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Entry version 173 (18 Sep 2019)
Sequence version 1 (01 Nov 1996)
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Protein

Opioid-binding protein/cell adhesion molecule

Gene

OPCML

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds opioids in the presence of acidic lipids; probably involved in cell contact.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • cell adhesion Source: ProtInc
  • neuron recognition Source: ProtInc

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Opioid-binding protein/cell adhesion molecule
Short name:
OBCAM
Short name:
OPCML
Short name:
Opioid-binding cell adhesion molecule
Alternative name(s):
IgLON family member 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:OPCML
Synonyms:IGLON1, OBCAM
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:8143 OPCML

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600632 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q14982

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Ovarian cancer (OC)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionThe term ovarian cancer defines malignancies originating from ovarian tissue. Although many histologic types of ovarian tumors have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease.
Related information in OMIM

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
4978

MalaCards human disease database

More...
MalaCardsi
OPCML
MIMi167000 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000183715

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31930

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
OPCML

Domain mapping of disease mutations (DMDM)

More...
DMDMi
2497326

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27By similarityAdd BLAST27
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001511828 – 322Opioid-binding protein/cell adhesion moleculeAdd BLAST295
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000015119323 – 345Removed in mature formSequence analysisAdd BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi44N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi57 ↔ 115PROSITE-ProRule annotation
Glycosylationi70N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi140N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi157 ↔ 202PROSITE-ProRule annotation
Disulfide bondi244 ↔ 296PROSITE-ProRule annotation
Glycosylationi285N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi293N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi306N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi322GPI-anchor amidated asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q14982

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q14982

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q14982

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q14982

PeptideAtlas

More...
PeptideAtlasi
Q14982

PRoteomics IDEntifications database

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PRIDEi
Q14982

ProteomicsDB human proteome resource

More...
ProteomicsDBi
3410
60274 [Q14982-1]
60275 [Q14982-2]
7231

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q14982

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q14982

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000183715 Expressed in 132 organ(s), highest expression level in Brodmann (1909) area 23

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q14982 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q14982 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111026, 14 interactors

Protein interaction database and analysis system

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IntActi
Q14982, 14 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000330862

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1345
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q14982

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini39 – 126Ig-like C2-type 1Add BLAST88
Domaini136 – 219Ig-like C2-type 2Add BLAST84
Domaini223 – 310Ig-like C2-type 3Add BLAST88

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IQJH Eukaryota
ENOG410XT1Y LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160304

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000019085

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q14982

KEGG Orthology (KO)

More...
KOi
K06773

Identification of Orthologs from Complete Genome Data

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OMAi
THRCTID

Database of Orthologous Groups

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OrthoDBi
583722at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q14982

TreeFam database of animal gene trees

More...
TreeFami
TF325565

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07679 I-set, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q14982-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGVCGYLFLP WKCLVVVSLR LLFLVPTGVP VRSGDATFPK AMDNVTVRQG
60 70 80 90 100
ESATLRCTID DRVTRVAWLN RSTILYAGND KWSIDPRVII LVNTPTQYSI
110 120 130 140 150
MIQNVDVYDE GPYTCSVQTD NHPKTSRVHL IVQVPPQIMN ISSDITVNEG
160 170 180 190 200
SSVTLLCLAI GRPEPTVTWR HLSVKEGQGF VSEDEYLEIS DIKRDQSGEY
210 220 230 240 250
ECSALNDVAA PDVRKVKITV NYPPYISKAK NTGVSVGQKG ILSCEASAVP
260 270 280 290 300
MAEFQWFKEE TRLATGLDGM RIENKGRMST LTFFNVSEKD YGNYTCVATN
310 320 330 340
KLGNTNASIT LYGPGAVIDG VNSASRALAC LWLSGTLLAH FFIKF
Length:345
Mass (Da):38,008
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE7AD17BEA1AA3FF4
GO
Isoform 2 (identifier: Q14982-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: MGVCGYLFLPWKCLVVVSLRLLFLVPT → MYHPAYWVVFSATTALLFIP

Show »
Length:338
Mass (Da):37,267
Checksum:iEDD86EE2C57B09E3
GO
Isoform 3 (identifier: Q14982-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: Missing.

Show »
Length:304
Mass (Da):33,574
Checksum:i697F8D7D53994A82
GO
Isoform 4 (identifier: Q14982-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     312-312: Y → YEISPSSAVA

Note: No experimental confirmation available.
Show »
Length:354
Mass (Da):38,849
Checksum:i185C69C6FBA2839C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05542195P → R in ovarian cancer; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs137852691Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0477301 – 41Missing in isoform 3. 2 PublicationsAdd BLAST41
Alternative sequenceiVSP_0434401 – 27MGVCG…FLVPT → MYHPAYWVVFSATTALLFIP in isoform 2. 3 PublicationsAdd BLAST27
Alternative sequenceiVSP_054155312Y → YEISPSSAVA in isoform 4. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L34774 mRNA Translation: AAA36387.1
EU562296 mRNA Translation: ACB56656.1
EU562297 mRNA Translation: ACB56657.1
EU562299 mRNA Translation: ACB56659.1
AK299908 mRNA Translation: BAG61748.1
AK316491 mRNA Translation: BAH14862.1
BX537377 mRNA Translation: CAD97619.1
AP000843 Genomic DNA No translation available.
AP000863 Genomic DNA No translation available.
AP000903 Genomic DNA No translation available.
AP003029 Genomic DNA No translation available.
AP003784 Genomic DNA No translation available.
AP003972 Genomic DNA No translation available.
AP004606 Genomic DNA No translation available.
AP004782 Genomic DNA No translation available.
AP005122 Genomic DNA No translation available.
AP005133 Genomic DNA No translation available.
AP005638 Genomic DNA No translation available.
BC074773 mRNA Translation: AAH74773.1
BC117254 mRNA Translation: AAI17255.1
BC126251 mRNA Translation: AAI26252.1
BC143946 mRNA Translation: AAI43947.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31722.1 [Q14982-2]
CCDS81649.1 [Q14982-3]
CCDS8492.1 [Q14982-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
JC4025

