Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 216 (13 Nov 2019)
Sequence version 2 (15 May 2002)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Importin subunit beta-1

Gene

KPNB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with IPO7 mediates the nuclear import of H1 histone. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Imports SNAI1 and PRKCI into the nucleus.5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processHost-virus interaction, Protein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1169408 ISG15 antiviral mechanism
R-HSA-140342 Apoptosis induced DNA fragmentation
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF)
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus
R-HSA-168276 NS1 Mediated Effects on Host Pathways
R-HSA-180746 Nuclear import of Rev protein
R-HSA-6798695 Neutrophil degranulation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q14974

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q14974

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Importin subunit beta-1
Alternative name(s):
Importin-90
Karyopherin subunit beta-1
Nuclear factor p97
Pore targeting complex 97 kDa subunit
Short name:
PTAC97
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KPNB1
Synonyms:NTF97
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6400 KPNB1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602738 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q14974

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi178I → A: Largely reduced binding to FxFG repeats and reduced nuclear import. 1 Publication1
Mutagenesisi178I → F or D: Loss of binding to FxFG repeats and reduced nuclear import. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
3837

Open Targets

More...
OpenTargetsi
ENSG00000108424

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30191

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q14974

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3885569

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KPNB1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20981701

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001207451 – 876Importin subunit beta-1Add BLAST876

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1 Publication1
Modified residuei12PhosphoserineCombined sources1
Modified residuei211N6-acetyllysineCombined sources1
Modified residuei835N6-acetyllysineCombined sources1
Modified residuei867N6-acetyllysineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Mono-ADP-ribosylated by PARP16.

Keywords - PTMi

Acetylation, ADP-ribosylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q14974

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q14974

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q14974

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q14974

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q14974

PeptideAtlas

More...
PeptideAtlasi
Q14974

PRoteomics IDEntifications database

More...
PRIDEi
Q14974

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
60268 [Q14974-1]
7089

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q14974-1 [Q14974-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q14974

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q14974

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q14974

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000108424 Expressed in 238 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q14974 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q14974 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB034449
HPA029878
HPA050302

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a complex with an importin alpha subunit (PubMed:8617227, PubMed:8692944).

Forms a heterodimer with IPO7.

Interacts with IPO7, SNUPN, RPL23A and XPO1. The KPNB1/IPO7 heterodimer interacts with H1 histone.

Interacts with H2A, H2B, H3 and H4 histones (By similarity).

Component of an import snRNP complex composed of KPNB1, SNUPN, SMN1 and ZNF259.

Component of a nuclear export receptor complex composed of KPNB1, Ran, SNUPN and XPO1.

Interacts with SRY.

Interacts with PRKCI/atypical protein kinase C iota.

Interacts with KPNA7.

Interacts with SNAI1 (via zinc fingers) and SNAI2 (via zinc fingers).

Interacts with SLC35G1 and STIM1.

Interacts with DCAF8.

Interacts with RAN (By similarity).

Interacts with NUMA1 (via C-terminus); this interaction is inhibited by RanGTP (PubMed:11229403).

By similarity18 Publications

(Microbial infection) Interacts with HIV-1 Rev and Tat.

2 Publications

(Microbial infection) Interacts with HTLV-1 Rex.

1 Publication

(Microbial infection) Interacts with human respiratory syncytial virus (HRSV) protein M.

2 Publications

(Microbial infection)

Part of a tetrameric complex composed of CRM1, importin alpha/beta dimer and the Venezuelan equine encephalitis virus (VEEV) capsid; this complex blocks the receptor-mediated transport through the nuclear pore.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110035, 317 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1027 Importin complex, KPNA2 variant
CPX-1032 Importin complex, Snurportin variant
CPX-1055 Importin complex, KPNA1 variant
CPX-1057 Importin complex, KPNA3 variant
CPX-1060 Importin complex, KPNA4 variant
CPX-1063 Importin complex, KPNA5 variant
CPX-1064 Importin complex, KPNA6 variant
CPX-1066 Importin complex, KPNA7 variant

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q14974

Database of interacting proteins

More...
DIPi
DIP-6204N

Protein interaction database and analysis system

More...
IntActi
Q14974, 199 interactors

Molecular INTeraction database

More...
MINTi
Q14974

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000290158

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1876
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q14974

