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Protein

Killer cell immunoglobulin-like receptor 2DS3

Gene

KIR2DS3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.

GO - Biological processi

  • cellular defense response Source: ProtInc

Keywordsi

Molecular functionReceptor

Names & Taxonomyi

Protein namesi
Recommended name:
Killer cell immunoglobulin-like receptor 2DS3
Alternative name(s):
MHC class I NK cell receptor
Natural killer-associated transcript 7
Short name:
NKAT-7
Gene namesi
Name:KIR2DS3
Synonyms:NKAT7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:6335 KIR2DS3
MIMi604954 gene
neXtProtiNX_Q14952

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 245ExtracellularSequence analysisAdd BLAST224
Transmembranei246 – 264HelicalSequence analysisAdd BLAST19
Topological domaini265 – 304CytoplasmicSequence analysisAdd BLAST40

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3808
PharmGKBiPA30120

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000001508422 – 304Killer cell immunoglobulin-like receptor 2DS3Add BLAST283

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 100By similarity
Glycosylationi67N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi84N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi149 ↔ 198By similarity
Glycosylationi178N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PeptideAtlasiQ14952
PRIDEiQ14952
ProteomicsDBi60255

PTM databases

iPTMnetiQ14952
PhosphoSitePlusiQ14952

Interactioni

Protein-protein interaction databases

BioGridi110009, 1 interactor
IntActiQ14952, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ14952
SMRiQ14952
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 107Ig-like C2-type 1Add BLAST66
Domaini142 – 205Ig-like C2-type 2Add BLAST64

Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG074353
InParanoidiQ14952
KOiK07982
PhylomeDBiQ14952

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013151 Immunoglobulin
PfamiView protein in Pfam
PF00047 ig, 2 hits
SMARTiView protein in SMART
SM00409 IG, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q14952-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLMVISMAC VGFFWLQGAW PHEGFRRKPS LLAHPGRLVK SEETVILQCW
60 70 80 90 100
SDVMFEHFLL HREGTFNDTL RLIGEHIDGV SKANFSIGRM RQDLAGTYRC
110 120 130 140 150
YGSVPHSPYQ FSAPSDPLDI VITGLYEKPS LSAQPGPTVL AGESVTLSCS
160 170 180 190 200
SWSSYDMYHL STEGEAHERR FSAGPKVNGT FQADFPLGPA TQGGTYRCFG
210 220 230 240 250
SFHDSPYEWS KSSDPLLVSV TGNPSNSWPS PTEPSSKTGN PRHLHVLIGT
260 270 280 290 300
SVVKLPFTIL LFFLLHRWCS DKKNASVMDQ GPAGNRTVNR EDSDEQDHQE

VSYA
Length:304
Mass (Da):33,717
Last modified:November 1, 1996 - v1
Checksum:i80693F79844F9E7E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L76670 mRNA Translation: AAB36598.1
X97231 mRNA Translation: CAA65870.1
AF022047 mRNA Translation: AAB95320.1
RefSeqiNP_036445.1, NM_012313.1
UniGeneiHs.744266

Genome annotation databases

EnsembliENST00000611193; ENSP00000479108; ENSG00000277657
ENST00000613265; ENSP00000480969; ENSG00000278306
ENST00000614725; ENSP00000483315; ENSG00000277163
ENST00000638688; ENSP00000491727; ENSG00000284039
ENST00000646148; ENSP00000496477; ENSG00000284039
GeneIDi3808
KEGGihsa:3808
UCSCiuc032lso.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L76670 mRNA Translation: AAB36598.1
X97231 mRNA Translation: CAA65870.1
AF022047 mRNA Translation: AAB95320.1
RefSeqiNP_036445.1, NM_012313.1
UniGeneiHs.744266

3D structure databases

ProteinModelPortaliQ14952
SMRiQ14952
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110009, 1 interactor
IntActiQ14952, 1 interactor

PTM databases

iPTMnetiQ14952
PhosphoSitePlusiQ14952

Proteomic databases

PeptideAtlasiQ14952
PRIDEiQ14952
ProteomicsDBi60255

Protocols and materials databases

DNASUi3808
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000611193; ENSP00000479108; ENSG00000277657
ENST00000613265; ENSP00000480969; ENSG00000278306
ENST00000614725; ENSP00000483315; ENSG00000277163
ENST00000638688; ENSP00000491727; ENSG00000284039
ENST00000646148; ENSP00000496477; ENSG00000284039
GeneIDi3808
KEGGihsa:3808
UCSCiuc032lso.2 human

Organism-specific databases

CTDi3808
DisGeNETi3808
GeneCardsiKIR2DS3
HGNCiHGNC:6335 KIR2DS3
MIMi604954 gene
neXtProtiNX_Q14952
PharmGKBiPA30120
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG074353
InParanoidiQ14952
KOiK07982
PhylomeDBiQ14952

Miscellaneous databases

GenomeRNAii3808
PROiPR:Q14952
SOURCEiSearch...

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013151 Immunoglobulin
PfamiView protein in Pfam
PF00047 ig, 2 hits
SMARTiView protein in SMART
SM00409 IG, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiKI2S3_HUMAN
AccessioniPrimary (citable) accession number: Q14952
Secondary accession number(s): O00644
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 10, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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