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Protein

Zinc finger protein 638

Gene

ZNF638

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Early regulator of adipogenesis that works as a transcription cofactor of CEBPs, controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). Binds to cytidine clusters in double-stranded DNA (PubMed:8647861). May also regulate alternative splicing of target genes during adipogenesis (By similarity).By similarity1 Publication

Miscellaneous

Isoform 5 is a tumor-associated antigen found in several cutaneous T-cell lymphoma (CTCL), and in particular in mycosis fungoides patients and in Sezary syndrome patients.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi1353 – 1477Add BLAST125
Zinc fingeri1928 – 1958Matrin-typePROSITE-ProRule annotationAdd BLAST31

GO - Molecular functioni

  • double-stranded DNA binding Source: ProtInc
  • RNA binding Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, RNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-381340 Transcriptional regulation of white adipocyte differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 638
Alternative name(s):
Cutaneous T-cell lymphoma-associated antigen se33-1
Short name:
CTCL-associated antigen se33-1
Nuclear protein 220
Zinc finger matrin-like protein
Gene namesi
Name:ZNF638
Synonyms:NP220, ZFML
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000075292.18
HGNCiHGNC:17894 ZNF638
MIMi614349 gene
neXtProtiNX_Q14966

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi27332
OpenTargetsiENSG00000075292
PharmGKBiPA134983478

Polymorphism and mutation databases

BioMutaiZNF638
DMDMi71153483

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000820111 – 1978Zinc finger protein 638Add BLAST1978

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei47Asymmetric dimethylarginineCombined sources1
Modified residuei49Asymmetric dimethylarginineCombined sources1
Modified residuei54Asymmetric dimethylarginineCombined sources1
Modified residuei128PhosphoserineCombined sources1
Modified residuei289PhosphoserineCombined sources1
Cross-linki292Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei299PhosphoserineCombined sources1
Modified residuei369PhosphoserineCombined sources1
Modified residuei383PhosphoserineCombined sources1
Modified residuei420PhosphoserineCombined sources1
Modified residuei552PhosphoserineCombined sources1
Modified residuei605PhosphoserineCombined sources1
Modified residuei614PhosphoserineCombined sources1
Modified residuei636PhosphoserineCombined sources1
Cross-linki775Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1100PhosphoserineCombined sources1
Modified residuei1401PhosphoserineCombined sources1
Modified residuei1641PhosphoserineBy similarity1
Modified residuei1667PhosphoserineCombined sources1
Cross-linki1676Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1820Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1882PhosphoserineCombined sources1
Isoform 6 (identifier: Q14966-6)
Cross-linki913Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ14966
MaxQBiQ14966
PaxDbiQ14966
PeptideAtlasiQ14966
PRIDEiQ14966
ProteomicsDBi60262
60263 [Q14966-2]
60264 [Q14966-3]
60265 [Q14966-4]
60266 [Q14966-5]

PTM databases

iPTMnetiQ14966
PhosphoSitePlusiQ14966

Expressioni

Gene expression databases

BgeeiENSG00000075292 Expressed in 238 organ(s), highest expression level in corpus callosum
CleanExiHS_ZNF638
ExpressionAtlasiQ14966 baseline and differential
GenevisibleiQ14966 HS

Organism-specific databases

HPAiHPA036784
HPA057395

Interactioni

Subunit structurei

Interacts with FHL2 (PubMed:11813260). Interacts with CEBPA, CEBPD and CEBPG (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi118145, 141 interactors
DIPiDIP-42386N
IntActiQ14966, 34 interactors
MINTiQ14966
STRINGi9606.ENSP00000264447

Structurei

3D structure databases

ProteinModelPortaliQ14966
SMRiQ14966
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini676 – 751RRM 1PROSITE-ProRule annotationAdd BLAST76
Domaini905 – 979RRM 2PROSITE-ProRule annotationAdd BLAST75

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni472 – 571Involved in localization to nuclear specklesBy similarityAdd BLAST100

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi472 – 574Arg-richAdd BLAST103
Compositional biasi1087 – 1355Glu-richAdd BLAST269
Compositional biasi1580 – 1585Poly-Lys6

Domaini

The matrin-type zinc finger domain is required for localization to nuclear speckles.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1928 – 1958Matrin-typePROSITE-ProRule annotationAdd BLAST31

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IN3N Eukaryota
ENOG4111GCE LUCA
GeneTreeiENSGT00850000132416
HOVERGENiHBG094186
InParanoidiQ14966
OMAiFYTCFPI
OrthoDBiEOG091G02SU
PhylomeDBiQ14966
TreeFamiTF333921