NCBI Reference Sequences

More...
RefSeqi
NP_001012393.1, NM_001012393.2 [Q14982-2]
NP_001306032.1, NM_001319103.1 [Q14982-4]
NP_001306033.1, NM_001319104.1
NP_001306034.1, NM_001319105.1 [Q14982-3]
NP_001306035.1, NM_001319106.1
NP_002536.1, NM_002545.4 [Q14982-1]
XP_011541158.1, XM_011542856.2 [Q14982-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000331898; ENSP00000330862; ENSG00000183715 [Q14982-1]
ENST00000374778; ENSP00000363910; ENSG00000183715 [Q14982-3]
ENST00000524381; ENSP00000434750; ENSG00000183715 [Q14982-2]
ENST00000541867; ENSP00000445496; ENSG00000183715 [Q14982-4]
ENST00000612177; ENSP00000482061; ENSG00000183715 [Q14982-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
4978

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4978

UCSC genome browser

More...
UCSCi
uc001qgs.4 human [Q14982-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34774 mRNA Translation: AAA36387.1
EU562296 mRNA Translation: ACB56656.1
EU562297 mRNA Translation: ACB56657.1
EU562299 mRNA Translation: ACB56659.1
AK299908 mRNA Translation: BAG61748.1
AK316491 mRNA Translation: BAH14862.1
BX537377 mRNA Translation: CAD97619.1
AP000843 Genomic DNA No translation available.
AP000863 Genomic DNA No translation available.
AP000903 Genomic DNA No translation available.
AP003029 Genomic DNA No translation available.
AP003784 Genomic DNA No translation available.
AP003972 Genomic DNA No translation available.
AP004606 Genomic DNA No translation available.
AP004782 Genomic DNA No translation available.
AP005122 Genomic DNA No translation available.
AP005133 Genomic DNA No translation available.
AP005638 Genomic DNA No translation available.
BC074773 mRNA Translation: AAH74773.1
BC117254 mRNA Translation: AAI17255.1
BC126251 mRNA Translation: AAI26252.1
BC143946 mRNA Translation: AAI43947.1
CCDSiCCDS31722.1 [Q14982-2]
CCDS81649.1 [Q14982-3]
CCDS8492.1 [Q14982-1]
PIRiJC4025
RefSeqiNP_001012393.1, NM_001012393.2 [Q14982-2]
NP_001306032.1, NM_001319103.1 [Q14982-4]
NP_001306033.1, NM_001319104.1
NP_001306034.1, NM_001319105.1 [Q14982-3]
NP_001306035.1, NM_001319106.1
NP_002536.1, NM_002545.4 [Q14982-1]
XP_011541158.1, XM_011542856.2 [Q14982-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5UV6X-ray2.65A/B36-316[»]
SMRiQ14982
ModBaseiSearch...

Protein-protein interaction databases

BioGridi111026, 14 interactors
IntActiQ14982, 14 interactors
STRINGi9606.ENSP00000330862

PTM databases

iPTMnetiQ14982
PhosphoSitePlusiQ14982

Polymorphism and mutation databases

BioMutaiOPCML
DMDMi2497326

Proteomic databases

jPOSTiQ14982
MassIVEiQ14982
MaxQBiQ14982
PaxDbiQ14982
PeptideAtlasiQ14982
PRIDEiQ14982
ProteomicsDBi3410
60274 [Q14982-1]
60275 [Q14982-2]
7231

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
4978
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331898; ENSP00000330862; ENSG00000183715 [Q14982-1]
ENST00000374778; ENSP00000363910; ENSG00000183715 [Q14982-3]
ENST00000524381; ENSP00000434750; ENSG00000183715 [Q14982-2]
ENST00000541867; ENSP00000445496; ENSG00000183715 [Q14982-4]
ENST00000612177; ENSP00000482061; ENSG00000183715 [Q14982-1]
GeneIDi4978
KEGGihsa:4978
UCSCiuc001qgs.4 human [Q14982-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
4978
DisGeNETi4978

GeneCards: human genes, protein and diseases

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GeneCardsi
OPCML
HGNCiHGNC:8143 OPCML
MalaCardsiOPCML
MIMi167000 phenotype
600632 gene
neXtProtiNX_Q14982
OpenTargetsiENSG00000183715
PharmGKBiPA31930

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IQJH Eukaryota
ENOG410XT1Y LUCA
GeneTreeiENSGT00940000160304
HOGENOMiHOG000019085
InParanoidiQ14982
KOiK06773
OMAiTHRCTID
OrthoDBi583722at2759
PhylomeDBiQ14982
TreeFamiTF325565

Enzyme and pathway databases

ReactomeiR-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
OPCML human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
OPCML

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
4978

Pharos

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Pharosi
Q14982

Protein Ontology

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PROi
PR:Q14982

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000183715 Expressed in 132 organ(s), highest expression level in Brodmann (1909) area 23
ExpressionAtlasiQ14982 baseline and differential
GenevisibleiQ14982 HS

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF07679 I-set, 2 hits
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOPCM_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14982
Secondary accession number(s): B2CZX2
, B7ZLQ1, Q17RN7, Q7Z3W6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 18, 2019
This is version 173 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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