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UniProtKB - Q14966 (ZN638_HUMAN)

Protein

Zinc finger protein 638

Gene

ZNF638

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Early regulator of adipogenesis that works as a transcription cofactor of CEBPs, controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). Binds to cytidine clusters in double-stranded DNA (PubMed:8647861). May also regulate alternative splicing of target genes during adipogenesis (By similarity).By similarity1 Publication

Miscellaneous

Isoform 5 is a tumor-associated antigen found in several cutaneous T-cell lymphoma (CTCL), and in particular in mycosis fungoides patients and in Sezary syndrome patients.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi1353 – 1477Add BLAST125
Zinc fingeri1928 – 1958Matrin-typePROSITE-ProRule annotationAdd BLAST31

GO - Molecular functioni

  • double-stranded DNA binding Source: ProtInc
  • RNA binding Source: UniProtKB
  • zinc ion binding Source: InterPro
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionActivator, DNA-binding, RNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-381340 Transcriptional regulation of white adipocyte differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 638
Alternative name(s):
Cutaneous T-cell lymphoma-associated antigen se33-1
Short name:
CTCL-associated antigen se33-1
Nuclear protein 220
Zinc finger matrin-like protein
Gene namesi
Name:ZNF638
Synonyms:NP220, ZFML
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000075292.18
HGNCiHGNC:17894 ZNF638
MIMi614349 gene
neXtProtiNX_Q14966

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi27332
OpenTargetsiENSG00000075292
PharmGKBiPA134983478

Polymorphism and mutation databases

BioMutaiZNF638
DMDMi71153483

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000820111 – 1978Zinc finger protein 638Add BLAST1978

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei47Asymmetric dimethylarginineCombined sources1
Modified residuei49Asymmetric dimethylarginineCombined sources1
Modified residuei54Asymmetric dimethylarginineCombined sources1
Modified residuei128PhosphoserineCombined sources1
Modified residuei289PhosphoserineCombined sources1
Cross-linki292Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei299PhosphoserineCombined sources1
Modified residuei369PhosphoserineCombined sources1
Modified residuei383PhosphoserineCombined sources1
Modified residuei420PhosphoserineCombined sources1
Modified residuei552PhosphoserineCombined sources1
Modified residuei605PhosphoserineCombined sources1
Modified residuei614PhosphoserineCombined sources1
Modified residuei636PhosphoserineCombined sources1
Cross-linki775Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1100PhosphoserineCombined sources1
Modified residuei1401PhosphoserineCombined sources1
Modified residuei1641PhosphoserineBy similarity1
Modified residuei1667PhosphoserineCombined sources1
Cross-linki1676Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1820Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1882PhosphoserineCombined sources1
Isoform 6 (identifier: Q14966-6)
Cross-linki913Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ14966
MaxQBiQ14966
PaxDbiQ14966
PeptideAtlasiQ14966
PRIDEiQ14966
ProteomicsDBi60262
60263 [Q14966-2]
60264 [Q14966-3]
60265 [Q14966-4]
60266 [Q14966-5]

PTM databases

iPTMnetiQ14966
PhosphoSitePlusiQ14966

Expressioni

Gene expression databases

BgeeiENSG00000075292 Expressed in 238 organ(s), highest expression level in corpus callosum
CleanExiHS_ZNF638
ExpressionAtlasiQ14966 baseline and differential
GenevisibleiQ14966 HS

Organism-specific databases

HPAiHPA036784
HPA057395

Interactioni

Subunit structurei

Interacts with FHL2 (PubMed:11813260). Interacts with CEBPA, CEBPD and CEBPG (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi118145, 141 interactors
DIPiDIP-42386N
IntActiQ14966, 34 interactors
MINTiQ14966
STRINGi9606.ENSP00000264447

Structurei

3D structure databases

ProteinModelPortaliQ14966
SMRiQ14966
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini676 – 751RRM 1PROSITE-ProRule annotationAdd BLAST76
Domaini905 – 979RRM 2PROSITE-ProRule annotationAdd BLAST75

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni472 – 571Involved in localization to nuclear specklesBy similarityAdd BLAST100

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi472 – 574Arg-richAdd BLAST103
Compositional biasi1087 – 1355Glu-richAdd BLAST269
Compositional biasi1580 – 1585Poly-Lys6

Domaini

The matrin-type zinc finger domain is required for localization to nuclear speckles.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1928 – 1958Matrin-typePROSITE-ProRule annotationAdd BLAST31

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IN3N Eukaryota
ENOG4111GCE LUCA
GeneTreeiENSGT00850000132416
HOVERGENiHBG094186
InParanoidiQ14966
OMAiFYTCFPI
OrthoDBiEOG091G02SU
PhylomeDBiQ14966
TreeFamiTF333921

