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Protein

Outer dense fiber protein 1

Gene

ODF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Outer dense fiber protein 1
Alternative name(s):
Heat shock protein beta-10
Short name:
HspB10
Gene namesi
Name:ODF1
Synonyms:HSPB10, ODFP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000155087.3
HGNCiHGNC:8113 ODF1
MIMi182878 gene
neXtProtiNX_Q14990

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi4956
OpenTargetsiENSG00000155087
PharmGKBiPA31901

Polymorphism and mutation databases

BioMutaiODF1
DMDMi145559511

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000580241 – 250Outer dense fiber protein 1Add BLAST250

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei5PhosphoserineBy similarity1
Modified residuei10PhosphoserineBy similarity1
Modified residuei64PhosphoserineBy similarity1
Modified residuei86PhosphoserineBy similarity1
Modified residuei122PhosphoserineBy similarity1
Modified residuei123PhosphoserineBy similarity1
Modified residuei151PhosphoserineBy similarity1
Modified residuei167PhosphoserineBy similarity1
Modified residuei189PhosphoserineBy similarity1
Modified residuei194PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ14990
PeptideAtlasiQ14990
PRIDEiQ14990
ProteomicsDBi60276

PTM databases

iPTMnetiQ14990
PhosphoSitePlusiQ14990

Expressioni

Tissue specificityi

Testis.

Gene expression databases

BgeeiENSG00000155087 Expressed in 66 organ(s), highest expression level in sperm
CleanExiHS_ODF1
ExpressionAtlasiQ14990 baseline and differential
GenevisibleiQ14990 HS

Organism-specific databases

HPAiHPA064295

Interactioni

Subunit structurei

Interact (via leucine zipper motif) with TCP11 isoform 2 and isoform 3 (PubMed:21597245). Interacts with SPAG4 (By similarity). Interacts with KLC3 (By similarity).By similarity1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111009, 20 interactors
IntActiQ14990, 10 interactors
STRINGi9606.ENSP00000285402

Structurei

3D structure databases

ProteinModelPortaliQ14990
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati34 – 3815
Repeati73 – 7725

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni34 – 772 X 5 AA repeats of [RC]-C-L-C-DAdd BLAST44
Regioni209 – 238C-X-P repeat regionAdd BLAST30

Domaini

The C-terminal contains many C-X-P repeats.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IHKT Eukaryota
ENOG4111C5F LUCA
GeneTreeiENSGT00440000038909
HOGENOMiHOG000290650
HOVERGENiHBG007863
InParanoidiQ14990
OMAiLYYPCCL
OrthoDBiEOG091G0QI9
PhylomeDBiQ14990
TreeFamiTF337986

Family and domain databases

CDDicd06482 ACD_HspB10, 1 hit
Gene3Di2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR002068 A-crystallin/Hsp20_dom
IPR008978 HSP20-like_chaperone
IPR037552 ODF1_ACD
IPR037389 ODFP
PANTHERiPTHR17125 PTHR17125, 1 hit
PfamiView protein in Pfam
PF00011 HSP20, 1 hit
SUPFAMiSSF49764 SSF49764, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q14990-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAALSCLLDS VRRDIKKVDR ELRQLRCIDE FSTRCLCDLY MHPYCCCDLH
60 70 80 90 100
PYPYCLCYSK RSRSCGLCDL YPCCLCDYKL YCLRPSLRSL ERKAIRAIED
110 120 130 140 150
EKRELAKLRR TTNRILASSC CSSNILGSVN VCGFEPDQVK VRVKDGKVCV
160 170 180 190 200
SAERENRYDC LGSKKYSYMN ICKEFSLPPC VDEKDVTYSY GLGSCVKIES
210 220 230 240 250
PCYPCTSPCS PCSPCSPCNP CSPCNPCSPY DPCNPCYPCG SRFSCRKMIL
Length:250
Mass (Da):28,366
Last modified:April 17, 2007 - v2
Checksum:i48E7FD05C2FB952B
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RH17E5RH17_HUMAN
Outer dense fiber protein 1
ODF1
43Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti143V → L in M93131 (PubMed:8305202).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031684216S → N2 PublicationsCorresponds to variant dbSNP:rs2916569Ensembl.1
Natural variantiVAR_005523219 – 227Missing 1 Publication9
Natural variantiVAR_051251243F → L. Corresponds to variant dbSNP:rs11995900Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M93131 Genomic DNA No translation available.
X74614 Genomic DNA Translation: CAA52685.1
BC104456 mRNA Translation: AAI04457.1
BC104457 mRNA Translation: AAI04458.1
CCDSiCCDS6293.1
PIRiS71522
RefSeqiNP_077721.2, NM_024410.3
UniGeneiHs.159274

Genome annotation databases

EnsembliENST00000285402; ENSP00000285402; ENSG00000155087
GeneIDi4956
KEGGihsa:4956
UCSCiuc003ykt.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M93131 Genomic DNA No translation available.
X74614 Genomic DNA Translation: CAA52685.1
BC104456 mRNA Translation: AAI04457.1
BC104457 mRNA Translation: AAI04458.1
CCDSiCCDS6293.1
PIRiS71522
RefSeqiNP_077721.2, NM_024410.3
UniGeneiHs.159274

3D structure databases

ProteinModelPortaliQ14990
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111009, 20 interactors
IntActiQ14990, 10 interactors
STRINGi9606.ENSP00000285402

PTM databases

iPTMnetiQ14990
PhosphoSitePlusiQ14990

Polymorphism and mutation databases

BioMutaiODF1
DMDMi145559511

Proteomic databases

PaxDbiQ14990
PeptideAtlasiQ14990
PRIDEiQ14990
ProteomicsDBi60276

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000285402; ENSP00000285402; ENSG00000155087
GeneIDi4956
KEGGihsa:4956
UCSCiuc003ykt.3 human

Organism-specific databases

CTDi4956
DisGeNETi4956
EuPathDBiHostDB:ENSG00000155087.3
GeneCardsiODF1
H-InvDBiHIX0034374
HGNCiHGNC:8113 ODF1
HPAiHPA064295
MIMi182878 gene
neXtProtiNX_Q14990
OpenTargetsiENSG00000155087
PharmGKBiPA31901
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHKT Eukaryota
ENOG4111C5F LUCA
GeneTreeiENSGT00440000038909
HOGENOMiHOG000290650
HOVERGENiHBG007863
InParanoidiQ14990
OMAiLYYPCCL
OrthoDBiEOG091G0QI9
PhylomeDBiQ14990
TreeFamiTF337986

Miscellaneous databases

GeneWikiiODF1
GenomeRNAii4956
PROiPR:Q14990
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000155087 Expressed in 66 organ(s), highest expression level in sperm
CleanExiHS_ODF1
ExpressionAtlasiQ14990 baseline and differential
GenevisibleiQ14990 HS

Family and domain databases

CDDicd06482 ACD_HspB10, 1 hit
Gene3Di2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR002068 A-crystallin/Hsp20_dom
IPR008978 HSP20-like_chaperone
IPR037552 ODF1_ACD
IPR037389 ODFP
PANTHERiPTHR17125 PTHR17125, 1 hit
PfamiView protein in Pfam
PF00011 HSP20, 1 hit
SUPFAMiSSF49764 SSF49764, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiODFP1_HUMAN
AccessioniPrimary (citable) accession number: Q14990
Secondary accession number(s): Q3SX72
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 17, 2007
Last modified: November 7, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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