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Protein

Opioid-binding protein/cell adhesion molecule

Gene

OPCML

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds opioids in the presence of acidic lipids; probably involved in cell contact.

GO - Biological processi

  • cell adhesion Source: ProtInc
  • neuron recognition Source: ProtInc

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins

Names & Taxonomyi

Protein namesi
Recommended name:
Opioid-binding protein/cell adhesion molecule
Short name:
OBCAM
Short name:
OPCML
Short name:
Opioid-binding cell adhesion molecule
Alternative name(s):
IgLON family member 1
Gene namesi
Name:OPCML
Synonyms:IGLON1, OBCAM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000183715.13
HGNCiHGNC:8143 OPCML
MIMi600632 gene
neXtProtiNX_Q14982

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Ovarian cancer (OC)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionThe term ovarian cancer defines malignancies originating from ovarian tissue. Although many histologic types of ovarian tumors have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease.
See also OMIM:167000

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi4978
MalaCardsiOPCML
MIMi167000 phenotype
OpenTargetsiENSG00000183715
PharmGKBiPA31930

Polymorphism and mutation databases

BioMutaiOPCML
DMDMi2497326

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27By similarityAdd BLAST27
ChainiPRO_000001511828 – 322Opioid-binding protein/cell adhesion moleculeAdd BLAST295
PropeptideiPRO_0000015119323 – 345Removed in mature formSequence analysisAdd BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi44N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi57 ↔ 115PROSITE-ProRule annotation
Glycosylationi70N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi140N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi157 ↔ 202PROSITE-ProRule annotation
Disulfide bondi244 ↔ 296PROSITE-ProRule annotation
Glycosylationi285N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi293N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi306N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi322GPI-anchor amidated asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

EPDiQ14982
MaxQBiQ14982
PaxDbiQ14982
PeptideAtlasiQ14982
PRIDEiQ14982
ProteomicsDBi60274
60275 [Q14982-2]

PTM databases

iPTMnetiQ14982
PhosphoSitePlusiQ14982

Expressioni

Gene expression databases

BgeeiENSG00000183715 Expressed in 132 organ(s), highest expression level in Brodmann (1909) area 23
CleanExiHS_OPCML
ExpressionAtlasiQ14982 baseline and differential
GenevisibleiQ14982 HS

Interactioni

Protein-protein interaction databases

BioGridi111026, 14 interactors
IntActiQ14982, 5 interactors
STRINGi9606.ENSP00000330862

Structurei

Secondary structure

1345
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ14982
SMRiQ14982
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 126Ig-like C2-type 1Add BLAST88
Domaini136 – 219Ig-like C2-type 2Add BLAST84
Domaini223 – 310Ig-like C2-type 3Add BLAST88

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IQJH Eukaryota
ENOG410XT1Y LUCA
GeneTreeiENSGT00860000133697
HOGENOMiHOG000019085
HOVERGENiHBG017341
InParanoidiQ14982
KOiK06773
OMAiWSIDNRV
OrthoDBiEOG091G0B5D
PhylomeDBiQ14982
TreeFamiTF325565

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF07679 I-set, 2 hits
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q14982-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGVCGYLFLP WKCLVVVSLR LLFLVPTGVP VRSGDATFPK AMDNVTVRQG
60 70 80 90 100
ESATLRCTID DRVTRVAWLN RSTILYAGND KWSIDPRVII LVNTPTQYSI
110 120 130 140 150
MIQNVDVYDE GPYTCSVQTD NHPKTSRVHL IVQVPPQIMN ISSDITVNEG
160 170 180 190 200
SSVTLLCLAI GRPEPTVTWR HLSVKEGQGF VSEDEYLEIS DIKRDQSGEY
210 220 230 240 250
ECSALNDVAA PDVRKVKITV NYPPYISKAK NTGVSVGQKG ILSCEASAVP
260 270 280 290 300
MAEFQWFKEE TRLATGLDGM RIENKGRMST LTFFNVSEKD YGNYTCVATN
310 320 330 340
KLGNTNASIT LYGPGAVIDG VNSASRALAC LWLSGTLLAH FFIKF
Length:345
Mass (Da):38,008
Last modified:November 1, 1996 - v1
Checksum:iE7AD17BEA1AA3FF4
GO
Isoform 2 (identifier: Q14982-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: MGVCGYLFLPWKCLVVVSLRLLFLVPT → MYHPAYWVVFSATTALLFIP