Family and domain databases

Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR000690 Matrin/U1-C_Znf_C2H2
IPR003604 Matrin/U1-like-C_Znf_C2H2
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR033096 ZNF638
IPR022755 Znf_C2H2_jaz
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR15592:SF1 PTHR15592:SF1, 1 hit
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
PF12171 zf-C2H2_jaz, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SM00355 ZnF_C2H2, 2 hits
SM00451 ZnF_U1, 2 hits
SUPFAMiSSF54928 SSF54928, 3 hits
SSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit
PS50171 ZF_MATRIN, 1 hit

Sequences (6+)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 6 described isoforms and 11 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q14966-1) [UniParc]FASTAAdd to basket
Also known as: Alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSRPRFNPRG DFPLQRPRAP NPSGMRPPGP FMRPGSMGLP RFYPAGRARG 
        60         70         80         90        100
IPHRFAGHES YQNMGPQRMN VQVTQHRTDP RLTKEKLDFH EAQQKKGKPH 
       110        120        130        140        150
GSRWDDEPHI SASVAVKQSS VTQVTEQSPK VQSRYTKESA SSILASFGLS 
       160        170        180        190        200
NEDLEELSRY PDEQLTPENM PLILRDIRMR KMGRRLPNLP SQSRNKETLG 
       210        220        230        240        250
SEAVSSNVID YGHASKYGYT EDPLEVRIYD PEIPTDEVEN EFQSQQNISA 
       260        270        280        290        300
SVPNPNVICN SMFPVEDVFR QMDFPGESSN NRSFFSVESG TKMSGLHISG 
       310        320        330        340        350
GQSVLEPIKS VNQSINQTVS QTMSQSLIPP SMNQQPFSSE LISSVSQQER 
       360        370        380        390        400
IPHEPVINSS NVHVGSRGSK KNYQSQADIP IRSPFGIVKA SWLPKFSHAD 
       410        420        430        440        450
AQKMKRLPTP SMMNDYYAAS PRIFPHLCSL CNVECSHLKD WIQHQNTSTH 
       460        470        480        490        500
IESCRQLRQQ YPDWNPEILP SRRNEGNRKE NETPRRRSHS PSPRRSRRSS 
       510        520        530        540        550
SSHRFRRSRS PMHYMYRPRS RSPRICHRFI SRYRSRSRSR SPYRIRNPFR 
       560        570        580        590        600
GSPKCFRSVS PERMSRRSVR SSDRKKALED VVQRSGHGTE FNKQKHLEAA 
       610        620        630        640        650
DKGHSPAQKP KTSSGTKPSV KPTSATKSDS NLGGHSIRCK SKNLEDDTLS 
       660        670        680        690        700
ECKQVSDKAV SLQRKLRKEQ SLHYGSVLLI TELPEDGCTE EDVRKLFQPF 
       710        720        730        740        750
GKVNDVLIVP YRKEAYLEME FKEAITAIMK YIETTPLTIK GKSVKICVPG 
       760        770        780        790        800
KKKAQNKEVK KKTLESKKVS ASTLKRDADA SKAVEIVTST SAAKTGQAKA 
       810        820        830        840        850
SVAKVNKSTG KSASSVKSVV TVAVKGNKAS IKTAKSGGKK SLEAKKTGNV 
       860        870        880        890        900
KNKDSNKPVT IPENSEIKTS IEVKATENCA KEAISDAALE ATENEPLNKE 
       910        920        930        940        950
TEEMCVMLVS NLPNKGYSVE EVYDLAKPFG GLKDILILSS HKKAYIEINR 
       960        970        980        990       1000
KAAESMVKFY TCFPVLMDGN QLSISMAPEN MNIKDEEAIF ITLVKENDPE 
      1010       1020       1030       1040       1050
ANIDTIYDRF VHLDNLPEDG LQCVLCVGLQ FGKVDHHVFI SNRNKAILQL 
      1060       1070       1080       1090       1100
DSPESAQSMY SFLKQNPQNI GDHMLTCSLS PKIDLPEVQI EHDPELEKES 
      1110       1120       1130       1140       1150
PGLKNSPIDE SEVQTATDSP SVKPNELEEE STPSIQTETL VQQEEPCEEE 
      1160       1170       1180       1190       1200
AEKATCDSDF AVETLELETQ GEEVKEEIPL VASASVSIEQ FTENAEECAL 
      1210       1220       1230       1240       1250
NQQMFNSDLE KKGAEIINPK TALLPSDSVF AEERNLKGIL EESPSEAEDF 
      1260       1270       1280       1290       1300
ISGITQTMVE AVAEVEKNET VSEILPSTCI VTLVPGIPTG DEKTVDKKNI 
      1310       1320       1330       1340       1350
SEKKGNMDEK EEKEFNTKET RMDLQIGTEK AEKNEGRMDA EKVEKMAAMK 
      1360       1370       1380       1390       1400
EKPAENTLFK AYPNKGVGQA NKPDETSKTS ILAVSDVSSS KPSIKAVIVS 
      1410       1420       1430       1440       1450
SPKAKATVSK TENQKSFPKS VPRDQINAEK KLSAKEFGLL KPTSARSGLA 
      1460       1470       1480       1490       1500
ESSSKFKPTQ SSLTRGGSGR ISALQGKLSK LDYRDITKQS QETEARPSIM 
      1510       1520       1530       1540       1550
KRDDSNNKTL AEQNTKNPKS TTGRSSKSKE EPLFPFNLDE FVTVDEVIEE 
      1560       1570       1580       1590       1600
VNPSQAKQNP LKGKRKETLK NVPFSELNLK KKKGKTSTPR GVEGELSFVT 
      1610       1620       1630       1640       1650
LDEIGEEEDA AAHLAQALVT VDEVIDEEEL NMEEMVKNSN SLFTLDELID 
      1660       1670       1680       1690       1700
QDDCISHSEP KDVTVLSVAE EQDLLKQERL VTVDEIGEVE ELPLNESADI 
      1710       1720       1730       1740       1750
TFATLNTKGN EGDTVRDSIG FISSQVPEDP STLVTVDEIQ DDSSDLHLVT 
      1760       1770       1780       1790       1800
LDEVTEEDED SLADFNNLKE ELNFVTVDEV GEEEDGDNDL KVELAQSKND 
      1810       1820       1830       1840       1850
HPTDKKGNRK KRAVDTKKTK LESLSQVGPV NENVMEEDLK TMIERHLTAK 
      1860       1870       1880       1890       1900
TPTKRVRIGK TLPSEKAVVT EPAKGEEAFQ MSEVDEESGL KDSEPERKRK 
      1910       1920       1930       1940       1950
KTEDSSSGKS VASDVPEELD FLVPKAGFFC PICSLFYSGE KAMTNHCKST 
      1960       1970 
RHKQNTEKFM AKQRKEKEQN EAEERSSR
Length:1,978
Mass (Da):220,625
Last modified:July 19, 2005 - v2
Checksum:iFC006A4BA4885455
GO
Isoform 2 (identifier: Q14966-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     793-814: AKTGQAKASVAKVNKSTGKSAS → GLLPTGGGNNYPQIVLAPGLCH
     815-1978: Missing.

