UniProtKB - Q14966 (ZN638_HUMAN)
Zinc finger protein 638
ZNF638
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 1353 – 1477 | 1 PublicationAdd BLAST | 125 | |
Zinc fingeri | 1928 – 1958 | Matrin-typePROSITE-ProRule annotationAdd BLAST | 31 |
GO - Molecular functioni
- double-stranded DNA binding Source: ProtInc
- RNA binding Source: UniProtKB
- zinc ion binding Source: InterPro
GO - Biological processi
- RNA splicing Source: ProtInc
Keywordsi
Molecular function | Activator, DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q14966 |
Reactomei | R-HSA-381340, Transcriptional regulation of white adipocyte differentiation |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 638Alternative name(s): Cutaneous T-cell lymphoma-associated antigen se33-11 Publication Short name: CTCL-associated antigen se33-11 Publication Nuclear protein 2201 Publication Zinc finger matrin-like protein |
Gene namesi | Name:ZNF638 Synonyms:NP2201 Publication, ZFML |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17894, ZNF638 |
MIMi | 614349, gene |
neXtProti | NX_Q14966 |
VEuPathDBi | HostDB:ENSG00000075292.18 |
Subcellular locationi
Nucleus
- Nucleus speckle PROSITE-ProRule annotation2 Publications
Nucleus
- nuclear speck Source: UniProtKB-SubCell
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Other locations
- cytoplasm Source: ProtInc
- intracellular membrane-bounded organelle Source: HPA
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 27332 |
OpenTargetsi | ENSG00000075292 |
PharmGKBi | PA134983478 |
Miscellaneous databases
Pharosi | Q14966, Tbio |
Genetic variation databases
BioMutai | ZNF638 |
DMDMi | 71153483 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000082011 | 1 – 1978 | Zinc finger protein 638Add BLAST | 1978 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 47 | Asymmetric dimethylarginineCombined sources | 1 | ||
Modified residuei | 49 | Asymmetric dimethylarginineCombined sources | 1 | ||
Modified residuei | 54 | Asymmetric dimethylarginineCombined sources | 1 | ||
Modified residuei | 128 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 289 | PhosphoserineCombined sources | 1 | ||
Cross-linki | 292 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | |||
Modified residuei | 299 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 369 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 383 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 420 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 552 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 605 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 614 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 636 | PhosphoserineCombined sources | 1 | ||
Cross-linki | 775 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | |||
Modified residuei | 1100 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1401 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1641 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 1667 | PhosphoserineCombined sources | 1 | ||
Cross-linki | 1676 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | |||
Cross-linki | 1820 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | |||
Modified residuei | 1882 | PhosphoserineCombined sources | 1 | ||
Isoform 6 (identifier: Q14966-6) | |||||
Cross-linki | 913 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
CPTACi | CPTAC-1371 |
EPDi | Q14966 |
jPOSTi | Q14966 |
MassIVEi | Q14966 |
MaxQBi | Q14966 |
PaxDbi | Q14966 |
PeptideAtlasi | Q14966 |
PRIDEi | Q14966 |
ProteomicsDBi | 60262 [Q14966-1] 60263 [Q14966-2] 60264 [Q14966-3] 60265 [Q14966-4] 60266 [Q14966-5] |
PTM databases
iPTMneti | Q14966 |
PhosphoSitePlusi | Q14966 |
Expressioni
Gene expression databases
Bgeei | ENSG00000075292, Expressed in corpus callosum and 249 other tissues |
ExpressionAtlasi | Q14966, baseline and differential |
Genevisiblei | Q14966, HS |
Organism-specific databases
HPAi | ENSG00000075292, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with FHL2 (PubMed:11813260).
Interacts with CEBPA, CEBPD and CEBPG (By similarity).
Interacts with MPHOSPH8 and TASOR components of the HUSH complex; leading to recruitment of the HUSH complex (PubMed:30487602).
Interacts with SETDB1 (PubMed:30487602).
