Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q14872 (MTF1_HUMAN)

Entry version 167 (07 Apr 2021)
Sequence version 2 (21 Jun 2005)
Previous versions | rss
Add a publicationFeedback
Protein

Metal regulatory transcription factor 1

Gene

MTF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Zinc-dependent transcriptional regulator of cellular adaption to conditions of exposure to heavy metals (PubMed:8065932). Binds to metal responsive elements (MRE) in promoters and activates the transcription of metallothionein genes like metallothionein-2/MT2A (PubMed:8065932). Also regulates the expression of metalloproteases in response to intracellular zinc and functions as a catabolic regulator of cartilages (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri140 – 164C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri170 – 194C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri200 – 224C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri229 – 253C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri259 – 283C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri289 – 313C2H2-type 6PROSITE-ProRule annotationAdd BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q14872

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1989781, PPARA activates gene expression
R-HSA-2426168, Activation of gene expression by SREBF (SREBP)
R-HSA-5660489, MTF1 activates gene expression

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q14872

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Metal regulatory transcription factor 1
Alternative name(s):
MRE-binding transcription factor
Transcription factor MTF-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MTF1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:7428, MTF1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600172, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q14872

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000188786.9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		4520

Open Targets

More...OpenTargetsi		ENSG00000188786

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA31235

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q14872, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB09130, Copper
DB12965, Silver

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MTF1

Domain mapping of disease mutations (DMDM)

More...DMDMi		68052403

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000472202 – 753Metal regulatory transcription factor 1Add BLAST752

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylglycineBy similarity1
Modified residuei5PhosphoserineBy similarity1
Modified residuei305PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q14872

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q14872

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q14872

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q14872

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q14872

PeptideAtlas

More...PeptideAtlasi		Q14872

PRoteomics IDEntifications database

More...PRIDEi		Q14872

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		60214

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q14872

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q14872

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000188786, Expressed in mouth mucosa and 245 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q14872, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000188786, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110620, 115 interactors

Protein interaction database and analysis system

More...IntActi		Q14872, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000362127

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q14872, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q14872

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi133 – 138Nuclear localization signalSequence analysis6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi420 – 497Pro-richAdd BLAST78

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri140 – 164C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri170 – 194C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri200 – 224C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri229 – 253C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri259 – 283C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri289 – 313C2H2-type 6PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157291

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_026685_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q14872

Identification of Orthologs from Complete Genome Data

More...OMAi		EGCTKYF

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q14872

TreeFam database of animal gene trees

More...TreeFami		TF106493

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029796, Metal_TF1
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

The PANTHER Classification System

More...PANTHERi		PTHR19818:SF131, PTHR19818:SF131, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00096, zf-C2H2, 6 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00355, ZnF_C2H2, 6 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57667, SSF57667, 4 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 6 hits
PS50157, ZINC_FINGER_C2H2_2, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q14872-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGEHSPDNNI IYFEAEEDEL TPDDKMLRFV DKNGLVPSSS GTVYDRTTVL 
        60         70         80         90        100
IEQDPGTLED EDDDGQCGEH LPFLVGGEEG FHLIDHEAMS QGYVQHIISP 
       110        120        130        140        150
DQIHLTINPG STPMPRNIEG ATLTLQSECP ETKRKEVKRY QCTFEGCPRT 
       160        170        180        190        200
YSTAGNLRTH QKTHRGEYTF VCNQEGCGKA FLTSYSLRIH VRVHTKEKPF 
       210        220        230        240        250
ECDVQGCEKA FNTLYRLKAH QRLHTGKTFN CESEGCSKYF TTLSDLRKHI 
       260        270        280        290        300
RTHTGEKPFR CDHDGCGKAF AASHHLKTHV RTHTGERPFF CPSNGCEKTF 
       310        320        330        340        350
STQYSLKSHM KGHDNKGHSY NALPQHNGSE DTNHSLCLSD LSLLSTDSEL 
       360        370        380        390        400
RENSSTTQGQ DLSTISPAII FESMFQNSDD TAIQEDPQQT ASLTESFNGD 
       410        420        430        440        450
AESVSDVPPS TGNSASLSLP LVLQPGLSEP PQPLLPASAP SAPPPAPSLG 
       460        470        480        490        500
PGSQQAAFGN PPALLQPPEV PVPHSTQFAA NHQEFLPHPQ APQPIVPGLS 
       510        520        530        540        550
VVAGASASAA AVASAVAAPA PPQSTTEPLP AMVQTLPLGA NSVLTNNPTI 
       560        570        580        590        600
TITPTPNTAI LQSSLVMGEQ NLQWILNGAT SSPQNQEQIQ QASKVEKVFF 
       610        620        630        640        650
TTAVPVASSP GSSVQQIGLS VPVIIIKQEE ACQCQCACRD SAKERASSRR 
       660        670        680        690        700
KGCSSPPPPE PSPQAPDGPS LQLPAQTFSS APVPGSSSST LPSSCEQSRQ 
       710        720        730        740        750
AETPSDPQTE TLSAMDVSEF LSLQSLDTPS NLIPIEALLQ GEEEMGLTSS 

