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Entry version 170 (17 Jun 2020)
Sequence version 1 (01 Nov 1996)
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Protein

Sodium/bile acid cotransporter

Gene

SLC10A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium.
(Microbial infection) Acts as a receptor for hepatitis B virus.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHost cell receptor for virus entry, Receptor
Biological processHost-virus interaction, Ion transport, Sodium transport, Symport, Transport
LigandSodium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-159418 Recycling of bile acids and salts

Protein family/group databases

Transport Classification Database

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TCDBi
2.A.28.1.9 the bile acid:na(+) symporter (bass) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium/bile acid cotransporter
Alternative name(s):
Cell growth-inhibiting gene 29 protein
Na(+)/bile acid cotransporter
Na(+)/taurocholate transport protein
Sodium/taurocholate cotransporting polypeptide
Solute carrier family 10 member 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC10A1
Synonyms:NTCP
ORF Names:GIG29
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000100652.4

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10905 SLC10A1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
182396 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q14973

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei25 – 45HelicalSequence analysisAdd BLAST21
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Transmembranei91 – 111HelicalSequence analysisAdd BLAST21
Transmembranei120 – 140HelicalSequence analysisAdd BLAST21
Transmembranei156 – 176HelicalSequence analysisAdd BLAST21
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21
Transmembranei220 – 240HelicalSequence analysisAdd BLAST21
Transmembranei283 – 303HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6554

Open Targets

More...
OpenTargetsi
ENSG00000100652

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA317

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q14973 Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5287

Drug and drug target database

More...
DrugBanki
DB00887 Bumetanide
DB02659 Cholic Acid
DB00286 Conjugated estrogens
DB00091 Cyclosporine
DB03619 Deoxycholic acid
DB00977 Ethinylestradiol
DB02123 Glycochenodeoxycholic Acid
DB00328 Indomethacin
DB00279 Liothyronine
DB01583 Liotrix
DB08860 Pitavastatin
DB01032 Probenecid
DB00396 Progesterone
DB01098 Rosuvastatin
DB06290 Simeprevir
DB04348 Taurocholic acid
DB00624 Testosterone
DB13943 Testosterone cypionate
DB13944 Testosterone enanthate
DB13946 Testosterone undecanoate
DB01586 Ursodeoxycholic acid

DrugCentral

More...
DrugCentrali
Q14973

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
959

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
SLC10A1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
2498046

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000523351 – 349Sodium/bile acid cotransporterAdd BLAST349

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi11N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi117N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi336N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q14973

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q14973

PeptideAtlas

More...
PeptideAtlasi
Q14973

PRoteomics IDEntifications database

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PRIDEi
Q14973

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
60267

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q14973

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q14973

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000100652 Expressed in liver and 71 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q14973 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000100652 Tissue enriched (liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

