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UniProtKB - Q14872 (MTF1_HUMAN)
Protein
Metal regulatory transcription factor 1
Gene
MTF1
Organism
Homo sapiens (Human)
Status
Functioni
Zinc-dependent transcriptional regulator of cellular adaption to conditions of exposure to heavy metals (PubMed:8065932).
Binds to metal responsive elements (MRE) in promoters and activates the transcription of metallothionein genes like metallothionein-2/MT2A (PubMed:8065932).
Also regulates the expression of metalloproteases in response to intracellular zinc and functions as a catabolic regulator of cartilages (By similarity).
By similarity1 PublicationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 140 – 164 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 170 – 194 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 200 – 224 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 229 – 253 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 259 – 283 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 289 – 313 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- cis-regulatory region sequence-specific DNA binding Source: UniProtKB
- DNA binding Source: ProtInc
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity Source: ProtInc
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- histone acetyltransferase binding Source: Ensembl
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SB
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- cartilage homeostasis Source: Ensembl
- cellular response to zinc ion Source: Ensembl
- central nervous system development Source: GO_Central
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
- regulation of transcription by RNA polymerase II Source: GO_Central
- response to cadmium ion Source: Ensembl
- response to metal ion Source: ProtInc
- response to oxidative stress Source: Ensembl
- transcription, DNA-templated Source: Ensembl
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q14872 |
Reactomei | R-HSA-1989781, PPARA activates gene expression R-HSA-2426168, Activation of gene expression by SREBF (SREBP) R-HSA-5660489, MTF1 activates gene expression |
SignaLinki | Q14872 |
SIGNORi | Q14872 |
Names & Taxonomyi
Protein namesi | Recommended name: Metal regulatory transcription factor 1Alternative name(s): MRE-binding transcription factor Transcription factor MTF-1 |
Gene namesi | Name:MTF1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7428, MTF1 |
MIMi | 600172, gene |
neXtProti | NX_Q14872 |
VEuPathDBi | HostDB:ENSG00000188786 |
Subcellular locationi
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 4520 |
OpenTargetsi | ENSG00000188786 |
PharmGKBi | PA31235 |
Miscellaneous databases
Pharosi | Q14872, Tbio |
Chemistry databases
DrugBanki | DB09130, Copper DB12965, Silver |
Genetic variation databases
BioMutai | MTF1 |
DMDMi | 68052403 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000047220 | 2 – 753 | Metal regulatory transcription factor 1Add BLAST | 752 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylglycineBy similarity | 1 | |
Modified residuei | 5 | PhosphoserineBy similarity | 1 | |
Modified residuei | 305 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q14872 |
jPOSTi | Q14872 |
MassIVEi | Q14872 |
MaxQBi | Q14872 |
PaxDbi | Q14872 |
PeptideAtlasi | Q14872 |
PRIDEi | Q14872 |
ProteomicsDBi | 60214 |
PTM databases
iPTMneti | Q14872 |
PhosphoSitePlusi | Q14872 |
Expressioni
Gene expression databases
Bgeei | ENSG00000188786, Expressed in mouth mucosa and 246 other tissues |
Genevisiblei | Q14872, HS |
Organism-specific databases
HPAi | ENSG00000188786, Tissue enhanced (bone) |
Interactioni
Binary interactionsi
Q14872
With | #Exp. | IntAct |
---|---|---|
AP1M1 [Q9BXS5] | 3 | EBI-747024,EBI-541426 |
GO - Molecular functioni
- histone acetyltransferase binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 110620, 115 interactors |
IntActi | Q14872, 1 interactor |
STRINGi | 9606.ENSP00000362127 |
Miscellaneous databases
RNActi | Q14872, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 308 – 328 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 395 – 466 | DisorderedSequence analysisAdd BLAST | 72 | |
Regioni | 648 – 715 | DisorderedSequence analysisAdd BLAST | 68 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 133 – 138 | Nuclear localization signalSequence analysis | 6 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 395 – 421 | Polar residuesSequence analysisAdd BLAST | 27 | |
Compositional biasi | 426 – 450 | Pro residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 654 – 668 | Pro residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 669 – 715 | Polar residuesSequence analysisAdd BLAST | 47 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 140 – 164 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 170 – 194 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 200 – 224 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 229 – 253 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 259 – 283 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 289 – 313 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000157291 |
HOGENOMi | CLU_026685_0_0_1 |
InParanoidi | Q14872 |
OMAi | ESMFQSP |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q14872 |
TreeFami | TF106493 |
Family and domain databases
