UniProtKB - Q14978 (NOLC1_HUMAN)
Protein
Nucleolar and coiled-body phosphoprotein 1
Gene
NOLC1
Organism
Homo sapiens (Human)
Status
Functioni
Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786). It has intrinsic GTPase and ATPase activities (PubMed:9016786).3 Publications
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- box C/D snoRNA binding Source: Ensembl
- box C/D snoRNP complex binding Source: Ensembl
- box H/ACA snoRNA binding Source: Ensembl
- box H/ACA snoRNP complex binding Source: Ensembl
- DNA binding Source: Ensembl
- DNA-binding transcription factor activity Source: Ensembl
- GTP binding Source: UniProtKB-KW
- nuclear localization sequence binding Source: Ensembl
- protein domain specific binding Source: Ensembl
- protein heterodimerization activity Source: UniProtKB
- RNA binding Source: UniProtKB
- RNA polymerase I core binding Source: UniProtKB
- transcription factor binding Source: Ensembl
GO - Biological processi
- box H/ACA snoRNA metabolic process Source: Ensembl
- mitotic cell cycle Source: ProtInc
- neural crest cell development Source: UniProtKB
- neural crest formation Source: UniProtKB
- nucleolus organization Source: Ensembl
- positive regulation of cell population proliferation Source: Ensembl
- positive regulation of transcription, DNA-templated Source: Ensembl
- regulation of protein import into nucleus Source: Ensembl
- regulation of translation Source: UniProtKB
- response to osmotic stress Source: Ensembl
- rRNA processing Source: ProtInc
Keywordsi
Ligand | ATP-binding, GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q14978 |
SIGNORi | Q14978 |
Names & Taxonomyi
Protein namesi | Recommended name: Nucleolar and coiled-body phosphoprotein 1CuratedAlternative name(s): 140 kDa nucleolar phosphoprotein1 Publication Short name: Nopp1401 Publication Hepatitis C virus NS5A-transactivated protein 13 Short name: HCV NS5A-transactivated protein 13 Nucleolar 130 kDa protein1 Publication Nucleolar phosphoprotein p1301 Publication |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000166197.16 |
HGNCi | HGNC:15608, NOLC1 |
MIMi | 602394, gene |
neXtProti | NX_Q14978 |
Subcellular locationi
Nucleus
- box C/D snoRNP complex Source: Ensembl
- box H/ACA snoRNP complex Source: Ensembl
- Cajal body Source: Ensembl
- fibrillar center Source: HPA
- nucleolus Source: GO_Central
- nucleoplasm Source: GO_Central
Other locations
- cytoplasm Source: ProtInc
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 9221 |
OpenTargetsi | ENSG00000166197 |
PharmGKBi | PA31679 |
Miscellaneous databases
Pharosi | Q14978, Tbio |
Chemistry databases
DrugBanki | DB00997, Doxorubicin |
Polymorphism and mutation databases
BioMutai | NOLC1 |
DMDMi | 145559503 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000096942 | 1 – 699 | Nucleolar and coiled-body phosphoprotein 1Add BLAST | 699 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 33 | N6-acetyllysineCombined sources | 1 | |
Cross-linki | 67 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 76 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 87 | PhosphoserineCombined sources | 1 | |
Modified residuei | 90 | PhosphoserineCombined sources | 1 | |
Modified residuei | 91 | DiphosphoserineBy similarity | 1 | |
Modified residuei | 91 | PhosphoserineCombined sources | 1 | |
Cross-linki | 186 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 188 | PhosphothreonineCombined sources | 1 | |
Cross-linki | 193 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 342 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 347 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 362 | PhosphoserineCombined sources | 1 | |
Modified residuei | 363 | PhosphoserineCombined sources | 1 | |
Modified residuei | 366 | PhosphoserineCombined sources | 1 | |
Cross-linki | 390 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 396 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 397 | PhosphoserineCombined sources | 1 | |
