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Protein
Submitted name:

Serine peptidase inhibitor, Kazal type 5

Gene

Spink5

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • peptidase inhibitor activity Source: MGI
  • serine-type endopeptidase inhibitor activity Source: MGI

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-6809371 Formation of the cornified envelope

Protein family/group databases

MEROPSiI01.028

Names & Taxonomyi

Protein namesi
Submitted name:
Serine peptidase inhibitor, Kazal type 5Imported
Gene namesi
Name:Spink5Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1919682 Spink5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_501509702723 – 1017Sequence analysisAdd BLAST995

Expressioni

Gene expression databases

BgeeiENSMUSG00000055561 Expressed in 47 organ(s), highest expression level in prostate gland

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000066214

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini92 – 154Kazal-likeInterPro annotationAdd BLAST63
Domaini156 – 200Kazal-likeInterPro annotationAdd BLAST45
Domaini221 – 280Kazal-likeInterPro annotationAdd BLAST60
Domaini293 – 355Kazal-likeInterPro annotationAdd BLAST63
Domaini362 – 406Kazal-likeInterPro annotationAdd BLAST45
Domaini421 – 482Kazal-likeInterPro annotationAdd BLAST62
Domaini491 – 549Kazal-likeInterPro annotationAdd BLAST59
Domaini554 – 616Kazal-likeInterPro annotationAdd BLAST63
Domaini628 – 695Kazal-likeInterPro annotationAdd BLAST68
Domaini696 – 757Kazal-likeInterPro annotationAdd BLAST62
Domaini764 – 826Kazal-likeInterPro annotationAdd BLAST63
Domaini860 – 919Kazal-likeInterPro annotationAdd BLAST60
Domaini937 – 998Kazal-likeInterPro annotationAdd BLAST62

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili268 – 288Sequence analysisAdd BLAST21
Coiled coili413 – 433Sequence analysisAdd BLAST21
Coiled coili469 – 489Sequence analysisAdd BLAST21
Coiled coili734 – 769Sequence analysisAdd BLAST36

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410KCWU Eukaryota
ENOG4111TR7 LUCA
GeneTreeiENSGT00510000048608
HOGENOMiHOG000015390
HOVERGENiHBG006183
OMAiMHVNKCA
OrthoDBiEOG091G14HG
TreeFamiTF336724

Family and domain databases

InterProiView protein in InterPro
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
PfamiView protein in Pfam
PF00050 Kazal_1, 10 hits
SMARTiView protein in SMART
SM00280 KAZAL, 13 hits
SUPFAMiSSF100895 SSF100895, 14 hits
PROSITEiView protein in PROSITE
PS00282 KAZAL_1, 2 hits
PS51465 KAZAL_2, 13 hits

Sequencei

Sequence statusi: Complete.