InterProi | View protein in InterPro IPR029796, Metal_TF1 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR19818:SF131, PTHR19818:SF131, 1 hit |
Pfami | View protein in Pfam PF00096, zf-C2H2, 6 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 6 hits |
SUPFAMi | SSF57667, SSF57667, 4 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 6 hits PS50157, ZINC_FINGER_C2H2_2, 6 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q14872-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGEHSPDNNI IYFEAEEDEL TPDDKMLRFV DKNGLVPSSS GTVYDRTTVL
60 70 80 90 100
IEQDPGTLED EDDDGQCGEH LPFLVGGEEG FHLIDHEAMS QGYVQHIISP
110 120 130 140 150
DQIHLTINPG STPMPRNIEG ATLTLQSECP ETKRKEVKRY QCTFEGCPRT
160 170 180 190 200
YSTAGNLRTH QKTHRGEYTF VCNQEGCGKA FLTSYSLRIH VRVHTKEKPF
210 220 230 240 250
ECDVQGCEKA FNTLYRLKAH QRLHTGKTFN CESEGCSKYF TTLSDLRKHI
260 270 280 290 300
RTHTGEKPFR CDHDGCGKAF AASHHLKTHV RTHTGERPFF CPSNGCEKTF
310 320 330 340 350
STQYSLKSHM KGHDNKGHSY NALPQHNGSE DTNHSLCLSD LSLLSTDSEL
360 370 380 390 400
RENSSTTQGQ DLSTISPAII FESMFQNSDD TAIQEDPQQT ASLTESFNGD
410 420 430 440 450
AESVSDVPPS TGNSASLSLP LVLQPGLSEP PQPLLPASAP SAPPPAPSLG
460 470 480 490 500
PGSQQAAFGN PPALLQPPEV PVPHSTQFAA NHQEFLPHPQ APQPIVPGLS
510 520 530 540 550
VVAGASASAA AVASAVAAPA PPQSTTEPLP AMVQTLPLGA NSVLTNNPTI
560 570 580 590 600
TITPTPNTAI LQSSLVMGEQ NLQWILNGAT SSPQNQEQIQ QASKVEKVFF
610 620 630 640 650
TTAVPVASSP GSSVQQIGLS VPVIIIKQEE ACQCQCACRD SAKERASSRR
660 670 680 690 700
KGCSSPPPPE PSPQAPDGPS LQLPAQTFSS APVPGSSSST LPSSCEQSRQ
710 720 730 740 750
AETPSDPQTE TLSAMDVSEF LSLQSLDTPS NLIPIEALLQ GEEEMGLTSS
FSK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 185 | Y → H in CAA55363 (PubMed:8065932).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X78710 mRNA Translation: CAA55363.1 AK314233 mRNA Translation: BAG36903.1 AL929472 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07312.1 BC014454 mRNA Translation: AAH14454.1 |
CCDSi | CCDS30676.1 |
PIRi | S48059 |
RefSeqi | NP_005946.2, NM_005955.2 XP_011539793.1, XM_011541491.2 |
Genome annotation databases
Ensembli | ENST00000373036; ENSP00000362127; ENSG00000188786 |
GeneIDi | 4520 |
KEGGi | hsa:4520 |
MANE-Selecti | ENST00000373036.5; ENSP00000362127.3; NM_005955.3; NP_005946.2 |
UCSCi | uc001cce.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X78710 mRNA Translation: CAA55363.1 AK314233 mRNA Translation: BAG36903.1 AL929472 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07312.1 BC014454 mRNA Translation: AAH14454.1 |
CCDSi | CCDS30676.1 |
PIRi | S48059 |
RefSeqi | NP_005946.2, NM_005955.2 XP_011539793.1, XM_011541491.2 |
3D structure databases
SMRi | Q14872 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 110620, 115 interactors |
IntActi | Q14872, 1 interactor |
STRINGi | 9606.ENSP00000362127 |
Chemistry databases
DrugBanki | DB09130, Copper DB12965, Silver |
PTM databases
iPTMneti | Q14872 |
PhosphoSitePlusi | Q14872 |
Genetic variation databases
BioMutai | MTF1 |
DMDMi | 68052403 |
Proteomic databases
EPDi | Q14872 |
jPOSTi | Q14872 |
MassIVEi | Q14872 |
MaxQBi | Q14872 |
PaxDbi | Q14872 |
PeptideAtlasi | Q14872 |
PRIDEi | Q14872 |
ProteomicsDBi | 60214 |
Protocols and materials databases
Antibodypediai | 17617, 217 antibodies from 29 providers |
DNASUi | 4520 |
Genome annotation databases
Ensembli | ENST00000373036; ENSP00000362127; ENSG00000188786 |
GeneIDi | 4520 |
KEGGi | hsa:4520 |
MANE-Selecti | ENST00000373036.5; ENSP00000362127.3; NM_005955.3; NP_005946.2 |
UCSCi | uc001cce.1, human |
Organism-specific databases
CTDi | 4520 |
DisGeNETi | 4520 |
GeneCardsi | MTF1 |
HGNCi | HGNC:7428, MTF1 |
HPAi | ENSG00000188786, Tissue enhanced (bone) |
MIMi | 600172, gene |
neXtProti | NX_Q14872 |
OpenTargetsi | ENSG00000188786 |
PharmGKBi | PA31235 |
VEuPathDBi | HostDB:ENSG00000188786 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000157291 |
HOGENOMi | CLU_026685_0_0_1 |
InParanoidi | Q14872 |
OMAi | ESMFQSP |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q14872 |
TreeFami | TF106493 |
Enzyme and pathway databases
PathwayCommonsi | Q14872 |
Reactomei | R-HSA-1989781, PPARA activates gene expression R-HSA-2426168, Activation of gene expression by SREBF (SREBP) R-HSA-5660489, MTF1 activates gene expression |
SignaLinki | Q14872 |
SIGNORi | Q14872 |
Miscellaneous databases
BioGRID-ORCSi | 4520, 55 hits in 1074 CRISPR screens |
ChiTaRSi | MTF1, human |
GeneWikii | MTF1 |
GenomeRNAii | 4520 |
Pharosi | Q14872, Tbio |
PROi | PR:Q14872 |
RNActi | Q14872, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000188786, Expressed in mouth mucosa and 246 other tissues |
Genevisiblei | Q14872, HS |
Family and domain databases
InterProi | View protein in InterPro IPR029796, Metal_TF1 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR19818:SF131, PTHR19818:SF131, 1 hit |
Pfami | View protein in Pfam PF00096, zf-C2H2, 6 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 6 hits |
SUPFAMi | SSF57667, SSF57667, 4 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 6 hits PS50157, ZINC_FINGER_C2H2_2, 6 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | MTF1_HUMAN | |
Accessioni | Q14872Primary (citable) accession number: Q14872 Secondary accession number(s): B2RAK6, Q96CB1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 21, 2005 |
Last sequence update: | June 21, 2005 | |
Last modified: | February 23, 2022 | |
This is version 170 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot