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UniProtKB - Q14978 (NOLC1_HUMAN)

Entry version 205 (02 Jun 2021)
Sequence version 2 (17 Apr 2007)
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Protein

Nucleolar and coiled-body phosphoprotein 1

Gene

NOLC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832).

Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832).

Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786).

It has intrinsic GTPase and ATPase activities (PubMed:9016786).

3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-binding, GTP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q14978

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q14978

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nucleolar and coiled-body phosphoprotein 1Curated
Alternative name(s):
140 kDa nucleolar phosphoprotein1 Publication
Short name:
Nopp1401 Publication
Hepatitis C virus NS5A-transactivated protein 13
Short name:
HCV NS5A-transactivated protein 13
Nucleolar 130 kDa protein1 Publication
Nucleolar phosphoprotein p1301 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NOLC1Imported
Synonyms:KIAA00351 Publication, NS5ATP13
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:15608, NOLC1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602394, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q14978

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000166197.16

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		9221

Open Targets

More...OpenTargetsi		ENSG00000166197

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA31679

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q14978, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB00997, Doxorubicin

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NOLC1

Domain mapping of disease mutations (DMDM)

More...DMDMi		145559503

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000969421 – 699Nucleolar and coiled-body phosphoprotein 1Add BLAST699

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei33N6-acetyllysineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki67Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki76Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei87PhosphoserineCombined sources1
Modified residuei90PhosphoserineCombined sources1
Modified residuei91DiphosphoserineBy similarity1
Modified residuei91PhosphoserineCombined sources1
Cross-linki186Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei188PhosphothreonineCombined sources1
Cross-linki193Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki342Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki347Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei362PhosphoserineCombined sources1
Modified residuei363PhosphoserineCombined sources1
Modified residuei366PhosphoserineCombined sources1
Cross-linki390Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki396Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei397PhosphoserineCombined sources1
Cross-linki401Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki407Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei415N6-acetyllysine; alternateCombined sources1
Cross-linki415Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki415Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki440Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki452Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei456PhosphoserineCombined sources1
Cross-linki505Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei508PhosphoserineCombined sources1
Modified residuei538PhosphoserineCombined sources1
Modified residuei563PhosphoserineCombined sources1
Cross-linki572Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Cross-linki579Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei580PhosphoserineCombined sources1
Modified residuei582PhosphoserineCombined sources1
Cross-linki604Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei607PhosphothreonineCombined sources1
Modified residuei610PhosphothreonineCombined sources1
Cross-linki613Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei622PhosphoserineCombined sources1
Modified residuei643PhosphoserineCombined sources1
Cross-linki647Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei663N6-acetyllysine; alternateCombined sources1
Cross-linki663Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei683Omega-N-methylarginineCombined sources1
Modified residuei686PhosphoserineCombined sources1
Cross-linki695Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei698PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Undergoes rapid and massive phosphorylation/dephosphorylation cycles on CK2 and PKC sites. NOLC1 is one of the mostly phosphorylated proteins in the cell.1 Publication
Ubiquitinated. Monoubiquitination by the BCR(KBTBD8) complex promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832).1 Publication
Pyrophosphorylated by 5-diphosphoinositol pentakisphosphate (5-IP7). Serine pyrophosphorylation is achieved by Mg2+-dependent, but enzyme independent transfer of a beta-phosphate from a inositol pyrophosphate to a pre-phosphorylated serine residue.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q14978

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q14978

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q14978

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q14978

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q14978

PeptideAtlas

More...PeptideAtlasi		Q14978

PRoteomics IDEntifications database

More...PRIDEi		Q14978

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		60269 [Q14978-1]
60270 [Q14978-2]
60271 [Q14978-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q14978

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q14978

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q14978

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000166197, Expressed in middle temporal gyrus and 252 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q14978, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q14978, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000166197, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer; heterodimerizes with TCOF1 following monoubiquitination (PubMed:26399832).

Interacts with RNA polymerase I 194 kDa subunit (RPA194) and with casein kinase-II (PubMed:10567578).

Interacts with DKC1/NAP57, NOP58 and fibrillarin (By similarity).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114654, 198 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q14978

Protein interaction database and analysis system

More...IntActi		Q14978, 83 interactors

Molecular INTeraction database

More...MINTi		Q14978

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000385410

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q14978, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q14978

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini10 – 42LisHPROSITE-ProRule annotationAdd BLAST33
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati84 – 95Acidic serine cluster 1Add BLAST12
Repeati125 – 136Acidic serine cluster 2Add BLAST12
Repeati167 – 178Acidic serine cluster 3Add BLAST12
Repeati221 – 232Acidic serine cluster 4Add BLAST12
Repeati264 – 275Acidic serine cluster 5Add BLAST12
Repeati325 – 336Acidic serine cluster 6Add BLAST12
Repeati363 – 375Acidic serine cluster 7Add BLAST13
Repeati425 – 436Acidic serine cluster 8Add BLAST12
Repeati470 – 481Acidic serine cluster 9Add BLAST12
Repeati519 – 529Acidic serine cluster 10Add BLAST11
Repeati555 – 566Acidic serine cluster 11Add BLAST12

