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Entry version 160 (12 Aug 2020)
Sequence version 2 (01 Dec 2000)
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Protein

Sodium/hydrogen exchanger 5

Gene

SLC9A5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction (By similarity).By similarity

Caution

The number, localization and denomination of hydrophobic domains in the Na+/H+ exchangers vary among authors.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAntiport, Ion transport, Sodium transport, Transport
LigandSodium

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q14940

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-425986, Sodium/Proton exchangers

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.36.1.16, the monovalent cation:proton antiporter-1 (cpa1) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium/hydrogen exchanger 5
Alternative name(s):
Na(+)/H(+) exchanger 5
Short name:
NHE-5
Solute carrier family 9 member 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC9A5
Synonyms:NHE5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000135740.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11078, SLC9A5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600477, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q14940

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei46 – 66HelicalSequence analysisAdd BLAST21
Transmembranei74 – 94HelicalSequence analysisAdd BLAST21
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21
Transmembranei135 – 155HelicalSequence analysisAdd BLAST21
Transmembranei174 – 194HelicalSequence analysisAdd BLAST21
Transmembranei201 – 221HelicalSequence analysisAdd BLAST21
Transmembranei247 – 267HelicalSequence analysisAdd BLAST21
Transmembranei277 – 297HelicalSequence analysisAdd BLAST21
Transmembranei332 – 352HelicalSequence analysisAdd BLAST21
Transmembranei361 – 381HelicalSequence analysisAdd BLAST21
Transmembranei399 – 419HelicalSequence analysisAdd BLAST21
Transmembranei429 – 449HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6553

Open Targets

More...
OpenTargetsi
ENSG00000135740

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35934

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q14940, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3058

DrugCentral

More...
DrugCentrali
Q14940

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
952

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC9A5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
12644417

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000523601 – 896Sodium/hydrogen exchanger 5Add BLAST896

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi199N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi319N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated (Possible).

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q14940

PeptideAtlas

More...
PeptideAtlasi
Q14940

PRoteomics IDEntifications database

More...
PRIDEi
Q14940

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
60252

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q14940, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q14940

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q14940

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain, testis, spleen, and skeletal muscle.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000135740, Expressed in cerebellar vermis and 125 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q14940, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q14940, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000135740, Tissue enhanced (brain, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CHP1 and CHP2 (By similarity).

Interacts with ARRB2.

By similarity1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
112442, 11 interactors

Protein interaction database and analysis system

More...
IntActi
Q14940, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000299798

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q14940

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q14940, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q14940

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1966, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159190

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005912_4_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q14940

KEGG Orthology (KO)

More...
KOi
K14723

Identification of Orthologs from Complete Genome Data

More...
OMAi
CPSPRVI

Database of Orthologous Groups

More...
OrthoDBi
389547at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q14940

TreeFam database of animal gene trees

More...
TreeFami
TF317212

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006153, Cation/H_exchanger
IPR018422, Cation/H_exchanger_CPA1
IPR018410, Na/H_exchanger_3/5
IPR004709, NaH_exchanger

The PANTHER Classification System

More...
PANTHERi
PTHR10110, PTHR10110, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00999, Na_H_Exchanger, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01084, NAHEXCHNGR
PR01087, NAHEXCHNGR3

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00840, b_cpa1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q14940-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRAALSLLA LPLAGAAEEP TQKPESPGEP PPGLELFRWQ WHEVEAPYLV
60 70 80 90 100
ALWILVASLA KIVFHLSRKV TSLVPESCLL ILLGLVLGGI VLAVAKKAEY
110 120 130 140 150
QLEPGTFFLF LLPPIVLDSG YFMPSRLFFD NLGAILTYAV VGTLWNAFTT
160 170 180 190 200
GAALWGLQQA GLVAPRVQAG LLDFLLFGSL ISAVDPVAVL AVFEEVHVNE
210 220 230 240 250
TLFIIVFGES LLNDAVTVVL YKVCNSFVEM GSANVQATDY LKGVASLFVV
260 270 280 290 300
SLGGAAVGLV FAFLLALTTR FTKRVRIIEP LLVFLLAYAA YLTAEMASLS
310 320 330 340 350
AILAVTMCGL GCKKYVEANI SHKSRTTVKY TMKTLASCAE TVIFMLLGIS
360 370 380 390 400
AVDSSKWAWD SGLVLGTLIF ILFFRALGVV LQTWVLNQFR LVPLDKIDQV
410 420 430 440 450
VMSYGGLRGA VAFALVILLD RTKVPAKDYF VATTIVVVFF TVIVQGLTIK
460 470 480 490 500
PLVKWLKVKR SEHHKPTLNQ ELHEHTFDHI LAAVEDVVGH HGYHYWRDRW
510 520 530 540 550
EQFDKKYLSQ LLMRRSAYRI RDQIWDVYYR LNIRDAISFV DQGGHVLSST
560 570 580 590 600
GLTLPSMPSR NSVAETSVTN LLRESGSGAC LDLQVIDTVR SGRDREDAVM
610 620 630 640 650
HHLLCGGLYK PRRRYKASCS RHFISEDAQE RQDKEVFQQN MKRRLESFKS
660 670 680 690 700
TKHNICFTKS KPRPRKTGRR KKDGVANAEA TNGKHRGLGF QDTAAVILTV
710 720 730 740 750
ESEEEEEESD SSETEKEDDE GIIFVARATS EVLQEGKVSG SLEVCPSPRI
760 770 780 790 800
IPPSPTCAEK ELPWKSGQGD LAVYVSSETT KIVPVDMQTG WNQSISSLES
810 820 830 840 850
LASPPCNQAP ILTCLPPHPR GTEEPQVPLH LPSDPRSSFA FPPSLAKAGR
860 870 880 890
SRSESSADLP QQQELQPLMG HKDHTHLSPG TATSHWCIQF NRGSRL
Length:896
Mass (Da):99,011
Last modified:December 1, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB9D234BFE0922269
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BNY2H3BNY2_HUMAN
Sodium/hydrogen exchanger 5
SLC9A5
175Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KSB3J3KSB3_HUMAN
Sodium/hydrogen exchanger 5
SLC9A5
273Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KSE2J3KSE2_HUMAN
Sodium/hydrogen exchanger 5
SLC9A5
171Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QRV1J3QRV1_HUMAN
Sodium/hydrogen exchanger 5
SLC9A5
178Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti202L → V in AAA87678 (PubMed:7759094).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF111173 mRNA Translation: AAC98696.1
CH471092 Genomic DNA Translation: EAW83114.1
BC142671 mRNA Translation: AAI42672.1
U08607 Genomic DNA Translation: AAA87678.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS42178.1

