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Entry version 185 (02 Jun 2021)
Sequence version 3 (22 Sep 2009)
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Protein

Zinc finger protein 169

Gene

ZNF169

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri234 – 256C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri262 – 284C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri290 – 312C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri318 – 340C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri346 – 368C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri374 – 396C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri402 – 424C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri430 – 452C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri458 – 480C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri486 – 508C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri514 – 536C2H2-type 11; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri542 – 564C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri570 – 592C2H2-type 13; degeneratePROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q14929

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436, Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 169
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF169
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12957, ZNF169

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603404, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q14929

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000175787.16

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
169841

Open Targets

More...
OpenTargetsi
ENSG00000175787

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37539

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q14929, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF169

Domain mapping of disease mutations (DMDM)

More...
DMDMi
259016472

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000474381 – 603Zinc finger protein 169Add BLAST603

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q14929

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q14929

PeptideAtlas

More...
PeptideAtlasi
Q14929

PRoteomics IDEntifications database

More...
PRIDEi
Q14929

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
60222

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q14929

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q14929

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in kidney, weakly expressed in heart, liver, spleen, and small intestine. Not expressed in adult brain or spinal cord.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000175787, Expressed in parotid gland and 186 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q14929, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q14929, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000175787, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
127990, 57 interactors

Protein interaction database and analysis system

More...
IntActi
Q14929, 48 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000378792

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q14929, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q14929

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini14 – 85KRABPROSITE-ProRule annotationAdd BLAST72

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni121 – 181DisorderedSequence analysisAdd BLAST61
Regioni583 – 603DisorderedSequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi138 – 157Basic and acidic residuesSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri234 – 256C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri262 – 284C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri290 – 312C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri318 – 340C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri346 – 368C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri374 – 396C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri402 – 424C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri430 – 452C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri458 – 480C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri486 – 508C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri514 – 536C2H2-type 11; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri542 – 564C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri570 – 592C2H2-type 13; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163169

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002678_44_5_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q14929

Identification of Orthologs from Complete Genome Data

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OMAi
DQRTHSG

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q14929

TreeFam database of animal gene trees

More...
TreeFami
TF338096

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765, KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 12 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 12 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 7 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 11 hits
PS50157, ZINC_FINGER_C2H2_2, 13 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q14929-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSPGLLTTRK EALMAFRDVA VAFTQKEWKL LSSAQRTLYR EVMLENYSHL
60 70 80 90 100
VSLGIAFSKP KLIEQLEQGD EPWREENEHL LDLCPEPRTE FQPSFPHLVA
110 120 130 140 150
FSSSQLLRQY ALSGHPTQIF PSSSAGGDFQ LEAPRCSSEK GESGETEGPD
160 170 180 190 200
SSLRKRPSRI SRTFFSPHQG DPVEWVEGNR EGGTDLRLAQ RMSLGGSDTM
210 220 230 240 250
LKGADTSESG AVIRGNYRLG LSKKSSLFSH QKHHVCPECG RGFCQRSDLI
260 270 280 290 300
KHQRTHTGEK PYLCPECGRR FSQKASLSIH QRKHSGEKPY VCRECGRHFR
310 320 330 340 350
YTSSLTNHKR IHSGERPFVC QECGRGFRQK IALLLHQRTH LEEKPFVCPE
360 370 380 390 400
CGRGFCQKAS LLQHQSSHTG ERPFLCLECG RSFRQQSLLL SHQVTHSGEK
410 420 430 440 450
PYVCAECGHS FRQKVTLIRH QRTHTGEKPY LCPQCGRGFS QKVTLIGHQR
460 470 480 490 500
THTGEKPYLC PDCGRGFGQK VTLIRHQRTH TGEKPYLCPK CGRAFGFKSL
510 520 530 540 550
LTRHQRTHSE EELYVDRVCG QGLGQKSHLI SDQRTHSGEK PCICDECGRG
560 570 580 590 600
FGFKSALIRH QRTHSGEKPY VCRECGRGFS QKSHLHRHRR TKSGHQLLPQ