(Microbial infection) Interacts with hepatitis B virus large envelope protein.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q14973
With#Exp.IntAct
ABHD16A [O95870]3EBI-3923031,EBI-348517
ACSL5 [Q9ULC5]3EBI-3923031,EBI-2876927
AGPAT3 [Q9NRZ7]3EBI-3923031,EBI-2803601
ARL6IP6 [Q8N6S5]3EBI-3923031,EBI-2808844
ASGR1 [P07306]3EBI-3923031,EBI-1172335
ATP6V0B [Q99437]3EBI-3923031,EBI-3904417
BMP10 [O95393]3EBI-3923031,EBI-3922513
C16orf58 [Q96GQ5]3EBI-3923031,EBI-8636004
C2 [P06681]3EBI-3923031,EBI-2835920
C8A [P07357]3EBI-3923031,EBI-9021639
CFHR5 [Q9BXR6]3EBI-3923031,EBI-11579371
CLDN19 - isoform 2 [Q8N6F1-2]3EBI-3923031,EBI-12256978
CMTM3 [Q96MX0]3EBI-3923031,EBI-7247651
COX20 [Q5RI15]3EBI-3923031,EBI-2834035
CXCL9 [Q07325]3EBI-3923031,EBI-3911467
CYB5R3 [P00387]3EBI-3923031,EBI-1046040
DERL1 [Q9BUN8]3EBI-3923031,EBI-398977
DGAT2L6 [Q6ZPD8]3EBI-3923031,EBI-12831978
FA2H [Q7L5A8]3EBI-3923031,EBI-11337888
FAM241B - isoform 2 [Q96D05-2]3EBI-3923031,EBI-12118888
FAXDC2 [Q96IV6]3EBI-3923031,EBI-12142299
FDFT1 [P37268]3EBI-3923031,EBI-714550
FXYD3 - isoform 3 [Q14802-3]3EBI-3923031,EBI-12175685
FXYD6 [Q9H0Q3]3EBI-3923031,EBI-713304
GAST [P01350]3EBI-3923031,EBI-3436637
GDE1 [Q9NZC3]3EBI-3923031,EBI-2833330
GIMAP5 [Q96F15]3EBI-3923031,EBI-6166686
GOSR2 [O14653]3EBI-3923031,EBI-4401517
GPR151 [Q8TDV0]3EBI-3923031,EBI-11955647
GPR152 [Q8TDT2]3EBI-3923031,EBI-13345167
IFITM2 [Q6IBB0]3EBI-3923031,EBI-12167419
IFITM3 [Q01628]3EBI-3923031,EBI-7932862
LRP10 [Q7Z4F1]3EBI-3923031,EBI-2830349
LSS [P48449]3EBI-3923031,EBI-3930711
MAL [P21145]3EBI-3923031,EBI-3932027
MALL [Q13021]3EBI-3923031,EBI-750078
MFSD6 [Q6ZSS7]3EBI-3923031,EBI-2858252
MS4A1 [P11836]3EBI-3923031,EBI-2808234
MYADML2 [A6NDP7]3EBI-3923031,EBI-17641390
NEU1 [Q99519]3EBI-3923031,EBI-721517
NINJ2 [Q9NZG7]3EBI-3923031,EBI-10317425
ORMDL1 [Q9P0S3]3EBI-3923031,EBI-1054848
ORMDL2 [Q53FV1]3EBI-3923031,EBI-11075081
ORMDL3 [Q8N138]3EBI-3923031,EBI-721750
OTOP3 [Q7RTS5]3EBI-3923031,EBI-12853910
PEX16 [Q9Y5Y5]3EBI-3923031,EBI-981985
PKMYT1 - isoform 2 [Q99640-2]3EBI-3923031,EBI-12257782
SACM1L [Q9NTJ5]3EBI-3923031,EBI-3917235
SCAMP4 [Q969E2]3EBI-3923031,EBI-4403649
SELENOK [Q9Y6D0]3EBI-3923031,EBI-9679163
SFT2D1 [Q8WV19]3EBI-3923031,EBI-2854842
SFT2D2 [O95562]3EBI-3923031,EBI-4402330
SFXN1 [Q9H9B4]3EBI-3923031,EBI-355861
SLC12A7 - isoform 2 [Q9Y666-2]3EBI-3923031,EBI-12854384
SLC16A13 [Q7RTY0]3EBI-3923031,EBI-12243266
SLC25A46 [Q96AG3]3EBI-3923031,EBI-10281975
SLC35E4 [Q6ICL7]3EBI-3923031,EBI-12867720
SLC38A1 [Q9H2H9]3EBI-3923031,EBI-9978441
SLC38A7 [Q9NVC3]3EBI-3923031,EBI-10314552
SLC41A1 [Q8IVJ1]3EBI-3923031,EBI-12266234
SLC66A2 [Q8N2U9]3EBI-3923031,EBI-3907610
SLC7A3 [Q8WY07]3EBI-3923031,EBI-13066314
SMPD2 [O60906]3EBI-3923031,EBI-12828299
STX7 [O15400]3EBI-3923031,EBI-3221827
TAP1 [Q03518]3EBI-3923031,EBI-747259
TFRC [P02786]3EBI-3923031,EBI-355727
TMBIM1 [Q969X1]3EBI-3923031,EBI-2820569
TMEM120B [A0PK00]3EBI-3923031,EBI-10171534
TMEM121 [Q9BTD3]3EBI-3923031,EBI-12155101
TMEM147 [Q9BVK8]3EBI-3923031,EBI-348587
TMEM189-UBE2V1 [I3L0A0]3EBI-3923031,EBI-12213001
TMEM222 [Q9H0R3]3EBI-3923031,EBI-347385
TMEM234 [Q8WY98]3EBI-3923031,EBI-8642211
TMEM239 - isoform 2 [Q8WW34-2]3EBI-3923031,EBI-11528917
TMEM242 [Q9NWH2]3EBI-3923031,EBI-10315004
TMEM60 [Q9H2L4]3EBI-3923031,EBI-2852148
TMUB2 [Q71RG4]3EBI-3923031,EBI-2820477
TOMM6 [Q96B49]3EBI-3923031,EBI-10826510
TSPO2 [Q5TGU0]3EBI-3923031,EBI-12195249
TUSC5 [A5PKU2]3EBI-3923031,EBI-11988865
TVP23B [Q9NYZ1]3EBI-3923031,EBI-11343401
UNC50 [Q53HI1]3EBI-3923031,EBI-7601760
VAMP3 [Q15836]3EBI-3923031,EBI-722343
YIF1A [O95070]3EBI-3923031,EBI-2799703
YIPF4 [Q9BSR8]3EBI-3923031,EBI-751253
YIPF6 [Q96EC8]3EBI-3923031,EBI-751210
Q96FB23EBI-3923031,EBI-2857623

