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Protein

Metal regulatory transcription factor 1

Gene

MTF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Activates the metallothionein I promoter. Binds to the metal responsive element (MRE).1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri140 – 164C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri170 – 194C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri200 – 224C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri229 – 253C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri259 – 283C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri289 – 313C2H2-type 6PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

  • DNA binding Source: ProtInc
  • DNA binding transcription factor activity Source: ProtInc
  • histone acetyltransferase binding Source: Ensembl
  • metal ion binding Source: UniProtKB-KW
  • proximal promoter sequence-specific DNA binding Source: UniProtKB
  • RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
  • transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB
  • transcription coactivator activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-1989781 PPARA activates gene expression
R-HSA-2426168 Activation of gene expression by SREBF (SREBP)
R-HSA-5660489 MTF1 activates gene expression
SIGNORiQ14872

Names & Taxonomyi

Protein namesi
Recommended name:
Metal regulatory transcription factor 1
Alternative name(s):
MRE-binding transcription factor
Transcription factor MTF-1
Gene namesi
Name:MTF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000188786.9
HGNCiHGNC:7428 MTF1
MIMi600172 gene
neXtProtiNX_Q14872

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi4520
OpenTargetsiENSG00000188786
PharmGKBiPA31235

Polymorphism and mutation databases

BioMutaiMTF1
DMDMi68052403

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000472202 – 753Metal regulatory transcription factor 1Add BLAST752

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylglycineBy similarity1
Modified residuei5PhosphoserineBy similarity1
Modified residuei305PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ14872
MaxQBiQ14872
PaxDbiQ14872
PeptideAtlasiQ14872
PRIDEiQ14872
ProteomicsDBi60214

PTM databases

iPTMnetiQ14872
PhosphoSitePlusiQ14872

Expressioni

Gene expression databases

BgeeiENSG00000188786
CleanExiHS_MTF1
GenevisibleiQ14872 HS

Organism-specific databases

HPAiHPA028604
HPA028689

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
AP1M1Q9BXS53EBI-747024,EBI-541426

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110620, 109 interactors
IntActiQ14872, 1 interactor
STRINGi9606.ENSP00000362127

Structurei

3D structure databases

ProteinModelPortaliQ14872
SMRiQ14872
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi133 – 138Nuclear localization signalSequence analysis6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi420 – 497Pro-richAdd BLAST78

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri140 – 164C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri170 – 194C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri200 – 224C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri229 – 253C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri259 – 283C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri289 – 313C2H2-type 6PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144040
HOGENOMiHOG000059609
HOVERGENiHBG006412
InParanoidiQ14872
OMAiEDTNHSL
OrthoDBiEOG091G06R4
PhylomeDBiQ14872
TreeFamiTF106493

Family and domain databases

InterProiView protein in InterPro
IPR029796 Metal_TF1
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR44900 PTHR44900, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 6 hits
SUPFAMiSSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 6 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q14872-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEHSPDNNI IYFEAEEDEL TPDDKMLRFV DKNGLVPSSS GTVYDRTTVL
60 70 80 90 100
IEQDPGTLED EDDDGQCGEH LPFLVGGEEG FHLIDHEAMS QGYVQHIISP
110 120 130 140 150
DQIHLTINPG STPMPRNIEG ATLTLQSECP ETKRKEVKRY QCTFEGCPRT
160 170 180 190 200
YSTAGNLRTH QKTHRGEYTF VCNQEGCGKA FLTSYSLRIH VRVHTKEKPF
210 220 230 240 250
ECDVQGCEKA FNTLYRLKAH QRLHTGKTFN CESEGCSKYF TTLSDLRKHI
260 270 280 290 300
RTHTGEKPFR CDHDGCGKAF AASHHLKTHV RTHTGERPFF CPSNGCEKTF
310 320 330 340 350
STQYSLKSHM KGHDNKGHSY NALPQHNGSE DTNHSLCLSD LSLLSTDSEL
360 370 380 390 400
RENSSTTQGQ DLSTISPAII FESMFQNSDD TAIQEDPQQT ASLTESFNGD
410 420 430 440 450
AESVSDVPPS TGNSASLSLP LVLQPGLSEP PQPLLPASAP SAPPPAPSLG
460 470 480 490 500
PGSQQAAFGN PPALLQPPEV PVPHSTQFAA NHQEFLPHPQ APQPIVPGLS
510 520 530 540 550
VVAGASASAA AVASAVAAPA PPQSTTEPLP AMVQTLPLGA NSVLTNNPTI
560 570 580 590 600
TITPTPNTAI LQSSLVMGEQ NLQWILNGAT SSPQNQEQIQ QASKVEKVFF
610 620 630 640 650
TTAVPVASSP GSSVQQIGLS VPVIIIKQEE ACQCQCACRD SAKERASSRR
660 670 680 690 700
KGCSSPPPPE PSPQAPDGPS LQLPAQTFSS APVPGSSSST LPSSCEQSRQ
710 720 730 740 750
AETPSDPQTE TLSAMDVSEF LSLQSLDTPS NLIPIEALLQ GEEEMGLTSS

FSK
Length:753
Mass (Da):80,957
Last modified:June 21, 2005 - v2
Checksum:iCC96518824170E98
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti185Y → H in CAA55363 (PubMed:8065932).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78710 mRNA Translation: CAA55363.1
AK314233 mRNA Translation: BAG36903.1
AL929472 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07312.1
BC014454 mRNA Translation: AAH14454.1
CCDSiCCDS30676.1
PIRiS48059
RefSeqiNP_005946.2, NM_005955.2
XP_011539793.1, XM_011541491.2
UniGeneiHs.471991

Genome annotation databases

EnsembliENST00000373036; ENSP00000362127; ENSG00000188786
GeneIDi4520
KEGGihsa:4520
UCSCiuc001cce.1 human

Similar proteinsi

Entry informationi

Entry nameiMTF1_HUMAN
AccessioniPrimary (citable) accession number: Q14872
Secondary accession number(s): B2RAK6, Q96CB1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 21, 2005
Last modified: July 18, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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