Interacts with HDAC1 (PubMed:30487602).
Interacts with HDAC4 (PubMed:30487602).
By similarity2 PublicationsBinary interactionsi
Hide detailsIsoform 2 [Q14966-2]
With | #Exp. | IntAct |
---|---|---|
DNM2 - isoform 2 [P50570-2] | 3 | EBI-25845021,EBI-10968534 |
GDAP1 [Q8TB36] | 3 | EBI-25845021,EBI-11110431 |
Protein-protein interaction databases
BioGRIDi | 118145, 171 interactors |
DIPi | DIP-42386N |
IntActi | Q14966, 60 interactors |
MINTi | Q14966 |
STRINGi | 9606.ENSP00000386433 |
Miscellaneous databases
RNActi | Q14966, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q14966 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 676 – 751 | RRM 1PROSITE-ProRule annotationAdd BLAST | 76 | |
Domaini | 905 – 979 | RRM 2PROSITE-ProRule annotationAdd BLAST | 75 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 472 – 571 | Involved in localization to nuclear specklesBy similarityAdd BLAST | 100 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 472 – 574 | Arg-richAdd BLAST | 103 | |
Compositional biasi | 1087 – 1355 | Glu-richAdd BLAST | 269 | |
Compositional biasi | 1580 – 1585 | Poly-Lys | 6 |
Domaini
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 1928 – 1958 | Matrin-typePROSITE-ProRule annotationAdd BLAST | 31 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | ENOG502QVQ7, Eukaryota |
GeneTreei | ENSGT00940000153322 |
HOGENOMi | CLU_002180_0_0_1 |
InParanoidi | Q14966 |
OMAi | STMKRDD |
OrthoDBi | 301913at2759 |
PhylomeDBi | Q14966 |
TreeFami | TF333921 |
Family and domain databases
Gene3Di | 3.30.70.330, 3 hits |
InterProi | View protein in InterPro IPR000690, Matrin/U1-C_Znf_C2H2 IPR003604, Matrin/U1-like-C_Znf_C2H2 IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom IPR033096, ZNF638 IPR022755, Znf_C2H2_jaz IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR15592:SF1, PTHR15592:SF1, 1 hit |
Pfami | View protein in Pfam PF00076, RRM_1, 1 hit PF12171, zf-C2H2_jaz, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 2 hits SM00355, ZnF_C2H2, 2 hits SM00451, ZnF_U1, 2 hits |
SUPFAMi | SSF54928, SSF54928, 3 hits SSF57667, SSF57667, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 1 hit PS50171, ZF_MATRIN, 1 hit |
s (6+)i Sequence
Sequence statusi: Complete.
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSRPRFNPRG DFPLQRPRAP NPSGMRPPGP FMRPGSMGLP RFYPAGRARG
60 70 80 90 100
IPHRFAGHES YQNMGPQRMN VQVTQHRTDP RLTKEKLDFH EAQQKKGKPH
110 120 130 140 150
GSRWDDEPHI SASVAVKQSS VTQVTEQSPK VQSRYTKESA SSILASFGLS
160 170 180 190 200
NEDLEELSRY PDEQLTPENM PLILRDIRMR KMGRRLPNLP SQSRNKETLG
210 220 230 240 250
SEAVSSNVID YGHASKYGYT EDPLEVRIYD PEIPTDEVEN EFQSQQNISA
260 270 280 290 300
SVPNPNVICN SMFPVEDVFR QMDFPGESSN NRSFFSVESG TKMSGLHISG