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni65 – 637DisorderedSequence analysisAdd BLAST573
Regioni84 – 56611 X 12 AA approximate repeats of an acidic serine clusterAdd BLAST483
Regioni204 – 382Interaction with RPA194Add BLAST179

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi68 – 82Nuclear localization signalSequence analysisAdd BLAST15
Motifi384 – 587Nuclear localization signalSequence analysisAdd BLAST204
Motifi601 – 617Nuclear localization signalSequence analysisAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi161 – 183Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi212 – 226Polar residuesSequence analysisAdd BLAST15
Compositional biasi267 – 283Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi287 – 305Pro residuesSequence analysisAdd BLAST19
Compositional biasi380 – 395Polar residuesSequence analysisAdd BLAST16
Compositional biasi421 – 443Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi543 – 559Polar residuesSequence analysisAdd BLAST17
Compositional biasi560 – 575Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi583 – 600Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi611 – 637Basic and acidic residuesSequence analysisAdd BLAST27

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NOLC1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2992, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00730000111092

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_014527_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q14978

Identification of Orthologs from Complete Genome Data

More...OMAi		DNGFKKH

Database of Orthologous Groups

More...OrthoDBi		1610147at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q14978

TreeFam database of animal gene trees

More...TreeFami		TF341730

Family and domain databases

Database of protein disorder

More...DisProti		DP01178

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR006594, LisH
IPR007718, Srp40_C

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05022, SRP40_C, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50896, LISH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform Alpha (identifier: Q14978-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADAGIRRVV PSDLYPLVLG FLRDNQLSEV ANKFAKATGA TQQDANASSL 
        60         70         80         90        100
LDIYSFWLKS AKVPERKLQA NGPVAKKAKK KASSSDSEDS SEEEEEVQGP 
       110        120        130        140        150
PAKKAAVPAK RVGLPPGKAA AKASESSSSE ESSDDDDEED QKKQPVQKGV 
       160        170        180        190        200
KPQAKAAKAP PKKAKSSDSD SDSSSEDEPP KNQKPKITPV TVKAQTKAPP 
       210        220        230        240        250
KPARAAPKIA NGKAASSSSS SSSSSSSDDS EEEKAAATPK KTVPKKQVVA 
       260        270        280        290        300
KAPVKAATTP TRKSSSSEDS SSDEEEEQKK PMKNKPGPYS SVPPPSAPPP 
       310        320        330        340        350
KKSLGTQPPK KAVEKQQPVE SSEDSSDESD SSSEEEKKPP TKAVVSKATT 
       360        370        380        390        400
KPPPAKKAAE SSSDSSDSDS SEDDEAPSKP AGTTKNSSNK PAVTTKSPAV 
       410        420        430        440        450
KPAAAPKQPV GGGQKLLTRK ADSSSSEEES SSSEEEKTKK MVATTKPKAT 
       460        470        480        490        500
AKAALSLPAK QAPQGSRDSS SDSDSSSSEE EEEKTSKSAV KKKPQKVAGG 
       510        520        530        540        550
AAPSKPASAK KGKAESSNSS SSDDSSEEEE EKLKGKGSPR PQAPKANGTS 
       560        570        580        590        600
ALTAQNGKAA KNSEEEEEEK KKAAVVVSKS GSLKKRKQNE AAKEAETPQA 
       610        620        630        640        650
KKIKLQTPNT FPKRKKGEKR ASSPFRRVRE EEIEVDSRVA DNSFDAKRGA 
       660        670        680        690 
AGDWGERANQ VLKFTKGKSF RHEKTKKKRG SYRGGSISVQ VNSIKFDSE
Length:699
Mass (Da):73,603
Last modified:April 17, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7C5C4F25677E2E61
GO
Isoform Beta (identifier: Q14978-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     241-241: K → KVWTITSVRAE

Show »
Length:709
Mass (Da):74,747
Checksum:i5A02742A231255AB
GO
Isoform 3 (identifier: Q14978-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     58-59: LK → LNR

Show »
Length:700
Mass (Da):73,745
Checksum:i5F8699563FBA24A9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MRM9A0A0A0MRM9_HUMAN
Nucleolar and coiled-body phosphopr...
NOLC1
708Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R349S4R349_HUMAN
Nucleolar and coiled-body phosphopr...
NOLC1
258Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R3C2S4R3C2_HUMAN
Nucleolar and coiled-body phosphopr...
NOLC1
281Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R341S4R341_HUMAN
Nucleolar and coiled-body phosphopr...
NOLC1
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R402S4R402_HUMAN
Nucleolar and coiled-body phosphopr...
NOLC1
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti3D → A in BAA04803 (PubMed:7584026).Curated1
Sequence conflicti133S → R in CAA84063 (PubMed:7657714).Curated1
Sequence conflicti291 – 292SV → YA in CAA84063 (PubMed:7657714).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_031677412G → V. Corresponds to variant dbSNP:rs11191224EnsemblClinVar.1
Natural variantiVAR_031678456S → P1 PublicationCorresponds to variant dbSNP:rs1049455Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03541558 – 59LK → LNR in isoform 3. 2 Publications2
Alternative sequenceiVSP_004338241K → KVWTITSVRAE in isoform Beta. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Z34289 mRNA Translation: CAA84063.1
AY820769 mRNA Translation: AAV67777.1
AL500527 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49714.1
CH471066 Genomic DNA Translation: EAW49715.1
BC001883 mRNA Translation: AAH01883.1
D21262 mRNA Translation: BAA04803.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS65925.1 [Q14978-3]
CCDS65926.1 [Q14978-2]
CCDS7530.1 [Q14978-1]

