBI-960794,EBI-852851 |
Protein-protein interaction databases
BioGRIDi | 115295, 39 interactors |
IntActi | Q14994, 20 interactors |
STRINGi | 9606.ENSP00000356959 |
Chemistry databases
BindingDBi | Q14994 |
Miscellaneous databases
RNActi | Q14994, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q14994 |
SMRi | Q14994 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q14994 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 109 – 352 | NR LBDPROSITE-ProRule annotationAdd BLAST | 244 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 11 – 31 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 47 – 71 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00940000160641 |
HOGENOMi | CLU_007368_12_0_1 |
InParanoidi | Q14994 |
OMAi | VHAGFQE |
OrthoDBi | 297114at2759 |
PhylomeDBi | Q14994 |
TreeFami | TF316304 |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
IDEALi | IID00475 |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR001728, ThyrH_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR00398, STRDHORMONER PR00047, STROIDFINGER PR00546, THYROIDHORMR |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
s (15+)i Sequence
Sequence statusi: Complete.
This entry describes 15 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 15 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MASREDELRN CVVCGDQATG YHFNALTCEG CKGFFRRTVS KSIGPTCPFA
60 70 80 90 100
GSCEVSKTQR RHCPACRLQK CLDAGMRKDM ILSAEALALR RAKQAQRRAQ
110 120 130 140 150
QTPVQLSKEQ EELIRTLLGA HTRHMGTMFE QFVQFRPPAH LFIHHQPLPT
160 170 180 190 200
LAPVLPLVTH FADINTFMVL QVIKFTKDLP VFRSLPIEDQ ISLLKGAAVE
210 220 230 240 250
ICHIVLNTTF CLQTQNFLCG PLRYTIEDGA RVSPTVGFQV EFLELLFHFH
260 270 280 290 300
GTLRKLQLQE PEYVLLAAMA LFSPDRPGVT QRDEIDQLQE EMALTLQSYI
310 320 330 340 350
KGQQRRPRDR FLYAKLLGLL AELRSINEAY GYQIQHIQGL SAMMPLLQEI
CS
The sequence of this isoform differs from the canonical sequence as follows:
1-35: MASREDELRNCVVCGDQATGYHFNALTCEGCKGFF → MLPKRS
233-236: Missing.
274-274: P → PAPYLT
311-352: FLYAKLLGLLAELRSINEAYGYQIQHIQGLSAMMPLLQEICS → SPGTPWIHWSGKMLGPKIGPGSKGAQWLQ
The sequence of this isoform differs from the canonical sequence as follows:
1-35: MASREDELRNCVVCGDQATGYHFNALTCEGCKGFF → MLPKRS
274-274: P → PAPYLT
311-352: FLYAKLLGLLAELRSINEAYGYQIQHIQGLSAMMPLLQEICS → SPGTPWIHWSGKMLGPKIGPGSKGAQWLQ
The sequence of this isoform differs from the canonical sequence as follows:
311-352: FLYAKLLGLLAELRSINEAYGYQIQHIQGLSAMMPLLQEICS → SPGTPWIHWSGKMLGPKIGPGSKGAQWLQ
The sequence of this isoform differs from the canonical sequence as follows:
232-235: Missing.
274-274: P → PAPYLT
311-352: FLYAKLLGLLAELRSINEAYGYQIQHIQGLSAMMPLLQEICS → SPGTPWIHWSGKMLGPKIGPGSKGAQWLQ
The sequence of this isoform differs from the canonical sequence as follows:
232-274: Missing.
311-352: FLYAKLLGLLAELRSINEAYGYQIQHIQGLSAMMPLLQEICS → SPGTPWIHWSGKMLGPKIGPGSKGAQWLQ
The sequence of this isoform differs from the canonical sequence as follows:
1-35: MASREDELRNCVVCGDQATGYHFNALTCEGCKGFF → MLPKRS
232-274: Missing.
