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Protein

Sodium-dependent phosphate transport protein 1

Gene

SLC17A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na+ cotransport in the renal brush border membrane. Plays a role in urate transport in the kidney (PubMed:27906618).1 Publication

Caution

It is uncertain whether Met-1 or Met-3 is the initiator.Curated

GO - Molecular functioni

GO - Biological processi

  • ion transport Source: Reactome
  • phosphate ion transport Source: ProtInc
  • sodium ion transmembrane transport Source: GO_Central
  • urate metabolic process Source: BHF-UCL
  • urate transport Source: UniProtKB

Keywordsi

Biological processIon transport, Sodium transport, Symport, Transport
LigandSodium

Enzyme and pathway databases

ReactomeiR-HSA-428643 Organic anion transporters

Protein family/group databases

TCDBi2.A.1.14.27 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent phosphate transport protein 1
Alternative name(s):
Na(+)/PI cotransporter 1
Na/Pi-4
Renal Na(+)-dependent phosphate cotransporter 1
Renal sodium-dependent phosphate transport protein 1
Short name:
Renal sodium-phosphate transport protein 1
Sodium/phosphate cotransporter 1
Solute carrier family 17 member 1
Gene namesi
Name:SLC17A1
Synonyms:NPT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000124568.10
HGNCiHGNC:10929 SLC17A1
MIMi182308 gene
neXtProtiNX_Q14916

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Transmembranei178 – 198HelicalSequence analysisAdd BLAST21
Transmembranei200 – 220HelicalSequence analysisAdd BLAST21
Transmembranei257 – 277HelicalSequence analysisAdd BLAST21
Transmembranei301 – 321HelicalSequence analysisAdd BLAST21
Transmembranei339 – 359HelicalSequence analysisAdd BLAST21
Transmembranei365 – 385HelicalSequence analysisAdd BLAST21
Transmembranei401 – 421HelicalSequence analysisAdd BLAST21
Transmembranei433 – 453HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6568
OpenTargetsiENSG00000124568
PharmGKBiPA35820

Chemistry databases

ChEMBLiCHEMBL3769298

Polymorphism and mutation databases

BioMutaiSLC17A1
DMDMi205371809

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002209361 – 467Sodium-dependent phosphate transport protein 1Add BLAST467

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi41N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi49N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi58N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ14916
PeptideAtlasiQ14916
PRIDEiQ14916
ProteomicsDBi60218
60219 [Q14916-2]

PTM databases

PhosphoSitePlusiQ14916

Expressioni

Tissue specificityi

Expressed in kidney cortex, liver and brain but not in other tissues.

Gene expression databases

BgeeiENSG00000124568 Expressed in 54 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_SLC17A1
ExpressionAtlasiQ14916 baseline and differential
GenevisibleiQ14916 HS

Organism-specific databases

HPAiHPA050513

Interactioni

Subunit structurei

Interacts with PDZK1.By similarity

Protein-protein interaction databases

BioGridi112456, 2 interactors
STRINGi9606.ENSP00000244527

Structurei

3D structure databases

ProteinModelPortaliQ14916
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2532 Eukaryota
ENOG410XPWC LUCA
GeneTreeiENSGT00760000119079
HOVERGENiHBG008834
InParanoidiQ14916
KOiK12300
OMAiIKNPVYN
OrthoDBiEOG091G08YP
PhylomeDBiQ14916
TreeFamiTF313535

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR004745 Pi_cotranspt
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00894 2A0114euk, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q14916-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQMDNRLPPK KVPGFCSFRY GLSFLVHCCN VIITAQRACL NLTMVVMVNS
60 70 80 90 100
TDPHGLPNTS TKKLLDNIKN PMYNWSPDIQ GIILSSTSYG VIIIQVPVGY
110 120 130 140 150
FSGIYSTKKM IGFALCLSSV LSLLIPPAAG IGVAWVVVCR AVQGAAQGIV
160 170 180 190 200
ATAQFEIYVK WAPPLERGRL TSMSTSGFLL GPFIVLLVTG VICESLGWPM
210 220 230 240 250
VFYIFGACGC AVCLLWFVLF YDDPKDHPCI SISEKEYITS SLVQQVSSSR
260 270 280 290 300
QSLPIKAILK SLPVWAISTG SFTFFWSHNI MTLYTPMFIN SMLHVNIKEN
310 320 330 340 350
GFLSSLPYLF AWICGNLAGQ LSDFFLTRNI LSVIAVRKLF TAAGFLLPAI
360 370 380 390 400
FGVCLPYLSS TFYSIVIFLI LAGATGSFCL GGVFINGLDI APRYFGFIKA
410 420 430 440 450
CSTLTGMIGG LIASTLTGLI LKQDPESAWF KTFILMAAIN VTGLIFYLIV
460
ATAEIQDWAK EKQHTRL
Length:467
Mass (Da):51,132
Last modified:September 2, 2008 - v2
Checksum:i10FE6C7E202BCFF7
GO
Isoform 2 (identifier: Q14916-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     246-299: Missing.