Cross-linki | 401 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 407 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 415 | N6-acetyllysine; alternateCombined sources | 1 | |
Cross-linki | 415 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources | ||
Cross-linki | 415 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Cross-linki | 440 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 452 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 456 | PhosphoserineCombined sources | 1 | |
Cross-linki | 505 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 508 | PhosphoserineCombined sources | 1 | |
Modified residuei | 538 | PhosphoserineCombined sources | 1 | |
Modified residuei | 563 | PhosphoserineCombined sources | 1 | |
Cross-linki | 572 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources | ||
Cross-linki | 579 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 580 | PhosphoserineCombined sources | 1 | |
Modified residuei | 582 | PhosphoserineCombined sources | 1 | |
Cross-linki | 604 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 607 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 610 | PhosphothreonineCombined sources | 1 | |
Cross-linki | 613 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 622 | PhosphoserineCombined sources | 1 | |
Modified residuei | 643 | PhosphoserineCombined sources | 1 | |
Cross-linki | 647 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 663 | N6-acetyllysine; alternateCombined sources | 1 | |
Cross-linki | 663 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Modified residuei | 683 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 686 | PhosphoserineCombined sources | 1 | |
Cross-linki | 695 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 698 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Undergoes rapid and massive phosphorylation/dephosphorylation cycles on CK2 and PKC sites. NOLC1 is one of the mostly phosphorylated proteins in the cell.1 Publication
Ubiquitinated. Monoubiquitination by the BCR(KBTBD8) complex promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832).1 Publication
Pyrophosphorylated by 5-diphosphoinositol pentakisphosphate (5-IP7). Serine pyrophosphorylation is achieved by Mg2+-dependent, but enzyme independent transfer of a beta-phosphate from a inositol pyrophosphate to a pre-phosphorylated serine residue.By similarity
Keywords - PTMi
Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q14978 |
jPOSTi | Q14978 |
MassIVEi | Q14978 |
MaxQBi | Q14978 |
PaxDbi | Q14978 |
PeptideAtlasi | Q14978 |
PRIDEi | Q14978 |
ProteomicsDBi | 60269 [Q14978-1] 60270 [Q14978-2] 60271 [Q14978-3] |
PTM databases
iPTMneti | Q14978 |
PhosphoSitePlusi | Q14978 |
SwissPalmi | Q14978 |
Expressioni
Gene expression databases
Bgeei | ENSG00000166197, Expressed in middle temporal gyrus and 251 other tissues |
ExpressionAtlasi | Q14978, baseline and differential |
Genevisiblei | Q14978, HS |
Organism-specific databases
HPAi | ENSG00000166197, Low tissue specificity |
Interactioni
Subunit structurei
Binary interactionsi
Hide detailsQ14978
GO - Molecular functioni
- protein domain specific binding Source: Ensembl
- protein heterodimerization activity Source: UniProtKB
- RNA polymerase I core binding Source: UniProtKB
- transcription factor binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 114654, 170 interactors |
CORUMi | Q14978 |
IntActi | Q14978, 83 interactors |
MINTi | Q14978 |
STRINGi | 9606.ENSP00000385410 |
Miscellaneous databases
RNActi | Q14978, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 10 – 42 | LisHPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 84 – 95 | Acidic serine cluster 1Add BLAST | 12 | |
Repeati | 125 – 136 | Acidic serine cluster 2Add BLAST | 12 | |
Repeati | 167 – 178 | Acidic serine cluster 3Add BLAST | 12 | |
Repeati | 221 – 232 | Acidic serine cluster 4Add BLAST | 12 | |
Repeati | 264 – 275 | Acidic serine cluster 5Add BLAST | 12 | |
Repeati | 325 – 336 | Acidic serine cluster 6Add BLAST | 12 | |