EVF
Length:603
Mass (Da):68,488
Last modified:September 22, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE50538A48E248AB9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5SR55Q5SR55_HUMAN
Zinc finger protein 169
ZNF169
125Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q7Z761Q7Z761_HUMAN
ZNF169 protein
ZNF169
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R440S4R440_HUMAN
Zinc finger protein 169
ZNF169
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH47702 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAF82431 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti91 – 99FQPSFPHLV → IPAKFSPPG in AAA70188 (PubMed:9071574).Curated9
Sequence conflicti276 – 278SLS → PSP in AAA70188 (PubMed:9071574).Curated3
Sequence conflicti343E → D in BAF82431 (PubMed:14702039).Curated1
Sequence conflicti349 – 356PECGRGFC → LSVGEAL in AAA70188 (PubMed:9071574).Curated8
Sequence conflicti376C → S in AAA70188 (PubMed:9071574).Curated1
Sequence conflicti382S → T in AAA70188 (PubMed:9071574).Curated1
Sequence conflicti470 – 471KV → NG in AAA70188 (PubMed:9071574).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02419872P → L. Corresponds to variant dbSNP:rs1536690Ensembl.1
Natural variantiVAR_05906578E → K. Corresponds to variant dbSNP:rs35177967Ensembl.1
Natural variantiVAR_059066152S → L. Corresponds to variant dbSNP:rs34433105Ensembl.1
Natural variantiVAR_024199381R → C. Corresponds to variant dbSNP:rs12236219Ensembl.1
Natural variantiVAR_059067596Q → H1 PublicationCorresponds to variant dbSNP:rs12350212Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK289742 mRNA Translation: BAF82431.1 Different initiation.
AL691447 Genomic DNA No translation available.
CH471089 Genomic DNA Translation: EAW62879.1
BC047702 mRNA Translation: AAH47702.1 Different initiation.
U28251 Genomic DNA Translation: AAA70188.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6709.2

NCBI Reference Sequences

More...
RefSeqi
NP_919301.2, NM_194320.3
XP_016869853.1, XM_017014364.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000395395; ENSP00000378792; ENSG00000175787

Database of genes from NCBI RefSeq genomes

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GeneIDi
169841

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:169841

UCSC genome browser

More...
UCSCi
uc004aum.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289742 mRNA Translation: BAF82431.1 Different initiation.
AL691447 Genomic DNA No translation available.
CH471089 Genomic DNA Translation: EAW62879.1
BC047702 mRNA Translation: AAH47702.1 Different initiation.
U28251 Genomic DNA Translation: AAA70188.1
CCDSiCCDS6709.2
RefSeqiNP_919301.2, NM_194320.3
XP_016869853.1, XM_017014364.1

3D structure databases

SMRiQ14929
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi127990, 57 interactors
IntActiQ14929, 48 interactors
STRINGi9606.ENSP00000378792

PTM databases

iPTMnetiQ14929
PhosphoSitePlusiQ14929

Genetic variation databases

BioMutaiZNF169
DMDMi259016472

Proteomic databases

MassIVEiQ14929
PaxDbiQ14929
PeptideAtlasiQ14929
PRIDEiQ14929
ProteomicsDBi60222

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
28458, 161 antibodies

The DNASU plasmid repository

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DNASUi
169841

Genome annotation databases

EnsembliENST00000395395; ENSP00000378792; ENSG00000175787
GeneIDi169841
KEGGihsa:169841
UCSCiuc004aum.2, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
169841
DisGeNETi169841

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF169
HGNCiHGNC:12957, ZNF169
HPAiENSG00000175787, Low tissue specificity
MIMi603404, gene
neXtProtiNX_Q14929
OpenTargetsiENSG00000175787
PharmGKBiPA37539
VEuPathDBiHostDB:ENSG00000175787.16

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000163169
HOGENOMiCLU_002678_44_5_1
InParanoidiQ14929
OMAiDQRTHSG
OrthoDBi1318335at2759
PhylomeDBiQ14929
TreeFamiTF338096

Enzyme and pathway databases

PathwayCommonsiQ14929
ReactomeiR-HSA-212436, Generic Transcription Pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
169841, 30 hits in 1011 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNF169, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
169841
PharosiQ14929, Tbio

Protein Ontology

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PROi
PR:Q14929
RNActiQ14929, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000175787, Expressed in parotid gland and 186 other tissues
ExpressionAtlasiQ14929, baseline and differential
GenevisibleiQ14929, HS

Family and domain databases

CDDicd07765, KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 12 hits
SMARTiView protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 12 hits
SUPFAMiSSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 11 hits
PS50157, ZINC_FINGER_C2H2_2, 13 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN169_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14929
Secondary accession number(s): A2AGP5, A8K127, Q6PI28
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: September 22, 2009
Last modified: June 2, 2021
This is version 185 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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