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Entry version 168 (31 Jul 2019)
Sequence version 2 (19 Jul 2005)
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Protein

Zinc finger protein 638

Gene

ZNF638

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:8647861, PubMed:30487602). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity).By similarity2 Publications

Miscellaneous

Isoform 5: Tumor-associated antigen found in several cutaneous T-cell lymphoma (CTCL), and in particular in mycosis fungoides patients and in Sezary syndrome patients.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi1353 – 14771 PublicationAdd BLAST125
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1928 – 1958Matrin-typePROSITE-ProRule annotationAdd BLAST31

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 638
Alternative name(s):
Cutaneous T-cell lymphoma-associated antigen se33-11 Publication
Short name:
CTCL-associated antigen se33-11 Publication
Nuclear protein 2201 Publication
Zinc finger matrin-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF638
Synonyms:NP2201 Publication, ZFML
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17894 ZNF638

Online Mendelian Inheritance in Man (OMIM)

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MIMi
614349 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q14966

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
27332

Open Targets

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OpenTargetsi
ENSG00000075292

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134983478

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF638

Domain mapping of disease mutations (DMDM)

More...
DMDMi
71153483

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000820111 – 1978Zinc finger protein 638Add BLAST1978

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei47Asymmetric dimethylarginineCombined sources1
Modified residuei49Asymmetric dimethylarginineCombined sources1
Modified residuei54Asymmetric dimethylarginineCombined sources1
Modified residuei128PhosphoserineCombined sources1
Modified residuei289PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki292Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei299PhosphoserineCombined sources1
Modified residuei369PhosphoserineCombined sources1
Modified residuei383PhosphoserineCombined sources1
Modified residuei420PhosphoserineCombined sources1
Modified residuei552PhosphoserineCombined sources1
Modified residuei605PhosphoserineCombined sources1
Modified residuei614PhosphoserineCombined sources1
Modified residuei636PhosphoserineCombined sources1
Cross-linki775Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1100PhosphoserineCombined sources1
Modified residuei1401PhosphoserineCombined sources1
Modified residuei1641PhosphoserineBy similarity1
Modified residuei1667PhosphoserineCombined sources1
Cross-linki1676Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1820Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1882PhosphoserineCombined sources1
Isoform 6 (identifier: Q14966-6)
Cross-linki913Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
CPTAC-1371

Encyclopedia of Proteome Dynamics

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EPDi
Q14966

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q14966

MaxQB - The MaxQuant DataBase

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MaxQBi
Q14966

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q14966

PeptideAtlas

More...
PeptideAtlasi
Q14966

PRoteomics IDEntifications database

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PRIDEi
Q14966

ProteomicsDB human proteome resource

More...
ProteomicsDBi
60262 [Q14966-1]
60263 [Q14966-2]
60264 [Q14966-3]
60265 [Q14966-4]
60266 [Q14966-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q14966

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q14966

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000075292 Expressed in 238 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q14966 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q14966 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA036784
HPA057395

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with FHL2 (PubMed:11813260).

Interacts with CEBPA, CEBPD and CEBPG (By similarity).

Interacts with MPHOSPH8 and TASOR components of the HUSH complex; leading to recruitment of the HUSH complex (PubMed:30487602).

Interacts with SETDB1 (PubMed:30487602).

Interacts with HDAC1 (PubMed:30487602).

Interacts with HDAC4 (PubMed:30487602).

By similarity2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
118145, 150 interactors

Database of interacting proteins

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DIPi
DIP-42386N

Protein interaction database and analysis system

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IntActi
Q14966, 37 interactors

Molecular INTeraction database

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MINTi
Q14966

STRING: functional protein association networks

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STRINGi
9606.ENSP00000386433

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q14966

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini676 – 751RRM 1PROSITE-ProRule annotationAdd BLAST76
Domaini905 – 979RRM 2PROSITE-ProRule annotationAdd BLAST75

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni472 – 571Involved in localization to nuclear specklesBy similarityAdd BLAST100

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi472 – 574Arg-richAdd BLAST103
Compositional biasi1087 – 1355Glu-richAdd BLAST269
Compositional biasi1580 – 1585Poly-Lys6

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The matrin-type zinc finger domain is required for localization to nuclear speckles.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1928 – 1958Matrin-typePROSITE-ProRule annotationAdd BLAST31

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IN3N Eukaryota
ENOG4111GCE LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153322

