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Entry version 142 (11 Dec 2019)
Sequence version 2 (28 Feb 2018)
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Protein

Killer cell immunoglobulin-like receptor 2DS5

Gene

KIR2DS5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Activating natural killer (NK) receptor that recognizes C2 epitopes of HLA-C alleles. Bridging the innate and adaptive immune systems, NK cells express a number of cell surface receptors which either inhibit or stimulate their cytotoxicity (PubMed:28685972, PubMed:18624290, PubMed:18682925). Able to activate NK cells citotoxicity and cytokine production such as IFNG (PubMed:18624290, PubMed:24269691). Receptor functions are attenuated even lost in some alleles, such as KIR2DS5*002 reprensented in this entry (PubMed:28685972).4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-2172127 DAP12 interactions

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Killer cell immunoglobulin-like receptor 2DS5
Alternative name(s):
CD158 antigen-like family member G
MHC class I NK cell receptor
Natural killer-associated transcript 9
Short name:
NKAT-9
CD_antigen: CD158g
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KIR2DS5
Synonyms:CD158G, NKAT9
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6337 KIR2DS5

Online Mendelian Inheritance in Man (OMIM)

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MIMi
604956 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q14953

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 245ExtracellularSequence analysisAdd BLAST224
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei246 – 264HelicalSequence analysisAdd BLAST19
Topological domaini265 – 304CytoplasmicSequence analysisAdd BLAST40

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi68H → D: Increases expression at the cell surface. 1 Publication1
Mutagenesisi68H → L: Reduces expression at the cell surface. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
3810

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q14953 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
KIR2DS5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
2833260

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21By similarityAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001508622 – 304Killer cell immunoglobulin-like receptor 2DS5Add BLAST283

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi49 ↔ 100By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi67N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi84N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi149 ↔ 198By similarity
Glycosylationi178N-linked (GlcNAc...) asparagineSequence analysis1 Publication1
Glycosylationi223N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated, glycosylation varies depending on the allele which alters cell surface expression levels.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q14953

PeptideAtlas

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PeptideAtlasi
Q14953

PRoteomics IDEntifications database

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PRIDEi
Q14953

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
60256

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q14953

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed on a discrete subset of peripheral blood NK cells.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TYROBP.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q14953, 8 interactors

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q14953 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q14953

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini42 – 107Ig-like C2-type 1Add BLAST66
Domaini142 – 205Ig-like C2-type 2Add BLAST64

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q14953

KEGG Orthology (KO)

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KOi
K07982

Database of Orthologous Groups

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OrthoDBi
1055520at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q14953

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013151 Immunoglobulin

Pfam protein domain database

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Pfami
View protein in Pfam
PF00047 ig, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00409 IG, 2 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48726 SSF48726, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q14953-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLMVISMAC VAFFLLQGAW PHEGFRRKPS LLAHPGPLVK SEETVILQCW
60 70 80 90 100
SDVMFEHFLL HREGTFNHTL RLIGEHIDGV SKGNFSIGRM TQDLAGTYRC
110 120 130 140 150
YGSVTHSPYQ LSAPSDPLDI VITGLYEKPS LSAQPGPTVL AGESVTLSCS
160 170 180 190 200
SRSSYDMYHL SREGEAHERR LPAGPKVNRT FQADFPLDPA THGGTYRCFG
210 220 230 240 250
SFRDSPYEWS KSSDPLLVSV TGNSSNSWPS PTEPSSETGN PRHLHVLIGT
260 270 280 290 300
SVVKLPFTIL LFFLLHRWCS NKKNASVMDQ GPAGNRTVNR EDSDEQDHQE

VSYA
Length:304
Mass (Da):33,698
Last modified:February 28, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i83AFBB6A08D8DC9B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A376A8X2A0A376A8X2_HUMAN
KIR2DL5A protein
KIR2DS5 KIR2DL5A, KIR2DL5B
277Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

