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UniProtKB - Q148W0 (AT8B1_MOUSE)

Entry version 130 (25 May 2022)
Sequence version 2 (05 May 2009)
Previous versions | rss
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Protein

Phospholipid-transporting ATPase IC

Gene

Atp8b1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of phospholipids, in particular phosphatidylcholines (PC), from the outer to the inner leaflet of the plasma membrane (By similarity).

May participate in the establishment of the canalicular membrane integrity by ensuring asymmetric distribution of phospholipids in the canicular membrane (PubMed:21820390).

Thus may have a role in the regulation of bile acids transport into the canaliculus, uptake of bile acids from intestinal contents into intestinal mucosa or both and protect hepatocytes from bile salts (PubMed:14976163, PubMed:21820390, PubMed:20126555).

Involved in the microvillus formation in polarized epithelial cells; the function seems to be independent from its flippase activity (By similarity).

Participates in correct apical membrane localization of CDC42, CFTR and SLC10A2 (PubMed:26416959).

Enables CDC42 clustering at the apical membrane during enterocyte polarization through the interaction between CDC42 polybasic region and negatively charged membrane lipids provided by ATP8B1 (PubMed:26416959).

Together with TMEM30A is involved in uptake of the synthetic drug alkylphospholipid perifosine (By similarity).

Required for the preservation of cochlear hair cells in the inner ear (PubMed:19478059).

According PubMed:20852622 is proposed to act as cardiolipin transporter during inflammatory injury; the function is questioned by PubMed:21475228 (PubMed:20852622, PubMed:21475228).

By similarity7 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei4544-aspartylphosphate intermediateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi893MagnesiumBy similarity1
Metal bindingi897MagnesiumBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTranslocase
Biological processHearing, Lipid transport, Transport
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		7.6.2.1, 3474

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-936837, Ion transport by P-type ATPases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phospholipid-transporting ATPase ICCurated (EC:7.6.2.1By similarity)
Alternative name(s):
ATPase class I type 8B member 1
P4-ATPase flippase complex alpha subunit ATP8B1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Atp8b1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1859665, Atp8b1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000039529

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 121CytoplasmicSequence analysisAdd BLAST121
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei122 – 142HelicalSequence analysisAdd BLAST21
Topological domaini143 – 144Exoplasmic loopSequence analysis2
Transmembranei145 – 165HelicalSequence analysisAdd BLAST21
Topological domaini166 – 339CytoplasmicSequence analysisAdd BLAST174
Transmembranei340 – 360HelicalSequence analysisAdd BLAST21
Topological domaini361 – 385Exoplasmic loopSequence analysisAdd BLAST25
Transmembranei386 – 406HelicalSequence analysisAdd BLAST21
Topological domaini407 – 952CytoplasmicSequence analysisAdd BLAST546
Transmembranei953 – 973HelicalSequence analysisAdd BLAST21
Topological domaini974 – 982Exoplasmic loopSequence analysis9
Transmembranei983 – 1003HelicalSequence analysisAdd BLAST21
Topological domaini1004 – 1032CytoplasmicSequence analysisAdd BLAST29
Transmembranei1033 – 1053HelicalSequence analysisAdd BLAST21
Topological domaini1054 – 1071Exoplasmic loopSequence analysisAdd BLAST18
Transmembranei1072 – 1092HelicalSequence analysisAdd BLAST21
Topological domaini1093 – 1094CytoplasmicSequence analysis2
Transmembranei1095 – 1115HelicalSequence analysisAdd BLAST21
Topological domaini1116 – 1142Exoplasmic loopSequence analysisAdd BLAST27
Transmembranei1143 – 1163HelicalSequence analysisAdd BLAST21
Topological domaini1164 – 1251CytoplasmicSequence analysisAdd BLAST88