Family and domain databases

Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR000690 Matrin/U1-C_Znf_C2H2
IPR003604 Matrin/U1-like-C_Znf_C2H2
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR033096 ZNF638
IPR022755 Znf_C2H2_jaz
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR15592:SF1 PTHR15592:SF1, 1 hit
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
PF12171 zf-C2H2_jaz, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SM00355 ZnF_C2H2, 2 hits
SM00451 ZnF_U1, 2 hits
SUPFAMiSSF54928 SSF54928, 3 hits
SSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit
PS50171 ZF_MATRIN, 1 hit

Sequences (6+)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 6 described isoforms and 11 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q14966-1) [UniParc]FASTAAdd to basket
Also known as: Alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSRPRFNPRG DFPLQRPRAP NPSGMRPPGP FMRPGSMGLP RFYPAGRARG
60 70 80 90 100
IPHRFAGHES YQNMGPQRMN VQVTQHRTDP RLTKEKLDFH EAQQKKGKPH
110 120 130 140 150
GSRWDDEPHI SASVAVKQSS VTQVTEQSPK VQSRYTKESA SSILASFGLS
160 170 180 190 200
NEDLEELSRY PDEQLTPENM PLILRDIRMR KMGRRLPNLP SQSRNKETLG
210 220 230 240 250
SEAVSSNVID YGHASKYGYT EDPLEVRIYD PEIPTDEVEN EFQSQQNISA
260 270 280 290 300
SVPNPNVICN SMFPVEDVFR QMDFPGESSN NRSFFSVESG TKMSGLHISG
310 320 330 340 350
GQSVLEPIKS VNQSINQTVS QTMSQSLIPP SMNQQPFSSE LISSVSQQER
360 370 380 390 400
IPHEPVINSS NVHVGSRGSK KNYQSQADIP IRSPFGIVKA SWLPKFSHAD
410 420 430 440 450
AQKMKRLPTP SMMNDYYAAS PRIFPHLCSL CNVECSHLKD WIQHQNTSTH
460 470 480 490 500
IESCRQLRQQ YPDWNPEILP SRRNEGNRKE NETPRRRSHS PSPRRSRRSS
510 520 530 540 550
SSHRFRRSRS PMHYMYRPRS RSPRICHRFI SRYRSRSRSR SPYRIRNPFR
560 570 580 590 600
GSPKCFRSVS PERMSRRSVR SSDRKKALED VVQRSGHGTE FNKQKHLEAA
610 620 630 640 650
DKGHSPAQKP KTSSGTKPSV KPTSATKSDS NLGGHSIRCK SKNLEDDTLS
660 670 680 690 700
ECKQVSDKAV SLQRKLRKEQ SLHYGSVLLI TELPEDGCTE EDVRKLFQPF
710 720 730 740 750
GKVNDVLIVP YRKEAYLEME FKEAITAIMK YIETTPLTIK GKSVKICVPG
760 770 780 790 800
KKKAQNKEVK KKTLESKKVS ASTLKRDADA SKAVEIVTST SAAKTGQAKA
810 820 830 840 850
SVAKVNKSTG KSASSVKSVV TVAVKGNKAS IKTAKSGGKK SLEAKKTGNV
860 870 880 890 900
KNKDSNKPVT IPENSEIKTS IEVKATENCA KEAISDAALE ATENEPLNKE
910 920 930 940 950
TEEMCVMLVS NLPNKGYSVE EVYDLAKPFG GLKDILILSS HKKAYIEINR
960 970 980 990 1000
KAAESMVKFY TCFPVLMDGN QLSISMAPEN MNIKDEEAIF ITLVKENDPE
1010 1020 1030 1040 1050
ANIDTIYDRF VHLDNLPEDG LQCVLCVGLQ FGKVDHHVFI SNRNKAILQL
1060 1070 1080 1090 1100
DSPESAQSMY SFLKQNPQNI GDHMLTCSLS PKIDLPEVQI EHDPELEKES
1110 1120 1130 1140 1150
PGLKNSPIDE SEVQTATDSP SVKPNELEEE STPSIQTETL VQQEEPCEEE
1160 1170 1180 1190 1200
AEKATCDSDF AVETLELETQ GEEVKEEIPL VASASVSIEQ FTENAEECAL
1210 1220 1230 1240 1250
NQQMFNSDLE KKGAEIINPK TALLPSDSVF AEERNLKGIL EESPSEAEDF
1260 1270 1280 1290 1300
ISGITQTMVE AVAEVEKNET VSEILPSTCI VTLVPGIPTG DEKTVDKKNI
1310 1320 1330 1340 1350
SEKKGNMDEK EEKEFNTKET RMDLQIGTEK AEKNEGRMDA EKVEKMAAMK
1360 1370 1380 1390 1400
EKPAENTLFK AYPNKGVGQA NKPDETSKTS ILAVSDVSSS KPSIKAVIVS
1410 1420 1430 1440 1450
SPKAKATVSK TENQKSFPKS VPRDQINAEK KLSAKEFGLL KPTSARSGLA
1460 1470 1480 1490 1500
ESSSKFKPTQ SSLTRGGSGR ISALQGKLSK LDYRDITKQS QETEARPSIM
1510 1520 1530 1540 1550
KRDDSNNKTL AEQNTKNPKS TTGRSSKSKE EPLFPFNLDE FVTVDEVIEE
1560 1570 1580 1590 1600
VNPSQAKQNP LKGKRKETLK NVPFSELNLK KKKGKTSTPR GVEGELSFVT
1610 1620 1630 1640 1650
LDEIGEEEDA AAHLAQALVT VDEVIDEEEL NMEEMVKNSN SLFTLDELID
1660 1670 1680 1690 1700
QDDCISHSEP KDVTVLSVAE EQDLLKQERL VTVDEIGEVE ELPLNESADI
1710 1720 1730 1740 1750
TFATLNTKGN EGDTVRDSIG FISSQVPEDP STLVTVDEIQ DDSSDLHLVT
1760 1770 1780 1790 1800
LDEVTEEDED SLADFNNLKE ELNFVTVDEV GEEEDGDNDL KVELAQSKND
1810 1820 1830 1840 1850
HPTDKKGNRK KRAVDTKKTK LESLSQVGPV NENVMEEDLK TMIERHLTAK
1860 1870 1880 1890 1900
TPTKRVRIGK TLPSEKAVVT EPAKGEEAFQ MSEVDEESGL KDSEPERKRK
1910 1920 1930 1940 1950
KTEDSSSGKS VASDVPEELD FLVPKAGFFC PICSLFYSGE KAMTNHCKST
1960 1970
RHKQNTEKFM AKQRKEKEQN EAEERSSR
Length:1,978
Mass (Da):220,625
Last modified:July 19, 2005 - v2
Checksum:iFC006A4BA4885455
GO
Isoform 2 (identifier: Q14966-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     793-814: AKTGQAKASVAKVNKSTGKSAS → GLLPTGGGNNYPQIVLAPGLCH
     815-1978: Missing.