Note: No experimental confirmation available.
Show »
Length:814
Mass (Da):92,052
Checksum:iD3DEC862617E65FF
GO
Isoform 3 (identifier: Q14966-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1918-1938: Missing.

Note: No experimental confirmation available.
Show »
Length:1,957
Mass (Da):218,246
Checksum:i7BFD62828B7911B8
GO
Isoform 4 (identifier: Q14966-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1100-1139: SPGLKNSPID...ESTPSIQTET → RLWLSKTLRI...WMNLLLWMRL
     1140-1978: Missing.

Show »
Length:1,139
Mass (Da):128,489
Checksum:iBD7EAA34D634A34D
GO
Isoform 5 (identifier: Q14966-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-903: Missing.

Note: Broadly expressed.
Show »
Length:1,075
Mass (Da):119,295
Checksum:i8927B07C562F396B
GO
Isoform 6 (identifier: Q14966-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     793-918: AKTGQAKASV...VSNLPNKGYS → ESVDQTQQLV...SGDAKPEYEQ
     919-1978: Missing.

Show »
Length:918
Mass (Da):104,049
Checksum:i4F58E01899922C23
GO

Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A096LPK8A0A096LPK8_HUMAN
Zinc finger protein 638
ZNF638
285Annotation score:
A0A096LNS4A0A096LNS4_HUMAN
Zinc finger protein 638
ZNF638
158Annotation score:
C9JWN0C9JWN0_HUMAN
Zinc finger protein 638
ZNF638
197Annotation score:
A0A096LPB4A0A096LPB4_HUMAN
Zinc finger protein 638
ZNF638
184Annotation score:
C9JSD0C9JSD0_HUMAN
Zinc finger protein 638
ZNF638
36Annotation score:
A0A096LNX0A0A096LNX0_HUMAN
Zinc finger protein 638
ZNF638
98Annotation score:
C9JMR2C9JMR2_HUMAN
Zinc finger protein 638
ZNF638
62Annotation score:
A0A096LNQ0A0A096LNQ0_HUMAN
Zinc finger protein 638
ZNF638
171Annotation score:
A0A096LPI0A0A096LPI0_HUMAN
Zinc finger protein 638
ZNF638
153Annotation score:
A0A096LNR2A0A096LNR2_HUMAN
Zinc finger protein 638
ZNF638
90Annotation score:
There is more potential isoformShow all