310 320 330 340 350
GQSVLEPIKS VNQSINQTVS QTMSQSLIPP SMNQQPFSSE LISSVSQQER
360 370 380 390 400
IPHEPVINSS NVHVGSRGSK KNYQSQADIP IRSPFGIVKA SWLPKFSHAD
410 420 430 440 450
AQKMKRLPTP SMMNDYYAAS PRIFPHLCSL CNVECSHLKD WIQHQNTSTH
460 470 480 490 500
IESCRQLRQQ YPDWNPEILP SRRNEGNRKE NETPRRRSHS PSPRRSRRSS
510 520 530 540 550
SSHRFRRSRS PMHYMYRPRS RSPRICHRFI SRYRSRSRSR SPYRIRNPFR
560 570 580 590 600
GSPKCFRSVS PERMSRRSVR SSDRKKALED VVQRSGHGTE FNKQKHLEAA
610 620 630 640 650
DKGHSPAQKP KTSSGTKPSV KPTSATKSDS NLGGHSIRCK SKNLEDDTLS
660 670 680 690 700
ECKQVSDKAV SLQRKLRKEQ SLHYGSVLLI TELPEDGCTE EDVRKLFQPF
710 720 730 740 750
GKVNDVLIVP YRKEAYLEME FKEAITAIMK YIETTPLTIK GKSVKICVPG
760 770 780 790 800
KKKAQNKEVK KKTLESKKVS ASTLKRDADA SKAVEIVTST SAAKTGQAKA
810 820 830 840 850
SVAKVNKSTG KSASSVKSVV TVAVKGNKAS IKTAKSGGKK SLEAKKTGNV
860 870 880 890 900
KNKDSNKPVT IPENSEIKTS IEVKATENCA KEAISDAALE ATENEPLNKE
910 920 930 940 950
TEEMCVMLVS NLPNKGYSVE EVYDLAKPFG GLKDILILSS HKKAYIEINR
960 970 980 990 1000
KAAESMVKFY TCFPVLMDGN QLSISMAPEN MNIKDEEAIF ITLVKENDPE
1010 1020 1030 1040 1050
ANIDTIYDRF VHLDNLPEDG LQCVLCVGLQ FGKVDHHVFI SNRNKAILQL
1060 1070 1080 1090 1100
DSPESAQSMY SFLKQNPQNI GDHMLTCSLS PKIDLPEVQI EHDPELEKES
1110 1120 1130 1140 1150
PGLKNSPIDE SEVQTATDSP SVKPNELEEE STPSIQTETL VQQEEPCEEE
1160 1170 1180 1190 1200
AEKATCDSDF AVETLELETQ GEEVKEEIPL VASASVSIEQ FTENAEECAL
1210 1220 1230 1240 1250
NQQMFNSDLE KKGAEIINPK TALLPSDSVF AEERNLKGIL EESPSEAEDF
1260 1270 1280 1290 1300
ISGITQTMVE AVAEVEKNET VSEILPSTCI VTLVPGIPTG DEKTVDKKNI
1310 1320 1330 1340 1350
SEKKGNMDEK EEKEFNTKET RMDLQIGTEK AEKNEGRMDA EKVEKMAAMK
1360 1370 1380 1390 1400
EKPAENTLFK AYPNKGVGQA NKPDETSKTS ILAVSDVSSS KPSIKAVIVS
1410 1420 1430 1440 1450
SPKAKATVSK TENQKSFPKS VPRDQINAEK KLSAKEFGLL KPTSARSGLA
1460 1470 1480 1490 1500
ESSSKFKPTQ SSLTRGGSGR ISALQGKLSK LDYRDITKQS QETEARPSIM
1510 1520 1530 1540 1550
KRDDSNNKTL AEQNTKNPKS TTGRSSKSKE EPLFPFNLDE FVTVDEVIEE
1560 1570 1580 1590 1600
VNPSQAKQNP LKGKRKETLK NVPFSELNLK KKKGKTSTPR GVEGELSFVT
1610 1620 1630 1640 1650
LDEIGEEEDA AAHLAQALVT VDEVIDEEEL NMEEMVKNSN SLFTLDELID
1660 1670 1680 1690 1700
QDDCISHSEP KDVTVLSVAE EQDLLKQERL VTVDEIGEVE ELPLNESADI
1710 1720 1730 1740 1750
TFATLNTKGN EGDTVRDSIG FISSQVPEDP STLVTVDEIQ DDSSDLHLVT
1760 1770 1780 1790 1800
LDEVTEEDED SLADFNNLKE ELNFVTVDEV GEEEDGDNDL KVELAQSKND
1810 1820 1830 1840 1850
HPTDKKGNRK KRAVDTKKTK LESLSQVGPV NENVMEEDLK TMIERHLTAK
1860 1870 1880 1890 1900
TPTKRVRIGK TLPSEKAVVT EPAKGEEAFQ MSEVDEESGL KDSEPERKRK
1910 1920 1930 1940 1950
KTEDSSSGKS VASDVPEELD FLVPKAGFFC PICSLFYSGE KAMTNHCKST
1960 1970
RHKQNTEKFM AKQRKEKEQN EAEERSSR
The sequence of this isoform differs from the canonical sequence as follows:
1-903: Missing.