Note: No experimental confirmation available.
Show »
Length:814
Mass (Da):92,052
Checksum:iD3DEC862617E65FF
GO
Isoform 3 (identifier: Q14966-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1918-1938: Missing.

Note: No experimental confirmation available.
Show »
Length:1,957
Mass (Da):218,246
Checksum:i7BFD62828B7911B8
GO
Isoform 4 (identifier: Q14966-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1100-1139: SPGLKNSPID...ESTPSIQTET → RLWLSKTLRI...WMNLLLWMRL
     1140-1978: Missing.

Show »
Length:1,139
Mass (Da):128,489
Checksum:iBD7EAA34D634A34D
GO
Isoform 5 (identifier: Q14966-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-903: Missing.

Note: Broadly expressed.
Show »
Length:1,075
Mass (Da):119,295
Checksum:i8927B07C562F396B
GO
Isoform 6 (identifier: Q14966-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     793-918: AKTGQAKASV...VSNLPNKGYS → ESVDQTQQLV...SGDAKPEYEQ
     919-1978: Missing.

Show »
Length:918
Mass (Da):104,049
Checksum:i4F58E01899922C23
GO

Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A096LPK8A0A096LPK8_HUMAN
Zinc finger protein 638
ZNF638
285Annotation score:
A0A096LNS4A0A096LNS4_HUMAN
Zinc finger protein 638
ZNF638
158Annotation score:
C9JWN0C9JWN0_HUMAN
Zinc finger protein 638
ZNF638
197Annotation score:
A0A096LPB4A0A096LPB4_HUMAN
Zinc finger protein 638
ZNF638
184Annotation score:
C9JSD0C9JSD0_HUMAN
Zinc finger protein 638
ZNF638
36Annotation score:
A0A096LNX0A0A096LNX0_HUMAN
Zinc finger protein 638
ZNF638
98Annotation score:
C9JMR2C9JMR2_HUMAN
Zinc finger protein 638
ZNF638
62Annotation score:
A0A096LNQ0A0A096LNQ0_HUMAN
Zinc finger protein 638
ZNF638
171Annotation score:
A0A096LPI0A0A096LPI0_HUMAN
Zinc finger protein 638
ZNF638
153Annotation score:
A0A096LNR2A0A096LNR2_HUMAN
Zinc finger protein 638
ZNF638
90Annotation score:
There is more potential isoformShow all