Show »
Length:338
Mass (Da):37,267
Checksum:iEDD86EE2C57B09E3
GO
Isoform 3 (identifier: Q14982-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: Missing.

Show »
Length:304
Mass (Da):33,574
Checksum:i697F8D7D53994A82
GO
Isoform 4 (identifier: Q14982-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     312-312: Y → YEISPSSAVA

Note: No experimental confirmation available.
Show »
Length:354
Mass (Da):38,849
Checksum:i185C69C6FBA2839C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05542195P → R in ovarian cancer; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs137852691Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0477301 – 41Missing in isoform 3. 2 PublicationsAdd BLAST41
Alternative sequenceiVSP_0434401 – 27MGVCG…FLVPT → MYHPAYWVVFSATTALLFIP in isoform 2. 3 PublicationsAdd BLAST27
Alternative sequenceiVSP_054155312Y → YEISPSSAVA in isoform 4. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34774 mRNA Translation: AAA36387.1
EU562296 mRNA Translation: ACB56656.1
EU562297 mRNA Translation: ACB56657.1
EU562299 mRNA Translation: ACB56659.1
AK299908 mRNA Translation: BAG61748.1
AK316491 mRNA Translation: BAH14862.1
BX537377 mRNA Translation: CAD97619.1
AP000843 Genomic DNA No translation available.
AP000863 Genomic DNA No translation available.
AP000903 Genomic DNA No translation available.
AP003029 Genomic DNA No translation available.
AP003784 Genomic DNA No translation available.
AP003972 Genomic DNA No translation available.
AP004606 Genomic DNA No translation available.
AP004782 Genomic DNA No translation available.
AP005122 Genomic DNA No translation available.
AP005133 Genomic DNA No translation available.
AP005638 Genomic DNA No translation available.
BC074773 mRNA Translation: AAH74773.1
BC117254 mRNA Translation: AAI17255.1
BC126251 mRNA Translation: AAI26252.1
BC143946 mRNA Translation: AAI43947.1
CCDSiCCDS31722.1 [Q14982-2]
CCDS81649.1 [Q14982-3]
CCDS8492.1 [Q14982-1]
PIRiJC4025
RefSeqiNP_001012393.1, NM_001012393.2 [Q14982-2]
NP_001306032.1, NM_001319103.1 [Q14982-4]
NP_001306033.1, NM_001319104.1
NP_001306034.1, NM_001319105.1 [Q14982-3]
NP_001306035.1, NM_001319106.1
NP_002536.1, NM_002545.4 [Q14982-1]
XP_011541158.1, XM_011542856.2 [Q14982-3]
UniGeneiHs.4817

