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Entry version 101 (13 Nov 2019)
Sequence version 1 (22 Aug 2006)
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Protein

Inactive dual specificity phosphatase 27

Gene

Dusp27

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be required for myofiber maturation.By similarity

Caution

Ser-225 is present instead of the conserved Cys which is expected to be an active site residue suggesting that this protein has lost its phosphatase activity.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inactive dual specificity phosphatase 27Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dusp27Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2685055 Dusp27

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003028391 – 1138Inactive dual specificity phosphatase 27Add BLAST1138

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei291PhosphoserineCombined sources1
Modified residuei373PhosphoserineCombined sources1
Modified residuei427PhosphothreonineCombined sources1
Modified residuei503PhosphoserineCombined sources1
Modified residuei555PhosphoserineCombined sources1
Modified residuei862PhosphoserineCombined sources1
Modified residuei929PhosphoserineCombined sources1
Modified residuei966PhosphoserineCombined sources1
Modified residuei1016PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q148W8

PeptideAtlas

More...
PeptideAtlasi
Q148W8

PRoteomics IDEntifications database

More...
PRIDEi
Q148W8

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q148W8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q148W8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000026564 Expressed in 91 organ(s), highest expression level in quadriceps femoris

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q148W8 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000083155

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q148W8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini201 – 259Tyrosine-protein phosphataseAdd BLAST59

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi273 – 416Glu-richAdd BLAST144
Compositional biasi872 – 1016Ser-richAdd BLAST145

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1716 Eukaryota
COG2453 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159723

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112296

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q148W8

KEGG Orthology (KO)

More...
KOi
K14165

Identification of Orthologs from Complete Genome Data

More...
OMAi
ESTWDMW

Database of Orthologous Groups

More...
OrthoDBi
1576308at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q148W8

TreeFam database of animal gene trees

More...
TreeFami
TF351505

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.190.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR020417 Atypical_DUSP
IPR020405 Atypical_DUSP_subfamA
IPR000340 Dual-sp_phosphatase_cat-dom
IPR029021 Prot-tyrosine_phosphatase-like
IPR000387 TYR_PHOSPHATASE_dom
IPR020422 TYR_PHOSPHATASE_DUAL_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00782 DSPc, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01908 ADSPHPHTASE
PR01909 ADSPHPHTASEA

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00195 DSPc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52799 SSF52799, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50054 TYR_PHOSPHATASE_DUAL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q148W8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATGGDAEEE QVVPNEEDEA DVRAVQARYL RSPSPSQYSV VSEAETESIF
60 70 80 90 100
MEPIHLSSAV AAKQIINEEL KPRGLRTDTE CPGMLESAEQ LLVEDLYNRV
110 120 130 140 150
REKMDDRSLF NTPCVLDLQR ALTQDRQEAP RNEVDEVWPN VFIAEKSVAV
160 170 180 190 200
NKGRLKRLGI THILNAAHGT GVYTGSEFYT GLEIQYLGVE VDDFPEVDIS
210 220 230 240 250
QHFRKAAEFL DEALLTYRGK VLVSSEMGIS RSAVLVVAYL MIFHSMAILE
260 270 280 290 300
ALMTVRRKRA IYPNDGFLKQ LRELNEKLME EREEEDGEEE SEEDAGSMLG
310 320 330 340 350
ARVNSLMVEE EDDATSHLSG SSLGKASQVS KPVTLIDDEE EEKKLYEEWR
360 370 380 390 400
KGQGFPKGEA AQGRKGRSCS MSSAQDGDDC EDEDVERIIQ EWQSRNERYQ
410 420 430 440 450
AKGREQWNRE EEEEEENSYS SRRRRHTLSE SSASESVSSH DIRILKQQLE
460 470 480 490 500
RSTQSRRGRY RSDSESSEST WDMWNERLVE IEKEAARKYR SKSKREELDG
510 520 530 540 550
DCSEAGGRVR EDDEESVLSE ASSFYNFCSR NKDKLTPLER WKIKRIQFGF
560 570 580 590 600
HKKDSEAGDG GSEHGTEEAA AGEKNLSDVN LTAYQAWKLK HQKKVGSENK
610 620 630 640 650
EEVVEMSKGE DTVLAKKRQR RLELLERSRQ TLEESQSMGS WEADSSTASR
660 670 680 690 700
SIPLSAFSSA APSVSADGDT ASVLSTQSHR SHASNMPATP LPNLPVGPGD
710 720 730 740 750
TISIASIQNW IANVVNETLA QKQNEMLLLS RPPSVASMKA APAACGLGGD
760 770 780 790 800
DQLSVLSTSL SGCLPPPSQG RPSSDVQSVL SSTSSLTSRA EGSGNKVRGT
810 820 830 840 850
SKPIYSLFAD NVDLKELGRK EKEMQMELQE KMSEYKMEKL ASDNKRSSLF
860 870 880 890 900
KKKKAKDDED MSVGDRDEDT DSAIGSFRYS SRSNSQKPET DASSSLAISD
910 920 930 940 950
HYRNGRSMGN EMDSNINTWL SGLRMEEKSP PQSDWSGSSR GRYTRSSLLR
960 970 980 990 1000
ETESKSCSYK FSKSRSQEQD TSFHEANGDT VRNTSRFSSS TTKEAREMHK
1010 1020 1030 1040 1050
FSRSTFSETS SSREESPEPY FFRRTPEPSD GEESPEPRRP NWTRPRDWED
1060 1070 1080 1090 1100
VEESSKSDFA EFGAKRKFTQ SFMRSEEEGE KERTENREEG RFASGRQSQY
1110 1120 1130
RRSTNQQEEE EMDDEAIIAA WRKRQEETRT KLQRRRED
Length:1,138
Mass (Da):128,575
Last modified:August 22, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0187A4C2D943AA11
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti145E → D in BAE25001 (PubMed:16141072).Curated1
Sequence conflicti856K → R in BAC33386 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK048603 mRNA Translation: BAC33386.1
AK142263 mRNA Translation: BAE25001.1
BC059034 mRNA Translation: AAH59034.1
BC117936 mRNA Translation: AAI17937.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS15446.1