Keywords - Cellular componenti

Cell membrane, Cell projection, Endoplasmic reticulum, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice have unimpaired bile secretion, and no liver damage, but show mild abnormalities including depressed weight at weaning and elevated serum bile salt levels. Do not suffer from jaundice or diarrhea and have normal serum bilirubin levels and normal liver enzyme activities, except for mildly elevated serum AST (aspartate aminotransferase) activity. Display unimpaired transhepatic bile salt transport and are resistant to bile salt-induced cholestasis. Upon bile salt feeding, demonstrate serum bile salt accumulation, hepatic injury and expansion of the systemic bile salt pool and this failure of bile salt homeostasis occurs in the absence of any defect in hepatic bile secretion (PubMed:14976163). Mutant mice with B6 background show greater abnormalities than 129 and/or F1 background ones. Pups of B6 background gain less weight. In adult B6 background has lower serum cholesterol levels, higher serum alkaline phosphatase levels, and larger livers. After challenge with cholate-supplemented diet, these mice exhibit higher serum alkaline phosphatase and bilirubin levels, greater weight loss and larger livers (PubMed:20126555).2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi308G → V: Markly decreased expression, hearing loss associated with degeneration of cochlear hair cells and spiral ganglion cells. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003708621 – 1251Phospholipid-transporting ATPase ICAdd BLAST1251

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1223PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q148W0

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q148W0

PeptideAtlas

More...PeptideAtlasi		Q148W0

PRoteomics IDEntifications database

More...PRIDEi		Q148W0

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		265134

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q148W0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q148W0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Hepatocytes, bile duct, intestinal epithelial cells (cholangiocytes and ileocytes), and pancreatic acinar cells.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000039529, Expressed in intestine and 190 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q148W0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q148W0, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit ATP8B1 and an accessory beta subunit TMEM30A (PubMed:30018401). The flippase ATP8B1:TMEM30A complex can form an intermediate phosphoenzyme in vitro.

Also interacts with beta subunit TMEM30B.

By similarity1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		207714, 1 interactor

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000025482

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q148W0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q148W0

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q148W0

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 52DisorderedSequence analysisAdd BLAST52

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi13 – 38Acidic residuesSequence analysisAdd BLAST26

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0206, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158002

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000846_3_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q148W0

Identification of Orthologs from Complete Genome Data

More...OMAi		VQEPFFP

Database of Orthologous Groups

More...OrthoDBi		587717at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q148W0

TreeFam database of animal gene trees

More...TreeFami		TF300654

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.1110.10, 1 hit
3.40.50.1000, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR030346, ATP8B1
IPR023299, ATPase_P-typ_cyto_dom_N
IPR018303, ATPase_P-typ_P_site
IPR023298, ATPase_P-typ_TM_dom_sf
IPR008250, ATPase_P-typ_transduc_dom_A_sf
IPR036412, HAD-like_sf
IPR023214, HAD_sf
IPR006539, P-type_ATPase_IV
IPR032631, P-type_ATPase_N
IPR001757, P_typ_ATPase
IPR032630, P_typ_ATPase_c
IPR044492, P_typ_ATPase_HD_dom

The PANTHER Classification System

More...PANTHERi		PTHR24092:SF48, PTHR24092:SF48, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF16212, PhoLip_ATPase_C, 1 hit
PF16209, PhoLip_ATPase_N, 1 hit