Computationally mapped potential isoform sequencesi
There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A096LPK8 | A0A096LPK8_HUMAN | Zinc finger protein 638 | ZNF638 | 285 | Annotation score: | ||
A0A096LNS4 | A0A096LNS4_HUMAN | Zinc finger protein 638 | ZNF638 | 158 | Annotation score: | ||
C9JWN0 | C9JWN0_HUMAN | Zinc finger protein 638 | ZNF638 | 197 | Annotation score: | ||
A0A096LPB4 | A0A096LPB4_HUMAN | Zinc finger protein 638 | ZNF638 | 184 | Annotation score: | ||
A0A096LNQ0 | A0A096LNQ0_HUMAN | Zinc finger protein 638 | ZNF638 | 171 | Annotation score: | ||
A0A096LNX0 | A0A096LNX0_HUMAN | Zinc finger protein 638 | ZNF638 | 98 | Annotation score: | ||
A0A096LPI0 | A0A096LPI0_HUMAN | Zinc finger protein 638 | ZNF638 | 153 | Annotation score: | ||
A0A096LNR2 | A0A096LNR2_HUMAN | Zinc finger protein 638 | ZNF638 | 90 | Annotation score: | ||
C9JSD0 | C9JSD0_HUMAN | Zinc finger protein 638 | ZNF638 | 36 | Annotation score: | ||
C9JMR2 | C9JMR2_HUMAN | Zinc finger protein 638 | ZNF638 | 62 | Annotation score: | ||
There is more potential isoformShow all |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 58 | H → L in BAA11748 (PubMed:8647861).Curated | 1 | |
Sequence conflicti | 209 | I → V in AAM97681 (Ref. 3) Curated | 1 | |
Sequence conflicti | 262 | M → I in CAD97667 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 599 | A → V in CAH18177 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 801 | S → C in BAA11748 (PubMed:8647861).Curated | 1 | |
Sequence conflicti | 977 | A → D in CAD97667 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 1205 | F → L in CAD97667 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 1243 | S → P in CAD97667 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 1336 | G → S in CAH18177 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 1404 | A → T in CAD97667 (PubMed:17974005).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_023069 | 110 | I → V1 PublicationCorresponds to variant dbSNP:rs12612365Ensembl. | 1 | |
Natural variantiVAR_023070 | 980 | N → S1 PublicationCorresponds to variant dbSNP:rs3732235Ensembl. | 1 | |
Natural variantiVAR_052238 | 1462 | S → N. Corresponds to variant dbSNP:rs10427371Ensembl. | 1 | |
Natural variantiVAR_023071 | 1726 | V → M1 PublicationCorresponds to variant dbSNP:rs1804020Ensembl. | 1 | |
Natural variantiVAR_023072 | 1912 | A → V1 PublicationCorresponds to variant dbSNP:rs11542286Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_014801 | 1 – 903 | Missing in isoform 5. 1 PublicationAdd BLAST | 903 | |
Alternative sequenceiVSP_059342 | 793 – 918 | AKTGQ…NKGYS → ESVDQTQQLVPLVRNTARDH DGTPENEGEETVQSALFGFQ YDASDHTMAWLGPNTVPEVK EMILQDPQLQTTQLPQTTQA PDITWGMLKKTTYKAEQILL QTQKPFTPDNLFLALLSGDA KPEYEQ in isoform 6. Add BLAST | 126 | |
Alternative sequenceiVSP_014802 | 793 – 814 | AKTGQ…GKSAS → GLLPTGGGNNYPQIVLAPGL CH in isoform 2. 1 PublicationAdd BLAST | 22 | |