Sequence cautioni

The sequence AAH64530 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti58H → L in BAA11748 (PubMed:8647861).Curated1
Sequence conflicti209I → V in AAM97681 (Ref. 3) Curated1
Sequence conflicti262M → I in CAD97667 (PubMed:17974005).Curated1
Sequence conflicti599A → V in CAH18177 (PubMed:17974005).Curated1
Sequence conflicti801S → C in BAA11748 (PubMed:8647861).Curated1
Sequence conflicti977A → D in CAD97667 (PubMed:17974005).Curated1
Sequence conflicti1205F → L in CAD97667 (PubMed:17974005).Curated1
Sequence conflicti1243S → P in CAD97667 (PubMed:17974005).Curated1
Sequence conflicti1336G → S in CAH18177 (PubMed:17974005).Curated1
Sequence conflicti1404A → T in CAD97667 (PubMed:17974005).Curated1
Sequence conflicti1714T → I (PubMed:8647861).Curated1
Sequence conflicti1714T → I (PubMed:11149944).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_023069110I → V1 PublicationCorresponds to variant dbSNP:rs12612365Ensembl.1
Natural variantiVAR_023070980N → S1 PublicationCorresponds to variant dbSNP:rs3732235Ensembl.1
Natural variantiVAR_0522381462S → N. Corresponds to variant dbSNP:rs10427371Ensembl.1
Natural variantiVAR_0230711726V → M1 PublicationCorresponds to variant dbSNP:rs1804020Ensembl.1
Natural variantiVAR_0230721912A → V1 PublicationCorresponds to variant dbSNP:rs11542286Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0148011 – 903Missing in isoform 5. 1 PublicationAdd BLAST903
Alternative sequenceiVSP_059342793 – 918AKTGQ…NKGYS → ESVDQTQQLVPLVRNTARDH DGTPENEGEETVQSALFGFQ YDASDHTMAWLGPNTVPEVK EMILQDPQLQTTQLPQTTQA PDITWGMLKKTTYKAEQILL QTQKPFTPDNLFLALLSGDA KPEYEQ in isoform 6. Add BLAST126
Alternative sequenceiVSP_014802793 – 814AKTGQ…GKSAS → GLLPTGGGNNYPQIVLAPGL CH in isoform 2. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_014803815 – 1978Missing in isoform 2. 1 PublicationAdd BLAST1164
Alternative sequenceiVSP_059343919 – 1978Missing in isoform 6. Add BLAST1060
Alternative sequenceiVSP_0148041100 – 1139SPGLK…IQTET → RLWLSKTLRILKALLVEVPN LKRSHYFHLIWMNLLLWMRL in isoform 4. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_0148051140 – 1978Missing in isoform 4. 1 PublicationAdd BLAST839
Alternative sequenceiVSP_0148061918 – 1938Missing in isoform 3. 1 PublicationAdd BLAST21

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83032 mRNA Translation: BAA11748.1
AF273049 mRNA Translation: AAG34909.1
AF534078 mRNA Translation: AAM97681.1
BX537425 mRNA Translation: CAD97667.1
CR749322 mRNA Translation: CAH18177.1
AC007878 Genomic DNA Translation: AAF66079.1
AC096569 Genomic DNA Translation: AAY14979.1
AC104084 Genomic DNA No translation available.
AC109343 Genomic DNA No translation available.
BC024000 mRNA Translation: AAH24000.1
BC064530 mRNA Translation: AAH64530.1 Sequence problems.
BC083513 mRNA Translation: AAH83513.1
BC143728 mRNA Translation: AAI43729.1
CCDSiCCDS1917.1 [Q14966-1]
PIRiJU0239
JU0240
RefSeqiNP_001014972.1, NM_001014972.2 [Q14966-1]
NP_001239541.1, NM_001252612.1 [Q14966-1]
NP_001239542.1, NM_001252613.1 [Q14966-3]
NP_055312.2, NM_014497.4 [Q14966-1]
UniGeneiHs.434401
Hs.732823

Genome annotation databases

EnsembliENST00000264447; ENSP00000264447; ENSG00000075292 [Q14966-1]
ENST00000409544; ENSP00000386433; ENSG00000075292 [Q14966-1]
ENST00000410075; ENSP00000485608; ENSG00000075292 [Q14966-6]
GeneIDi27332
KEGGihsa:27332
UCSCiuc002shx.4 human [Q14966-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN638_HUMAN
AccessioniPrimary (citable) accession number: Q14966
Secondary accession number(s): A0A096LPH6
, B5MDV1, B7ZLD1, Q53R34, Q5XJ05, Q68DP3, Q6P2H2, Q7Z3T7, Q8NF92, Q8TCA1, Q9H2G1, Q9NP37
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: September 12, 2018
This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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