FSK
Length:753
Mass (Da):80,957
Last modified:June 21, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCC96518824170E98
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti185Y → H in CAA55363 (PubMed:8065932).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X78710 mRNA Translation: CAA55363.1
AK314233 mRNA Translation: BAG36903.1
AL929472 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07312.1
BC014454 mRNA Translation: AAH14454.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS30676.1

Protein sequence database of the Protein Information Resource

More...PIRi		S48059

NCBI Reference Sequences

More...RefSeqi		NP_005946.2, NM_005955.2
XP_011539793.1, XM_011541491.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000373036; ENSP00000362127; ENSG00000188786

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4520

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4520

UCSC genome browser

More...UCSCi		uc001cce.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78710 mRNA Translation: CAA55363.1
AK314233 mRNA Translation: BAG36903.1
AL929472 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07312.1
BC014454 mRNA Translation: AAH14454.1
CCDSiCCDS30676.1
PIRiS48059
RefSeqiNP_005946.2, NM_005955.2
XP_011539793.1, XM_011541491.2

3D structure databases

SMRiQ14872
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi110620, 115 interactors
IntActiQ14872, 1 interactor
STRINGi9606.ENSP00000362127

Chemistry databases

DrugBankiDB09130, Copper
DB12965, Silver

PTM databases

iPTMnetiQ14872
PhosphoSitePlusiQ14872

Genetic variation databases

BioMutaiMTF1
DMDMi68052403

Proteomic databases

EPDiQ14872
jPOSTiQ14872
MassIVEiQ14872
MaxQBiQ14872
PaxDbiQ14872
PeptideAtlasiQ14872
PRIDEiQ14872
ProteomicsDBi60214

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		17617, 214 antibodies

Genome annotation databases

EnsembliENST00000373036; ENSP00000362127; ENSG00000188786
GeneIDi4520
KEGGihsa:4520
UCSCiuc001cce.1, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4520
DisGeNETi4520

GeneCards: human genes, protein and diseases

More...GeneCardsi		MTF1
HGNCiHGNC:7428, MTF1
HPAiENSG00000188786, Low tissue specificity
MIMi600172, gene
neXtProtiNX_Q14872
OpenTargetsiENSG00000188786
PharmGKBiPA31235
VEuPathDBiHostDB:ENSG00000188786.9

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000157291
HOGENOMiCLU_026685_0_0_1
InParanoidiQ14872
OMAiEGCTKYF
OrthoDBi1318335at2759
PhylomeDBiQ14872
TreeFamiTF106493

Enzyme and pathway databases

PathwayCommonsiQ14872
ReactomeiR-HSA-1989781, PPARA activates gene expression
R-HSA-2426168, Activation of gene expression by SREBF (SREBP)
R-HSA-5660489, MTF1 activates gene expression
SIGNORiQ14872

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4520, 54 hits in 1022 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MTF1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		MTF1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4520
PharosiQ14872, Tbio

Protein Ontology

More...PROi		PR:Q14872
RNActiQ14872, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000188786, Expressed in mouth mucosa and 245 other tissues
GenevisibleiQ14872, HS

Family and domain databases

InterProiView protein in InterPro
IPR029796, Metal_TF1
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PANTHERiPTHR19818:SF131, PTHR19818:SF131, 1 hit
PfamiView protein in Pfam
PF00096, zf-C2H2, 6 hits
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 6 hits
SUPFAMiSSF57667, SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 6 hits
PS50157, ZINC_FINGER_C2H2_2, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMTF1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14872
Secondary accession number(s): B2RAK6, Q96CB1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 21, 2005
Last modified: April 7, 2021
This is version 167 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again