The following alleles are known: KIR2DS5*001, KIR2DS5*002, KIR2DS5*003, KIR2DS5*004, KIR2DS5*005, KIR2DS5*006, KIR2DS5*007, KIR2DS5*008, KIR2DS5*009, KIR2DS5*010 and KIR2DS5*011. Allele KIR2DS5*002 is represented in this entry. Allele KIR2DS5*001 product is not expressed at the surface (PubMed:24269691, PubMed:18682925). In Europeans, KIR2DS5 is essentially monomorphic, with allele KIR2DS5*002 being predominant (PubMed:28685972). However, KIR2DS5 is highly polymorphic in Africans (PubMed:28685972). Alleles KIR2DS5*003, KIR2DS5*004, KIR2DS5*005, KIR2DS5*006, KIR2DS5*007 and KIR2DS5*008 have activating potential and recocognize C2 epitopes of HLA-C alleles (PubMed:28685972). Alleles KIR2DS5*002, KIR2DS5*009, KIR2DS5*010 and KIR2DS5*011 have activating potential but do not recocognize (or with very slight avidity) C2 epitopes of HLA-C alleles (PubMed:28685972). Allele KIR2DS5*006 protects pregnant women from pre-eclampsia (PubMed:28685972). Allele KIR2DS5*003 has increased glycosylation levels due to the variant Asn-144 instead of Ser-144, it also has increased cell surface expression. Alleles with variant Gly-179 instead of Arg-179 show lower levels of glycosylation (PubMed:24269691).3 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0801262S → L in allele KIR2DS5*001; not expressed at the cell surface when associated with P-132, S-185 and A-195 in allele KIR2DS5*001; no effect cell surface expression. 1 Publication1
Natural variantiVAR_08012722H → R in allele KIR2DS5*008; increases binding to C2 epitopes of HLA-C alleles when associated with G-179 in allele KIR2DS5*008. 1 Publication1
Natural variantiVAR_080128132S → P in allele KIR2DS5*001; not expressed at the cell surface when associated with R-22, S-185 and A-195 in allele KIR2DS5*001; abolishes cell surface expression. 1 Publication1
Natural variantiVAR_080129144S → N in allele KIR2DS5*003; increases cell surface expression, glycosylation levels and binding to C2 epitopes of HLA-C alleles when associated with G-179 in allele KIR2DS5*003. 2 Publications1
Natural variantiVAR_080130148S → F in allele KIR2DS5*010; decreases binding to C2 epitopes of HLA-C alleles when associated with G-179 and H-203 in allele KIR2DS5*010. 1 Publication1
Natural variantiVAR_080131175P → T in alleles KIR2DS5*006 and KIR2DS5*011; increases binding to C2 epitopes of HLA-C alleles when associated with G-179 in allele KIR2DS5*006; decreases binding to C2 epitopes of HLA-C alleles when associated with T-197 in allele KIR2DS5*011. 1 Publication1
Natural variantiVAR_080132179R → G in alleles KIR2DS5*003, KIR2DS5*004, KIR2DS5*005, KIR2DS5*006, KIR2DS5*007, KIR2DS5*008 and KIR2DS5*010; increases binding to C2 epitopes of HLA-C alleles in allele KIR2DS5*005; increases binding to C2 epitopes of HLA-C alleles but no effect on cell surface expression when associated with R-22 in allele KIR2DS5*008; increases cell surface expression, glycosylation levels and binding to C2 epitopes of HLA-C alleles when associated with N-144 in allele KIR2DS5*003; decreases binding to C2 epitopes of HLA-C alleles when associated with F-148 and H-203 in allele KIR2DS5*010; increases binding to C2 epitopes of HLA-C alleles when associated with T-175 in allele KIR2DS5*006; increases binding to C2 epitopes of HLA-C alleles when associated with H-203 in allele KIR2DS5*004; increases binding to C2 epitopes of HLA-C alleles when associated with K-237 in allele KIR2DS5*007. 2 Publications1
Natural variantiVAR_080133185F → S in allele KIR2DS5*001; not expressed at the cell surface when associated with R-22, P-132 and A-195 in allele KIR2DS5*001; abolishes cell surface expression. 1 Publication1
Natural variantiVAR_080134195T → A in allele KIR2DS5*001; not expressed at the cell surface when associated with R-22, P-132 and S-185 in allele KIR2DS5*001; decreases cell surface expression. 1 Publication1
Natural variantiVAR_080135197R → T in alleles KIR2DS5*009 and KIR2DS5*011; decreases binding to C2 epitopes of HLA-C alleles but no effect on cell surface expression in allele KIR2DS5*009; decreases binding to C2 epitopes of HLA-C alleles when associated with T-175 in allele KIR2DS5*011. 2 Publications1
Natural variantiVAR_080136203R → H in alleles KIR2DS5*004 and KIR2DS5*010; increases binding to C2 epitopes of HLA-C alleles when associated with G-179 in allele KIR2DS5*004; decreases binding to C2 epitopes of HLA-C alleles when associated with F-148 and G-179 in allele KIR2DS5*010. 1 Publication1
Natural variantiVAR_080137237E → K in allele KIR2DS5*007; increases binding to C2 epitopes of HLA-C alleles when associated with G-179 in allele KIR2DS5*007. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
L76672 mRNA Translation: AAB36600.1
KU645197 Genomic DNA Translation: ANJ04806.1
KU645196 Genomic DNA Translation: ANJ04799.1
KP420441 Genomic DNA Translation: AJI81015.1
AL133414 Genomic DNA No translation available.
GU182355 Genomic DNA No translation available.
CU459006 Genomic DNA No translation available.