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q14974

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati2 – 31HEAT 12 PublicationsAdd BLAST30
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini21 – 101Importin N-terminalPROSITE-ProRule annotationAdd BLAST81
Repeati33 – 65HEAT 22 PublicationsAdd BLAST33
Repeati85 – 123HEAT 32 PublicationsAdd BLAST39
Repeati129 – 160HEAT 42 PublicationsAdd BLAST32
Repeati170 – 202HEAT 52 PublicationsAdd BLAST33
Repeati212 – 247HEAT 62 PublicationsAdd BLAST36
Repeati253 – 302HEAT 72 PublicationsAdd BLAST50
Repeati314 – 360HEAT 82 PublicationsAdd BLAST47
Repeati364 – 394HEAT 92 PublicationsAdd BLAST31
Repeati402 – 438HEAT 102 PublicationsAdd BLAST37
Repeati449 – 485HEAT 111 PublicationAdd BLAST37
Repeati500 – 537HEAT 121 PublicationAdd BLAST38
Repeati544 – 592HEAT 131 PublicationAdd BLAST49
Repeati600 – 639HEAT 141 PublicationAdd BLAST40
Repeati644 – 681HEAT 151 PublicationAdd BLAST38
Repeati686 – 724HEAT 161 PublicationAdd BLAST39
Repeati732 – 776HEAT 171 PublicationAdd BLAST45
Repeati786 – 829HEAT 181 PublicationAdd BLAST44
Repeati831 – 873HEAT 191 PublicationAdd BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni329 – 342IAB-bindingAdd BLAST14
Regioni334 – 419Ran-GTP bindingAdd BLAST86

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi337 – 341Poly-Asp5

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1241 Eukaryota
COG5215 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00550000074898

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000204108

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q14974

KEGG Orthology (KO)

More...
KOi
K14293

Identification of Orthologs from Complete Genome Data

More...
OMAi
KNHLTSK

Database of Orthologous Groups

More...
OrthoDBi
769199at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q14974

TreeFam database of animal gene trees

More...
TreeFami
TF105655

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
IPR021133 HEAT_type_2
IPR001494 Importin-beta_N
IPR040122 Importin_beta

The PANTHER Classification System

More...
PANTHERi
PTHR10527 PTHR10527, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03810 IBN_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00185 ARM, 3 hits
SM00913 IBN_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50077 HEAT_REPEAT, 1 hit
PS50166 IMPORTIN_B_NT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q14974-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MELITILEKT VSPDRLELEA AQKFLERAAV ENLPTFLVEL SRVLANPGNS
60 70 80 90 100
QVARVAAGLQ IKNSLTSKDP DIKAQYQQRW LAIDANARRE VKNYVLQTLG
110 120 130 140 150
TETYRPSSAS QCVAGIACAE IPVNQWPELI PQLVANVTNP NSTEHMKEST
160 170 180 190 200
LEAIGYICQD IDPEQLQDKS NEILTAIIQG MRKEEPSNNV KLAATNALLN
210 220 230 240 250
SLEFTKANFD KESERHFIMQ VVCEATQCPD TRVRVAALQN LVKIMSLYYQ
260 270 280 290 300
YMETYMGPAL FAITIEAMKS DIDEVALQGI EFWSNVCDEE MDLAIEASEA
310 320 330 340 350
AEQGRPPEHT SKFYAKGALQ YLVPILTQTL TKQDENDDDD DWNPCKAAGV
360 370 380 390 400
CLMLLATCCE DDIVPHVLPF IKEHIKNPDW RYRDAAVMAF GCILEGPEPS
410 420 430 440 450
QLKPLVIQAM PTLIELMKDP SVVVRDTAAW TVGRICELLP EAAINDVYLA
460 470 480 490 500
PLLQCLIEGL SAEPRVASNV CWAFSSLAEA AYEAADVADD QEEPATYCLS
510 520 530 540 550
SSFELIVQKL LETTDRPDGH QNNLRSSAYE SLMEIVKNSA KDCYPAVQKT
560 570 580 590 600
TLVIMERLQQ VLQMESHIQS TSDRIQFNDL QSLLCATLQN VLRKVQHQDA
610 620 630 640 650
LQISDVVMAS LLRMFQSTAG SGGVQEDALM AVSTLVEVLG GEFLKYMEAF
660 670 680 690 700
KPFLGIGLKN YAEYQVCLAA VGLVGDLCRA LQSNIIPFCD EVMQLLLENL
710 720 730 740 750
GNENVHRSVK PQILSVFGDI ALAIGGEFKK YLEVVLNTLQ QASQAQVDKS
760 770 780 790 800
DYDMVDYLNE LRESCLEAYT GIVQGLKGDQ ENVHPDVMLV QPRVEFILSF
810 820 830 840 850
IDHIAGDEDH TDGVVACAAG LIGDLCTAFG KDVLKLVEAR PMIHELLTEG
860 870
RRSKTNKAKT LATWATKELR KLKNQA
Length:876
Mass (Da):97,170
Last modified:May 15, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF3BB8B73E7E51639
GO
Isoform 2 (identifier: Q14974-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-145: Missing.