Q148R4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKTATVPMLL TLAFYLTQDA AGEKGNQDPC MKFQAQMKNG TLTCPKGNNS
60 70 80 90 100
SQSLNDIIFQ SECILCKRAL EQGAPTKIMN VKVLSRANRA TDPAKLNCES
110 120 130 140 150
FKQRRKDGDF ICPSDTSSVC GTDGKTYRSR CELCAENAKS QNHVDVKSEG
160 170 180 190 200
ECGSSHLETD MCSDFRAYVQ DGRLGCTRES DPILGPDGRT HGNRCAMCAE
210 220 230 240 250
LFLKEAKENA TRNRESRIRR DAEKELCKEF ENQVRNGRLF CTRESDPIRG
260 270 280 290 300
PDGKMHGNKC ALCAEIFMRQ FTEEKGKAEK NQKDAEERAK AKMEIQKRCS
310 320 330 340 350
EFQDRARNGT LFCTRENDPI RGLDGKTHGN LCSMCQAFFK TEAEEKKAEA
360 370 380 390 400
GSRNRRGSEE SETYAKLCDE YRKARKNGQL YCTRENAPIR GPDGKIHGNT
410 420 430 440 450
CSMCQAFFIQ EDKARAKVKR EAAKEMCSEF RNQARNGMLM CTRENDPVVG
460 470 480 490 500
PDGKRHSNKC AMCASVFLLE EEEKKKDDKT EKVDAGKAKK EAVQELCRKY
510 520 530 540 550
HTQLRNGPLR CTRRNNPIEG LDGKMYKNAC FMCWAFFQQE AKKSGAGFRP
560 570 580 590 600
KVKREVKVDC SEYLALSKRG EIFCTRENDP VRGPDGKTHG NKCAMCKAVF
610 620 630 640 650
KKENEERKRK EGENQRITSG ESSSGGNPKA KDECAQYRES MKHGQLSCTR
660 670 680 690 700
ESDPVRGVDG EHYNNKCVMC KELLQKEMEE TNKNSASRSN GTGSATGKDV
710 720 730 740 750
CDQFRSQMKN GKLLCTRESD PTRGPDGAMH GNKCAMCKER LEKEAAEKKK
760 770 780 790 800
KEDEEKRNTE TNKSDKEDKC HEYRSMQLDG RLICTRENDP VRDADGKMHV
810 820 830 840 850
NKCAMCQMMF EREANERKMR EENSRSQPTN EAKDQCGEVH NSVEDAKPRP
860 870 880 890 900
ARSSLPSIRG ISKDECSEFQ NLMKNEKLTC PETDDPVRGA DGTFYQNKCH
910 920 930 940 950
MCRDVLKNEA MKRSGLQEKS SDIRSTKEGD PEFSSSSRDS DMCKNYRILP
960 970 980 990 1000
RMGYLCPKNL NPVCGDDGQT YSNPCMLCHE NLMRQTNTRI HKQGACEESS
1010
NLKTVSTGTP ASEKMMQ
Length:1,017
Mass (Da):114,891
Last modified:August 22, 2006 - v1
Checksum:iFE32F4B2D9A4BB66
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC138293 Genomic DNA No translation available.
BC118011 mRNA Translation: AAI18012.1
RefSeqiNP_001074649.1, NM_001081180.1
XP_006526342.1, XM_006526279.3
XP_006526343.1, XM_006526280.3
UniGeneiMm.35369

Genome annotation databases

EnsembliENSMUST00000069245; ENSMUSP00000066214; ENSMUSG00000055561
GeneIDi72432
KEGGimmu:72432
UCSCiuc008eup.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC138293 Genomic DNA No translation available.
BC118011 mRNA Translation: AAI18012.1
RefSeqiNP_001074649.1, NM_001081180.1
XP_006526342.1, XM_006526279.3
XP_006526343.1, XM_006526280.3
UniGeneiMm.35369

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000066214

Protein family/group databases

MEROPSiI01.028

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000069245; ENSMUSP00000066214; ENSMUSG00000055561
GeneIDi72432
KEGGimmu:72432
UCSCiuc008eup.1 mouse

Organism-specific databases

CTDi11005
MGIiMGI:1919682 Spink5

Phylogenomic databases

eggNOGiENOG410KCWU Eukaryota
ENOG4111TR7 LUCA
GeneTreeiENSGT00510000048608
HOGENOMiHOG000015390
HOVERGENiHBG006183
OMAiMHVNKCA
OrthoDBiEOG091G14HG
TreeFamiTF336724

Enzyme and pathway databases

ReactomeiR-MMU-6809371 Formation of the cornified envelope

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000055561 Expressed in 47 organ(s), highest expression level in prostate gland

Family and domain databases

InterProiView protein in InterPro
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
PfamiView protein in Pfam
PF00050 Kazal_1, 10 hits
SMARTiView protein in SMART
SM00280 KAZAL, 13 hits
SUPFAMiSSF100895 SSF100895, 14 hits
PROSITEiView protein in PROSITE
PS00282 KAZAL_1, 2 hits
PS51465 KAZAL_2, 13 hits
ProtoNetiSearch...

Entry informationi

Entry nameiQ148R4_MOUSE
AccessioniPrimary (citable) accession number: Q148R4
Entry historyiIntegrated into UniProtKB/TrEMBL: August 22, 2006
Last sequence update: August 22, 2006
Last modified: November 7, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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