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Protein

Killer cell immunoglobulin-like receptor 3DS1

Gene

KIR3DS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.

GO - Molecular functioni

  • MHC class I receptor activity Source: UniProtKB

GO - Biological processi

  • immune response Source: UniProtKB
  • innate immune response Source: Reactome
  • natural killer cell activation Source: UniProtKB

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-HSA-2172127 DAP12 interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Killer cell immunoglobulin-like receptor 3DS1
Alternative name(s):
MHC class I NK cell receptor
Natural killer-associated transcript 10
Short name:
NKAT-10
Gene namesi
Name:KIR3DS1
Synonyms:NKAT10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:6340 KIR3DS1
MIMi604946 gene
neXtProtiNX_Q14943

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 340ExtracellularSequence analysisAdd BLAST319
Transmembranei341 – 360HelicalSequence analysisAdd BLAST20
Topological domaini361 – 382CytoplasmicSequence analysisAdd BLAST22

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3813
OpenTargetsiENSG00000275434

Polymorphism and mutation databases

DMDMi2833258

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000001509222 – 382Killer cell immunoglobulin-like receptor 3DS1Add BLAST361

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 95By similarity
Glycosylationi92N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi144 ↔ 195By similarity
Glycosylationi179N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi244 ↔ 293By similarity
Glycosylationi273N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PeptideAtlasiQ14943
PRIDEiQ14943
ProteomicsDBi60253

PTM databases

iPTMnetiQ14943
PhosphoSitePlusiQ14943

Expressioni

Tissue specificityi

Expressed in NK and T-cell lines but not in B-lymphoblastoid cell lines or in a colon carcinoma cell line.

Gene expression databases

BgeeiENSG00000215764
CleanExiHS_KIR3DS1

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi306831, 25 interactors
IntActiQ14943, 16 interactors
STRINGi9606.ENSP00000375608

Structurei

3D structure databases

ProteinModelPortaliQ14943
SMRiQ14943
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 102Ig-like C2-type 1Add BLAST61
Domaini137 – 202Ig-like C2-type 2Add BLAST66
Domaini237 – 300Ig-like C2-type 3Add BLAST64

Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JAMM Eukaryota
ENOG410ZT7K LUCA
HOVERGENiHBG074353
InParanoidiQ14943
PhylomeDBiQ14943

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013151 Immunoglobulin
PfamiView protein in Pfam
PF00047 ig, 3 hits
SMARTiView protein in SMART
SM00409 IG, 3 hits
SUPFAMiSSF48726 SSF48726, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q14943-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLMVVSMAC VGLFLVQRAG PHMGGQDKPF LSAWPSAVVP RGGHVTLRCH
60 70 80 90 100
YRHRFNNFML YKEDRIHVPI FHGRIFQEGF NMSPVTTAHA GNYTCRGSHP
110 120 130 140 150
HSPTGWSAPS NPMVIMVTGN HRKPSLLAHP GPLVKSGERV ILQCWSDIMF
160 170 180 190 200
EHFFLHREWI SKDPSRLVGQ IHDGVSKANF SIGSMMRALA GTYRCYGSVT
210 220 230 240 250
HTPYQLSAPS DPLDIVVTGL YEKPSLSAQP GPKVQAGESV TLSCSSRSSY
260 270 280 290 300
DMYHLSREGG AHERRLPAVR KVNRTFQADF PLGPATHGGT YRCFGSFRHS
310 320 330 340 350
PYEWSDPSDP LLVSVTGNPS SSWPSPTEPS SKSGNLRHLH ILIGTSVVKI
360 370 380
PFTILLFFLL HRWCSNKKKC CCNGPRACRE QK
Length:382
Mass (Da):42,475
Last modified:September 27, 2017 - v2
Checksum:iC6897933BCEA2EE0
GO

Polymorphismi

The KIR genes are located in a segment of DNA on 19q13.4 in the leukocyte receptor complex that has undergone expansion and contraction over time, probably through unequal crossing-over. Thus, KIR haplotypes vary in the number and types of genes, although a few framework loci, such as the gene KIR3DL1, are present on all or nearly all haplotypes. KIR3DL1 and KIR3DS1 segregate as alleles of the locus KIR3DL1/3DS1.2 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0560932L → S in allele KIR3DS1*010. Corresponds to variant dbSNP:rs605219Ensembl.1
Natural variantiVAR_07899213L → F in allele KIR3DS1*014. Corresponds to variant dbSNP:rs1142881Ensembl.1
Natural variantiVAR_05609468V → I. Corresponds to variant dbSNP:rs643347Ensembl.1
Natural variantiVAR_078993157 – 159REW → KEG in allele KIR3DS1*014. 3
Natural variantiVAR_078994157R → K in allele KIR3DS1*010. 1
Natural variantiVAR_010377166R → H1 PublicationCorresponds to variant dbSNP:rs375468097Ensembl.1
Natural variantiVAR_056095203P → S. Corresponds to variant dbSNP:rs2273731Ensembl.1
Natural variantiVAR_056096220L → P. Corresponds to variant dbSNP:rs680891Ensembl.1
Natural variantiVAR_056097259G → R. Corresponds to variant dbSNP:rs1049215Ensembl.1
Natural variantiVAR_078995369 – 382KCCCN…CREQK → NAAVMDQEPAGNRSEQRGF in allele KIR3DS1*010. Add BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L76661 mRNA Translation: AAB36589.1
AY760033 Genomic DNA Translation: AAV32446.1
JX008031 Genomic DNA Translation: AFV74772.1
CU459006 Genomic DNA No translation available.
RefSeqiNP_001077008.1, NM_001083539.2
NP_001269099.1, NM_001282170.1
NP_001269100.1, NM_001282171.1
XP_016885749.1, XM_017030260.1
UniGeneiHs.645228
Hs.743496

Genome annotation databases

EnsembliENST00000613279; ENSP00000484010; ENSG00000276534
ENST00000614217; ENSP00000481772; ENSG00000275434
ENST00000615275; ENSP00000481993; ENSG00000276498
ENST00000616075; ENSP00000477733; ENSG00000275037
ENST00000616388; ENSP00000480199; ENSG00000274465
ENST00000616583; ENSP00000483460; ENSG00000275608
ENST00000619911; ENSP00000477859; ENSG00000274283
GeneIDi3813
KEGGihsa:3813
UCSCiuc061dvg.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKI3S1_HUMAN
AccessioniPrimary (citable) accession number: Q14943
Secondary accession number(s): A0A0G2JNN4, Q5UCD2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 27, 2017
Last modified: July 18, 2018
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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