Sequence cautioni

The sequence AAH64530 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti58H → L in BAA11748 (PubMed:8647861).Curated1
Sequence conflicti209I → V in AAM97681 (Ref. 3) Curated1
Sequence conflicti262M → I in CAD97667 (PubMed:17974005).Curated1
Sequence conflicti599A → V in CAH18177 (PubMed:17974005).Curated1
Sequence conflicti801S → C in BAA11748 (PubMed:8647861).Curated1
Sequence conflicti977A → D in CAD97667 (PubMed:17974005).Curated1
Sequence conflicti1205F → L in CAD97667 (PubMed:17974005).Curated1
Sequence conflicti1243S → P in CAD97667 (PubMed:17974005).Curated1
Sequence conflicti1336G → S in CAH18177 (PubMed:17974005).Curated1
Sequence conflicti1404A → T in CAD97667 (PubMed:17974005).Curated1
Sequence conflicti1714T → I (PubMed:8647861).Curated1
Sequence conflicti1714T → I (PubMed:11149944).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_023069110I → V1 PublicationCorresponds to variant dbSNP:rs12612365Ensembl.1
Natural variantiVAR_023070980N → S1 PublicationCorresponds to variant dbSNP:rs3732235Ensembl.1
Natural variantiVAR_0522381462S → N. Corresponds to variant dbSNP:rs10427371Ensembl.1
Natural variantiVAR_0230711726V → M1 PublicationCorresponds to variant dbSNP:rs1804020Ensembl.1
Natural variantiVAR_0230721912A → V1 PublicationCorresponds to variant dbSNP:rs11542286Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0148011 – 903Missing in isoform 5. 1 PublicationAdd BLAST903
Alternative sequenceiVSP_059342793 – 918AKTGQ…NKGYS → ESVDQTQQLVPLVRNTARDH DGTPENEGEETVQSALFGFQ YDASDHTMAWLGPNTVPEVK EMILQDPQLQTTQLPQTTQA PDITWGMLKKTTYKAEQILL QTQKPFTPDNLFLALLSGDA KPEYEQ in isoform 6. Add BLAST126
Alternative sequenceiVSP_014802793 – 814AKTGQ…GKSAS → GLLPTGGGNNYPQIVLAPGL CH in isoform 2. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_014803815 – 1978Missing in isoform 2. 1 PublicationAdd BLAST1164
Alternative sequenceiVSP_059343919 – 1978Missing in isoform 6. Add BLAST1060
Alternative sequenceiVSP_0148041100 – 1139SPGLK…IQTET → RLWLSKTLRILKALLVEVPN LKRSHYFHLIWMNLLLWMRL in isoform 4. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_0148051140 – 1978Missing in isoform 4. 1 PublicationAdd BLAST839
Alternative sequenceiVSP_0148061918 – 1938Missing in isoform 3. 1 PublicationAdd BLAST21

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83032 mRNA Translation: BAA11748.1
AF273049 mRNA Translation: AAG34909.1
AF534078 mRNA Translation: AAM97681.1
BX537425 mRNA Translation: CAD97667.1
CR749322 mRNA Translation: CAH18177.1
AC007878 Genomic DNA Translation: AAF66079.1
AC096569 Genomic DNA Translation: AAY14979.1
AC104084 Genomic DNA No translation available.
AC109343 Genomic DNA No translation available.
BC024000 mRNA Translation: AAH24000.1
BC064530 mRNA Translation: AAH64530.1 Sequence problems.
BC083513 mRNA Translation: AAH83513.1
BC143728 mRNA Translation: AAI43729.1
CCDSiCCDS1917.1 [Q14966-1]
PIRiJU0239
JU0240
RefSeqiNP_001014972.1, NM_001014972.2 [Q14966-1]
NP_001239541.1, NM_001252612.1 [Q14966-1]
NP_001239542.1, NM_001252613.1 [Q14966-3]
NP_055312.2, NM_014497.4 [Q14966-1]
UniGeneiHs.434401
Hs.732823

Genome annotation databases

EnsembliENST00000264447; ENSP00000264447; ENSG00000075292 [Q14966-1]
ENST00000409544; ENSP00000386433; ENSG00000075292 [Q14966-1]
ENST00000410075; ENSP00000485608; ENSG00000075292 [Q14966-6]
GeneIDi27332
KEGGihsa:27332
UCSCiuc002shx.4 human [Q14966-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN638_HUMAN
AccessioniPrimary (citable) accession number: Q14966
Secondary accession number(s): A0A096LPH6
, B5MDV1, B7ZLD1, Q53R34, Q5XJ05, Q68DP3, Q6P2H2, Q7Z3T7, Q8NF92, Q8TCA1, Q9H2G1, Q9NP37
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: September 12, 2018
This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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