MTF1

Functionⁱ

Activates the metallothionein I promoter. Binds to the metal responsive element (MRE).1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	140 – 164	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	170 – 194	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	200 – 224	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	229 – 253	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	259 – 283	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	289 – 313	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	25

GO - Molecular functionⁱ

DNA binding
Source: ProtInc
Traceable author statementⁱ
- 8065932
DNA-binding transcription factor activity
Source: ProtInc
Traceable author statementⁱ
- 3208749
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
histone acetyltransferase binding Source: Ensembl
metal ion binding Source: UniProtKB-KW
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific
Source: NTNU_SB
Inferred from direct assayⁱ
- 9582278
proximal promoter sequence-specific DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 15735762
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 9582278
RNA polymerase II regulatory region sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription coactivator activity
Source: ProtInc
Traceable author statementⁱ
- 3208749

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

positive regulation of transcription by RNA polymerase II
Source: NTNU_SB
Inferred from direct assayⁱ
- 9582278
regulation of transcription by RNA polymerase II
Source: ProtInc
Traceable author statementⁱ
- 3208749
response to cadmium ion Source: Ensembl
response to metal ion Source: Reactome
response to oxidative stress Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1989781 PPARA activates gene expression R-HSA-2426168 Activation of gene expression by SREBF (SREBP) R-HSA-5660489 MTF1 activates gene expression
SIGNORⁱ	Q14872

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Metal regulatory transcription factor 1 Alternative name(s): MRE-binding transcription factor Transcription factor MTF-1
Gene namesⁱ	Name:MTF1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000188786.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7428 MTF1
MIMⁱ	600172 gene
neXtProtⁱ	NX_Q14872

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	4520
Open Targets More...OpenTargetsⁱ	ENSG00000188786
PharmGKBⁱ	PA31235

Polymorphism and mutation databases

BioMutaⁱ	MTF1
DMDMⁱ	68052403

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedBy similarity
ChainⁱPRO_0000047220	2 – 753	Metal regulatory transcription factor 1Add BLAST		752

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylglycineBy similarity	1
Modified residueⁱ	5	PhosphoserineBy similarity	1
Modified residueⁱ	305	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q14872
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q14872
PaxDbⁱ	Q14872
PeptideAtlas More...PeptideAtlasⁱ	Q14872
PRIDEⁱ	Q14872
ProteomicsDBⁱ	60214

PTM databases

iPTMnetⁱ	Q14872
PhosphoSitePlusⁱ	Q14872

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000188786 Expressed in 230 organ(s), highest expression level in mouth mucosa
CleanExⁱ	HS_MTF1
Genevisibleⁱ	Q14872 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA028604 HPA028689

HPAⁱ

HPA028604
HPA028689

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
AP1M1	Q9BXS5	3	EBI-747024,EBI-541426

With

Entry

#Exp.

IntAct

Notes

AP1M1

Q9BXS5

3

EBI-747024,EBI-541426

GO - Molecular functionⁱ

histone acetyltransferase binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	110620, 109 interactors
IntActⁱ	Q14872, 1 interactor
STRINGⁱ	9606.ENSP00000362127

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q14872
SMRⁱ	Q14872
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	133 – 138	Nuclear localization signalSequence analysis		6

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	420 – 497	Pro-richAdd BLAST		78

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	140 – 164	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	170 – 194	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	200 – 224	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	229 – 253	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	259 – 283	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	289 – 313	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	25

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144040
HOGENOMⁱ	HOG000059609
HOVERGENⁱ	HBG006412
InParanoidⁱ	Q14872
OMAⁱ	QEESCQC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06R4
PhylomeDBⁱ	Q14872
TreeFamⁱ	TF106493

Family and domain databases

InterProⁱ	View protein in InterPro IPR029796 Metal_TF1 IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
PANTHERⁱ	PTHR44900 PTHR44900, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 6 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 6 hits
SUPFAMⁱ	SSF57667 SSF57667, 4 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 6 hits PS50157 ZINC_FINGER_C2H2_2, 6 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q14872-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGEHSPDNNI IYFEAEEDEL TPDDKMLRFV DKNGLVPSSS GTVYDRTTVL 
        60         70         80         90        100
IEQDPGTLED EDDDGQCGEH LPFLVGGEEG FHLIDHEAMS QGYVQHIISP 
       110        120        130        140        150
DQIHLTINPG STPMPRNIEG ATLTLQSECP ETKRKEVKRY QCTFEGCPRT 
       160        170        180        190        200
YSTAGNLRTH QKTHRGEYTF VCNQEGCGKA FLTSYSLRIH VRVHTKEKPF 
       210        220        230        240        250
ECDVQGCEKA FNTLYRLKAH QRLHTGKTFN CESEGCSKYF TTLSDLRKHI 
       260        270        280        290        300
RTHTGEKPFR CDHDGCGKAF AASHHLKTHV RTHTGERPFF CPSNGCEKTF 
       310        320        330        340        350
STQYSLKSHM KGHDNKGHSY NALPQHNGSE DTNHSLCLSD LSLLSTDSEL 
       360        370        380        390        400
RENSSTTQGQ DLSTISPAII FESMFQNSDD TAIQEDPQQT ASLTESFNGD 
       410        420        430        440        450
AESVSDVPPS TGNSASLSLP LVLQPGLSEP PQPLLPASAP SAPPPAPSLG 
       460        470        480        490        500
PGSQQAAFGN PPALLQPPEV PVPHSTQFAA NHQEFLPHPQ APQPIVPGLS 
       510        520        530        540        550
VVAGASASAA AVASAVAAPA PPQSTTEPLP AMVQTLPLGA NSVLTNNPTI 
       560        570        580        590        600
TITPTPNTAI LQSSLVMGEQ NLQWILNGAT SSPQNQEQIQ QASKVEKVFF 
       610        620        630        640        650
TTAVPVASSP GSSVQQIGLS VPVIIIKQEE ACQCQCACRD SAKERASSRR 
       660        670        680        690        700
KGCSSPPPPE PSPQAPDGPS LQLPAQTFSS APVPGSSSST LPSSCEQSRQ 
       710        720        730        740        750
AETPSDPQTE TLSAMDVSEF LSLQSLDTPS NLIPIEALLQ GEEEMGLTSS 

FSK

Length:753

Mass (Da):80,957

Last modified:June 21, 2005 - v2

Checksum:ⁱCC96518824170E98

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	185	Y → H in CAA55363 (PubMed:8065932).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X78710 mRNA Translation: CAA55363.1 AK314233 mRNA Translation: BAG36903.1 AL929472 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07312.1 BC014454 mRNA Translation: AAH14454.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS30676.1
PIRⁱ	S48059
NCBI Reference Sequences More...RefSeqⁱ	NP_005946.2, NM_005955.2 XP_011539793.1, XM_011541491.2
UniGeneⁱ	Hs.471991

Genome annotation databases

Ensemblⁱ	ENST00000373036; ENSP00000362127; ENSG00000188786
GeneIDⁱ	4520
KEGGⁱ	hsa:4520
UCSC genome browser More...UCSCⁱ	uc001cce.1 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q14872	Zinc regulatory factor (Fragment)		HUMAN		200	UniRef100_Q14872
UPI0005D0303F		HUMAN		444

Protein	Similar proteins		Species	Score	Length	Source
Q14872	Zinc regulatory factor (Fragment)		HUMAN		200	UniRef90_Q14872
Metal regulatory transcription factor 1		MYOBR		903
Metal-regulatory transcription factor 1 (Fragment)		MUSPF		98
Metal regulatory transcription factor 1		TUPCH		900
Uncharacterized protein		MYOLU		759
+140

Protein	Similar proteins		Species	Score	Length	Source
Q14872	Metal regulatory transcription factor 1		MOUSE		675	UniRef50_Q14872
Zinc regulatory factor (Fragment)		HUMAN		200
Metal regulatory transcription factor 1		MYOBR		903
Metal-regulatory transcription factor 1 (Fragment)		MUSPF		98
Metal regulatory transcription factor 1		TUPCH		900
+329

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X78710 mRNA Translation: CAA55363.1 AK314233 mRNA Translation: BAG36903.1 AL929472 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07312.1 BC014454 mRNA Translation: AAH14454.1
CCDSⁱ	CCDS30676.1
PIRⁱ	S48059
RefSeqⁱ	NP_005946.2, NM_005955.2 XP_011539793.1, XM_011541491.2
UniGeneⁱ	Hs.471991

3D structure databases

ProteinModelPortalⁱ	Q14872
SMRⁱ	Q14872
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110620, 109 interactors
IntActⁱ	Q14872, 1 interactor
STRINGⁱ	9606.ENSP00000362127

PTM databases

iPTMnetⁱ	Q14872
PhosphoSitePlusⁱ	Q14872

Polymorphism and mutation databases

BioMutaⁱ	MTF1
DMDMⁱ	68052403

Proteomic databases

EPDⁱ	Q14872
MaxQBⁱ	Q14872
PaxDbⁱ	Q14872
PeptideAtlasⁱ	Q14872
PRIDEⁱ	Q14872
ProteomicsDBⁱ	60214

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000373036; ENSP00000362127; ENSG00000188786
GeneIDⁱ	4520
KEGGⁱ	hsa:4520
UCSCⁱ	uc001cce.1 human

Organism-specific databases

CTDⁱ	4520
DisGeNETⁱ	4520
EuPathDBⁱ	HostDB:ENSG00000188786.9
GeneCardsⁱ	MTF1
HGNCⁱ	HGNC:7428 MTF1
HPAⁱ	HPA028604 HPA028689
MIMⁱ	600172 gene
neXtProtⁱ	NX_Q14872
OpenTargetsⁱ	ENSG00000188786
PharmGKBⁱ	PA31235
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00910000144040
HOGENOMⁱ	HOG000059609
HOVERGENⁱ	HBG006412
InParanoidⁱ	Q14872
OMAⁱ	QEESCQC
OrthoDBⁱ	EOG091G06R4
PhylomeDBⁱ	Q14872
TreeFamⁱ	TF106493

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1989781 PPARA activates gene expression R-HSA-2426168 Activation of gene expression by SREBF (SREBP) R-HSA-5660489 MTF1 activates gene expression
SIGNORⁱ	Q14872

Miscellaneous databases

ChiTaRSⁱ	MTF1 human
GeneWikiⁱ	MTF1
GenomeRNAiⁱ	4520
Protein Ontology More...PROⁱ	PR:Q14872
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000188786 Expressed in 230 organ(s), highest expression level in mouth mucosa
CleanExⁱ	HS_MTF1
Genevisibleⁱ	Q14872 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR029796 Metal_TF1 IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
PANTHERⁱ	PTHR44900 PTHR44900, 1 hit
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 6 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 6 hits
SUPFAMⁱ	SSF57667 SSF57667, 4 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 6 hits PS50157 ZINC_FINGER_C2H2_2, 6 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MTF1_HUMAN
Accessionⁱ	Q14872Primary (citable) accession number: Q14872 Secondary accession number(s): B2RAK6, Q96CB1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 21, 2005
	Last sequence update:	June 21, 2005
	Last modified:	November 7, 2018
	This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q14872 (MTF1_HUMAN)

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Metal regulatory transcription factor 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Compositional bias

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