Note: No experimental confirmation available.
Show »
Length:413
Mass (Da):44,978
Checksum:i30B74AC95A0C1CBB
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PGW3E9PGW3_HUMAN
Sodium-dependent phosphate transpor...
SLC17A1
209Annotation score:

Sequence cautioni

The sequence BAA05888 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37 – 38RA → LM in BAA05888 (PubMed:7826357).Curated2
Sequence conflicti79I → V in BAA05888 (PubMed:7826357).Curated1
Sequence conflicti100Y → H in AAV98361 (Ref. 2) Curated1
Sequence conflicti117L → P in BAF83472 (PubMed:14702039).Curated1
Sequence conflicti209G → C in BAA05888 (PubMed:7826357).Curated1
Sequence conflicti215L → F in AAV98361 (Ref. 2) Curated1
Sequence conflicti233S → G in BAA05888 (PubMed:7826357).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05006076S → N. Corresponds to variant dbSNP:rs6933573Ensembl.1
Natural variantiVAR_050061269T → I Increased urate transport. 3 PublicationsCorresponds to variant dbSNP:rs1165196Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_035012246 – 299Missing in isoform 2. 1 PublicationAdd BLAST54

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71355 mRNA Translation: CAA50490.1
AY780791 mRNA Translation: AAV98361.1
AK290783 mRNA Translation: BAF83472.1
AL138726 Genomic DNA No translation available.
CH471087 Genomic DNA Translation: EAW55494.1
BC101745 mRNA Translation: AAI01746.1
BC101747 mRNA Translation: AAI01748.1
AF362494, AF362490, AF362492 Genomic DNA Translation: AAL04478.1
D83236 Genomic DNA Translation: BAA25645.1
D28532 mRNA Translation: BAA05888.1 Different initiation.
CCDSiCCDS4565.1 [Q14916-1]
PIRiA48916
I39473
RefSeqiNP_005065.2, NM_005074.3 [Q14916-1]
UniGeneiHs.205816

Genome annotation databases

EnsembliENST00000244527; ENSP00000244527; ENSG00000124568 [Q14916-1]
ENST00000468082; ENSP00000420546; ENSG00000124568 [Q14916-2]
ENST00000476801; ENSP00000420614; ENSG00000124568 [Q14916-1]
GeneIDi6568
KEGGihsa:6568
UCSCiuc003nfh.5 human [Q14916-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71355 mRNA Translation: CAA50490.1
AY780791 mRNA Translation: AAV98361.1
AK290783 mRNA Translation: BAF83472.1
AL138726 Genomic DNA No translation available.
CH471087 Genomic DNA Translation: EAW55494.1
BC101745 mRNA Translation: AAI01746.1
BC101747 mRNA Translation: AAI01748.1
AF362494, AF362490, AF362492 Genomic DNA Translation: AAL04478.1
D83236 Genomic DNA Translation: BAA25645.1
D28532 mRNA Translation: BAA05888.1 Different initiation.
CCDSiCCDS4565.1 [Q14916-1]
PIRiA48916
I39473
RefSeqiNP_005065.2, NM_005074.3 [Q14916-1]
UniGeneiHs.205816

3D structure databases

ProteinModelPortaliQ14916
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112456, 2 interactors
STRINGi9606.ENSP00000244527

Chemistry databases

ChEMBLiCHEMBL3769298

Protein family/group databases

TCDBi2.A.1.14.27 the major facilitator superfamily (mfs)

PTM databases

PhosphoSitePlusiQ14916

Polymorphism and mutation databases

BioMutaiSLC17A1
DMDMi205371809

Proteomic databases

PaxDbiQ14916
PeptideAtlasiQ14916
PRIDEiQ14916
ProteomicsDBi60218
60219 [Q14916-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000244527; ENSP00000244527; ENSG00000124568 [Q14916-1]
ENST00000468082; ENSP00000420546; ENSG00000124568 [Q14916-2]
ENST00000476801; ENSP00000420614; ENSG00000124568 [Q14916-1]
GeneIDi6568
KEGGihsa:6568
UCSCiuc003nfh.5 human [Q14916-1]

Organism-specific databases

CTDi6568
DisGeNETi6568
EuPathDBiHostDB:ENSG00000124568.10
GeneCardsiSLC17A1
HGNCiHGNC:10929 SLC17A1
HPAiHPA050513
MIMi182308 gene
neXtProtiNX_Q14916
OpenTargetsiENSG00000124568
PharmGKBiPA35820
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2532 Eukaryota
ENOG410XPWC LUCA
GeneTreeiENSGT00760000119079
HOVERGENiHBG008834
InParanoidiQ14916
KOiK12300
OMAiIKNPVYN
OrthoDBiEOG091G08YP
PhylomeDBiQ14916
TreeFamiTF313535

Enzyme and pathway databases

ReactomeiR-HSA-428643 Organic anion transporters

Miscellaneous databases

GeneWikiiSLC17A1
GenomeRNAii6568
PROiPR:Q14916
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000124568 Expressed in 54 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_SLC17A1
ExpressionAtlasiQ14916 baseline and differential
GenevisibleiQ14916 HS

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR004745 Pi_cotranspt
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00894 2A0114euk, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNPT1_HUMAN
AccessioniPrimary (citable) accession number: Q14916
Secondary accession number(s): A8K418
, O60761, Q13783, Q3MIP5, Q5MJP8, Q5TB83, Q96KL8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 2, 2008
Last modified: September 12, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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