Note: No experimental confirmation available.
Show »
Length:731
Mass (Da):81,179
Checksum:i03F6C311DF096541
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KTM9J3KTM9_HUMAN
Importin subunit beta-1
KPNB1
690Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QKQ5J3QKQ5_HUMAN
Importin subunit beta-1
KPNB1
248Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QR48J3QR48_HUMAN
Importin subunit beta-1
KPNB1
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QRG4J3QRG4_HUMAN
Importin subunit beta-1
KPNB1
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KS06J3KS06_HUMAN
Importin subunit beta-1
KPNB1
22Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti97Q → H in AAA82869 (PubMed:7615630).Curated1
Sequence conflicti200N → NA AA sequence (PubMed:8617227).Curated1
Sequence conflicti863T → R in AAA82869 (PubMed:7615630).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0546121 – 145Missing in isoform 2. 1 PublicationAdd BLAST145

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L39793 Genomic DNA Translation: AAA82869.1
L38951 mRNA Translation: AAC41763.1
BT009797 mRNA Translation: AAP88799.1
AK316421 mRNA Translation: BAH14792.1
AC015674 Genomic DNA No translation available.
AC025682 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94807.1
CH471109 Genomic DNA Translation: EAW94808.1
CH471109 Genomic DNA Translation: EAW94810.1
BC003572 mRNA Translation: AAH03572.1
BC024045 mRNA Translation: AAH24045.1
BC036703 mRNA Translation: AAH36703.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11513.1 [Q14974-1]
CCDS62228.1 [Q14974-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
I52907

NCBI Reference Sequences

More...
RefSeqi
NP_001263382.1, NM_001276453.1 [Q14974-2]
NP_002256.2, NM_002265.5 [Q14974-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000290158; ENSP00000290158; ENSG00000108424 [Q14974-1]
ENST00000535458; ENSP00000438253; ENSG00000108424 [Q14974-2]
ENST00000540627; ENSP00000438964; ENSG00000108424 [Q14974-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3837