NCBI Reference Sequences

More...
RefSeqi
NP_004585.1, NM_004594.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000299798; ENSP00000299798; ENSG00000135740

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6553

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6553

UCSC genome browser

More...
UCSCi
uc002esm.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF111173 mRNA Translation: AAC98696.1
CH471092 Genomic DNA Translation: EAW83114.1
BC142671 mRNA Translation: AAI42672.1
U08607 Genomic DNA Translation: AAA87678.1
CCDSiCCDS42178.1
RefSeqiNP_004585.1, NM_004594.2

3D structure databases

SMRiQ14940
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi112442, 11 interactors
IntActiQ14940, 1 interactor
STRINGi9606.ENSP00000299798

Chemistry databases

BindingDBiQ14940
ChEMBLiCHEMBL3058
DrugCentraliQ14940
GuidetoPHARMACOLOGYi952

Protein family/group databases

TCDBi2.A.36.1.16, the monovalent cation:proton antiporter-1 (cpa1) family

PTM databases

GlyGeniQ14940, 2 sites
iPTMnetiQ14940
PhosphoSitePlusiQ14940

Polymorphism and mutation databases

BioMutaiSLC9A5
DMDMi12644417

Proteomic databases

PaxDbiQ14940
PeptideAtlasiQ14940
PRIDEiQ14940
ProteomicsDBi60252

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
44267, 57 antibodies

Genome annotation databases

EnsembliENST00000299798; ENSP00000299798; ENSG00000135740
GeneIDi6553
KEGGihsa:6553
UCSCiuc002esm.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6553
DisGeNETi6553
EuPathDBiHostDB:ENSG00000135740.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SLC9A5
HGNCiHGNC:11078, SLC9A5
HPAiENSG00000135740, Tissue enhanced (brain, lymphoid tissue)
MIMi600477, gene
neXtProtiNX_Q14940
OpenTargetsiENSG00000135740
PharmGKBiPA35934

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1966, Eukaryota
GeneTreeiENSGT00940000159190
HOGENOMiCLU_005912_4_2_1
InParanoidiQ14940
KOiK14723
OMAiCPSPRVI
OrthoDBi389547at2759
PhylomeDBiQ14940
TreeFamiTF317212

Enzyme and pathway databases

PathwayCommonsiQ14940
ReactomeiR-HSA-425986, Sodium/Proton exchangers

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
6553, 2 hits in 869 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SLC9A5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6553
PharosiQ14940, Tchem

Protein Ontology

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PROi
PR:Q14940
RNActiQ14940, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000135740, Expressed in cerebellar vermis and 125 other tissues
ExpressionAtlasiQ14940, baseline and differential
GenevisibleiQ14940, HS

Family and domain databases

InterProiView protein in InterPro
IPR006153, Cation/H_exchanger
IPR018422, Cation/H_exchanger_CPA1
IPR018410, Na/H_exchanger_3/5
IPR004709, NaH_exchanger
PANTHERiPTHR10110, PTHR10110, 1 hit
PfamiView protein in Pfam
PF00999, Na_H_Exchanger, 1 hit
PRINTSiPR01084, NAHEXCHNGR
PR01087, NAHEXCHNGR3
TIGRFAMsiTIGR00840, b_cpa1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSL9A5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14940
Secondary accession number(s): A5PKY7, Q9Y626
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 1, 2000
Last modified: August 12, 2020
This is version 160 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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