Structure-Function Linkage Database

More...SFLDi		SFLDF00027, p-type_atpase, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56784, SSF56784, 1 hit
SSF81653, SSF81653, 1 hit
SSF81660, SSF81660, 1 hit
SSF81665, SSF81665, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01652, ATPase-Plipid, 1 hit
TIGR01494, ATPase_P-type, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00154, ATPASE_E1_E2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q148W0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTERDSETT FDEESQPNDE VVPYSDDETE DELEDQGSTV EPEQNRVNRE 
        60         70         80         90        100
AEKKRETFRK DCTWQVKAND RKFHEQPHFM NTKFFCIKES KYASNAIKTY 
       110        120        130        140        150
KYNGFTFLPM NLFEQFKRAA NFYFLILLIL QAIPQISTLA WYTTLVPLLL 
       160        170        180        190        200
VLGITAIKDL VDDVARHKMD KEINNRTCEV IKDGRFKIIK WKDIQVGDVI 
       210        220        230        240        250
RLKKNDFIPA DILLLSSSEP NSLCYVETAE LDGETNLKFK MALEITDQYL 
       260        270        280        290        300
QIEDNLATFD GFIECEEPNN RLDKFTGTLF WKNQSFPLDA DKILLRGCVI 
       310        320        330        340        350
RNTDVCHGLV IFAGADTKIM KNSGKTRFKR TKIDYLMNYM VYTIFIVLIL 
       360        370        380        390        400
VSAGLAIGHA YWEAQVGNYS WYLYDGENAT PSYRGFLNFW GYIIVLNTMV 
       410        420        430        440        450
PISLYVSVEV IRLGQSHFIN WDLQMYYAEK DTPAKARTTT LNEQLGQIHY 
       460        470        480        490        500
IFSDKTGTLT QNIMTFKKCC INGTIYGDHR DASQHSHSKI ELVDFSWNTF 
       510        520        530        540        550
ADGKLAFYDH YLIEQIQSGK EPEVRQFFFL LSICHTVMVD RIDGQINYQA 
       560        570        580        590        600
ASPDEGALVN AARNFGFAFL ARTQNTITVS ELGSERTYNV LAILDFNSDR 
       610        620        630        640        650
KRMSIIVRTP EGSIRLYCKG ADTVIYERLH RMNPTKQETQ DALDIFASET 
       660        670        680        690        700
LRTLCLCYKE IEEKEFTEWN NKFMAASVAS SNRDEALDKV YEEIEKDLIL 
       710        720        730        740        750
LGATAIEDKL QDGVPETISK LAKADIKIWV LTGDKKETAE NIGFACELLT 
       760        770        780        790        800
EDTTICYGED INSLLHTRME NQRNRGGVSA KFAPPVYEPF FPPGENRALI 
       810        820        830        840        850
ITGSWLNEIL LEKKTKRSKI LKLKFPRTEE ERRMRSQSRR RLEEKKEQRQ 
       860        870        880        890        900
KNFVDLACEC SAVICCRVTP KQKAMVVDLV KRYKKAITLA IGDGANDVNM 
       910        920        930        940        950
IKTAHIGVGI SGQEGMQAVM SSDYSFAQFR YLQRLLLVHG RWSYIRMCKF 
       960        970        980        990       1000
LRYFFYKNFA FTLVHFWYSF FNGYSAQTAY EDWFITLYNV LYSSLPVLLM 
      1010       1020       1030       1040       1050
GLLDQDVSDK LSLRFPGLYV VGQRDLLFNY KRFFVSLLHG VLTSMVLFFI 
      1060       1070       1080       1090       1100
PLGAYLQTVG QDGEAPSDYQ SFAVTVASAL VITVNFQIGL DTSYWTFVNA 
      1110       1120       1130       1140       1150
FSIFGSIALY FGIMFDFHSA GIHVLFPSAF QFTGTASNAL RQPYIWLTII 
      1160       1170       1180       1190       1200
LTVAVCLLPV VAIRFLSMTI WPSESDKIQK HRKRLKAEEQ WKRRQSVFRR 
      1210       1220       1230       1240       1250
GVSSRRSAYA FSHQRGYADL ISSGRSIRKK RSPLDAIIAD GTAEYRRTVE 

S
Length:1,251
Mass (Da):143,798
Last modified:May 5, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i394920189075875D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A494BB33A0A494BB33_MOUSE
Phospholipid-transporting ATPase IC
Atp8b1
245Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494B9Z8A0A494B9Z8_MOUSE
Phospholipid-transporting ATPase IC
Atp8b1
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti104G → A in AAR90342 (PubMed:14976163).Curated1
Sequence conflicti108L → I in AAR90342 (PubMed:14976163).Curated1
Sequence conflicti155T → M in BAE34046 (PubMed:16141072).Curated1
Sequence conflicti174N → S in AAR90342 (PubMed:14976163).Curated1
Sequence conflicti176R → M in AAR90342 (PubMed:14976163).Curated1
Sequence conflicti531L → P in BAE34046 (PubMed:16141072).Curated1
Sequence conflicti575N → Y in BAE34046 (PubMed:16141072).Curated1
Sequence conflicti667T → A in AAI17947 (PubMed:15489334).Curated1
Sequence conflicti671N → K in AAI17947 (PubMed:15489334).Curated1
Sequence conflicti893D → E in BAE34046 (PubMed:16141072).Curated1
Sequence conflicti1226S → C in BAE34046 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY506548 mRNA Translation: AAR90342.1
AK157316 mRNA Translation: BAE34046.1
BC117946 mRNA Translation: AAI17947.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS29304.1