Alternative sequenceiVSP_014803 | 815 – 1978 | Missing in isoform 2. 1 PublicationAdd BLAST | 1164 | |
Alternative sequenceiVSP_059343 | 919 – 1978 | Missing in isoform 6. Add BLAST | 1060 | |
Alternative sequenceiVSP_014804 | 1100 – 1139 | SPGLK…IQTET → RLWLSKTLRILKALLVEVPN LKRSHYFHLIWMNLLLWMRL in isoform 4. 1 PublicationAdd BLAST | 40 | |
Alternative sequenceiVSP_014805 | 1140 – 1978 | Missing in isoform 4. 1 PublicationAdd BLAST | 839 | |
Alternative sequenceiVSP_014806 | 1918 – 1938 | Missing in isoform 3. 1 PublicationAdd BLAST | 21 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D83032 mRNA Translation: BAA11748.1 AF273049 mRNA Translation: AAG34909.1 AF534078 mRNA Translation: AAM97681.1 BX537425 mRNA Translation: CAD97667.1 CR749322 mRNA Translation: CAH18177.1 AC007878 Genomic DNA Translation: AAF66079.1 AC096569 Genomic DNA Translation: AAY14979.1 AC104084 Genomic DNA No translation available. AC109343 Genomic DNA No translation available. BC024000 mRNA Translation: AAH24000.1 BC064530 mRNA Translation: AAH64530.1 Sequence problems. BC083513 mRNA Translation: AAH83513.1 BC143728 mRNA Translation: AAI43729.1 |
CCDSi | CCDS1917.1 [Q14966-1] |
PIRi | JU0239 JU0240 |
RefSeqi | NP_001014972.1, NM_001014972.2 [Q14966-1] NP_001239541.1, NM_001252612.1 [Q14966-1] NP_001239542.1, NM_001252613.1 [Q14966-3] NP_055312.2, NM_014497.4 [Q14966-1] |
Genome annotation databases
Ensembli | ENST00000264447; ENSP00000264447; ENSG00000075292 [Q14966-1] ENST00000409544; ENSP00000386433; ENSG00000075292 [Q14966-1] ENST00000410075; ENSP00000485608; ENSG00000075292 [Q14966-6] |
GeneIDi | 27332 |
KEGGi | hsa:27332 |
UCSCi | uc002shx.4, human [Q14966-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D83032 mRNA Translation: BAA11748.1 AF273049 mRNA Translation: AAG34909.1 AF534078 mRNA Translation: AAM97681.1 BX537425 mRNA Translation: CAD97667.1 CR749322 mRNA Translation: CAH18177.1 AC007878 Genomic DNA Translation: AAF66079.1 AC096569 Genomic DNA Translation: AAY14979.1 AC104084 Genomic DNA No translation available. AC109343 Genomic DNA No translation available. BC024000 mRNA Translation: AAH24000.1 BC064530 mRNA Translation: AAH64530.1 Sequence problems. BC083513 mRNA Translation: AAH83513.1 BC143728 mRNA Translation: AAI43729.1 |
CCDSi | CCDS1917.1 [Q14966-1] |
PIRi | JU0239 JU0240 |
RefSeqi | NP_001014972.1, NM_001014972.2 [Q14966-1] NP_001239541.1, NM_001252612.1 [Q14966-1] NP_001239542.1, NM_001252613.1 [Q14966-3] NP_055312.2, NM_014497.4 [Q14966-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6SXW | X-ray | 2.75 | A | 676-749 | [»] | |
SMRi | Q14966 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 118145, 171 interactors |
DIPi | DIP-42386N |
IntActi | Q14966, 60 interactors |
MINTi | Q14966 |
STRINGi | 9606.ENSP00000386433 |
PTM databases
iPTMneti | Q14966 |
PhosphoSitePlusi | Q14966 |