Protein sequence database of the Protein Information Resource

More...PIRi		I38073

NCBI Reference Sequences

More...RefSeqi		NP_001271317.1, NM_001284388.1 [Q14978-2]
NP_001271318.1, NM_001284389.1 [Q14978-3]
NP_004732.2, NM_004741.4 [Q14978-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000405356; ENSP00000385410; ENSG00000166197 [Q14978-2]
ENST00000488254; ENSP00000475080; ENSG00000166197 [Q14978-3]
ENST00000605788; ENSP00000474710; ENSG00000166197 [Q14978-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9221

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9221

UCSC genome browser

More...UCSCi		uc001kuo.4, human [Q14978-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z34289 mRNA Translation: CAA84063.1
AY820769 mRNA Translation: AAV67777.1
AL500527 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49714.1
CH471066 Genomic DNA Translation: EAW49715.1
BC001883 mRNA Translation: AAH01883.1
D21262 mRNA Translation: BAA04803.1
CCDSiCCDS65925.1 [Q14978-3]
CCDS65926.1 [Q14978-2]
CCDS7530.1 [Q14978-1]
PIRiI38073
RefSeqiNP_001271317.1, NM_001284388.1 [Q14978-2]
NP_001271318.1, NM_001284389.1 [Q14978-3]
NP_004732.2, NM_004741.4 [Q14978-1]

3D structure databases

SMRiQ14978
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi114654, 198 interactors
CORUMiQ14978
IntActiQ14978, 83 interactors
MINTiQ14978
STRINGi9606.ENSP00000385410

Chemistry databases

DrugBankiDB00997, Doxorubicin

PTM databases

iPTMnetiQ14978
PhosphoSitePlusiQ14978
SwissPalmiQ14978

Genetic variation databases

BioMutaiNOLC1
DMDMi145559503

Proteomic databases

EPDiQ14978
jPOSTiQ14978
MassIVEiQ14978
MaxQBiQ14978
PaxDbiQ14978
PeptideAtlasiQ14978
PRIDEiQ14978
ProteomicsDBi60269 [Q14978-1]
60270 [Q14978-2]
60271 [Q14978-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		31392, 277 antibodies

The DNASU plasmid repository

More...DNASUi		9221

Genome annotation databases

EnsembliENST00000405356; ENSP00000385410; ENSG00000166197 [Q14978-2]
ENST00000488254; ENSP00000475080; ENSG00000166197 [Q14978-3]
ENST00000605788; ENSP00000474710; ENSG00000166197 [Q14978-1]
GeneIDi9221
KEGGihsa:9221
UCSCiuc001kuo.4, human [Q14978-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9221
DisGeNETi9221

GeneCards: human genes, protein and diseases

More...GeneCardsi		NOLC1
HGNCiHGNC:15608, NOLC1
HPAiENSG00000166197, Low tissue specificity
MIMi602394, gene
neXtProtiNX_Q14978
OpenTargetsiENSG00000166197
PharmGKBiPA31679
VEuPathDBiHostDB:ENSG00000166197.16

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2992, Eukaryota
GeneTreeiENSGT00730000111092
HOGENOMiCLU_014527_0_0_1
InParanoidiQ14978
OMAiDNGFKKH
OrthoDBi1610147at2759
PhylomeDBiQ14978
TreeFamiTF341730

Enzyme and pathway databases

PathwayCommonsiQ14978
SIGNORiQ14978

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		9221, 452 hits in 1009 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NOLC1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Nucleolar_phosphoprotein_p130

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9221
PharosiQ14978, Tbio

Protein Ontology

More...PROi		PR:Q14978
RNActiQ14978, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000166197, Expressed in middle temporal gyrus and 252 other tissues
ExpressionAtlasiQ14978, baseline and differential
GenevisibleiQ14978, HS

Family and domain databases

DisProtiDP01178
InterProiView protein in InterPro
IPR006594, LisH
IPR007718, Srp40_C
PfamiView protein in Pfam
PF05022, SRP40_C, 1 hit
PROSITEiView protein in PROSITE
PS50896, LISH, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNOLC1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14978
Secondary accession number(s): Q15030, Q5VV70, Q9BUV3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: April 17, 2007
Last modified: June 2, 2021
This is version 205 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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