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
112443, 1 interactor

Protein interaction database and analysis system

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IntActi
Q14973, 88 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000216540

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q14973

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q14973 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2718 Eukaryota
COG0385 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182808

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_034788_7_5_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q14973

KEGG Orthology (KO)

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KOi
K14341

Identification of Orthologs from Complete Genome Data

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OMAi
KSIMFVM

Database of Orthologous Groups

More...
OrthoDBi
1148347at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q14973

TreeFam database of animal gene trees

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TreeFami
TF315811

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.1530.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002657 BilAc:Na_symport/Acr3
IPR004710 Bilac:Na_transpt
IPR038770 Na+/solute_symporter_sf
IPR030208 SLC10A1

The PANTHER Classification System

More...
PANTHERi
PTHR10361 PTHR10361, 1 hit
PTHR10361:SF40 PTHR10361:SF40, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01758 SBF, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00841 bass, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q14973-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAHNASAPF NFTLPPNFGK RPTDLALSVI LVFMLFFIML SLGCTMEFSK
60 70 80 90 100
IKAHLWKPKG LAIALVAQYG IMPLTAFVLG KVFRLKNIEA LAILVCGCSP
110 120 130 140 150
GGNLSNVFSL AMKGDMNLSI VMTTCSTFCA LGMMPLLLYI YSRGIYDGDL
160 170 180 190 200
KDKVPYKGIV ISLVLVLIPC TIGIVLKSKR PQYMRYVIKG GMIIILLCSV
210 220 230 240 250
AVTVLSAINV GKSIMFAMTP LLIATSSLMP FIGFLLGYVL SALFCLNGRC
260 270 280 290 300
RRTVSMETGC QNVQLCSTIL NVAFPPEVIG PLFFFPLLYM IFQLGEGLLL
310 320 330 340
IAIFWCYEKF KTPKDKTKMI YTAATTEETI PGALGNGTYK GEDCSPCTA
Length:349
Mass (Da):38,119
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF3AB2CC2FBD925E3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_022113267S → F. Corresponds to variant dbSNP:rs2296651EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
L21893 mRNA Translation: AAA36381.1
AY544127 mRNA Translation: AAT11158.1
CH471061 Genomic DNA Translation: EAW81011.1
BC069799 mRNA Translation: AAH69799.1
BC069822 mRNA Translation: AAH69822.1
BC074724 mRNA Translation: AAH74724.1
BC126298 mRNA Translation: AAI26299.1
BC136355 mRNA Translation: AAI36356.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS9797.1

Protein sequence database of the Protein Information Resource

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PIRi
I55601

NCBI Reference Sequences

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RefSeqi
NP_003040.1, NM_003049.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000216540; ENSP00000216540; ENSG00000100652