311-352: FLYAKLLGLLAELRSINEAYGYQIQHIQGLSAMMPLLQEICS → SPGTPWIHWSGKMLGPKIGPGSKGAQWLQ
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD6REZ7 | D6REZ7_HUMAN | Nuclear receptor subfamily 1 group ... | NR1I3 | 273 | Annotation score: | ||
E9PCF2 | E9PCF2_HUMAN | Nuclear receptor subfamily 1 group ... | NR1I3 | 297 | Annotation score: | ||
B7Z8R7 | B7Z8R7_HUMAN | Nuclear receptor subfamily 1 group ... | NR1I3 | 238 | Annotation score: | ||
Q6GZ81 | Q6GZ81_HUMAN | Constitutive androstane receptor SV... | NR1I3 | 90 | Annotation score: | ||
Q6GZ72 | Q6GZ72_HUMAN | Constitutive androstane receptor SV... | NR1I3 | 147 | Annotation score: | ||
C0H5Y2 | C0H5Y2_HUMAN | NR1I3 protein | NR1I3 hCG_1766510 | 274 | Annotation score: | ||
Q6GZ69 | Q6GZ69_HUMAN | Constitutive androstane receptor SV... | NR1I3 | 119 | Annotation score: | ||
Q6GZ70 | Q6GZ70_HUMAN | Constitutive androstane receptor SV... | NR1I3 | 118 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_018344 | 133 | V → G1 Publication | 1 | |
Natural variantiVAR_080264 | 247 | F → S Found in a patient with Kleefstra syndrome; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs398122411Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043730 | 1 – 35 | MASRE…CKGFF → MLPKRS in isoform 4, isoform 5, isoform 6, isoform 9, isoform 10, isoform 11 and isoform 15. 1 PublicationAdd BLAST | 35 | |
Alternative sequenceiVSP_043144 | 232 – 274 | VSPTV…ALFSP → APYLT in isoform 3. 2 PublicationsAdd BLAST | 43 | |
Alternative sequenceiVSP_043731 | 232 – 274 | Missing in isoform 4, isoform 7, isoform 14 and isoform 15. 3 PublicationsAdd BLAST | 43 | |
Alternative sequenceiVSP_055180 | 232 – 235 | Missing in isoform 13. 1 Publication | 4 | |
Alternative sequenceiVSP_010634 | 233 – 236 | Missing in isoform 2, isoform 5, isoform 6, isoform 9 and isoform 10. 3 Publications | 4 | |
Alternative sequenceiVSP_043732 | 274 | P → PAPYLT in isoform 6, isoform 8, isoform 10, isoform 11 and isoform 13. 2 Publications | 1 | |
Alternative sequenceiVSP_046144 | 311 – 352 | FLYAK…QEICS → SPGTPWIHWSGKMLGPKIGP GSKGAQWLQ in isoform 9, isoform 10, isoform 11, isoform 12, isoform 13, isoform 14 and isoform 15. 1 PublicationAdd BLAST | 42 |
Sequence databases
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1XV9 | X-ray | 2.70 | B/D | 103-352 | [»] | |
1XVP | X-ray | 2.60 | B/D | 103-352 | [»] | |
AlphaFoldDBi | Q14994 | |||||
SMRi | Q14994 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115295, 39 interactors |
IntActi | Q14994, 20 interactors |
STRINGi | 9606.ENSP00000356959 |
Chemistry databases
BindingDBi | Q14994 |
ChEMBLi | CHEMBL5503 |
DrugBanki | DB01889, 16,17-Androstene-3-Ol DB07557, 3,20-Pregnanedione DB01076, Atorvastatin DB04540, Cholesterol DB00366, Doxylamine DB07931, Hexestrol DB01026, Ketoconazole DB00836, Loperamide DB00737, Meclizine DB01620, Pheniramine DB04824, Phenolphthalein DB01708, Prasterone DB02709, Resveratrol DB08604, Triclosan |
DrugCentrali | Q14994 |
GuidetoPHARMACOLOGYi | 607 |
SwissLipidsi | SLP:000001585 |
PTM databases
iPTMneti | Q14994 |
PhosphoSitePlusi | Q14994 |
Genetic variation databases
BioMutai | NR1I3 |
DMDMi | 49066046 |
Proteomic databases
jPOSTi | Q14994 |
PaxDbi | Q14994 |
PeptideAtlasi | Q14994 |
PRIDEi | Q14994 |
ProteomicsDBi | 19747 20507 60278 [Q14994-1] 60279 [Q14994-2] 60280 [Q14994-3] 60281 [Q14994-4] 60282 [Q14994-5] 60283 [Q14994-6] 60284 [Q14994-7] 62261 |
Protocols and materials databases
Antibodypediai | 20508, 455 antibodies from 32 providers |
DNASUi | 9970 |
Genome annotation databases
Organism-specific databases
CTDi | 9970 |
DisGeNETi | 9970 |
GeneCardsi | NR1I3 |
HGNCi | HGNC:7969, NR1I3 |
HPAi | ENSG00000143257, Tissue enriched (liver) |
MIMi | 603881, gene |
neXtProti | NX_Q14994 |
OpenTargetsi | ENSG00000143257 |
PharmGKBi | PA391 |
VEuPathDBi | HostDB:ENSG00000143257 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00940000160641 |
HOGENOMi | CLU_007368_12_0_1 |
InParanoidi | Q14994 |
OMAi | VHAGFQE |
OrthoDBi | 297114at2759 |
PhylomeDBi | Q14994 |
TreeFami | TF316304 |
Enzyme and pathway databases
PathwayCommonsi | Q14994 |
Reactomei | R-HSA-383280, Nuclear Receptor transcription pathway |
SignaLinki | Q14994 |
SIGNORi | Q14994 |
Miscellaneous databases
BioGRID-ORCSi | 9970, 15 hits in 1094 CRISPR screens |
ChiTaRSi | NR1I3, human |
EvolutionaryTracei | Q14994 |
GeneWikii | Constitutive_androstane_receptor |
GenomeRNAii | 9970 |
Pharosi | Q14994, Tchem |
PROi | PR:Q14994 |
RNActi | Q14994, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000143257, Expressed in right lobe of liver and 125 other tissues |
ExpressionAtlasi | Q14994, baseline and differential |
Genevisiblei | Q14994, HS |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
IDEALi | IID00475 |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR001728, ThyrH_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR00398, STRDHORMONER PR00047, STROIDFINGER PR00546, THYROIDHORMR |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NR1I3_HUMAN | |
Accessioni | Q14994Primary (citable) accession number: Q14994 Secondary accession number(s): E9PB75 Q6GZ89 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | June 21, 2004 | |
Last modified: | May 25, 2022 | |
This is version 208 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families