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3837

UCSC genome browser

More...
UCSCi
uc002ilt.3 human [Q14974-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39793 Genomic DNA Translation: AAA82869.1
L38951 mRNA Translation: AAC41763.1
BT009797 mRNA Translation: AAP88799.1
AK316421 mRNA Translation: BAH14792.1
AC015674 Genomic DNA No translation available.
AC025682 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94807.1
CH471109 Genomic DNA Translation: EAW94808.1
CH471109 Genomic DNA Translation: EAW94810.1
BC003572 mRNA Translation: AAH03572.1
BC024045 mRNA Translation: AAH24045.1
BC036703 mRNA Translation: AAH36703.1
CCDSiCCDS11513.1 [Q14974-1]
CCDS62228.1 [Q14974-2]
PIRiI52907
RefSeqiNP_001263382.1, NM_001276453.1 [Q14974-2]
NP_002256.2, NM_002265.5 [Q14974-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1F59X-ray2.80A/B1-442[»]
1IBRX-ray2.30B/D1-462[»]
1M5NX-ray2.90S1-485[»]
1O6OX-ray2.80A/B/C1-442[»]
1O6PX-ray2.80A/B1-442[»]
1QGKX-ray2.50A1-876[»]
1QGRX-ray2.30A1-876[»]
2P8QX-ray2.35A1-876[»]
2Q5DX-ray3.20A/B1-876[»]
2QNAX-ray2.84A127-875[»]
3LWWX-ray3.15A/C1-876[»]
3W5KX-ray2.60A1-876[»]
6N88electron microscopy6.20B1-876[»]
6N89electron microscopy7.50A1-876[»]
SMRiQ14974
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi110035, 317 interactors
ComplexPortaliCPX-1027 Importin complex, KPNA2 variant
CPX-1032 Importin complex, Snurportin variant
CPX-1055 Importin complex, KPNA1 variant
CPX-1057 Importin complex, KPNA3 variant
CPX-1060 Importin complex, KPNA4 variant
CPX-1063 Importin complex, KPNA5 variant
CPX-1064 Importin complex, KPNA6 variant
CPX-1066 Importin complex, KPNA7 variant
CORUMiQ14974
DIPiDIP-6204N
IntActiQ14974, 199 interactors
MINTiQ14974
STRINGi9606.ENSP00000290158

Chemistry databases

ChEMBLiCHEMBL3885569

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

PTM databases

iPTMnetiQ14974
PhosphoSitePlusiQ14974
SwissPalmiQ14974

Polymorphism and mutation databases

BioMutaiKPNB1
DMDMi20981701

Proteomic databases

EPDiQ14974
jPOSTiQ14974
MassIVEiQ14974
MaxQBiQ14974
PaxDbiQ14974
PeptideAtlasiQ14974
PRIDEiQ14974
ProteomicsDBi60268 [Q14974-1]
7089
TopDownProteomicsiQ14974-1 [Q14974-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3837

Genome annotation databases

EnsembliENST00000290158; ENSP00000290158; ENSG00000108424 [Q14974-1]
ENST00000535458; ENSP00000438253; ENSG00000108424 [Q14974-2]
ENST00000540627; ENSP00000438964; ENSG00000108424 [Q14974-2]
GeneIDi3837
KEGGihsa:3837
UCSCiuc002ilt.3 human [Q14974-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3837
DisGeNETi3837

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KPNB1
HGNCiHGNC:6400 KPNB1
HPAiCAB034449
HPA029878
HPA050302
MIMi602738 gene
neXtProtiNX_Q14974
OpenTargetsiENSG00000108424
PharmGKBiPA30191

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1241 Eukaryota
COG5215 LUCA
GeneTreeiENSGT00550000074898
HOGENOMiHOG000204108
InParanoidiQ14974
KOiK14293
OMAiKNHLTSK
OrthoDBi769199at2759
PhylomeDBiQ14974
TreeFamiTF105655

Enzyme and pathway databases

ReactomeiR-HSA-1169408 ISG15 antiviral mechanism
R-HSA-140342 Apoptosis induced DNA fragmentation
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF)
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus
R-HSA-168276 NS1 Mediated Effects on Host Pathways
R-HSA-180746 Nuclear import of Rev protein
R-HSA-6798695 Neutrophil degranulation
SignaLinkiQ14974
SIGNORiQ14974

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
KPNB1 human
EvolutionaryTraceiQ14974

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
KPNB1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3837
PharosiQ14974

Protein Ontology

More...
PROi
PR:Q14974

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000108424 Expressed in 238 organ(s), highest expression level in testis
ExpressionAtlasiQ14974 baseline and differential
GenevisibleiQ14974 HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
IPR021133 HEAT_type_2
IPR001494 Importin-beta_N
IPR040122 Importin_beta
PANTHERiPTHR10527 PTHR10527, 1 hit
PfamiView protein in Pfam
PF03810 IBN_N, 1 hit
SMARTiView protein in SMART
SM00185 ARM, 3 hits
SM00913 IBN_N, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50077 HEAT_REPEAT, 1 hit
PS50166 IMPORTIN_B_NT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIMB1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14974
Secondary accession number(s): B7ZAV6
, D3DTT3, Q14637, Q53XN2, Q96J27
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 15, 2002
Last modified: November 13, 2019
This is version 216 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again