Repeati | 363 – 375 | Acidic serine cluster 7Add BLAST | 13 | |
Repeati | 425 – 436 | Acidic serine cluster 8Add BLAST | 12 | |
Repeati | 470 – 481 | Acidic serine cluster 9Add BLAST | 12 | |
Repeati | 519 – 529 | Acidic serine cluster 10Add BLAST | 11 | |
Repeati | 555 – 566 | Acidic serine cluster 11Add BLAST | 12 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 84 – 566 | 11 X 12 AA approximate repeats of an acidic serine clusterAdd BLAST | 483 | |
Regioni | 204 – 382 | Interaction with RPA194Add BLAST | 179 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 68 – 82 | Nuclear localization signalSequence analysisAdd BLAST | 15 | |
Motifi | 384 – 587 | Nuclear localization signalSequence analysisAdd BLAST | 204 | |
Motifi | 601 – 617 | Nuclear localization signalSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Belongs to the NOLC1 family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG2992, Eukaryota |
GeneTreei | ENSGT00730000111092 |
HOGENOMi | CLU_014527_0_0_1 |
InParanoidi | Q14978 |
OMAi | DNGFKKH |
OrthoDBi | 1610147at2759 |
PhylomeDBi | Q14978 |
TreeFami | TF341730 |
Family and domain databases
DisProti | DP01178 |
InterProi | View protein in InterPro IPR006594, LisH IPR039191, Srp40/Nopp140 IPR007718, Srp40_C |
PANTHERi | PTHR23216, PTHR23216, 1 hit |
Pfami | View protein in Pfam PF05022, SRP40_C, 1 hit |
PROSITEi | View protein in PROSITE PS50896, LISH, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
Isoform Alpha (identifier: Q14978-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MADAGIRRVV PSDLYPLVLG FLRDNQLSEV ANKFAKATGA TQQDANASSL
60 70 80 90 100
LDIYSFWLKS AKVPERKLQA NGPVAKKAKK KASSSDSEDS SEEEEEVQGP
110 120 130 140 150
PAKKAAVPAK RVGLPPGKAA AKASESSSSE ESSDDDDEED QKKQPVQKGV
160 170 180 190 200
KPQAKAAKAP PKKAKSSDSD SDSSSEDEPP KNQKPKITPV TVKAQTKAPP
210 220 230 240 250
KPARAAPKIA NGKAASSSSS SSSSSSSDDS EEEKAAATPK KTVPKKQVVA
260 270 280 290 300
KAPVKAATTP TRKSSSSEDS SSDEEEEQKK PMKNKPGPYS SVPPPSAPPP
310 320 330 340 350
KKSLGTQPPK KAVEKQQPVE SSEDSSDESD SSSEEEKKPP TKAVVSKATT
360 370 380 390 400
KPPPAKKAAE SSSDSSDSDS SEDDEAPSKP AGTTKNSSNK PAVTTKSPAV
410 420 430 440 450
KPAAAPKQPV GGGQKLLTRK ADSSSSEEES SSSEEEKTKK MVATTKPKAT
460 470 480 490 500
AKAALSLPAK QAPQGSRDSS SDSDSSSSEE EEEKTSKSAV KKKPQKVAGG
510 520 530 540 550
AAPSKPASAK KGKAESSNSS SSDDSSEEEE EKLKGKGSPR PQAPKANGTS
560 570 580 590 600
ALTAQNGKAA KNSEEEEEEK KKAAVVVSKS GSLKKRKQNE AAKEAETPQA
610 620 630 640 650
KKIKLQTPNT FPKRKKGEKR ASSPFRRVRE EEIEVDSRVA DNSFDAKRGA
660 670 680 690
AGDWGERANQ VLKFTKGKSF RHEKTKKKRG SYRGGSISVQ VNSIKFDSE
Isoform Beta (identifier: Q14978-2) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
241-241: K → KVWTITSVRAE
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0A0MRM9 | A0A0A0MRM9_HUMAN | Nucleolar and coiled-body phosphopr... | NOLC1 | 708 | Annotation score: | ||
S4R349 | S4R349_HUMAN | Nucleolar and coiled-body phosphopr... | NOLC1 | 258 | Annotation score: | ||
S4R3C2 | S4R3C2_HUMAN | Nucleolar and coiled-body phosphopr... | NOLC1 | 281 | Annotation score: | ||
S4R341 | S4R341_HUMAN | Nucleolar and coiled-body phosphopr... | NOLC1 | 73 | Annotation score: | ||
S4R402 | S4R402_HUMAN | Nucleolar and coiled-body phosphopr... | NOLC1 | 46 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 3 | D → A in BAA04803 (PubMed:7584026).Curated | 1 | |
Sequence conflicti | 133 | S → R in CAA84063 (PubMed:7657714).Curated | 1 | |
Sequence conflicti | 291 – 292 | SV → YA in CAA84063 (PubMed:7657714).Curated | 2 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_031677 | 412 | G → V. Corresponds to variant dbSNP:rs11191224EnsemblClinVar. | 1 | |
Natural variantiVAR_031678 | 456 | S → P1 PublicationCorresponds to variant dbSNP:rs1049455Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_035415 | 58 – 59 | LK → LNR in isoform 3. 2 Publications | 2 | |