Database of genes from NCBI RefSeq genomes

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GeneIDi
6554

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6554

UCSC genome browser

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UCSCi
uc001xlr.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L21893 mRNA Translation: AAA36381.1
AY544127 mRNA Translation: AAT11158.1
CH471061 Genomic DNA Translation: EAW81011.1
BC069799 mRNA Translation: AAH69799.1
BC069822 mRNA Translation: AAH69822.1
BC074724 mRNA Translation: AAH74724.1
BC126298 mRNA Translation: AAI26299.1
BC136355 mRNA Translation: AAI36356.1
CCDSiCCDS9797.1
PIRiI55601
RefSeqiNP_003040.1, NM_003049.3

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi112443, 1 interactor
IntActiQ14973, 88 interactors
STRINGi9606.ENSP00000216540

Chemistry databases

BindingDBiQ14973
ChEMBLiCHEMBL5287
DrugBankiDB00887 Bumetanide
DB02659 Cholic Acid
DB00286 Conjugated estrogens
DB00091 Cyclosporine
DB03619 Deoxycholic acid
DB00977 Ethinylestradiol
DB02123 Glycochenodeoxycholic Acid
DB00328 Indomethacin
DB00279 Liothyronine
DB01583 Liotrix
DB08860 Pitavastatin
DB01032 Probenecid
DB00396 Progesterone
DB01098 Rosuvastatin
DB06290 Simeprevir
DB04348 Taurocholic acid
DB00624 Testosterone
DB13943 Testosterone cypionate
DB13944 Testosterone enanthate
DB13946 Testosterone undecanoate
DB01586 Ursodeoxycholic acid
DrugCentraliQ14973
GuidetoPHARMACOLOGYi959

Protein family/group databases

TCDBi2.A.28.1.9 the bile acid:na(+) symporter (bass) family

PTM databases

iPTMnetiQ14973
PhosphoSitePlusiQ14973

Polymorphism and mutation databases

BioMutaiSLC10A1
DMDMi2498046

Proteomic databases

MassIVEiQ14973
PaxDbiQ14973
PeptideAtlasiQ14973
PRIDEiQ14973
ProteomicsDBi60267

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
47330 209 antibodies

The DNASU plasmid repository

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DNASUi
6554

Genome annotation databases

EnsembliENST00000216540; ENSP00000216540; ENSG00000100652
GeneIDi6554
KEGGihsa:6554
UCSCiuc001xlr.3 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6554
DisGeNETi6554
EuPathDBiHostDB:ENSG00000100652.4

GeneCards: human genes, protein and diseases

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GeneCardsi
SLC10A1
HGNCiHGNC:10905 SLC10A1
HPAiENSG00000100652 Tissue enriched (liver)
MIMi182396 gene
neXtProtiNX_Q14973
OpenTargetsiENSG00000100652
PharmGKBiPA317

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2718 Eukaryota
COG0385 LUCA
GeneTreeiENSGT00950000182808
HOGENOMiCLU_034788_7_5_1
InParanoidiQ14973
KOiK14341
OMAiKSIMFVM
OrthoDBi1148347at2759
PhylomeDBiQ14973
TreeFamiTF315811

Enzyme and pathway databases

ReactomeiR-HSA-159418 Recycling of bile acids and salts

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
6554 1 hit in 781 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SLC10A1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SLC10A1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6554
PharosiQ14973 Tchem

Protein Ontology

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PROi
PR:Q14973
RNActiQ14973 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000100652 Expressed in liver and 71 other tissues
GenevisibleiQ14973 HS

Family and domain databases

Gene3Di1.20.1530.20, 1 hit
InterProiView protein in InterPro
IPR002657 BilAc:Na_symport/Acr3
IPR004710 Bilac:Na_transpt
IPR038770 Na+/solute_symporter_sf
IPR030208 SLC10A1
PANTHERiPTHR10361 PTHR10361, 1 hit
PTHR10361:SF40 PTHR10361:SF40, 1 hit
PfamiView protein in Pfam
PF01758 SBF, 1 hit
TIGRFAMsiTIGR00841 bass, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNTCP_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14973
Secondary accession number(s): B9EGB6, Q2TU29
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 17, 2020
This is version 170 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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