Genome annotation databases

EnsembliENST00000331898; ENSP00000330862; ENSG00000183715 [Q14982-1]
ENST00000374778; ENSP00000363910; ENSG00000183715 [Q14982-3]
ENST00000524381; ENSP00000434750; ENSG00000183715 [Q14982-2]
ENST00000541867; ENSP00000445496; ENSG00000183715 [Q14982-4]
ENST00000612177; ENSP00000482061; ENSG00000183715 [Q14982-1]
GeneIDi4978
KEGGihsa:4978
UCSCiuc001qgs.4 human [Q14982-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34774 mRNA Translation: AAA36387.1
EU562296 mRNA Translation: ACB56656.1
EU562297 mRNA Translation: ACB56657.1
EU562299 mRNA Translation: ACB56659.1
AK299908 mRNA Translation: BAG61748.1
AK316491 mRNA Translation: BAH14862.1
BX537377 mRNA Translation: CAD97619.1
AP000843 Genomic DNA No translation available.
AP000863 Genomic DNA No translation available.
AP000903 Genomic DNA No translation available.
AP003029 Genomic DNA No translation available.
AP003784 Genomic DNA No translation available.
AP003972 Genomic DNA No translation available.
AP004606 Genomic DNA No translation available.
AP004782 Genomic DNA No translation available.
AP005122 Genomic DNA No translation available.
AP005133 Genomic DNA No translation available.
AP005638 Genomic DNA No translation available.
BC074773 mRNA Translation: AAH74773.1
BC117254 mRNA Translation: AAI17255.1
BC126251 mRNA Translation: AAI26252.1
BC143946 mRNA Translation: AAI43947.1
CCDSiCCDS31722.1 [Q14982-2]
CCDS81649.1 [Q14982-3]
CCDS8492.1 [Q14982-1]
PIRiJC4025
RefSeqiNP_001012393.1, NM_001012393.2 [Q14982-2]
NP_001306032.1, NM_001319103.1 [Q14982-4]
NP_001306033.1, NM_001319104.1
NP_001306034.1, NM_001319105.1 [Q14982-3]
NP_001306035.1, NM_001319106.1
NP_002536.1, NM_002545.4 [Q14982-1]
XP_011541158.1, XM_011542856.2 [Q14982-3]
UniGeneiHs.4817

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5UV6X-ray2.65A/B36-316[»]
ProteinModelPortaliQ14982
SMRiQ14982
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111026, 14 interactors
IntActiQ14982, 5 interactors
STRINGi9606.ENSP00000330862

PTM databases

iPTMnetiQ14982
PhosphoSitePlusiQ14982

Polymorphism and mutation databases

BioMutaiOPCML
DMDMi2497326

Proteomic databases

EPDiQ14982
MaxQBiQ14982
PaxDbiQ14982
PeptideAtlasiQ14982
PRIDEiQ14982
ProteomicsDBi60274
60275 [Q14982-2]

Protocols and materials databases

DNASUi4978
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331898; ENSP00000330862; ENSG00000183715 [Q14982-1]
ENST00000374778; ENSP00000363910; ENSG00000183715 [Q14982-3]
ENST00000524381; ENSP00000434750; ENSG00000183715 [Q14982-2]
ENST00000541867; ENSP00000445496; ENSG00000183715 [Q14982-4]
ENST00000612177; ENSP00000482061; ENSG00000183715 [Q14982-1]
GeneIDi4978
KEGGihsa:4978
UCSCiuc001qgs.4 human [Q14982-1]

Organism-specific databases

CTDi4978
DisGeNETi4978
EuPathDBiHostDB:ENSG00000183715.13
GeneCardsiOPCML
HGNCiHGNC:8143 OPCML
MalaCardsiOPCML
MIMi167000 phenotype
600632 gene
neXtProtiNX_Q14982
OpenTargetsiENSG00000183715
PharmGKBiPA31930
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQJH Eukaryota
ENOG410XT1Y LUCA
GeneTreeiENSGT00860000133697
HOGENOMiHOG000019085
HOVERGENiHBG017341
InParanoidiQ14982
KOiK06773
OMAiWSIDNRV
OrthoDBiEOG091G0B5D
PhylomeDBiQ14982
TreeFamiTF325565

Enzyme and pathway databases

ReactomeiR-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins

Miscellaneous databases

ChiTaRSiOPCML human
GeneWikiiOPCML
GenomeRNAii4978
PROiPR:Q14982
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000183715 Expressed in 132 organ(s), highest expression level in Brodmann (1909) area 23
CleanExiHS_OPCML
ExpressionAtlasiQ14982 baseline and differential
GenevisibleiQ14982 HS

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF07679 I-set, 2 hits
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiOPCM_HUMAN
AccessioniPrimary (citable) accession number: Q14982
Secondary accession number(s): B2CZX2
, B7ZLQ1, Q17RN7, Q7Z3W6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 166 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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