Alternative sequenceiVSP_004338 | 241 | K → KVWTITSVRAE in isoform Beta. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z34289 mRNA Translation: CAA84063.1 AY820769 mRNA Translation: AAV67777.1 AL500527 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW49714.1 CH471066 Genomic DNA Translation: EAW49715.1 BC001883 mRNA Translation: AAH01883.1 D21262 mRNA Translation: BAA04803.1 |
CCDSi | CCDS65925.1 [Q14978-3] CCDS65926.1 [Q14978-2] CCDS7530.1 [Q14978-1] |
PIRi | I38073 |
RefSeqi | NP_001271317.1, NM_001284388.1 [Q14978-2] NP_001271318.1, NM_001284389.1 [Q14978-3] NP_004732.2, NM_004741.4 [Q14978-1] |
Genome annotation databases
Ensembli | ENST00000405356; ENSP00000385410; ENSG00000166197 [Q14978-2] ENST00000488254; ENSP00000475080; ENSG00000166197 [Q14978-3] ENST00000605788; ENSP00000474710; ENSG00000166197 [Q14978-1] |
GeneIDi | 9221 |
KEGGi | hsa:9221 |
UCSCi | uc001kuo.4, human [Q14978-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z34289 mRNA Translation: CAA84063.1 AY820769 mRNA Translation: AAV67777.1 AL500527 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW49714.1 CH471066 Genomic DNA Translation: EAW49715.1 BC001883 mRNA Translation: AAH01883.1 D21262 mRNA Translation: BAA04803.1 |
CCDSi | CCDS65925.1 [Q14978-3] CCDS65926.1 [Q14978-2] CCDS7530.1 [Q14978-1] |
PIRi | I38073 |
RefSeqi | NP_001271317.1, NM_001284388.1 [Q14978-2] NP_001271318.1, NM_001284389.1 [Q14978-3] NP_004732.2, NM_004741.4 [Q14978-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 114654, 170 interactors |
CORUMi | Q14978 |
IntActi | Q14978, 83 interactors |
MINTi | Q14978 |
STRINGi | 9606.ENSP00000385410 |
Chemistry databases
DrugBanki | DB00997, Doxorubicin |
PTM databases
iPTMneti | Q14978 |
PhosphoSitePlusi | Q14978 |
SwissPalmi | Q14978 |
Polymorphism and mutation databases
BioMutai | NOLC1 |
DMDMi | 145559503 |
Proteomic databases
EPDi | Q14978 |
jPOSTi | Q14978 |
MassIVEi | Q14978 |
MaxQBi | Q14978 |
PaxDbi | Q14978 |
PeptideAtlasi | Q14978 |
PRIDEi | Q14978 |
ProteomicsDBi | 60269 [Q14978-1] 60270 [Q14978-2] 60271 [Q14978-3] |
Protocols and materials databases
Antibodypediai | 31392, 270 antibodies |
DNASUi | 9221 |
Genome annotation databases
Ensembli | ENST00000405356; ENSP00000385410; ENSG00000166197 [Q14978-2] ENST00000488254; ENSP00000475080; ENSG00000166197 [Q14978-3] ENST00000605788; ENSP00000474710; ENSG00000166197 [Q14978-1] |
GeneIDi | 9221 |
KEGGi | hsa:9221 |
UCSCi | uc001kuo.4, human [Q14978-1] |
Organism-specific databases
CTDi | 9221 |
DisGeNETi | 9221 |
EuPathDBi | HostDB:ENSG00000166197.16 |
GeneCardsi | NOLC1 |
HGNCi | HGNC:15608, NOLC1 |
HPAi | ENSG00000166197, Low tissue specificity |
MIMi | 602394, gene |
neXtProti | NX_Q14978 |
OpenTargetsi | ENSG00000166197 |
PharmGKBi | PA31679 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2992, Eukaryota |
GeneTreei | ENSGT00730000111092 |
HOGENOMi | CLU_014527_0_0_1 |
InParanoidi | Q14978 |
OMAi | DNGFKKH |
OrthoDBi | 1610147at2759 |
PhylomeDBi | Q14978 |
TreeFami | TF341730 |
Enzyme and pathway databases
PathwayCommonsi | Q14978 |
SIGNORi | Q14978 |
Miscellaneous databases
BioGRID-ORCSi | 9221, 432 hits in 857 CRISPR screens |
ChiTaRSi | NOLC1, human |
GeneWikii | Nucleolar_phosphoprotein_p130 |
GenomeRNAii | 9221 |
Pharosi | Q14978, Tbio |
PROi | PR:Q14978 |
RNActi | Q14978, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000166197, Expressed in middle temporal gyrus and 251 other tissues |
ExpressionAtlasi | Q14978, baseline and differential |
Genevisiblei | Q14978, HS |
Family and domain databases
DisProti | DP01178 |
InterProi | View protein in InterPro IPR006594, LisH IPR039191, Srp40/Nopp140 IPR007718, Srp40_C |
PANTHERi | PTHR23216, PTHR23216, 1 hit |
Pfami | View protein in Pfam PF05022, SRP40_C, 1 hit |
PROSITEi | View protein in PROSITE PS50896, LISH, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NOLC1_HUMAN | |
Accessioni | Q14978Primary (citable) accession number: Q14978 Secondary accession number(s): Q15030, Q5VV70, Q9BUV3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | April 17, 2007 | |
Last modified: | December 2, 2020 | |
This is version 202 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations