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Protein

Regulator of G-protein signaling 9-binding protein

Gene

Rgs9bp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulator of G protein-coupled receptor (GPCR) signaling in phototransduction. Participates in the recovery phase of visual transduction via its interaction with RGS9-1 isoform. Acts as a membrane-anchor that mediates the targeting of RGS9-1 to the photoreceptor outer segment, where phototransduction takes place. Enhances the ability of RGS9-1 to stimulate G protein GTPase activity, allowing the visual signal to be terminated on the physiologically time scale. It also controls the proteolytic stability of RGS9-1, probably by protecting it from degradation.4 Publications

GO - Biological processi

  • detection of light stimulus involved in visual perception Source: MGI
  • negative regulation of signal transduction Source: UniProtKB-KW

Keywordsi

Molecular functionSignal transduction inhibitor
Biological processSensory transduction, Vision

Enzyme and pathway databases

ReactomeiR-MMU-2514859 Inactivation, recovery and regulation of the phototransduction cascade

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 9-binding protein
Alternative name(s):
RGS9-anchoring protein
Gene namesi
Name:Rgs9bp
Synonyms:R9ap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2384418 Rgs9bp

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 212CytoplasmicSequence analysisAdd BLAST212
Transmembranei213 – 233Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini234 – 237ExtracellularSequence analysis4

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Mice show light responses that recover at a abnormally slow rate.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002875871 – 237Regulator of G-protein signaling 9-binding proteinAdd BLAST237

Proteomic databases

PaxDbiQ148R9
PRIDEiQ148R9

PTM databases

PhosphoSitePlusiQ148R9

Expressioni

Tissue specificityi

Predominantly expressed in photoreceptors of the retina. Weakly expressed in other areas of the central nervous system.2 Publications

Gene expression databases

BgeeiENSMUSG00000056043 Expressed in 50 organ(s), highest expression level in retina
GenevisibleiQ148R9 MM

Interactioni

Subunit structurei

Specifically interacts with isoform RGS9-1 of RGS9. Interaction is decreased when RGS9-1 is phosphorylated at 'Ser-475'. Component of the RGS9-1-Gbeta5 complex composed of RGS9-1, Gbeta5 (GNB5) and RGS9BP.4 Publications

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065511

Structurei

3D structure databases

ProteinModelPortaliQ148R9
SMRiQ148R9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni153 – 202SNARE-likeAdd BLAST50

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili30 – 54Sequence analysisAdd BLAST25

Sequence similaritiesi

Belongs to the RGS7BP/RGS9BP family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IG6Z Eukaryota
ENOG4111F7N LUCA
GeneTreeiENSGT00390000002155
HOGENOMiHOG000136373
HOVERGENiHBG059498
InParanoidiQ148R9
OMAiACYRHLV
OrthoDBiEOG091G0PAA
PhylomeDBiQ148R9
TreeFamiTF331562

Family and domain databases

InterProiView protein in InterPro
IPR026512 RGS7BP/RGS9BP
IPR026513 RGS9BP
PANTHERiPTHR21029 PTHR21029, 1 hit
PTHR21029:SF1 PTHR21029:SF1, 1 hit

Sequencei

Sequence statusi: Complete.

Q148R9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAREECKALL DALNKTTACY HHLVLTVGGS ADTQDLREEL QKTRQKAREL
60 70 80 90 100
AVATGARLTV ALRDRSLATE ERAEFERLWV AFSGCLDLLE ADMQRALALG
110 120 130 140 150
ATFPLHAPRR PLVRTGVTGG SSAVAARALS ARSLRHEAES DFDVADLPQL
160 170 180 190 200
EREVLQVGEM IDDMEMKVNV PRWTVQARQA AGAELLSGAS AGASSAGGIS
210 220 230
VEERAGPCDP SKALAATVFS AVLLVAVALA LCVAKLS
Length:237
Mass (Da):25,177
Last modified:May 15, 2007 - v2
Checksum:iEFDE190A142FF24F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti182G → D in AAI18007 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF483907 mRNA Translation: AAM76160.1
AY229888 mRNA Translation: AAP55847.1
BC118006 mRNA Translation: AAI18007.1
CCDSiCCDS21153.1
RefSeqiNP_665839.1, NM_145840.3
UniGeneiMm.222680

Genome annotation databases

EnsembliENSMUST00000069912; ENSMUSP00000065511; ENSMUSG00000056043
GeneIDi243923
KEGGimmu:243923
UCSCiuc009gkb.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF483907 mRNA Translation: AAM76160.1
AY229888 mRNA Translation: AAP55847.1
BC118006 mRNA Translation: AAI18007.1
CCDSiCCDS21153.1
RefSeqiNP_665839.1, NM_145840.3
UniGeneiMm.222680

3D structure databases

ProteinModelPortaliQ148R9
SMRiQ148R9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065511

PTM databases

PhosphoSitePlusiQ148R9

Proteomic databases

PaxDbiQ148R9
PRIDEiQ148R9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000069912; ENSMUSP00000065511; ENSMUSG00000056043
GeneIDi243923
KEGGimmu:243923
UCSCiuc009gkb.2 mouse

Organism-specific databases

CTDi388531
MGIiMGI:2384418 Rgs9bp

Phylogenomic databases

eggNOGiENOG410IG6Z Eukaryota
ENOG4111F7N LUCA
GeneTreeiENSGT00390000002155
HOGENOMiHOG000136373
HOVERGENiHBG059498
InParanoidiQ148R9
OMAiACYRHLV
OrthoDBiEOG091G0PAA
PhylomeDBiQ148R9
TreeFamiTF331562

Enzyme and pathway databases

ReactomeiR-MMU-2514859 Inactivation, recovery and regulation of the phototransduction cascade

Miscellaneous databases

ChiTaRSiRgs9bp mouse
PROiPR:Q148R9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000056043 Expressed in 50 organ(s), highest expression level in retina
GenevisibleiQ148R9 MM

Family and domain databases

InterProiView protein in InterPro
IPR026512 RGS7BP/RGS9BP
IPR026513 RGS9BP
PANTHERiPTHR21029 PTHR21029, 1 hit
PTHR21029:SF1 PTHR21029:SF1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiR9BP_MOUSE
AccessioniPrimary (citable) accession number: Q148R9
Secondary accession number(s): Q8K462
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: November 7, 2018
This is version 73 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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