NCBI Reference Sequences

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RefSeqi
NP_055328.2, NM_014513.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000618443; ENSP00000484843; ENSG00000274739
ENST00000639440; ENSP00000492394; ENSG00000288206
ENST00000639571; ENSP00000492015; ENSG00000288357
ENST00000644792; ENSP00000496107; ENSG00000288206
ENST00000645738; ENSP00000493745; ENSG00000288357

Database of genes from NCBI RefSeq genomes

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GeneIDi
3810

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3810

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L76672 mRNA Translation: AAB36600.1
KU645197 Genomic DNA Translation: ANJ04806.1
KU645196 Genomic DNA Translation: ANJ04799.1
KP420441 Genomic DNA Translation: AJI81015.1
AL133414 Genomic DNA No translation available.
GU182355 Genomic DNA No translation available.
CU459006 Genomic DNA No translation available.
RefSeqiNP_055328.2, NM_014513.2

3D structure databases

SMRiQ14953
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ14953, 8 interactors

PTM databases

iPTMnetiQ14953

Polymorphism and mutation databases

BioMutaiKIR2DS5
DMDMi2833260

Proteomic databases

MassIVEiQ14953
PeptideAtlasiQ14953
PRIDEiQ14953
ProteomicsDBi60256

Genome annotation databases

EnsembliENST00000618443; ENSP00000484843; ENSG00000274739
ENST00000639440; ENSP00000492394; ENSG00000288206
ENST00000639571; ENSP00000492015; ENSG00000288357
ENST00000644792; ENSP00000496107; ENSG00000288206
ENST00000645738; ENSP00000493745; ENSG00000288357
GeneIDi3810
KEGGihsa:3810

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3810
DisGeNETi3810

GeneCards: human genes, protein and diseases

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GeneCardsi
KIR2DS5
HGNCiHGNC:6337 KIR2DS5
MIMi604956 gene
neXtProtiNX_Q14953

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

InParanoidiQ14953
KOiK07982
OrthoDBi1055520at2759
PhylomeDBiQ14953

Enzyme and pathway databases

ReactomeiR-HSA-2172127 DAP12 interactions

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3810
PharosiQ14953 Tdark

Protein Ontology

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PROi
PR:Q14953
RNActiQ14953 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013151 Immunoglobulin
PfamiView protein in Pfam
PF00047 ig, 2 hits
SMARTiView protein in SMART
SM00409 IG, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKI2S5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14953
Secondary accession number(s): A0A0C4ZMZ1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 28, 2018
Last modified: December 11, 2019
This is version 142 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  6. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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