NCBI Reference Sequences

More...
RefSeqi
NP_001028516.2, NM_001033344.3
NP_001153521.1, NM_001160049.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000085992; ENSMUSP00000083155; ENSMUSG00000026564
ENSMUST00000192369; ENSMUSP00000141564; ENSMUSG00000026564

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
240892

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:240892

UCSC genome browser

More...
UCSCi
uc007dkh.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK048603 mRNA Translation: BAC33386.1
AK142263 mRNA Translation: BAE25001.1
BC059034 mRNA Translation: AAH59034.1
BC117936 mRNA Translation: AAI17937.1
CCDSiCCDS15446.1
RefSeqiNP_001028516.2, NM_001033344.3
NP_001153521.1, NM_001160049.1

3D structure databases

SMRiQ148W8
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000083155

PTM databases

iPTMnetiQ148W8
PhosphoSitePlusiQ148W8

Proteomic databases

PaxDbiQ148W8
PeptideAtlasiQ148W8
PRIDEiQ148W8

Genome annotation databases

EnsembliENSMUST00000085992; ENSMUSP00000083155; ENSMUSG00000026564
ENSMUST00000192369; ENSMUSP00000141564; ENSMUSG00000026564
GeneIDi240892
KEGGimmu:240892
UCSCiuc007dkh.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
92235
MGIiMGI:2685055 Dusp27

Phylogenomic databases

eggNOGiKOG1716 Eukaryota
COG2453 LUCA
GeneTreeiENSGT00940000159723
HOGENOMiHOG000112296
InParanoidiQ148W8
KOiK14165
OMAiESTWDMW
OrthoDBi1576308at2759
PhylomeDBiQ148W8
TreeFamiTF351505

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q148W8

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000026564 Expressed in 91 organ(s), highest expression level in quadriceps femoris
GenevisibleiQ148W8 MM

Family and domain databases

Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR020417 Atypical_DUSP
IPR020405 Atypical_DUSP_subfamA
IPR000340 Dual-sp_phosphatase_cat-dom
IPR029021 Prot-tyrosine_phosphatase-like
IPR000387 TYR_PHOSPHATASE_dom
IPR020422 TYR_PHOSPHATASE_DUAL_dom
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
PRINTSiPR01908 ADSPHPHTASE
PR01909 ADSPHPHTASEA
SMARTiView protein in SMART
SM00195 DSPc, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50054 TYR_PHOSPHATASE_DUAL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDUS27_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q148W8
Secondary accession number(s): Q3UQN8, Q6PCZ9, Q8BX87
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: August 22, 2006
Last modified: November 13, 2019
This is version 101 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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