NCBI Reference Sequences

More...RefSeqi		NP_001001488.2, NM_001001488.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000025482; ENSMUSP00000025482; ENSMUSG00000039529

Database of genes from NCBI RefSeq genomes

More...GeneIDi		54670

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:54670

UCSC genome browser

More...UCSCi		uc008fem.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY506548 mRNA Translation: AAR90342.1
AK157316 mRNA Translation: BAE34046.1
BC117946 mRNA Translation: AAI17947.1
CCDSiCCDS29304.1
RefSeqiNP_001001488.2, NM_001001488.3

3D structure databases

AlphaFoldDBiQ148W0
SMRiQ148W0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi207714, 1 interactor
STRINGi10090.ENSMUSP00000025482

PTM databases

iPTMnetiQ148W0
PhosphoSitePlusiQ148W0

Proteomic databases

MaxQBiQ148W0
PaxDbiQ148W0
PeptideAtlasiQ148W0
PRIDEiQ148W0
ProteomicsDBi265134

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		9722, 48 antibodies from 12 providers

The DNASU plasmid repository

More...DNASUi		54670

Genome annotation databases

EnsembliENSMUST00000025482; ENSMUSP00000025482; ENSMUSG00000039529
GeneIDi54670
KEGGimmu:54670
UCSCiuc008fem.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5205
MGIiMGI:1859665, Atp8b1
VEuPathDBiHostDB:ENSMUSG00000039529

Phylogenomic databases

eggNOGiKOG0206, Eukaryota
GeneTreeiENSGT00940000158002
HOGENOMiCLU_000846_3_2_1
InParanoidiQ148W0
OMAiVQEPFFP
OrthoDBi587717at2759
PhylomeDBiQ148W0
TreeFamiTF300654

Enzyme and pathway databases

BRENDAi7.6.2.1, 3474
ReactomeiR-MMU-936837, Ion transport by P-type ATPases

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		54670, 3 hits in 74 CRISPR screens

Protein Ontology

More...PROi		PR:Q148W0
RNActiQ148W0, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000039529, Expressed in intestine and 190 other tissues
ExpressionAtlasiQ148W0, baseline and differential
GenevisibleiQ148W0, MM

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR030346, ATP8B1
IPR023299, ATPase_P-typ_cyto_dom_N
IPR018303, ATPase_P-typ_P_site
IPR023298, ATPase_P-typ_TM_dom_sf
IPR008250, ATPase_P-typ_transduc_dom_A_sf
IPR036412, HAD-like_sf
IPR023214, HAD_sf
IPR006539, P-type_ATPase_IV
IPR032631, P-type_ATPase_N
IPR001757, P_typ_ATPase
IPR032630, P_typ_ATPase_c
IPR044492, P_typ_ATPase_HD_dom
PANTHERiPTHR24092:SF48, PTHR24092:SF48, 1 hit
PfamiView protein in Pfam
PF16212, PhoLip_ATPase_C, 1 hit
PF16209, PhoLip_ATPase_N, 1 hit
SFLDiSFLDF00027, p-type_atpase, 1 hit
SUPFAMiSSF56784, SSF56784, 1 hit
SSF81653, SSF81653, 1 hit
SSF81660, SSF81660, 1 hit
SSF81665, SSF81665, 1 hit
TIGRFAMsiTIGR01652, ATPase-Plipid, 1 hit
TIGR01494, ATPase_P-type, 1 hit
PROSITEiView protein in PROSITE
PS00154, ATPASE_E1_E2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAT8B1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q148W0
Secondary accession number(s): Q3U010, Q6R964
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 5, 2009
Last modified: May 25, 2022
This is version 130 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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