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q14966

Identification of Orthologs from Complete Genome Data

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OMAi
RSPIRYI

Database of Orthologous Groups

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OrthoDBi
301913at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q14966

TreeFam database of animal gene trees

More...
TreeFami
TF333921

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.70.330, 3 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000690 Matrin/U1-C_Znf_C2H2
IPR003604 Matrin/U1-like-C_Znf_C2H2
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR033096 ZNF638
IPR022755 Znf_C2H2_jaz
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

The PANTHER Classification System

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PANTHERi
PTHR15592:SF1 PTHR15592:SF1, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00076 RRM_1, 1 hit
PF12171 zf-C2H2_jaz, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00360 RRM, 2 hits
SM00355 ZnF_C2H2, 2 hits
SM00451 ZnF_U1, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928 SSF54928, 3 hits
SSF57667 SSF57667, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50102 RRM, 1 hit
PS50171 ZF_MATRIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 6 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q14966-1) [UniParc]FASTAAdd to basket
Also known as: Alpha

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSRPRFNPRG DFPLQRPRAP NPSGMRPPGP FMRPGSMGLP RFYPAGRARG
60 70 80 90 100
IPHRFAGHES YQNMGPQRMN VQVTQHRTDP RLTKEKLDFH EAQQKKGKPH
110 120 130 140 150
GSRWDDEPHI SASVAVKQSS VTQVTEQSPK VQSRYTKESA SSILASFGLS
160 170 180 190 200
NEDLEELSRY PDEQLTPENM PLILRDIRMR KMGRRLPNLP SQSRNKETLG
210 220 230 240 250
SEAVSSNVID YGHASKYGYT EDPLEVRIYD PEIPTDEVEN EFQSQQNISA
260 270 280 290 300
SVPNPNVICN SMFPVEDVFR QMDFPGESSN NRSFFSVESG TKMSGLHISG
310 320 330 340 350
GQSVLEPIKS VNQSINQTVS QTMSQSLIPP SMNQQPFSSE LISSVSQQER
360 370 380 390 400
IPHEPVINSS NVHVGSRGSK KNYQSQADIP IRSPFGIVKA SWLPKFSHAD
410 420 430 440 450
AQKMKRLPTP SMMNDYYAAS PRIFPHLCSL CNVECSHLKD WIQHQNTSTH
460 470 480 490 500
IESCRQLRQQ YPDWNPEILP SRRNEGNRKE NETPRRRSHS PSPRRSRRSS
510 520 530 540 550
SSHRFRRSRS PMHYMYRPRS RSPRICHRFI SRYRSRSRSR SPYRIRNPFR
560 570 580 590 600
GSPKCFRSVS PERMSRRSVR SSDRKKALED VVQRSGHGTE FNKQKHLEAA
610 620 630 640 650
DKGHSPAQKP KTSSGTKPSV KPTSATKSDS NLGGHSIRCK SKNLEDDTLS
660 670 680 690 700
ECKQVSDKAV SLQRKLRKEQ SLHYGSVLLI TELPEDGCTE EDVRKLFQPF
710 720 730 740 750
GKVNDVLIVP YRKEAYLEME FKEAITAIMK YIETTPLTIK GKSVKICVPG
760 770 780 790 800
KKKAQNKEVK KKTLESKKVS ASTLKRDADA SKAVEIVTST SAAKTGQAKA
810 820 830 840 850
SVAKVNKSTG KSASSVKSVV TVAVKGNKAS IKTAKSGGKK SLEAKKTGNV
860 870 880 890 900
KNKDSNKPVT IPENSEIKTS IEVKATENCA KEAISDAALE ATENEPLNKE
910 920 930 940 950
TEEMCVMLVS NLPNKGYSVE EVYDLAKPFG GLKDILILSS HKKAYIEINR
960 970 980 990 1000
KAAESMVKFY TCFPVLMDGN QLSISMAPEN MNIKDEEAIF ITLVKENDPE
1010 1020 1030 1040 1050
ANIDTIYDRF VHLDNLPEDG LQCVLCVGLQ FGKVDHHVFI SNRNKAILQL
1060 1070 1080 1090 1100
DSPESAQSMY SFLKQNPQNI GDHMLTCSLS PKIDLPEVQI EHDPELEKES
1110 1120 1130 1140 1150
PGLKNSPIDE SEVQTATDSP SVKPNELEEE STPSIQTETL VQQEEPCEEE
1160 1170 1180 1190 1200
AEKATCDSDF AVETLELETQ GEEVKEEIPL VASASVSIEQ FTENAEECAL
1210 1220 1230 1240 1250
NQQMFNSDLE KKGAEIINPK TALLPSDSVF AEERNLKGIL EESPSEAEDF
1260 1270 1280 1290 1300
ISGITQTMVE AVAEVEKNET VSEILPSTCI VTLVPGIPTG DEKTVDKKNI
1310 1320 1330 1340 1350
SEKKGNMDEK EEKEFNTKET RMDLQIGTEK AEKNEGRMDA EKVEKMAAMK
1360 1370 1380 1390 1400
EKPAENTLFK AYPNKGVGQA NKPDETSKTS ILAVSDVSSS KPSIKAVIVS
1410 1420 1430 1440 1450
SPKAKATVSK TENQKSFPKS VPRDQINAEK KLSAKEFGLL KPTSARSGLA
1460 1470 1480 1490 1500
ESSSKFKPTQ SSLTRGGSGR ISALQGKLSK LDYRDITKQS QETEARPSIM
1510 1520 1530 1540 1550
KRDDSNNKTL AEQNTKNPKS TTGRSSKSKE EPLFPFNLDE FVTVDEVIEE
1560 1570 1580 1590 1600
VNPSQAKQNP LKGKRKETLK NVPFSELNLK KKKGKTSTPR GVEGELSFVT
1610 1620 1630 1640 1650
LDEIGEEEDA AAHLAQALVT VDEVIDEEEL NMEEMVKNSN SLFTLDELID
1660 1670 1680 1690 1700
QDDCISHSEP KDVTVLSVAE EQDLLKQERL VTVDEIGEVE ELPLNESADI
1710 1720 1730 1740 1750
TFATLNTKGN EGDTVRDSIG FISSQVPEDP STLVTVDEIQ DDSSDLHLVT
1760 1770 1780 1790 1800
LDEVTEEDED SLADFNNLKE ELNFVTVDEV GEEEDGDNDL KVELAQSKND
1810 1820 1830 1840 1850
HPTDKKGNRK KRAVDTKKTK LESLSQVGPV NENVMEEDLK TMIERHLTAK
1860 1870 1880 1890 1900
TPTKRVRIGK TLPSEKAVVT EPAKGEEAFQ MSEVDEESGL KDSEPERKRK
1910 1920 1930 1940 1950
KTEDSSSGKS VASDVPEELD FLVPKAGFFC PICSLFYSGE KAMTNHCKST
1960 1970
RHKQNTEKFM AKQRKEKEQN EAEERSSR
Length:1,978
Mass (Da):220,625
Last modified:July 19, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFC006A4BA4885455
GO
Isoform 2 (identifier: Q14966-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     793-814: AKTGQAKASVAKVNKSTGKSAS → GLLPTGGGNNYPQIVLAPGLCH
     815-1978: Missing.

Note: No experimental confirmation available.
Show »
Length:814
Mass (Da):92,052
Checksum:iD3DEC862617E65FF
GO
Isoform 3 (identifier: Q14966-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1918-1938: Missing.

Note: No experimental confirmation available.
Show »
Length:1,957
Mass (Da):218,246
Checksum:i7BFD62828B7911B8
GO
Isoform 4 (identifier: Q14966-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1100-1139: SPGLKNSPID...ESTPSIQTET → RLWLSKTLRI...WMNLLLWMRL
     1140-1978: Missing.

Show »
Length:1,139
Mass (Da):128,489
Checksum:iBD7EAA34D634A34D
GO
Isoform 5 (identifier: Q14966-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-903: Missing.

Note: Broadly expressed.
Show »
Length:1,075
Mass (Da):119,295
Checksum:i8927B07C562F396B
GO
Isoform 6 (identifier: Q14966-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     793-918: AKTGQAKASV...VSNLPNKGYS → ESVDQTQQLV...SGDAKPEYEQ
     919-1978: Missing.

Show »
Length:918
Mass (Da):104,049
Checksum:i4F58E01899922C23
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A096LPK8A0A096LPK8_HUMAN
Zinc finger protein 638
ZNF638
285Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A096LNS4A0A096LNS4_HUMAN
Zinc finger protein 638
ZNF638
158Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JWN0C9JWN0_HUMAN
Zinc finger protein 638
ZNF638
197Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A096LPB4A0A096LPB4_HUMAN
Zinc finger protein 638
ZNF638
184Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A096LNR2A0A096LNR2_HUMAN
Zinc finger protein 638
ZNF638
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A096LPI0A0A096LPI0_HUMAN
Zinc finger protein 638
ZNF638
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A096LNX0A0A096LNX0_HUMAN
Zinc finger protein 638
ZNF638
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A096LNQ0A0A096LNQ0_HUMAN
Zinc finger protein 638
ZNF638
171Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JSD0C9JSD0_HUMAN
Zinc finger protein 638
ZNF638
36Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JMR2C9JMR2_HUMAN
Zinc finger protein 638
ZNF638
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH64530 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti58H → L in BAA11748 (PubMed:8647861).Curated1
Sequence conflicti209I → V in AAM97681 (Ref. 3) Curated1
Sequence conflicti262M → I in CAD97667 (PubMed:17974005).Curated1
Sequence conflicti599A → V in CAH18177 (PubMed:17974005).Curated1
Sequence conflicti801S → C in BAA11748 (PubMed:8647861).Curated1
Sequence conflicti977A → D in CAD97667 (PubMed:17974005).Curated1
Sequence conflicti1205F → L in CAD97667 (PubMed:17974005).Curated1
Sequence conflicti1243S → P in CAD97667 (PubMed:17974005).Curated1
Sequence conflicti1336G → S in CAH18177 (PubMed:17974005).Curated1
Sequence conflicti1404A → T in CAD97667 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_023069110I → V1 PublicationCorresponds to variant dbSNP:rs12612365Ensembl.1
Natural variantiVAR_023070980N → S1 PublicationCorresponds to variant dbSNP:rs3732235Ensembl.1
Natural variantiVAR_0522381462S → N. Corresponds to variant dbSNP:rs10427371Ensembl.1
Natural variantiVAR_0230711726V → M1 PublicationCorresponds to variant dbSNP:rs1804020Ensembl.1
Natural variantiVAR_0230721912A → V1 PublicationCorresponds to variant dbSNP:rs11542286Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0148011 – 903Missing in isoform 5. 1 PublicationAdd BLAST903
Alternative sequenceiVSP_059342793 – 918AKTGQ…NKGYS → ESVDQTQQLVPLVRNTARDH DGTPENEGEETVQSALFGFQ YDASDHTMAWLGPNTVPEVK EMILQDPQLQTTQLPQTTQA PDITWGMLKKTTYKAEQILL QTQKPFTPDNLFLALLSGDA KPEYEQ in isoform 6. Add BLAST126
Alternative sequenceiVSP_014802793 – 814AKTGQ…GKSAS → GLLPTGGGNNYPQIVLAPGL CH in isoform 2. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_014803815 – 1978Missing in isoform 2. 1 PublicationAdd BLAST1164
Alternative sequenceiVSP_059343919 – 1978Missing in isoform 6. Add BLAST1060
Alternative sequenceiVSP_0148041100 – 1139SPGLK…IQTET → RLWLSKTLRILKALLVEVPN LKRSHYFHLIWMNLLLWMRL in isoform 4. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_0148051140 – 1978Missing in isoform 4. 1 PublicationAdd BLAST839
Alternative sequenceiVSP_0148061918 – 1938Missing in isoform 3. 1 PublicationAdd BLAST21

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D83032 mRNA Translation: BAA11748.1
AF273049 mRNA Translation: AAG34909.1
AF534078 mRNA Translation: AAM97681.1
BX537425 mRNA Translation: CAD97667.1
CR749322 mRNA Translation: CAH18177.1
AC007878 Genomic DNA Translation: AAF66079.1
AC096569 Genomic DNA Translation: AAY14979.1
AC104084 Genomic DNA No translation available.
AC109343 Genomic DNA No translation available.
BC024000 mRNA Translation: AAH24000.1
BC064530 mRNA Translation: AAH64530.1 Sequence problems.
BC083513 mRNA Translation: AAH83513.1
BC143728 mRNA Translation: AAI43729.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1917.1 [Q14966-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
JU0239
JU0240

NCBI Reference Sequences

More...
RefSeqi
NP_001014972.1, NM_001014972.2 [Q14966-1]
NP_001239541.1, NM_001252612.1 [Q14966-1]
NP_001239542.1, NM_001252613.1 [Q14966-3]
NP_055312.2, NM_014497.4 [Q14966-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000264447; ENSP00000264447; ENSG00000075292 [Q14966-1]
ENST00000409544; ENSP00000386433; ENSG00000075292 [Q14966-1]
ENST00000410075; ENSP00000485608; ENSG00000075292 [Q14966-6]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
27332

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:27332

UCSC genome browser

More...
UCSCi
uc002shx.4 human [Q14966-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83032 mRNA Translation: BAA11748.1
AF273049 mRNA Translation: AAG34909.1
AF534078 mRNA Translation: AAM97681.1
BX537425 mRNA Translation: CAD97667.1
CR749322 mRNA Translation: CAH18177.1
AC007878 Genomic DNA Translation: AAF66079.1
AC096569 Genomic DNA Translation: AAY14979.1
AC104084 Genomic DNA No translation available.
AC109343 Genomic DNA No translation available.
BC024000 mRNA Translation: AAH24000.1
BC064530 mRNA Translation: AAH64530.1 Sequence problems.
BC083513 mRNA Translation: AAH83513.1
BC143728 mRNA Translation: AAI43729.1
CCDSiCCDS1917.1 [Q14966-1]
PIRiJU0239
JU0240
RefSeqiNP_001014972.1, NM_001014972.2 [Q14966-1]
NP_001239541.1, NM_001252612.1 [Q14966-1]
NP_001239542.1, NM_001252613.1 [Q14966-3]
NP_055312.2, NM_014497.4 [Q14966-1]

3D structure databases

SMRiQ14966
ModBaseiSearch...

Protein-protein interaction databases

BioGridi118145, 150 interactors
DIPiDIP-42386N
IntActiQ14966, 37 interactors
MINTiQ14966
STRINGi9606.ENSP00000386433

PTM databases

iPTMnetiQ14966
PhosphoSitePlusiQ14966

Polymorphism and mutation databases

BioMutaiZNF638
DMDMi71153483

Proteomic databases

CPTACiCPTAC-1371
EPDiQ14966
jPOSTiQ14966
MaxQBiQ14966
PaxDbiQ14966
PeptideAtlasiQ14966
PRIDEiQ14966
ProteomicsDBi60262 [Q14966-1]
60263 [Q14966-2]
60264 [Q14966-3]
60265 [Q14966-4]
60266 [Q14966-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264447; ENSP00000264447; ENSG00000075292 [Q14966-1]
ENST00000409544; ENSP00000386433; ENSG00000075292 [Q14966-1]
ENST00000410075; ENSP00000485608; ENSG00000075292 [Q14966-6]
GeneIDi27332
KEGGihsa:27332
UCSCiuc002shx.4 human [Q14966-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
27332
DisGeNETi27332

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZNF638
HGNCiHGNC:17894 ZNF638
HPAiHPA036784
HPA057395
MIMi614349 gene
neXtProtiNX_Q14966
OpenTargetsiENSG00000075292
PharmGKBiPA134983478

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IN3N Eukaryota
ENOG4111GCE LUCA
GeneTreeiENSGT00940000153322
InParanoidiQ14966
OMAiRSPIRYI
OrthoDBi301913at2759
PhylomeDBiQ14966
TreeFamiTF333921

Enzyme and pathway databases

ReactomeiR-HSA-381340 Transcriptional regulation of white adipocyte differentiation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ZNF638 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ZNF638

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
27332

Protein Ontology

More...
PROi
PR:Q14966

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000075292 Expressed in 238 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ14966 baseline and differential
GenevisibleiQ14966 HS

Family and domain databases

Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR000690 Matrin/U1-C_Znf_C2H2
IPR003604 Matrin/U1-like-C_Znf_C2H2
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR033096 ZNF638
IPR022755 Znf_C2H2_jaz
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR15592:SF1 PTHR15592:SF1, 1 hit
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
PF12171 zf-C2H2_jaz, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SM00355 ZnF_C2H2, 2 hits
SM00451 ZnF_U1, 2 hits
SUPFAMiSSF54928 SSF54928, 3 hits
SSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit
PS50171 ZF_MATRIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN638_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14966
Secondary accession number(s): A0A096LPH6
, B5MDV1, B7ZLD1, Q53R34, Q5XJ05, Q68DP3, Q6P2H2, Q7Z3T7, Q8NF92, Q8TCA1, Q9H2G1, Q9NP37
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: July 31, 2019
This is version 168 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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