Genetic variation databases
BioMutai | ZNF638 |
DMDMi | 71153483 |
Proteomic databases
CPTACi | CPTAC-1371 |
EPDi | Q14966 |
jPOSTi | Q14966 |
MassIVEi | Q14966 |
MaxQBi | Q14966 |
PaxDbi | Q14966 |
PeptideAtlasi | Q14966 |
PRIDEi | Q14966 |
ProteomicsDBi | 60262 [Q14966-1] 60263 [Q14966-2] 60264 [Q14966-3] 60265 [Q14966-4] 60266 [Q14966-5] |
Protocols and materials databases
Antibodypediai | 31207, 93 antibodies |
Genome annotation databases
Ensembli | ENST00000264447; ENSP00000264447; ENSG00000075292 [Q14966-1] ENST00000409544; ENSP00000386433; ENSG00000075292 [Q14966-1] ENST00000410075; ENSP00000485608; ENSG00000075292 [Q14966-6] |
GeneIDi | 27332 |
KEGGi | hsa:27332 |
UCSCi | uc002shx.4, human [Q14966-1] |
Organism-specific databases
CTDi | 27332 |
DisGeNETi | 27332 |
GeneCardsi | ZNF638 |
HGNCi | HGNC:17894, ZNF638 |
HPAi | ENSG00000075292, Low tissue specificity |
MIMi | 614349, gene |
neXtProti | NX_Q14966 |
OpenTargetsi | ENSG00000075292 |
PharmGKBi | PA134983478 |
VEuPathDBi | HostDB:ENSG00000075292.18 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QVQ7, Eukaryota |
GeneTreei | ENSGT00940000153322 |
HOGENOMi | CLU_002180_0_0_1 |
InParanoidi | Q14966 |
OMAi | STMKRDD |
OrthoDBi | 301913at2759 |
PhylomeDBi | Q14966 |
TreeFami | TF333921 |
Enzyme and pathway databases
PathwayCommonsi | Q14966 |
Reactomei | R-HSA-381340, Transcriptional regulation of white adipocyte differentiation |
Miscellaneous databases
BioGRID-ORCSi | 27332, 50 hits in 1000 CRISPR screens |
ChiTaRSi | ZNF638, human |
GeneWikii | ZNF638 |
GenomeRNAii | 27332 |
Pharosi | Q14966, Tbio |
PROi | PR:Q14966 |
RNActi | Q14966, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000075292, Expressed in corpus callosum and 249 other tissues |
ExpressionAtlasi | Q14966, baseline and differential |
Genevisiblei | Q14966, HS |
Family and domain databases
Gene3Di | 3.30.70.330, 3 hits |
InterProi | View protein in InterPro IPR000690, Matrin/U1-C_Znf_C2H2 IPR003604, Matrin/U1-like-C_Znf_C2H2 IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom IPR033096, ZNF638 IPR022755, Znf_C2H2_jaz IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR15592:SF1, PTHR15592:SF1, 1 hit |
Pfami | View protein in Pfam PF00076, RRM_1, 1 hit PF12171, zf-C2H2_jaz, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 2 hits SM00355, ZnF_C2H2, 2 hits SM00451, ZnF_U1, 2 hits |
SUPFAMi | SSF54928, SSF54928, 3 hits SSF57667, SSF57667, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 1 hit PS50171, ZF_MATRIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN638_HUMAN | |
Accessioni | Q14966Primary (citable) accession number: Q14966 Secondary accession number(s): A0A096LPH6 Q9NP37 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2005 |
Last sequence update: | July 19, 2005 | |
Last modified: | April 7, 2021 | |
This is version 178 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references